{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:45:31Z","timestamp":1781808331368,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"am","delay-in-days":288,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"US National Science Foundation","doi-asserted-by":"publisher","award":["CBET-1510674"],"award-info":[{"award-number":["CBET-1510674"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bob Allison Ataxia Research Center"},{"name":"Graduate School Doctoral Dissertation Fellowship"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.nbd.2018.05.003","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T19:15:36Z","timestamp":1526498136000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models"],"prefix":"10.1016","volume":"116","author":[{"given":"Chao J.","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orion","family":"Rainwater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Brent","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry T.","family":"Orr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taner","family":"Akkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2018.05.003_bb0005","doi-asserted-by":"crossref","first-page":"e0130133","DOI":"10.1371\/journal.pone.0130133","article-title":"In vivo high angular resolution diffusion-weighted imaging of mouse brain at 16.4\u202fTesla","volume":"10","author":"Alomair","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2018.05.003_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/srep43477","article-title":"Visualization of neuritic plaques in Alzheimer's disease by polarization-sensitive optical coherence microscopy","volume":"7","author":"Baumann","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2018.05.003_bb0015","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature22038","article-title":"Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice","volume":"544","author":"Becker","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2018.05.003_bb0020","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1364\/OL.22.000934","article-title":"Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography","volume":"22","author":"de Boer","year":"1997","journal-title":"Opt. Lett."},{"key":"10.1016\/j.nbd.2018.05.003_bb0025","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1364\/BOE.8.003248","article-title":"Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT [invited]","volume":"8","author":"de Boer","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.nbd.2018.05.003_bb0030","series-title":"Principles of Statistics","author":"Bulmer","year":"1979"},{"issue":"Pt 5","key":"10.1016\/j.nbd.2018.05.003_bb0035","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/brain\/119.5.1497","article-title":"Autosomal dominant cerebellar ataxia type I clinical features and MRI in families with SCA1, SCA2 and SCA3","volume":"119","author":"Burk","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2018.05.003_bb0040","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0092-8674(95)90273-2","article-title":"SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat","volume":"82","author":"Burright","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2018.05.003_bb0045","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1364\/OL.40.004911","article-title":"Noninvasive, in vivo imaging of subcortical mouse brain regions with 1.7 mum optical coherence tomography","volume":"40","author":"Chong","year":"2015","journal-title":"Opt. Lett."},{"key":"10.1016\/j.nbd.2018.05.003_bb0050","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1523\/JNEUROSCI.17-19-07385.1997","article-title":"Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations","volume":"17","author":"Clark","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2018.05.003_bb0055","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/00401706.1964.10490181","article-title":"Multiple comparisons using rank sums","volume":"6","author":"Dunn","year":"1964","journal-title":"Technometrics"},{"key":"10.1016\/j.nbd.2018.05.003_bb0060","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.neuron.2010.08.022","article-title":"SCA1-like disease in mice expressing wild-type Ataxin-1 with a serine to aspartic acid replacement at residue 776","volume":"67","author":"Duvick","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2018.05.003_bb0065","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1364\/BOE.6.001812","article-title":"Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography","volume":"6","author":"Eberle","year":"2015","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.nbd.2018.05.003_bb0070","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3010611","article-title":"Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography","volume":"7","author":"Kut","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2018.05.003_bb0075","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.4.1.011006","article-title":"Visualizing and mapping the cerebellum with serial optical coherence scanner","volume":"4","author":"Liu","year":"2016","journal-title":"Neurophotonics"},{"key":"10.1016\/j.nbd.2018.05.003_bb0080","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.21.7.070501","article-title":"Quantifying three-dimensional optic axis using polarization-sensitive optical coherence tomography","volume":"21","author":"Liu","year":"2016","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.nbd.2018.05.003_bb0085","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.1364\/BOE.7.005182","article-title":"Classification and analysis of human ovarian tissue using full field optical coherence tomography","volume":"7","author":"Nandy","year":"2016","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.nbd.2018.05.003_bb0090","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuroimage.2008.06.036","article-title":"Brain white matter damage in SCA1 and SCA2. An in vivo study using voxel-based morphometry, histogram analysis of mean diffusivity and tract-based spatial statistics","volume":"43","author":"Nave","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.nbd.2018.05.003_bb0095","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng0793-221","article-title":"Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1","volume":"4","author":"Orr","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2018.05.003_bb0100","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1523\/JNEUROSCI.5612-09.2010","article-title":"Noninvasive detection of presymptomatic and progressive neurodegeneration in a mouse model of spinocerebellar ataxia type 1","volume":"30","author":"Oz","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2018.05.003_bb0105","doi-asserted-by":"crossref","first-page":"25004","DOI":"10.1117\/1.NPh.1.2.025004","article-title":"Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography","volume":"1","author":"Rodriguez","year":"2014","journal-title":"Neurophotonics"},{"key":"10.1016\/j.nbd.2018.05.003_bb0110","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1365-2990.2012.01259.x","article-title":"Spinocerebellar ataxia type 1 (SCA1): new pathoanatomical and clinico-pathological insights","volume":"38","author":"R\u00fcb","year":"2012","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.nbd.2018.05.003_bb0115","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nature22044","article-title":"Antisense oligonucleotide therapy for spinocerebellar ataxia type 2","volume":"544","author":"Scoles","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2018.05.003_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-012-1000-x","article-title":"Brain pathology of spinocerebellar ataxias","volume":"124","author":"Seidel","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2018.05.003_bb0125","series-title":"GeneReviews\u00ae","author":"Subramony","year":"1998"},{"key":"10.1016\/j.nbd.2018.05.003_bb0130","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.neuroimage.2013.09.063","article-title":"Serial optical coherence scanner for large-scale brain imaging at microscopic resolution","volume":"84","author":"Wang","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.nbd.2018.05.003_bb0135","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.neuroimage.2014.06.032","article-title":"Cross-validation of serial optical coherence scanning and diffusion tensor imaging: a study on neural fiber maps in human medulla oblongata","volume":"100","author":"Wang","year":"2014","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.nbd.2018.05.003_bb0140","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/00031305.2014.917055","article-title":"Kurtosis as peakedness, 1905\u20132014. R.I.P.","volume":"68","author":"Westfall","year":"2014","journal-title":"Am. Stat."},{"key":"10.1016\/j.nbd.2018.05.003_bb0145","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/1043-4682(95)90012-8","article-title":"Spinocerebellar ataxia type 1","volume":"6","author":"Zoghbi","year":"1995","journal-title":"Semin. Cell Biol."},{"key":"10.1016\/j.nbd.2018.05.003_bb0150","doi-asserted-by":"crossref","first-page":"8853","DOI":"10.1523\/JNEUROSCI.2978-04.2004","article-title":"Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice","volume":"24","author":"Zu","year":"2004","journal-title":"J. Neurosci."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118301414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118301414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:11:22Z","timestamp":1760850682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996118301414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":30,"alternative-id":["S0969996118301414"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2018.05.003","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2018.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}