{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:50:50Z","timestamp":1789962650435,"version":"4.0.1"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"am","delay-in-days":276,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01 DA037830"],"award-info":[{"award-number":["P01 DA037830"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Temple University's Comprehensive NeuroAIDS Center","award":["P30 MH09217"],"award-info":[{"award-number":["P30 MH09217"]}]},{"name":"Temple University's Comprehensive NeuroAIDS Center","award":["P30 DA013429"],"award-info":[{"award-number":["P30 DA013429"]}]},{"name":"MacManus Foundation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.nbd.2018.05.017","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T13:25:26Z","timestamp":1527686726000},"page":"28-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production"],"prefix":"10.1016","volume":"117","author":[{"given":"Bianca","family":"Cotto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald F.","family":"Tuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Jane","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Langford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2018.05.017_bb0005","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.282.5387.298","article-title":"Transition from moderate to excessive drug intake: change in hedonic set point","volume":"282","author":"Ahmed","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.nbd.2018.05.017_bb0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2018.05.017_bb0015","doi-asserted-by":"crossref","first-page":"11435","DOI":"10.1073\/pnas.172091899","article-title":"CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli","volume":"99","author":"Barrot","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2018.05.017_bb0020","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fnint.2013.00106","article-title":"Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat","volume":"7","author":"Blanco-Calvo","year":"2014","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.nbd.2018.05.017_bb0025","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1017\/S1461145714000972","article-title":"Differential regulation of MeCP2 and PP1 in passive or voluntary administration of cocaine or food","volume":"17","author":"Bodetto","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.brainres.2009.11.002","article-title":"Molecular and genetic substrates linking stress and addiction","volume":"1314","author":"Briand","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2018.05.017_bb0035","doi-asserted-by":"crossref","first-page":"30967","DOI":"10.1074\/jbc.M112.382507","article-title":"Nuclear calcium signaling controls methyl-CpG-binding protein 2 (MeCP2) phosphorylation on serine 421 following synaptic activity","volume":"287","author":"Buchthal","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2018.05.017_bb0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1742-2094-9-43","article-title":"Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury","volume":"9","author":"Byrnes","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2018.05.017_bb0045","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tins.2005.06.005","article-title":"The many faces of CREB","volume":"28","author":"Carlezon","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2018.05.017_bb0050","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1124\/mol.106.022301","article-title":"Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain","volume":"70","author":"Cassel","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0055","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neubiorev.2016.03.030","article-title":"A place for the hippocampus in the cocaine addiction circuit: potential roles for adult hippocampal neurogenesis","volume":"66","author":"Castilla-Ortega","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nbd.2018.05.017_bb0060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","article-title":"The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression","volume":"49","author":"Chang","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2018.05.017_bb0065","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.nbd.2018.05.017_bb0070","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.neulet.2009.01.078","article-title":"Minocycline affects cocaine sensitization in mice","volume":"452","author":"Chen","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2018.05.017_bb0075","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11481-009-9164-4","article-title":"Heterogeneity of microglial activation in the innate immune response in the brain","volume":"4","author":"Colton","year":"2009","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0080","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s11481-013-9438-8","article-title":"Role of endoplasmic reticulum (ER) stress in cocaine-induced microglial cell death","volume":"8","author":"Costa","year":"2013","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0085","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.immuni.2015.03.013","article-title":"Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli","volume":"42","author":"Cronk","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2018.05.017_bb0090","series-title":"Trk Receptors in Neurotrophic Factors. Handbook of Experimental Pharmacology","author":"Deinhardt","year":"2014"},{"key":"10.1016\/j.nbd.2018.05.017_bb0095","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1471-4159.2007.04750.x","article-title":"Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons through TNF-alpha-mediated induction of Bax and phosphorylated c-Jun NH(2)-terminal kinase","volume":"103","author":"Dey","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2018.05.017_bb0100","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1006\/nbdi.2000.0318","article-title":"Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia\/macrophages after spinal cord injury","volume":"7","author":"Dougherty","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2018.05.017_bb0105","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1111\/j.1460-9568.2007.05473.x","article-title":"Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration","volume":"25","author":"Edwards","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2018.05.017_bb0110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neubiorev.2009.11.009","article-title":"Role of BDNF and GDNF in drug reward and relapse: a review","volume":"35","author":"Ghitza","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nbd.2018.05.017_bb0115","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1742-2094-10-16","article-title":"Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia","volume":"10","author":"Gomes","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2018.05.017_bb0120","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/15548627.2015.1052205","article-title":"Cocaine-mediated microglial activation involves the ER stress-autophagy axis","volume":"11","author":"Guo","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.nbd.2018.05.017_bb0125","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.expneurol.2007.11.017","article-title":"Increased MCP-1 and microglia in various regions of the human alcoholic brain","volume":"210","author":"He","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0130","first-page":"9","article-title":"Brain-derived neurotrophic factor: three ligands, many actions","volume":"126","author":"Hempstead","year":"2015","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"10.1016\/j.nbd.2018.05.017_bb0135","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.bbi.2008.07.008","article-title":"Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia","volume":"22","author":"Hutchinson","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2018.05.017_bb0140","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/nn.2615","article-title":"MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212","volume":"13","author":"Im","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2018.05.017_bb0145","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s11481-010-9236-5","article-title":"Neuronal PINCH is regulated by TNF-alpha and is required for neurite extension","volume":"6","author":"Jatiani","year":"2010","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0150","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fnmol.2012.00074","article-title":"Microglia and drug-induced plasticity in reward-related neuronal circuits","volume":"5","author":"Kovacs","year":"2012","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2018.05.017_bb0155","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.ajpath.2012.08.013","article-title":"Cocaine-induced loss of white matter proteins in the adult mouse nucleus accumbens is attenuated by administration of a beta-lactam antibiotic during cocaine withdrawal","volume":"181","author":"Kovalevich","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0160","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1471-4159.2012.07678.x","article-title":"Cocaine decreases expression of neurogranin via alterations in thyroid receptor\/retinoid X receptor signaling","volume":"121","author":"Kovalevich","year":"2012","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.nbd.2018.05.017_bb0165","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11481-014-9573-x","article-title":"Cocaine induces nuclear export and degradation of neuronal retinoid X receptor-\u03b3 via a TNF-\u03b1\/JNK- mediated mechanism","volume":"10","author":"Kovalevich","year":"2015","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0170","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuron.2005.09.023","article-title":"Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum","volume":"48","author":"Kumar","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2018.05.017_bb0175","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1371\/journal.pmed.0050117","article-title":"A mechanism for the inhibition of neural progenitor cell proliferation by cocaine","volume":"5","author":"Lee","year":"2008","journal-title":"PLoS Med."},{"key":"10.1016\/j.nbd.2018.05.017_bb0180","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/ADM.0b013e318199d863","article-title":"Gene expression profiling reveals distinct cocaine-responsive genes in human fetal CNS cell types","volume":"3","author":"Lee","year":"2009","journal-title":"J. Addict. Med."},{"key":"10.1016\/j.nbd.2018.05.017_bb0185","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbr.2014.11.018","article-title":"Multiple faces of BDNF in cocaine addiction","volume":"279","author":"Li","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2018.05.017_bb0190","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.devcel.2012.10.027","article-title":"Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo","volume":"23","author":"Li","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.nbd.2018.05.017_bb0195","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.psychres.2008.10.034","article-title":"Decreased brain dopamine cell numbers in human cocaine users","volume":"168","author":"Little","year":"2009","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.nbd.2018.05.017_bb0200","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuint.2011.04.013","article-title":"Cocaine increases phosphorylation of MeCP2 in the rat striatum in vivo: a differential role of NMDA receptors","volume":"59","author":"Mao","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2018.05.017_bb0205","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.brainres.2009.08.078","article-title":"Brain-derived neurotrophic factor and cocaine addiction","volume":"1314","author":"McGinty","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2018.05.017_bb0210","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuint.2006.08.018","article-title":"Phosphorylation of methyl-CpG binding protein 2 (MeCP2) regulates the intracellular localization during neuronal cell differentiation","volume":"50","author":"Miyake","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2018.05.017_bb0215","doi-asserted-by":"crossref","first-page":"18549","DOI":"10.1074\/jbc.M114.555334","article-title":"Brain-derived neurotrophic factor (BDNF) induces sustained intracellular Ca2+ elevation through the up-regulation of surface transient receptor potential 3 (TRPC3) channels in rodent microglia","volume":"289","author":"Mizoguchi","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2018.05.017_bb0220","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2018.05.017_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058232","article-title":"PINCH in the cellular stress response to tau-hyperphosphorylation","volume":"8","author":"Ozdemir","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2018.05.017_bb0230","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2018.05.017_bb0235","doi-asserted-by":"crossref","first-page":"E197","DOI":"10.1073\/pnas.1111098109","article-title":"Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission","volume":"109","author":"Pascual","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2018.05.017_bb0240","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2013"},{"issue":"4","key":"10.1016\/j.nbd.2018.05.017_bb0245","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1007\/s12035-017-0584-5","article-title":"Cocaine-mediated downregulation of miR-124 activates microglia by targeting KLF4 and TLR4 signaling","volume":"55","author":"Periyasamy","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0250","series-title":"ImageJ","author":"Rasband","year":"1997"},{"key":"10.1016\/j.nbd.2018.05.017_bb0255","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1523\/JNEUROSCI.5100-09.2010","article-title":"Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth","volume":"30","author":"Rauskolb","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2018.05.017_bb0260","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.neuron.2007.09.032","article-title":"Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli","volume":"56","author":"Renthal","year":"2007","journal-title":"Neuron"},{"issue":"Suppl 1","key":"10.1016\/j.nbd.2018.05.017_bb0265","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuropharm.2004.06.025","article-title":"Structural plasticity associated with exposure to drugs of abuse","volume":"47","author":"Robinson","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2018.05.017_bb0270","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s12031-014-0487-0","article-title":"Differential expression and regulation of brain-derived neurotrophic factor (BDNF) mRNA isoforms in brain cells from Mecp2(308\/y) mouse model","volume":"56","author":"Rousseaud","year":"2015","journal-title":"J. Mol. Neurosci."},{"issue":"Suppl 1","key":"10.1016\/j.nbd.2018.05.017_bb0275","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuropharm.2008.06.059","article-title":"Neurotrophic factors and structural plasticity in addiction","volume":"56","author":"Russo","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2018.05.017_bb0280","doi-asserted-by":"crossref","first-page":"11735","DOI":"10.1523\/JNEUROSCI.2328-10.2010","article-title":"Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine","volume":"30","author":"Sadri-Vakili","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2018.05.017_bb0285","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.stem.2010.08.014","article-title":"Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis","volume":"7","author":"Sierra","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.nbd.2018.05.017_bb0290","doi-asserted-by":"crossref","first-page":"12877","DOI":"10.1523\/JNEUROSCI.2674-14.2014","article-title":"Cell-type-specific repression by methyl-CpG-binding protein 2 is biased toward long genes","volume":"34","author":"Sugino","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2018.05.017_bb0295","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1017\/S1740925X12000087","article-title":"Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain","volume":"7","author":"Trang","year":"2011","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000527","article-title":"Microglial interactions with synapses are modulated by visual experience","volume":"8","author":"Tremblay","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0305","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1086\/444549","article-title":"Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males","volume":"77","author":"Van Esch","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2018.05.017_bb0310","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0091-3057(03)00087-X","article-title":"Beta-funaltrexamine affects cocaine self-administration in rats responding on a progressive ratio schedule of reinforcement","volume":"75","author":"Ward","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nbd.2018.05.017_bb0315","first-page":"164","article-title":"Cocaine and human immunodeficiency virus type 1 gp120 mediate neurotoxicity through overlapping signaling pathways","volume":"15","author":"Yao","year":"2009","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0320","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3844\/ajidsp.2009.26.30","article-title":"Cocaine exposure results in formation of dendritic varicosity in rat primary hippocampal neurons","volume":"5","author":"Yao","year":"2009","journal-title":"Am. J. Infect. Dis."},{"key":"10.1016\/j.nbd.2018.05.017_bb0325","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1159\/000363036","article-title":"Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation","volume":"34","author":"Zhang","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.nbd.2018.05.017_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002610","article-title":"Modeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abuse","volume":"8","author":"Zheng","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.nbd.2018.05.017_bb0335","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuron.2006.09.037","article-title":"Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation","volume":"52","author":"Zhou","year":"2006","journal-title":"Neuron"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118301554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118301554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:11:03Z","timestamp":1760850663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996118301554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":67,"alternative-id":["S0969996118301554"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2018.05.017","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2018.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}