{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:45:26Z","timestamp":1790167526188,"version":"4.1.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Norton Healthcare","award":["NS045734"],"award-info":[{"award-number":["NS045734"]}]},{"name":"Norton Healthcare","award":["GM10350"],"award-info":[{"award-number":["GM10350"]}]},{"name":"Commonwealth of Kentucky Research Challenge for Excellence Trust Fund","award":["U01 AA022618"],"award-info":[{"award-number":["U01 AA022618"]}]},{"name":"Commonwealth of Kentucky Research Challenge for Excellence Trust Fund","award":["R21 AA022189"],"award-info":[{"award-number":["R21 AA022189"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.nbd.2018.12.008","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T14:30:47Z","timestamp":1544797847000},"page":"353-363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"special_numbering":"C","title":["Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-7200","authenticated-orcid":false,"given":"Scott A.","family":"Myers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Gobejishvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Saraswat Ohri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garrett Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kariena R.","family":"Andres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amberly S.","family":"Riegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0660-4572","authenticated-orcid":false,"given":"Hridgandh","family":"Donde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Joshi-Barve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirish","family":"Barve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Whittemore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2018.12.008_bb0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/sj.sc.3101119","article-title":"Bowel dysfunction following spinal cord injury","volume":"39","author":"Lynch","year":"2001","journal-title":"Spinal Cord"},{"key":"10.1016\/j.nbd.2018.12.008_bb0010","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1084\/jem.20151345","article-title":"Gut dysbiosis impairs recovery after spinal cord injury","volume":"213","author":"Kigerl","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2018.12.008_bb0015","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pmr.2007.03.004","article-title":"Obesity after spinal cord injury","volume":"18","author":"Gater","year":"2007","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2018.12.008_bb0020","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1080\/10790268.2007.11754591","article-title":"Metabolic syndrome in adolescents with spinal cord dysfunction","volume":"30","author":"Nelson","year":"2007","journal-title":"J. Spinal Cord Med."},{"key":"10.1016\/j.nbd.2018.12.008_bb0025","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.gendis.2014.08.001","article-title":"Exploring gut microbes in human health and disease: pushing the envelope","volume":"1","author":"Sun","year":"2014","journal-title":"Genes Dis."},{"key":"10.1016\/j.nbd.2018.12.008_bb0030","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.3390\/nu6125786","article-title":"Dysbiotic events in gut microbiota: impact on human health","volume":"6","author":"Schippa","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.nbd.2018.12.008_bb0035","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/cei.12474","article-title":"Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota","volume":"179","author":"Peterson","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0040","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1177\/1352458514541579","article-title":"Digesting the emerging role for the gut microbiome in central nervous system demyelination","volume":"20","author":"Joscelyn","year":"2014","journal-title":"Mult. Scler."},{"key":"10.1016\/j.nbd.2018.12.008_bb0045","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/01.BRS.0000107234.74249.CD","article-title":"Study of bacterial translocation from gut after paraplegia caused by spinal cord injury in rats","volume":"29","author":"Liu","year":"2004","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.nbd.2018.12.008_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.aambs.2015.02.001","article-title":"Microbiota regulation of the Mammalian gut-brain axis","volume":"91","author":"Burokas","year":"2015","journal-title":"Adv. Appl. Microbiol."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2018.12.008_bb0055","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/nutrit\/nuv019","article-title":"Microbiota and the gut-brain axis","volume":"73","author":"Bienenstock","year":"2015","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.nbd.2018.12.008_bb0060","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1172\/JCI76304","article-title":"Gut\/brain axis and the microbiota","volume":"125","author":"Mayer","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2018.12.008_bb0065","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuroscience.2016.03.013","article-title":"The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder","volume":"324","author":"Li","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2018.12.008_bb0070","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrneurol.2015.197","article-title":"Pathogenesis of Parkinson disease--the gut-brain axis and environmental factors","volume":"11","author":"Klingelhoefer","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0075","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.3748\/wjg.v21.i37.10609","article-title":"Brain-gut-microbiota axis in Parkinson's disease","volume":"21","author":"Mulak","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pnpbp.2014.08.018","article-title":"Schizophrenia and the gut-brain axis","volume":"56","author":"Nemani","year":"2015","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2018.12.008_bb0085","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1002\/glia.22401","article-title":"Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury","volume":"60","author":"Ghosh","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2018.12.008_bb0090","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1146\/annurev.pa.35.040195.003255","article-title":"Macrophages and inflammatory mediators in tissue injury","volume":"35","author":"Laskin","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0095","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1002\/glia.22986","article-title":"PDE4B as a microglia target to reduce neuroinflammation","volume":"64","author":"Pearse","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2018.12.008_bb0100","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pharmthera.2005.07.003","article-title":"Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents","volume":"109","author":"Lugnier","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.nbd.2018.12.008_bb0105","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/bjp.2008.307","article-title":"PDE4 inhibitors: current status","volume":"155","author":"Spina","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tibs.2009.09.007","article-title":"Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown","volume":"35","author":"Houslay","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.nbd.2018.12.008_bb0115","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1073\/pnas.122041599","article-title":"Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses","volume":"99","author":"Jin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2018.12.008_bb0120","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.4049\/jimmunol.175.3.1523","article-title":"Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages","volume":"175","author":"Jin","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0125","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/sj.bjp.0701502","article-title":"Lipopolysaccharide induces expression of tumour necrosis factor alpha in rat brain: inhibition by methylprednisolone and by rolipram","volume":"122","author":"Buttini","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0130","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0028-3908(01)00174-5","article-title":"Suppressive effects of phosphodiesterase type IV inhibitors on rat cultured microglial cells: comparison with other types of cAMP-elevating agents","volume":"42","author":"Zhang","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2018.12.008_bb0135","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1523\/JNEUROSCI.3567-08.2009","article-title":"Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation","volume":"29","author":"D'Mello","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2018.12.008_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018633","article-title":"Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells","volume":"6","author":"Kiebala","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2018.12.008_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043634","article-title":"The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury","volume":"7","author":"Schaal","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2018.12.008_bb0150","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neurobiolaging.2005.03.024","article-title":"The cAMP-specific phosphodiesterase 4B mediates Abeta-induced microglial activation","volume":"27","author":"Sebastiani","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2018.12.008_bb0155","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.expneurol.2009.01.005","article-title":"Acute rolipram\/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury","volume":"216","author":"Koopmans","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0160","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neulet.2008.03.087","article-title":"Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury","volume":"438","author":"Whitaker","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2018.12.008_bb0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.expneurol.2010.03.010","article-title":"A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI","volume":"230","author":"Iannotti","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0170","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbr.2012.12.056","article-title":"Rolipram promotes functional recovery after contusive thoracic spinal cord injury in rats","volume":"243","author":"Costa","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2018.12.008_bb0175","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.neuroscience.2009.07.039","article-title":"Effects of rolipram on adult rat oligodendrocytes and functional recovery after contusive cervical spinal cord injury","volume":"163","author":"Beaumont","year":"2009","journal-title":"Neuroscience"},{"issue":"D1","key":"10.1016\/j.nbd.2018.12.008_bb0180","doi-asserted-by":"crossref","first-page":"D723","DOI":"10.1093\/nar\/gkw1040","article-title":"Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse","volume":"45","author":"Blake","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2018.12.008_bb0185","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/cne.21570","article-title":"Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse","volume":"507","author":"Benton","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0190","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/cne.21902","article-title":"ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice","volume":"512","author":"Mahoney","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0195","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/08977150360547099","article-title":"Experimental modeling of spinal cord injury: characterization of a force-defined injury device","volume":"20","author":"Scheff","year":"2003","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.nbd.2018.12.008_bb0200","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.nbd.2018.12.008_bb0205","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1089\/neu.2009.0914","article-title":"Gait analysis in normal and spinal contused mice using the TreadScan system","volume":"26","author":"Beare","year":"2009","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.nbd.2018.12.008_bb0210","series-title":"Animal Models of Acute Neurological Injuries","article-title":"Automated gait analysis following spinal cord injury","author":"Beare","year":"2011"},{"key":"10.1016\/j.nbd.2018.12.008_bb0215","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1124\/jpet.110.174268","article-title":"S-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP\/protein kinase A pathway","volume":"337","author":"Gobejishvili","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2018.12.008_bb0220","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1089\/neu.2005.22.529","article-title":"Functional consequences of lumbar spinal cord contusion injuries in the adult rat","volume":"22","author":"Magnuson","year":"2005","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.nbd.2018.12.008_bb0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.nbd.2010.12.010","article-title":"CD47 knockout mice exhibit improved recovery from spinal cord injury","volume":"42","author":"Myers","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2018.12.008_bb0230","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/jnr.10759","article-title":"Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing","volume":"74","author":"Whetstone","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2018.12.008_bb0235","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.expneurol.2010.12.002","article-title":"Activating Notch signaling post-SCI modulates angiogenesis in penumbral vascular beds but does not improve hindlimb locomotor recovery","volume":"227","author":"Fassbender","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0240","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jneumeth.2009.04.010","article-title":"An efficient and reproducible method for quantifying macrophages in different experimental models of central nervous system pathology","volume":"181","author":"Donnelly","year":"2009","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2018.12.008_bb0245","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1096\/fj.12-220806","article-title":"The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters","volume":"27","author":"Aagaard","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2018.12.008_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001377","article-title":"The Human Microbiome Project: a community resource for the healthy human microbiome","volume":"10","author":"Gevers","year":"2012","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0255","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ismej.2012.8","article-title":"Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms","volume":"6","author":"Caporaso","year":"2012","journal-title":"ISME J."},{"key":"10.1016\/j.nbd.2018.12.008_bb0260","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2018.12.008_bb0265","series-title":"Java Applets for Power and Sample size [Computer software]","author":"Lenth","year":"2006"},{"key":"10.1016\/j.nbd.2018.12.008_bb0270","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2016.048","article-title":"Analysis of longitudinal data from animals with missing values using SPSS","volume":"11","author":"Duricki","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2018.12.008_bb0275","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.expneurol.2007.08.011","article-title":"Modulation of the cAMP signaling pathway after traumatic brain injury","volume":"208","author":"Atkins","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0280","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nm1056","article-title":"cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury","volume":"10","author":"Pearse","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2018.12.008_bb0285","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/INF.0b013e31824da0f5","article-title":"Increased gut microbial translocation in HIV-infected children persists in virologic responders and virologic failures after antiretroviral therapy","volume":"31","author":"Pilakka-Kanthikeel","year":"2012","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.nbd.2018.12.008_bb0290","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.neuropharm.2017.08.011","article-title":"Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation","volume":"125","author":"Avila","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2018.12.008_bb0295","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/ibd.21402","article-title":"Serum lipopolysaccharide-binding protein and soluble CD14 are markers of disease activity in patients with Crohn's disease","volume":"17","author":"Lakatos","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.nbd.2018.12.008_bb0300","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1089\/neu.2013.3115","article-title":"Gait analysis at multiple speeds reveals differential functional and structural outcomes in response to graded spinal cord injury","volume":"31","author":"Krizsan-Agbas","year":"2014","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.nbd.2018.12.008_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145878","article-title":"Intestinal microbiota in patients with spinal cord injury","volume":"11","author":"Gungor","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2018.12.008_bb0310","first-page":"26191","article-title":"Dysbiosis of the gut microbiota in disease","volume":"26","author":"Carding","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.nbd.2018.12.008_bb0315","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s12013-014-9842-6","article-title":"Bowel dysfunction in spinal cord injury: current perspectives","volume":"69","author":"Pan","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.nbd.2018.12.008_bb0320","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000443353","article-title":"Helicobacter pylori and other gastric microbiota in gastroduodenal pathologies","volume":"34","author":"Schulz","year":"2016","journal-title":"Dig. Dis."},{"key":"10.1016\/j.nbd.2018.12.008_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053028","article-title":"Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment","volume":"8","author":"Bull-Otterson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2018.12.008_bb0330","doi-asserted-by":"crossref","first-page":"G966","DOI":"10.1152\/ajpgi.00380.2011","article-title":"Colonic microbiome is altered in alcoholism","volume":"302","author":"Mutlu","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0335","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1160\/TH04-12-0831","article-title":"Opposite relationship between circulating soluble CD14 concentration and endothelial function in diabetic and nondiabetic subjects","volume":"94","author":"Fernandez-Real","year":"2005","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.nbd.2018.12.008_bb0340","doi-asserted-by":"crossref","first-page":"G718","DOI":"10.1152\/ajpgi.90232.2008","article-title":"Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease","volume":"295","author":"Gobejishvili","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0345","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-3-540-68964-5_5","article-title":"Phosphodiesterases in the central nervous system","author":"Kleppisch","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0350","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/ana.20953","article-title":"Delayed Nogo receptor therapy improves recovery from spinal cord contusion","volume":"60","author":"Wang","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0355","series-title":"Psychopharmacology: The Third Generation of Progress","first-page":"545","article-title":"Monoamine oxidase inhibitors as antidepressants","author":"Murphy DLA","year":"1987"},{"key":"10.1016\/j.nbd.2018.12.008_bb0360","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0896-6273(02)01045-0","article-title":"The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease","volume":"36","author":"Southwood","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2018.12.008_bb0365","first-page":"278","article-title":"Diffusion tensor tractography-based group mapping of the pyramidal tract in relapsing-remitting multiple sclerosis patients","volume":"28","author":"Lin","year":"2007","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0370","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.neuron.2007.12.021","article-title":"Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice","volume":"57","author":"Pennuto","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2018.12.008_bb0375","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/glia.21191","article-title":"Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury","volume":"59","author":"Ohri","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2018.12.008_bb0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms19113528","article-title":"The two-faced cytokine IL-6 in host defense and diseases","volume":"19","author":"Narazaki","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2018.12.008_bb0385","series-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","first-page":"878","volume":"1813","author":"Scheller","year":"2011"},{"key":"10.1016\/j.nbd.2018.12.008_bb0390","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.nbd.2013.04.021","article-title":"Restoring endoplasmic reticulum homeostasis improves functional recovery after spinal cord injury","volume":"58","author":"Ohri","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2018.12.008_bb0395","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/ncomms2674","article-title":"Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD","volume":"4","author":"Komatsu","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2018.12.008_bb0400","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s13311-014-0309-7","article-title":"Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease","volume":"12","author":"Gurney","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2018.12.008_bb0405","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S1359-6446(05)03622-6","article-title":"Keynote review: phosphodiesterase-4 as a therapeutic target","volume":"10","author":"Houslay","year":"2005","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.nbd.2018.12.008_bb0410","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1002\/jnr.22440","article-title":"Combination of olfactory ensheathing cells with local versus systemic cAMP treatment after a cervical rubrospinal tract injury","volume":"88","author":"Bretzner","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2018.12.008_bb0415","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/bph.12308","article-title":"Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis","volume":"170","author":"Gonzalez-Garcia","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0420","first-page":"7428","article-title":"Microbiota dysbiosis controls the neuroinflammatory response after stroke","volume":"36","author":"Singh","year":"2016","journal-title":"Neuro Dis."},{"key":"10.1016\/j.nbd.2018.12.008_bb0425","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1016\/j.ajpath.2011.08.039","article-title":"Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury","volume":"179","author":"Wang","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0430","doi-asserted-by":"crossref","first-page":"1468S","DOI":"10.3945\/jn.116.240754","article-title":"Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes","volume":"147","author":"Wen","year":"2017","journal-title":"J. Nutr."},{"issue":"4","key":"10.1016\/j.nbd.2018.12.008_bb0435","first-page":"373","article-title":"Gut microbiota and inflammatory bowel disease: an update","volume":"63","author":"Holleran","year":"2017","journal-title":"Minerva Gastroenterol. Dietol."},{"key":"10.1016\/j.nbd.2018.12.008_bb0440","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.3892\/mmr.2015.4713","article-title":"Intrathecal injection of phosphodiesterase 4B-specific siRNA attenuates neuropathic pain in rats with L5 spinal nerve ligation","volume":"13","author":"Ji","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.nbd.2018.12.008_bb0445","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/npp.2015.240","article-title":"Specific inhibition of phosphodiesterase-4B results in anxiolysis and facilitates memory acquisition","volume":"41","author":"McGirr","year":"2016","journal-title":"Neuropsychopharmacology"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118306314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118306314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T06:40:23Z","timestamp":1720852823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996118306314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":89,"alternative-id":["S0969996118306314"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2018.12.008","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2018.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}