{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:26:02Z","timestamp":1779215162308,"version":"3.51.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"am","delay-in-days":276,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"United States Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-15-1-0545"],"award-info":[{"award-number":["W81XWH-15-1-0545"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"United States National Institute of Health Grants","award":["F31 NS103363"],"award-info":[{"award-number":["F31 NS103363"]}]},{"name":"United States National Institute of Health Grants","award":["T32 GM008602"],"award-info":[{"award-number":["T32 GM008602"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.nbd.2019.01.012","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T04:36:48Z","timestamp":1548823008000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia"],"prefix":"10.1016","volume":"125","author":[{"given":"Anthony M.","family":"Downs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueliang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Donsante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.A.","family":"Jinnah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen J.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.nbd.2019.01.012_bb0005","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/mds.25475","article-title":"Phenomenology and classification of dystonia: a consensus update","volume":"28","author":"Albanese","year":"2013","journal-title":"Mov. Disord."},{"issue":"4","key":"10.1016\/j.nbd.2019.01.012_bb0010","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/cne.1186","article-title":"Muscarinic m1 and m2 receptor proteins in local circuit and projection neurons of the primate striatum: anatomical evidence for cholinergic modulation of glutamatergic prefronto-striatal pathways","volume":"434","author":"Alcantara","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2019.01.012_bb0015","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14155","article-title":"DYT1 dystonia increases risk taking in humans","volume":"5","author":"Arkadir","year":"2016","journal-title":"elife"},{"issue":"2","key":"10.1016\/j.nbd.2019.01.012_bb0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1212\/01.WNL.0000149764.34953.BF","article-title":"Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation","volume":"64","author":"Asanuma","year":"2005","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.nbd.2019.01.012_bb0025","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1212\/WNL.59.3.445","article-title":"Dopamine transmission in DYT1 dystonia: a biochemical and autoradiographical study","volume":"59","author":"Augood","year":"2002","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.nbd.2019.01.012_bb0030","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1471-4159.2007.04590.x","article-title":"Dopamine release is impaired in a mouse model of DYT1 dystonia","volume":"102","author":"Balcioglu","year":"2007","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.nbd.2019.01.012_bb0035","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0306-4522(84)90165-9","article-title":"Characterization of cholinergic neurons in the rat neostriatum. A combination of choline acetyltransferase immunocytochemistry, Golgi-impregnation and electron microscopy","volume":"12","author":"Bolam","year":"1984","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.nbd.2019.01.012_bb0040","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0022-3565(25)11335-9","article-title":"Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells","volume":"260","author":"Bolden","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"24","key":"10.1016\/j.nbd.2019.01.012_bb0045","doi-asserted-by":"crossref","first-page":"6258","DOI":"10.1523\/JNEUROSCI.1678-08.2008","article-title":"Loss of muscarinic autoreceptor function impairs long-term depression but not long-term potentiation in the striatum","volume":"28","author":"Bonsi","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.012_bb0050","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fnana.2011.00006","article-title":"Centrality of striatal cholinergic transmission in Basal Ganglia function","volume":"5","author":"Bonsi","year":"2011","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.nbd.2019.01.012_bb0055","doi-asserted-by":"crossref","first-page":"e9283","DOI":"10.15252\/emmm.201809283","article-title":"RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models","volume":"11","author":"Bonsi","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2019.01.012_bb0060","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuroscience.2015.03.040","article-title":"Evidence for a role for alpha6(*) nAChRs in l-dopa-induced dyskinesias using Parkinsonian alpha6(*) nAChR gain-of-function mice","volume":"295","author":"Bordia","year":"2015","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.nbd.2019.01.012_bb0065","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0397-17.2018","article-title":"Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors","volume":"5","author":"Brimblecombe","year":"2018","journal-title":"eNeuro"},{"issue":"2","key":"10.1016\/j.nbd.2019.01.012_bb0070","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1212\/WNL.36.2.160","article-title":"Torsion dystonia: a double-blind, prospective trial of high-dosage trihexyphenidyl","volume":"36","author":"Burke","year":"1986","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.nbd.2019.01.012_bb0075","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nn.4335","article-title":"Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits","volume":"19","author":"Dautan","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2019.01.012_bb0080","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0022-3565(25)23208-6","article-title":"Antagonist binding profiles of five cloned human muscarinic receptor subtypes","volume":"256","author":"Dorje","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2019.01.012_bb0085","first-page":"S283","article-title":"Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission","volume":"153","author":"Exley","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.nbd.2019.01.012_bb0090","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1038\/sj.npp.1301617","article-title":"Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens","volume":"33","author":"Exley","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2019.01.012_bb0095","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1038\/ncomms6316","article-title":"Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia","volume":"5","author":"Fieblinger","year":"2014","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.nbd.2019.01.012_bb0100","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.neuron.2016.08.017","article-title":"Antipsychotic-like effects of M4 positive allosteric modulators are mediated by CB2 receptor-dependent inhibition of dopamine release","volume":"91","author":"Foster","year":"2016","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.nbd.2019.01.012_bb0105","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1212\/WNL.54.5.1193","article-title":"Striatal dopamine in early-onset primary torsion dystonia with the DYT1 mutation","volume":"54","author":"Furukawa","year":"2000","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.nbd.2019.01.012_bb0110","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1002\/cne.23295","article-title":"GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons in the primate putamen","volume":"521","author":"Gonzales","year":"2013","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.nbd.2019.01.012_bb0115","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.neuron.2005.11.010","article-title":"Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope","volume":"48","author":"Goodchild","year":"2005","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.nbd.2019.01.012_bb0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00004714-200002000-00013","article-title":"Comparison of central and peripheral pharmacologic effects of biperiden and trihexyphenidyl in human volunteers","volume":"20","author":"Guthrie","year":"2000","journal-title":"J. Clin. Psychopharmacol."},{"issue":"5","key":"10.1016\/j.nbd.2019.01.012_bb0125","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1046\/j.1471-4159.1996.67051953.x","article-title":"Multiple determinants of dihydro-beta-erythroidine sensitivity on rat neuronal nicotinic receptor alpha subunits","volume":"67","author":"Harvey","year":"1996","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.nbd.2019.01.012_bb0130","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1471-4159.2010.06590.x","article-title":"Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivo","volume":"113","author":"Hewett","year":"2010","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.nbd.2019.01.012_bb0135","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/nn.4332","article-title":"The mouse cortico-striatal projectome","volume":"19","author":"Hintiryan","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.012_bb0140","first-page":"195","article-title":"Molecular genetics of DOPA-responsive dystonia","volume":"80","author":"Ichinose","year":"1999","journal-title":"Adv. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2019.01.012_bb0145","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/mds.870040302","article-title":"Treatment of movement disorders with trihexyphenidyl","volume":"4","author":"Jabbari","year":"1989","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2019.01.012_bb0150","series-title":"Dystonic Disorders. Parkinson's Disease and Movement Disorders. J. J. T. E","first-page":"513","author":"Jankovic","year":"1998"},{"issue":"3 Pt 1","key":"10.1016\/j.nbd.2019.01.012_bb0155","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1523\/JNEUROSCI.14-03-01164.1994","article-title":"Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease","volume":"14","author":"Jinnah","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.012_bb0160","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1093\/cercor\/bhw252","article-title":"Cortical control of striatal dopamine transmission via striatal cholinergic interneurons","volume":"26","author":"Kosillo","year":"2016","journal-title":"Cereb Cortex"},{"issue":"8407","key":"10.1016\/j.nbd.2019.01.012_bb0165","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0140-6736(84)90908-5","article-title":"Hemidystonia relieved by nicotine","volume":"2","author":"Lees","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2019.01.012_bb0170","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.nbd.2015.01.003","article-title":"Enhanced histamine H2 excitation of striatal cholinergic interneurons in L-DOPA-induced dyskinesia","volume":"76","author":"Lim","year":"2015","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.nbd.2019.01.012_bb0175","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.nbd.2019.01.012_bb0180","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ejpn.2016.02.003","article-title":"Medication use in childhood dystonia","volume":"20","author":"Lumsden","year":"2016","journal-title":"Eur. J. Paediatr. Neurol."},{"issue":"13","key":"10.1016\/j.nbd.2019.01.012_bb0185","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/mds.26009","article-title":"Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: role of M1 muscarinic receptors","volume":"29","author":"Maltese","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2019.01.012_bb0190","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.33331","article-title":"Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum","volume":"7","author":"Maltese","year":"2018","journal-title":"elife"},{"issue":"Pt 9","key":"10.1016\/j.nbd.2019.01.012_bb0195","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/brain\/awp194","article-title":"Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine","volume":"132","author":"Martella","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2019.01.012_bb0200","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.nbd.2014.01.016","article-title":"Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia","volume":"65","author":"Martella","year":"2014","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.nbd.2019.01.012_bb0205","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng0997-40","article-title":"The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein","volume":"17","author":"Ozelius","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2019.01.012_bb0210","first-page":"93","article-title":"The gene (DYT1) for early-onset torsion dystonia encodes a novel protein related to the Clp protease\/heat shock family","volume":"78","author":"Ozelius","year":"1998","journal-title":"Adv. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2019.01.012_bb0215","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.nbd.2010.04.016","article-title":"Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice","volume":"39","author":"Page","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"6","key":"10.1016\/j.nbd.2019.01.012_bb0220","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nn1244","article-title":"Nicotine amplifies reward-related dopamine signals in striatum","volume":"7","author":"Rice","year":"2004","journal-title":"Nat. Neurosci."},{"issue":"Pt 10","key":"10.1016\/j.nbd.2019.01.012_bb0225","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1093\/brain\/awv212","article-title":"A new knock-in mouse model of l-DOPA-responsive dystonia","volume":"138","author":"Rose","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2019.01.012_bb0230","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.expneurol.2017.06.005","article-title":"Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia","volume":"295","author":"Scarduzio","year":"2017","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2019.01.012_bb0235","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ncl.2009.04.010","article-title":"Genetics and treatment of dystonia","volume":"27","author":"Schwarz","year":"2009","journal-title":"Neurol. Clin."},{"issue":"1","key":"10.1016\/j.nbd.2019.01.012_bb0240","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/hmg\/ddi012","article-title":"Transgenic mouse model of early-onset DYT1 dystonia","volume":"14","author":"Shashidharan","year":"2005","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.nbd.2019.01.012_bb0245","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF02252661","article-title":"Effects of trihexyphenidyl and L-dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography","volume":"7","author":"Shinotoh","year":"1994","journal-title":"J. Neural Transm. Park. Dis. Dement. Sect."},{"issue":"1","key":"10.1016\/j.nbd.2019.01.012_bb0250","first-page":"435","article-title":"Dopamine D3 receptor modulates l-DOPA-induced dyskinesia by targeting D1 receptor-mediated striatal signaling","volume":"27","author":"Solis","year":"2017","journal-title":"Cereb. Cortex"},{"issue":"1","key":"10.1016\/j.nbd.2019.01.012_bb0255","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nbd.2012.05.009","article-title":"Functional analysis of dopaminergic systems in a DYT1 knock-in mouse model of dystonia","volume":"48","author":"Song","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.nbd.2019.01.012_bb0260","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.brainresrev.2007.10.008","article-title":"Feedforward and feedback inhibition in neostriatal GABAergic spiny neurons","volume":"58","author":"Tepper","year":"2008","journal-title":"Brain Res. Rev."},{"issue":"1","key":"10.1016\/j.nbd.2019.01.012_bb0265","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s13311-013-0231-4","article-title":"Treatment of dystonia","volume":"11","author":"Thenganatt","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2019.01.012_bb0270","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fnsys.2011.00011","article-title":"Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons","volume":"5","author":"Threlfell","year":"2011","journal-title":"Front. Syst. Neurosci."},{"issue":"9","key":"10.1016\/j.nbd.2019.01.012_bb0275","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1523\/JNEUROSCI.5620-09.2010","article-title":"Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum","volume":"30","author":"Threlfell","year":"2010","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2019.01.012_bb0280","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2012.04.038","article-title":"Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons","volume":"75","author":"Threlfell","year":"2012","journal-title":"Neuron"},{"issue":"9077","key":"10.1016\/j.nbd.2019.01.012_bb0285","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(05)63142-X","article-title":"Treatment of spastic dystonia with transdermal nicotine","volume":"350","author":"Vaughan","year":"1997","journal-title":"Lancet"},{"issue":"1\u20133","key":"10.1016\/j.nbd.2019.01.012_bb0290","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-2999(00)00005-4","article-title":"Presynaptic nicotinic receptors modulating dopamine release in the rat striatum","volume":"393","author":"Wonnacott","year":"2000","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.nbd.2019.01.012_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072491","article-title":"Pre-synaptic release deficits in a DYT1 dystonia mouse model","volume":"8","author":"Yokoi","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.nbd.2019.01.012_bb0300","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jneumeth.2011.03.001","article-title":"Demon voltammetry and analysis software: analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures","volume":"202","author":"Yorgason","year":"2011","journal-title":"J. Neurosci. Methods"},{"issue":"5","key":"10.1016\/j.nbd.2019.01.012_bb0305","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1523\/JNEUROSCI.22-05-01709.2002","article-title":"Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice","volume":"22","author":"Zhang","year":"2002","journal-title":"J. Neurosci."},{"issue":"15","key":"10.1016\/j.nbd.2019.01.012_bb0310","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1523\/JNEUROSCI.22-15-06347.2002","article-title":"Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice","volume":"22","author":"Zhang","year":"2002","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2019.01.012_bb0315","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1124\/mol.104.000299","article-title":"Cholinergic drugs for Alzheimer's disease enhance in vitro dopamine release","volume":"66","author":"Zhang","year":"2004","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.nbd.2019.01.012_bb0320","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1124\/mol.109.056317","article-title":"Controls of tonic and phasic dopamine transmission in the dorsal and ventral striatum","volume":"76","author":"Zhang","year":"2009","journal-title":"Mol. Pharmacol."},{"issue":"13","key":"10.1016\/j.nbd.2019.01.012_bb0325","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1523\/JNEUROSCI.0261-09.2009","article-title":"Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine","volume":"29","author":"Zhang","year":"2009","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2019.01.012_bb0330","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.expneurol.2007.12.027","article-title":"Abnormal motor function and dopamine neurotransmission in DYT1 DeltaGAG transgenic mice","volume":"210","author":"Zhao","year":"2008","journal-title":"Exp. Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119300154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119300154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:13:05Z","timestamp":1760850785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996119300154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":66,"alternative-id":["S0969996119300154"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.01.012","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}