{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:00:43Z","timestamp":1792458043494,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R15NS091934"],"award-info":[{"award-number":["R15NS091934"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.nbd.2019.01.020","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T11:45:20Z","timestamp":1548848720000},"page":"123-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Multi-faceted therapeutic strategy for treatment of Alzheimer's disease by concurrent administration of etodolac and \u03b1-tocopherol"],"prefix":"10.1016","volume":"125","author":[{"given":"Khaled H.","family":"Elfakhri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab M.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Brannen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-7766","authenticated-orcid":false,"given":"Amal","family":"Kaddoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2019.01.020_bb0005","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.biopha.2018.06.147","article-title":"A molecular approach in drug development for Alzheimer's disease","volume":"106","author":"Agatonovic-Kustrin","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.nbd.2019.01.020_bb0010","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.2174\/138161210793176572","article-title":"Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease","volume":"16","author":"Agostinho","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.nbd.2019.01.020_bb0015","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer's disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2019.01.020_bb0020","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3390\/ijms17030338","article-title":"Amyloid-\u03b2 and Astrocytes interplay in Amyloid-\u03b2 related disorders","volume":"17","author":"Batarseh","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2019.01.020_bb0025","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jnutbio.2017.12.006","article-title":"Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-\u03b2 load and related toxicity in a mouse model of Alzheimer's disease","volume":"55","author":"Batarseh","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.nbd.2019.01.020_bb0030","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1212\/01.wnl.0000262031.18018.1a","article-title":"Blood-brain barrier impairment in Alzheimer's diease: stability and functional significance","volume":"68","author":"Bowman","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2019.01.020_bb0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.plefa.2006.05.012","article-title":"Polyunsaturated fatty acids and inflammation","volume":"75","author":"Calder","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.nbd.2019.01.020_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-018-1269-3","article-title":"K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-\u03baB-mediated CHI3L1 expression","volume":"15","author":"Choi","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2019.01.020_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2015.00094","article-title":"Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease","volume":"7","author":"De Felice","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2019.01.020_bb0050","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2019.01.020_bb0055","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neuroscience.2018.03.028","article-title":"Characterization of hit compounds identified from high-throughput screening for their effect on blood-brain barrier integrity and Amyloid-\u03b2 clearance: in vitro and in vivo studies","volume":"379","author":"Elfakhri","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2019.01.020_bb0060","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/jcbfm.2013.135","article-title":"Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease","volume":"33","author":"Erickson","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2019.01.020_bb0065","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000330247","article-title":"Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier","volume":"19","author":"Erickson","year":"2012","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.nbd.2019.01.020_bb0070","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.vaa.2016.09.007","article-title":"Preliminary pharmacokinetics of tramadol hydrochloride after administration via different routes in male and female B6 mice","volume":"45","author":"Evangelista Vaz","year":"2018","journal-title":"Vet. Anaesth. Analg."},{"key":"10.1016\/j.nbd.2019.01.020_bb0075","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.nbd.2016.01.001","article-title":"Cerebrovascular pathology during the progression of experimental Alzheimer's disease","volume":"88","author":"Giannoni","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.01.020_bb0080","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-015-0126-1","article-title":"Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease","volume":"7","author":"Gomez-Nicola","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nbd.2019.01.020_bb0085","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","author":"Grundke-Iqbal","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.01.020_bb0090","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.nbd.2019.01.020_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-2010-1414","article-title":"Neuroinflammation in Alzheimer's disease: mechanisms, pathologic consequences and potential for therapeutic manipulation","volume":"21","author":"Hensely","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2019.01.020_bb0100","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.trci.2018.09.001","article-title":"Synergism of antihypertensives and cholinesterase inhibitors in Alzheimer's disease","volume":"4","author":"Hu","year":"2018","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.1016\/j.nbd.2019.01.020_bb0105","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neurobiolaging.2013.09.035","article-title":"Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease","volume":"35","author":"Kamphuis","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"4","key":"10.1016\/j.nbd.2019.01.020_bb0110","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jalz.2018.03.002","article-title":"The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: perspectives from the research roundtable","author":"Knopman","year":"2018","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.nbd.2019.01.020_bb0115","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12868-018-0406-3","article-title":"Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer's disease","volume":"19","author":"Maiti","year":"2018","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.nbd.2019.01.020_bb0120","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.01.020_bb0125","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neurobiolaging.2006.03.013","article-title":"NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies","volume":"28","author":"McGeer","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2019.01.020_bb0130","first-page":"323","article-title":"Evaluation of hydration and nutritional gels as supportive care after total-body irradiation in mice (Mus musculus)","volume":"49","author":"Moccia","year":"2010","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.nbd.2019.01.020_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2014.00112","article-title":"Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches","volume":"8","author":"Morales","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.020_bb0140","doi-asserted-by":"crossref","first-page":"11310","DOI":"10.1074\/jbc.M116.762658","article-title":"Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease","volume":"292","author":"Mori","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2019.01.020_bb0145","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.020_bb0150","doi-asserted-by":"crossref","first-page":"163","DOI":"10.14336\/AD.2015.0907","article-title":"The neuroprotective properties of the amyloid precursor protein following traumatic brain injury","volume":"7","author":"Plummer","year":"2016","journal-title":"Aging Dis."},{"key":"10.1016\/j.nbd.2019.01.020_bb0155","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3181\/00379727-219-44323","article-title":"Prostaglandins as putative neurotoxins in Alzheimer's disease","volume":"219","author":"Prasad","year":"1998","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.nbd.2019.01.020_bb0160","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.neuropharm.2014.01.023","article-title":"Differences in amyloid-\u03b2 clearance across mouse and human blood\u2013brain barrier models: kinetic analysis and mechanistic modeling","volume":"79","author":"Qosa","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2019.01.020_bb0165","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3233\/JAD-2012-120319","article-title":"Enhanced brain amyloid-\u03b2 clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease","volume":"31","author":"Qosa","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2019.01.020_bb0170","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.bbadis.2014.06.029","article-title":"Mixed oligomers and monomeric amyloid-\u03b2 disrupts endothelial cells integrity and reduces monomeric amyloid-\u03b2 transport across hCMEC\/D3 cell line as an in vitro blood-brain barrier model","volume":"1842","author":"Qosa","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2019.01.020_bb0175","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3233\/JAD-151179","article-title":"High-throughput screening for identification of blood-brain barrier integrity enhancers: a drug repurposing opportunity to rectify vascular amyloid toxicity","volume":"53","author":"Qosa","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2019.01.020_bb0180","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/cpt.435","article-title":"Transporters as drug targets in neurological diseases","volume":"100","author":"Qosa","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.nbd.2019.01.020_bb0185","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011452","article-title":"Neurovascular dysfunction and faulty amyloid \u03b2-peptide clearance in Alzheimer disease","author":"Sagare","year":"2012","journal-title":"Cold Spring Harb. Perspect Med."},{"key":"10.1016\/j.nbd.2019.01.020_bb0190","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.nbd.2019.01.020_bb0195","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI10498","article-title":"Clearance of Alzheimer's amyloid-ss(1\u201340) peptide from brain by LDL receptor-related protein-1 at the blood\u2013brain barrier","volume":"106","author":"Shibata","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2019.01.020_bb0200","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuropharm.2018.09.017","article-title":"The 5-HT3 receptor antagonist ondansetron potentiates the effects of the acetylcholinesterase inhibitor donepezil on neuronal network oscillations in the rat dorsal hippocampus","volume":"143","author":"Skovgard","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2019.01.020_bb0205","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-2094-1-14","article-title":"Microglia and neuroinflammation: a pathological perspective","volume":"1","author":"Streit","year":"2004","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2019.01.020_bb0210","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/1073858411423441","article-title":"Structural remodeling of astrocytes in the injured CNS","volume":"18","author":"Sun","year":"2012","journal-title":"Neuroscientist"},{"key":"10.1016\/j.nbd.2019.01.020_bb0215","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/mutage\/gel055","article-title":"A review of genome mutation and Alzheimer's disease","volume":"22","author":"Thomas","year":"2007","journal-title":"Mutagenesis"},{"key":"10.1016\/j.nbd.2019.01.020_bb0220","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.freeradbiomed.2007.03.024","article-title":"Vitamin E, antioxidant and nothing more","volume":"43","author":"Traber","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2019.01.020_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(03)00089-3","article-title":"Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory","volume":"70","author":"Turner","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2019.01.020_bb0230","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1212\/01.wnl.0000311269.57716.63","article-title":"Protective effects of NSAIDs on the development of Alzheimer disease","volume":"70","author":"Vlad","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2019.01.020_bb0235","doi-asserted-by":"crossref","first-page":"316523","DOI":"10.1155\/2013\/316523","article-title":"Oxidative stress and the pathogenesis of Alzheimer's disease","volume":"2013","author":"Zhao","year":"2013","journal-title":"Oxid. Med. Cell Longev."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118305990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118305990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T11:24:44Z","timestamp":1606303484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996118305990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":47,"alternative-id":["S0969996118305990"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.01.020","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-faceted therapeutic strategy for treatment of Alzheimer's disease by concurrent administration of etodolac and \u03b1-tocopherol","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}