{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:35:44Z","timestamp":1788395744437,"version":"build-2803163510"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES0255855"],"award-info":[{"award-number":["R01 ES0255855"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH112763"],"award-info":[{"award-number":["R01 MH112763"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00 NS080911"],"award-info":[{"award-number":["R00 NS080911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 MH018399"],"award-info":[{"award-number":["T32 MH018399"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Affairs"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.nbd.2019.01.025","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T20:03:51Z","timestamp":1549051431000},"page":"211-218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex"],"prefix":"10.1016","volume":"125","author":[{"given":"Dionisio A.","family":"Amodeo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-1946","authenticated-orcid":false,"given":"Chi-Yu","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omron","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran A.","family":"Mukamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Margarita","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan B.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2019.01.025_bb0005","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbr.2011.10.032","article-title":"Differences in BTBR T+ tf\/J and C57BL\/6J mice on probabilistic reversal learning and stereotyped behaviors","volume":"227","author":"Amodeo","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2019.01.025_bb0010","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/aur.1395","article-title":"Risperidone and the 5-HT2A receptor antagonist M100907 improve probabilistic reversal learning in BTBR T + tf\/J mice","volume":"7","author":"Amodeo","year":"2014","journal-title":"Autism Res."},{"key":"10.1016\/j.nbd.2019.01.025_bb0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbr.2018.04.032","article-title":"5-HT6 receptor agonist EMD386088 impairs behavioral flexibility and working memory","volume":"349","author":"Amodeo","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2019.01.025_bb0020","article-title":"Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain","volume":"4","author":"Basil","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.025_bb0025","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.expneurol.2017.07.002","article-title":"Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders","volume":"299","author":"Bilbo","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2019.01.025_bb0030","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s10803-012-1671-0","article-title":"Subcategories of restricted and repetitive behaviors in children with autism spectrum disorders","volume":"43","author":"Bishop","year":"2013","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.nbd.2019.01.025_bb0035","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbi.2010.03.005","article-title":"Effects of prenatal infection on brain development and behavior: a review of findings from animal models","volume":"24","author":"Boksa","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2019.01.025_bb0040","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal infection and schizophrenia: a review of epidemiologic and translational studies","volume":"167","author":"Brown","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.025_bb0045","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1177\/0269881111430749","article-title":"The selective serotonin reuptake inhibitor, escitalopram, enhances inhibition of prepotent responding and spatial reversal learning","volume":"26","author":"Brown","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.nbd.2019.01.025_bb0050","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/mp.2015.222","article-title":"Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons","volume":"21","author":"Canetta","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.025_bb0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.schres.2012.06.037","article-title":"Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome","volume":"140","author":"Connor","year":"2012","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.nbd.2019.01.025_bb0060","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/nn.3546","article-title":"mTOR complexes in neurodevelopmental and neuropsychiatric disorders","volume":"16","author":"Costa-Mattioli","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0065","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1046\/j.1460-9568.2003.02667.x","article-title":"Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7","volume":"17","author":"Cryan","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0070","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1523\/JNEUROSCI.3366-15.2016","article-title":"Multifaceted contributions by different regions of the orbitofrontal and medial prefrontal cortex to probabilistic reversal learning","volume":"36","author":"Dalton","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0075","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.neuroimage.2011.01.068","article-title":"Human reversal learning under conditions of certain versus uncertain outcomes","volume":"56","author":"D'Cruz","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.nbd.2019.01.025_bb0080","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1037\/a0031721","article-title":"Reduced behavioral flexibility in autism spectrum disorders","volume":"27","author":"D'Cruz","year":"2013","journal-title":"Neuropsychology"},{"key":"10.1016\/j.nbd.2019.01.025_bb0085","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.161","article-title":"Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorders","volume":"6","author":"D'Cruz","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.025_bb0090","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1523\/JNEUROSCI.0450-17.2017","article-title":"Adaptive Encoding of Outcome Prediction by Prefrontal Cortex Ensembles Supports Behavioral Flexibility","volume":"37","author":"Del Arco","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-018-0021-0","article-title":"Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism","author":"Donegan","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2019.01.025_bb0100","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ng.1013","article-title":"Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder","volume":"44","author":"Elia","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2019.01.025_bb0105","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physrev.00029.2009","article-title":"Molecular background of leak k currents: two-pore domain potassium channels","volume":"90","author":"Enyedi","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.nbd.2019.01.025_bb0110","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nrn3978","article-title":"Immune mediators in the brain and peripheral tissues in autism spectrum disorder","volume":"16","author":"Estes","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0115","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1126\/science.aag3194","article-title":"Maternal immune activation: implications for neuropsychiatric disorders","volume":"353","author":"Estes","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.nbd.2019.01.025_bb0120","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/sj.npp.1300825","article-title":"Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting","volume":"31","author":"Floresco","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2019.01.025_bb0125","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1038\/tp.2012.24","article-title":"Effects of maternal immune activation on gene expression patterns in the fetal brain","volume":"2","author":"Garbett","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.025_bb0130","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nlm.2008.01.001","article-title":"Deficits in acquisition and extinction of conditioned responses in mGluR7 knockout mice","volume":"90","author":"Goddyn","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.nbd.2019.01.025_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00034","article-title":"Update on the implication of potassium channels in autism: K channelautism spectrum disorder","volume":"9","author":"Guglielmi","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0140","doi-asserted-by":"crossref","first-page":"12741","DOI":"10.1073\/pnas.0902417106","article-title":"Transcriptome of embryonic and neonatal mouse cortex by high-throughput RNA sequencing","volume":"106","author":"Han","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.01.025_bb0145","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbr.2004.03.015","article-title":"Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory","volume":"154","author":"H\u00f6lscher","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2019.01.025_bb0150","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1523\/JNEUROSCI.0995-04.2004","article-title":"Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression","volume":"24","author":"Hou","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0155","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bbi.2010.12.017","article-title":"Activation of the maternal immune system induces endocrine changes in the placenta via IL-6","volume":"25","author":"Hsiao","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2019.01.025_bb0160","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nn.3351","article-title":"mTORC2 controls actin polymerization required for consolidation of long-term memory","volume":"16","author":"Huang","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0165","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1038\/ncomms4227","article-title":"A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes","volume":"5","author":"Hwang","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2019.01.025_bb0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1214\/10-STS321","article-title":"Identification, inference and sensitivity analysis for causal mediation effects","volume":"25","author":"Imai","year":"2010","journal-title":"Stat. Sci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0175","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature10523","article-title":"Spatio-temporal transcriptome of the human brain","volume":"478","author":"Kang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2019.01.025_bb0180","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2013.132","article-title":"Long-term effects of maternal immune activation on depression-like behavior in the mouse","volume":"4","author":"Khan","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.025_bb0185","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1093\/hmg\/ddu056","article-title":"Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation","volume":"23","author":"Lee","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.01.025_bb0190","doi-asserted-by":"crossref","first-page":"1237905","DOI":"10.1126\/science.1237905","article-title":"Global epigenomic reconfiguration during mammalian brain development","volume":"341","author":"Lister","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.nbd.2019.01.025_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/mp.2017.15","article-title":"Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder","author":"Lombardo","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.025_bb0200","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.nbd.2019.01.025_bb0205","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1701799","article-title":"Systematic reconstruction of autism biology from massive genetic mutation profiles","volume":"4","author":"Luo","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.nbd.2019.01.025_bb0210","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbi.2012.01.011","article-title":"Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism","volume":"26","author":"Malkova","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2019.01.025_bb0215","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/nm.4225","article-title":"Developmental timing and critical windows for the treatment of psychiatric disorders","volume":"22","author":"Mar\u00edn","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2019.01.025_bb0220","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1601-183X.2007.00330.x","article-title":"Autism-like behavioral phenotypes in BTBR T+tf\/J mice","volume":"7","author":"McFarlane","year":"2008","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2019.01.025_bb0225","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.biopsych.2013.07.011","article-title":"Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems","volume":"75","author":"Meyer","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.025_bb0230","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pneurobio.2009.10.018","article-title":"Epidemiology-driven neurodevelopmental animal models of schizophrenia","volume":"90","author":"Meyer","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2019.01.025_bb0235","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1523\/JNEUROSCI.0099-06.2006","article-title":"The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology","volume":"26","author":"Meyer","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0240","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.neuron.2015.05.018","article-title":"Epigenomic signatures of neuronal diversity in the mammalian brain","volume":"86","author":"Mo","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.01.025_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057380","article-title":"Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model","volume":"8","author":"Naviaux","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2019.01.025_bb0250","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.33","article-title":"Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy","volume":"4","author":"Naviaux","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.025_bb0255","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","article-title":"Metabotropic glutamate receptors: physiology, pharmacology, and disease","volume":"50","author":"Niswender","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.nbd.2019.01.025_bb0260","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbi.2014.02.007","article-title":"Maternal immune activation leads to activated inflammatory macrophages in offspring","volume":"38","author":"Onore","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2019.01.025_bb0265","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.molmed.2011.03.001","article-title":"Maternal infection and immune involvement in autism","volume":"17","author":"Patterson","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.nbd.2019.01.025_bb0270","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/7854_2010_57","article-title":"Models of neurodevelopmental abnormalities in schizophrenia","volume":"4","author":"Powell","year":"2010","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0275","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbr.2009.04.021","article-title":"Prepulse inhibition and genetic mouse models of schizophrenia","volume":"204","author":"Powell","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2019.01.025_bb0280","first-page":"3397","article-title":"Genome-wide transcriptional profiling and structural magnetic resonance imaging in the maternal immune activation model of neurodevelopmental disorders","volume":"27","author":"Richetto","year":"2017","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2019.01.025_bb0285","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1017\/S0954579409990265","article-title":"Developmental trajectories of restricted and repetitive behaviors and interests in children with autism spectrum disorders","volume":"22","author":"Richler","year":"2010","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.nbd.2019.01.025_bb0290","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00702-014-1216-0","article-title":"The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment","volume":"121","author":"Rojas","year":"2014","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nbd.2019.01.025_bb0295","doi-asserted-by":"crossref","first-page":"re10","DOI":"10.1126\/scisignal.2005832","article-title":"Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders","volume":"7","author":"Santini","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.nbd.2019.01.025_bb0300","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2013.00222","article-title":"Channelopathy pathogenesis in autism spectrum disorders","volume":"4","author":"Schmunk","year":"2013","journal-title":"Front. Genet."},{"key":"10.1016\/j.nbd.2019.01.025_bb0305","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2013.16","article-title":"Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice","volume":"3","author":"Schwartzer","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.025_bb0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000393","article-title":"Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice","volume":"8","author":"Siuta","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2019.01.025_bb0315","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0320","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/dvdy.24612","article-title":"Maternal immune activation in neurodevelopmental disorders","volume":"247","author":"Solek","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.nbd.2019.01.025_bb0325","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.01.025_bb0330","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnmol.2014.00028","article-title":"mTOR signaling and its roles in normal and abnormal brain development","volume":"7","author":"Takei","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.025_bb0335","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbi.2013.01.086","article-title":"Epigenetic changes at gene promoters in response to immune activation in utero","volume":"30","author":"Tang","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2019.01.025_bb0340","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/WCO.0000000000000069","article-title":"The developmental transcriptome of the human brain","volume":"27","author":"Tebbenkamp","year":"2014","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.nbd.2019.01.025_bb0345","first-page":"1","article-title":"Mediation: R package for causal mediation analysis","volume":"59","author":"Tingley","year":"2014","journal-title":"J. Stat. Soft. Artic."},{"key":"10.1016\/j.nbd.2019.01.025_bb0350","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.bbr.2017.06.014","article-title":"Reversal learning in C58 mice: modeling higher order repetitive behavior","volume":"332","author":"Whitehouse","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2019.01.025_bb0355","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1017\/S1461145708009206","article-title":"Prenatal immune activation leads to multiple changes in basal neurotransmitter levels in the adult brain: implications for brain disorders of neurodevelopmental origin such as schizophrenia","volume":"12","author":"Winter","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.nbd.2019.01.025_bb0360","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13041-014-0080-z","article-title":"TWIK-1 contributes to the intrinsic excitability of dentate granule cells in mouse hippocampus","volume":"7","author":"Yarishkin","year":"2014","journal-title":"Mol. Brain"},{"key":"10.1016\/j.nbd.2019.01.025_bb0365","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.nbd.2019.01.025_bb0370","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.neuropharm.2011.02.022","article-title":"Prenatal exposure to a viral mimetic alters behavioural flexibility in male, but not female, rats","volume":"62","author":"Zhang","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2019.01.025_bb0375","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41467-017-02748-x","article-title":"Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118306041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118306041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T17:40:04Z","timestamp":1565199604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996118306041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":75,"alternative-id":["S0969996118306041"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.01.025","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.01.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}