{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:31:29Z","timestamp":1791361889936,"version":"4.3.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Malta Council of Science and Technology","award":["R&I-2013-14 EPILEFREE"],"award-info":[{"award-number":["R&I-2013-14 EPILEFREE"]}]},{"name":"EPILEFREE"},{"name":"University of Malta"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.nbd.2019.01.026","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T11:35:02Z","timestamp":1549020902000},"page":"135-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Synergistic action of CB1 and 5-HT2B receptors in preventing pilocarpine-induced status epilepticus in rats"],"prefix":"10.1016","volume":"125","author":[{"given":"Roberto","family":"Colangeli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Di Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Pierucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Deidda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-6621","authenticated-orcid":false,"given":"Maurizio","family":"Casarrubea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2006-563X","authenticated-orcid":false,"given":"Giuseppe","family":"Di Giovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2019.01.026_bb0005","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1006\/exnr.1998.6901","article-title":"Global increases in seizure susceptibility in mice lacking 5-HT2C receptors: a behavioral analysis","volume":"154","author":"Applegate","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0010","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1471-4159.2009.06025.x","article-title":"Lack of CB1 receptor activity impairs serotonergic negative feedback","volume":"109","author":"Aso","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.01.026_bb0015","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1471-4159.2006.04277.x","article-title":"Serotonin and epilepsy","volume":"100","author":"Bagdy","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.01.026_bb0020","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/s41386-018-0013-0","article-title":"Positive regulation of raphe serotonin neurons by serotonin 2B receptors","volume":"43","author":"Belmer","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2019.01.026_bb0025","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1523\/JNEUROSCI.0678-08.2008","article-title":"Serotonin evokes endocannabinoid release and retrogradely suppresses excitatory synapses","volume":"28","author":"Best","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.026_bb0030","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1124\/jpet.105.100354","article-title":"Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus","volume":"317","author":"Blair","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2019.01.026_bb0035","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1345\/aph.17367","article-title":"Role of propofol in refractory status epilepticus","volume":"32","author":"Brown","year":"1998","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.nbd.2019.01.026_bb0040","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/0014-4886(86)90174-3","article-title":"Modification of electroshock and pentylenetetrazol seizure patterns in rats after precollicular transections","volume":"93","author":"Browning","year":"1986","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0045","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1152\/jn.00498.2013","article-title":"Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid","volume":"111","author":"Burattini","year":"2014","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0050","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000338755","article-title":"Effects of cannabinoid receptor agonist WIN 55,212-2 on blood-brain barrier disruption in focal cerebral ischemia in rats","volume":"89","author":"Chi","year":"2012","journal-title":"Pharmacology"},{"key":"10.1016\/j.nbd.2019.01.026_bb0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/157015906776359540","article-title":"Serotonin as a modulator of glutamate- and GABA-mediated neurotransmission: implications in physiological functions and in pathology","volume":"4","author":"Ciranna","year":"2006","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0060","doi-asserted-by":"crossref","first-page":"11152","DOI":"10.1038\/s41598-017-11606-1","article-title":"The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity","volume":"7","author":"Colangeli","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2019.01.026_bb0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jneumeth.2008.04.019","article-title":"The pilocarpine model of temporal lobe epilepsy","volume":"172","author":"Curia","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2019.01.026_bb0070","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0091-3057(03)00150-3","article-title":"Behaviorally active doses of the CB1 receptor antagonist SR 141716A increase brain serotonin and dopamine levels and turnover","volume":"75","author":"Darmani","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nbd.2019.01.026_bb0075","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.pneurobio.2016.03.004","article-title":"Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications","volume":"151","author":"De Deurwaerdere","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0080","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pharmthera.2015.11.009","article-title":"New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders","volume":"157","author":"Di Giovanni","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.nbd.2019.01.026_bb0085","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.nbd.2014.10.018","article-title":"Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats","volume":"73","author":"Di Maio","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.01.026_bb0090","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0306-4522(98)00757-X","article-title":"Decreased chaos of midbrain dopaminergic neurons after serotonin denervation","volume":"92","author":"Di Mascio","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2019.01.026_bb0095","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/mp.2011.159","article-title":"5-HT(2B) receptors are required for serotonin-selective antidepressant actions","volume":"17","author":"Diaz","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2019.01.026_bb0100","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-2999(02)01755-7","article-title":"Involvement of 5-hydroxytryptamine neuronal system in Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory","volume":"445","author":"Egashira","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0105","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.neuropharm.2011.02.016","article-title":"Modulation of the serotonin system by endocannabinoid signaling","volume":"61","author":"Haj-Dahmane","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2019.01.026_bb0110","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1227\/01.NEU.0000097552.31763.AE","article-title":"Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus","volume":"54","author":"Hamani","year":"2004","journal-title":"Neurosurgery"},{"key":"10.1016\/j.nbd.2019.01.026_bb0115","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1097\/ALN.0b013e31821c120e","article-title":"Propofol enhances memory formation via an interaction with the endocannabinoid system","volume":"114","author":"Hauer","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nbd.2019.01.026_bb0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.54.2.161","article-title":"International Union of pharmacology. XXVII. Classification of Cannabinoid Receptors","volume":"54","author":"Howlett","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.nbd.2019.01.026_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.109.060251","article-title":"Ligand- and heterodimer-directed signaling of the CB(1) cannabinoid receptor","volume":"77","author":"Hudson","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0130","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1568026053386980","article-title":"Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs","volume":"5","author":"Isaac","year":"2005","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.nbd.2019.01.026_bb0135","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-3-319-20825-1_10","article-title":"Cannabis and Endocannabinoid Signaling in Epilepsy","volume":"231","author":"Katona","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0140","doi-asserted-by":"crossref","first-page":"e95922","DOI":"10.1371\/journal.pone.0095922","article-title":"Modulation of pilocarpine-induced seizures by cannabinoid receptor 1","volume":"9","author":"Kow","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2019.01.026_bb0145","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.yebeh.2009.07.031","article-title":"Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: antagonism by Bacopa monnieri","volume":"16","author":"Krishnakumar","year":"2009","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2019.01.026_bb0150","doi-asserted-by":"crossref","first-page":"19144","DOI":"10.1073\/pnas.0509588102","article-title":"The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq\/11 G proteins","volume":"102","author":"Lauckner","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.01.026_bb0155","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00230647","article-title":"Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats","volume":"102","author":"Lemos","year":"1995","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nbd.2019.01.026_bb0160","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jneumeth.2015.03.009","article-title":"Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration","volume":"260","author":"Levesque","year":"2016","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2019.01.026_bb0165","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jneumeth.2015.09.007","article-title":"Opportunities for improving animal welfare in rodent models of epilepsy and seizures","volume":"260","author":"Lidster","year":"2016","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2019.01.026_bb0170","first-page":"9768949","article-title":"Updates in Refractory Status Epilepticus","volume":"2018","author":"Marawar","year":"2018","journal-title":"Crit. Care Res. Pract."},{"key":"10.1016\/j.nbd.2019.01.026_bb0175","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1088208","article-title":"CB1 cannabinoid receptors and on-demand defense against excitotoxicity","volume":"302","author":"Marsicano","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.nbd.2019.01.026_bb0180","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1528-1167.2007.01384.x","article-title":"A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation","volume":"49","author":"Martin","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2019.01.026_bb0185","first-page":"913","article-title":"5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential","volume":"286","author":"Martin","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2019.01.026_bb0190","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/07391102.2013.869483","article-title":"Molecular interactions between general anesthetics and the 5HT2B receptor","volume":"33","author":"Matsunaga","year":"2015","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.nbd.2019.01.026_bb0195","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1468-1331.2009.02917.x","article-title":"EFNS guideline on the management of status epilepticus in adults","volume":"17","author":"Meierkord","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0200","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.lfs.2017.11.029","article-title":"Regulation of noradrenergic and serotonergic systems by cannabinoids: relevance to cannabinoid-induced effects","volume":"192","author":"Mendiguren","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.nbd.2019.01.026_bb0205","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.neuron.2006.07.006","article-title":"The endocannabinoid system controls key epileptogenic circuits in the hippocampus","volume":"51","author":"Monory","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.01.026_bb0210","doi-asserted-by":"crossref","first-page":"18333","DOI":"10.1073\/pnas.1420285111","article-title":"Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training","volume":"111","author":"Morena","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.01.026_bb0215","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11064-011-0607-y","article-title":"L-type calcium channel mediates anticonvulsant effect of cannabinoids in acute and chronic murine models of seizure","volume":"37","author":"Naderi","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2019.01.026_bb0220","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00221-013-3594-1","article-title":"High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo","volume":"230","author":"Orban","year":"2013","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nbd.2019.01.026_bb0225","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/cns.12285","article-title":"Role(s) of the 5-HT2C receptor in the development of maximal dentate activation in the hippocampus of anesthetized rats","volume":"20","author":"Orban","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.nbd.2019.01.026_bb0230","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/sj.bjp.0705334","article-title":"The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase","volume":"139","author":"Patel","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0235","doi-asserted-by":"crossref","first-page":"11533","DOI":"10.1073\/pnas.1411442111","article-title":"Critical role of canonical transient receptor potential channel 7 in initiation of seizures","volume":"111","author":"Phelan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.01.026_bb0240","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.eplepsyres.2015.09.008","article-title":"Pilocarpine-induced status epilepticus in mice: a comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale","volume":"117","author":"Phelan","year":"2015","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2019.01.026_bb0245","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/epi.13648","article-title":"TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice","volume":"58","author":"Phelan","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2019.01.026_bb0250","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation: II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0255","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neuropharm.2018.05.030","article-title":"Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation","volume":"138","author":"Ratano","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2019.01.026_bb0260","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1038\/npp.2012.123","article-title":"Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission","volume":"37","author":"Rey","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2019.01.026_bb0265","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1196\/annals.1369.049","article-title":"A potent serotonin-modulating compound AP-267 attenuates morphine withdrawal-induced blood-brain barrier dysfunction in rats","volume":"1074","author":"Sharma","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2019.01.026_bb0270","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.eplepsyres.2015.01.003","article-title":"Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in Guinea pigs","volume":"111","author":"Shubina","year":"2015","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2019.01.026_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2017.02.003","article-title":"Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in Guinea pigs","volume":"1661","author":"Shubina","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2019.01.026_bb0280","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3389\/fnins.2016.00492","article-title":"Monoaminergic mechanisms in epilepsy may offer innovative therapeutic opportunity for monoaminergic multi-target drugs","volume":"10","author":"Svob Strac","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2019.01.026_bb0285","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/epi.13950","article-title":"Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet","volume":"59","author":"Terrone","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2019.01.026_bb0290","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus","volume":"56","author":"Trinka","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2019.01.026_bb0295","first-page":"545","article-title":"The seizures induced by pilocarpine: behavioral, electroencephalographic and neuropathological studies in rodents","volume":"39","author":"Turski","year":"1987","journal-title":"Pol. J. Pharmacol. Pharm."},{"key":"10.1016\/j.nbd.2019.01.026_bb0300","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0014-2999(98)00621-9","article-title":"Studies on the role of 5-HT2C and 5-HT2B receptors in regulating generalised seizure threshold in rodents","volume":"359","author":"Upton","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0305","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuropharm.2016.04.016","article-title":"Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures","volume":"108","author":"Venzi","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2019.01.026_bb0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002194","article-title":"Cognitive impairment induced by Delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors","volume":"13","author":"Vinals","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2019.01.026_bb0315","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-2999(01)01243-2","article-title":"Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects","volume":"428","author":"Wallace","year":"2001","journal-title":"Eur. J. Pharmacol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119300336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119300336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T21:15:32Z","timestamp":1553721332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996119300336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":63,"alternative-id":["S0969996119300336"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.01.026","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic action of CB1 and 5-HT2B receptors in preventing pilocarpine-induced status epilepticus in rats","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.01.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}