{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:32:10Z","timestamp":1791844330535,"version":"4.3.4"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS065053"],"award-info":[{"award-number":["NS065053"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009340","name":"Children's Discovery Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009340","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["- 2016R1A6A3A11933750"],"award-info":[{"award-number":["- 2016R1A6A3A11933750"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["HI17C1459"],"award-info":[{"award-number":["HI17C1459"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2016R1C1B2006675"],"award-info":[{"award-number":["NRF-2016R1C1B2006675"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1C1B2008356"],"award-info":[{"award-number":["NRF-2017R1C1B2008356"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.nbd.2019.02.001","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T13:50:42Z","timestamp":1549374642000},"page":"178-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"C","title":["DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury"],"prefix":"10.1016","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-7979","authenticated-orcid":false,"given":"Jung Eun","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongseok","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcheol","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-0968","authenticated-orcid":false,"given":"Aaron","family":"DiAntonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2019.02.001_bb0005","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.conb.2008.06.005","article-title":"Nerve injury signaling","volume":"18","author":"Abe","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0010","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.conb.2018.07.002","article-title":"An axonal stress response pathway: degenerative and regenerative signaling by DLK","volume":"53","author":"Asghari Adib","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2019.02.001_bb0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13064-016-0068-8","article-title":"Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells","volume":"11","author":"Blondeau","year":"2016","journal-title":"Neural Dev."},{"key":"10.1016\/j.nbd.2019.02.001_bb0025","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1523\/JNEUROSCI.22-04-01303.2002","article-title":"Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth","volume":"22","author":"Bonilla","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrn3176","article-title":"Assembly of a new growth cone after axotomy: the precursor to axon regeneration","volume":"13","author":"Bradke","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0035","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.neuron.2013.11.019","article-title":"Insulin\/IGF1 signaling inhibits age-dependent axon regeneration","volume":"81","author":"Byrne","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0040","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1523\/JNEUROSCI.21-13-04731.2001","article-title":"Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate","volume":"21","author":"Cai","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0045","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.neuron.2016.01.034","article-title":"A systems-level analysis of the peripheral nerve intrinsic axonal growth program","volume":"89","author":"Chandran","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuron.2006.05.026","article-title":"Highwire restrains synaptic growth by attenuating a MAP kinase signal","volume":"51","author":"Collins","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0055","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-cellbio-100617-062508","article-title":"Axon regeneration in the central nervous system: facing the challenges from the inside","volume":"34","author":"Curcio","year":"2018","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0060","doi-asserted-by":"crossref","first-page":"28858","DOI":"10.1074\/jbc.M910358199","article-title":"c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity","volume":"275","author":"Dennler","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2019.02.001_bb0065","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2019.02.001_bb0070","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.cub.2010.05.055","article-title":"Electrical activity suppresses axon growth through Cav1.2 channels in adult primary sensory neurons","volume":"20","author":"Enes","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0075","doi-asserted-by":"crossref","first-page":"24788","DOI":"10.1074\/jbc.271.40.24788","article-title":"Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2","volume":"271","author":"Fan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2019.02.001_bb0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-pathol-012414-040354","article-title":"Intrinsic neuronal stress response pathways in injury and disease","volume":"13","author":"Farley","year":"2018","journal-title":"Ann. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.nbd.2019.02.001_bb0085","doi-asserted-by":"crossref","first-page":"19664","DOI":"10.1523\/JNEUROSCI.0589-13.2013","article-title":"Epigenetic regulation of sensory axon regeneration after spinal cord injury","volume":"33","author":"Finelli","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0090","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0095-18.2018","article-title":"TRPV1 agonist, capsaicin, induces axon outgrowth after injury via Ca2+\/PKA signaling","volume":"5","author":"Frey","year":"2018","journal-title":"Eneuro"},{"key":"10.1016\/j.nbd.2019.02.001_bb0095","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.celrep.2016.03.028","article-title":"Evidence for an Age-dependent decline in axon regeneration in the adult mammalian Central Nervous System","volume":"15","author":"Geoffroy","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2019.02.001_bb0100","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.neuron.2015.12.023","article-title":"Axon self-destruction: new links among SARM1, MAPKs, and NAD+ metabolism","volume":"89","author":"Gerdts","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0105","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1083\/jcb.201103153","article-title":"DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity","volume":"194","author":"Ghosh","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0110","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbrc.2016.07.067","article-title":"Global analysis of transcriptome in dorsal root ganglia following peripheral nerve injury in rats","volume":"478","author":"Gong","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2019.02.001_bb0115","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1523\/JNEUROSCI.6156-10.2011","article-title":"The basis for diminished functional recovery after delayed peripheral nerve repair","volume":"31","author":"Gordon","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0120","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nn.4189","article-title":"Injured sensory neuron\u2013derived CSF1 induces microglial proliferation and DAP12-dependent pain","volume":"19","author":"Guan","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0125","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1126\/science.1165527","article-title":"Axon regeneration requires a conserved MAP kinase pathway","volume":"323","author":"Hammarlund","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.nbd.2019.02.001_bb0130","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0896-6273(03)00770-0","article-title":"Axoplasmic importins enable retrograde injury signaling in lesioned nerve","volume":"40","author":"Hanz","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0135","doi-asserted-by":"crossref","first-page":"14404","DOI":"10.1523\/JNEUROSCI.4908-07.2007","article-title":"Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene","volume":"27","author":"Hasegawa","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0140","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.tins.2016.03.002","article-title":"Traumatic axonal injury: mechanisms and translational opportunities","volume":"39","author":"Hill","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0145","doi-asserted-by":"crossref","first-page":"11992","DOI":"10.1523\/JNEUROSCI.2272-06.2006","article-title":"The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex","volume":"26","author":"Hirai","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0150","doi-asserted-by":"crossref","first-page":"30808","DOI":"10.1016\/S0021-9258(18)47353-X","article-title":"Identification, molecular cloning, and characterization of dual Leucine zipper bearing kinase","volume":"269","author":"Holzman","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2019.02.001_bb0155","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1093\/bioinformatics\/btr490","article-title":"RNA-Seq analysis in MeV","volume":"27","author":"Howe","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2019.02.001_bb0160","first-page":"1","article-title":"Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2019.02.001_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2019.02.001_bb0170","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2019.02.001_bb0175","series-title":"Cell Biology of the Axon. Results and Problems in Cell Differentiation","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/400_2009_19","article-title":"Axon regeneration in the peripheral and central nervous systems","author":"Huebner","year":"2009"},{"key":"10.1016\/j.nbd.2019.02.001_bb0180","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbrc.2009.04.009","article-title":"Impaired regenerative response of primary sensory neurons in ZPK\/DLK gene-trap mice","volume":"383","author":"Itoh","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2019.02.001_bb0185","doi-asserted-by":"crossref","first-page":"10729","DOI":"10.1523\/JNEUROSCI.0539-14.2014","article-title":"ZPK\/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates","volume":"34","author":"Itoh","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0190","doi-asserted-by":"crossref","first-page":"reE14","DOI":"10.1126\/stke.2522004re14","article-title":"Cell signaling and the genesis of neuropathic pain","volume":"2004","author":"Ji","year":"2004","journal-title":"Sci. STKE"},{"key":"10.1016\/j.nbd.2019.02.001_bb0195","doi-asserted-by":"crossref","first-page":"19480","DOI":"10.1523\/JNEUROSCI.4067-13.2013","article-title":"Motor axon regeneration and muscle reinnervation in young adult and aged animals","volume":"33","author":"Kang","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0200","doi-asserted-by":"crossref","first-page":"15934","DOI":"10.1523\/JNEUROSCI.1924-15.2015","article-title":"CCL2 mediates neuron-macrophage interactions to drive proregenerative macrophage activation following preconditioning injury","volume":"35","author":"Kwon","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0205","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1523\/JNEUROSCI.0905-17.2017","article-title":"The Ste20 family kinases MAP4K4, MINK1, and TNIK converge to regulate stress-induced JNK signaling in neurons","volume":"37","author":"Larhammar","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0210","doi-asserted-by":"crossref","first-page":"eaag0394","DOI":"10.1126\/scitranslmed.aag0394","article-title":"Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease","volume":"9","author":"Le Pichon","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2019.02.001_bb0215","article-title":"The transcriptional landscape of dorsal root ganglia after sciatic nerve transection","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2019.02.001_bb0220","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.24271","article-title":"Restraint of presynaptic protein levels by Wnd\/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104","volume":"6","author":"Li","year":"2017","journal-title":"elife"},{"key":"10.1016\/j.nbd.2019.02.001_bb0225","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12974-018-1222-5","article-title":"Molecular and cellular identification of the immune response in peripheral ganglia following nerve injury","volume":"15","author":"Lindborg","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2019.02.001_bb0230","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.celrep.2017.07.010","article-title":"Enhanced neuronal regeneration in the CAST\/Ei mouse strain is linked to expression of differentiation markers after injury","volume":"20","author":"Lisi","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2019.02.001_bb0235","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-neuro-061010-113723","article-title":"Neuronal intrinsic mechanisms of axon regeneration","volume":"34","author":"Liu","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0240","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnmol.2015.00043","article-title":"What makes a RAG regeneration associated?","volume":"8","author":"Ma","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0245","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.expneurol.2007.05.028","article-title":"Reinnervation of the tibialis anterior following sciatic nerve crush injury: a confocal microscopic study in transgenic mice","volume":"207","author":"Magill","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0250","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41583-018-0001-8","article-title":"Intrinsic mechanisms of neuronal axon regeneration","volume":"19","author":"Mahar","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0255","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. J."},{"key":"10.1016\/j.nbd.2019.02.001_bb0260","doi-asserted-by":"crossref","first-page":"ra53","DOI":"10.1126\/scisignal.2000952","article-title":"Signaling to transcription networks in the neuronal retrograde injury response","volume":"3","author":"Michaelevski","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.nbd.2019.02.001_bb0265","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nn.2290","article-title":"A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration","volume":"12","author":"Miller","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0270","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pneurobio.2007.06.005","article-title":"Neural plasticity after peripheral nerve injury and regeneration","volume":"82","author":"Navarro","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0275","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0896-6273(00)80755-2","article-title":"Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury","volume":"23","author":"Neumann","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0280","doi-asserted-by":"crossref","first-page":"16236","DOI":"10.1523\/JNEUROSCI.3319-12.2013","article-title":"A critical role for macrophages near axotomized neuronal cell bodies in stimulating nerve regeneration","volume":"33","author":"Niemi","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0285","doi-asserted-by":"crossref","first-page":"11479","DOI":"10.1523\/JNEUROSCI.23-36-11479.2003","article-title":"Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo","volume":"23","author":"Pan","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0290","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neuron.2012.05.033","article-title":"Subcellular knockout of importin \u03b21 perturbs axonal retrograde signaling","volume":"75","author":"Perry","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0295","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.molcel.2018.09.021","article-title":"Regulation of neuroregeneration by long noncoding RNAs","volume":"72","author":"Perry","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2019.02.001_bb0300","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0014-4886(80)90006-0","article-title":"Effects of aging on nerve sprouting and regeneration","volume":"70","author":"Pestronk","year":"1980","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0305","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1113\/jphysiol.1975.sp011151","article-title":"Functional and structural changes in mammalian sympathetic neurones following interruption of their axons","volume":"252","author":"Purves","year":"1975","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0310","first-page":"774","article-title":"Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis","volume":"36","author":"Quigley","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0315","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/309791a0","article-title":"Peripheral injury enhances central regeneration of primary sensory neurones","volume":"309","author":"Richardson","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2019.02.001_bb0320","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrn3609","article-title":"Axon\u2013soma communication in neuronal injury","volume":"15","author":"Rishal","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.001_bb0325","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14348\/molcells.2017.2311","article-title":"Epigenetic regulation of axon regeneration after neural injury","volume":"40","author":"Shin","year":"2017","journal-title":"Mol. Cells"},{"key":"10.1016\/j.nbd.2019.02.001_bb0330","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2012.04.028","article-title":"Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration","volume":"74","author":"Shin","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2013.11.007","article-title":"Dynamic regulation of SCG10 in regenerating axons after injury","volume":"252","author":"Shin","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0340","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1523\/JNEUROSCI.17-02-00646.1997","article-title":"A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth","volume":"17","author":"Smith","year":"1997","journal-title":"J. Neurosci."},{"issue":"37","key":"10.1016\/j.nbd.2019.02.001_bb0345","doi-asserted-by":"crossref","first-page":"E8746","DOI":"10.1073\/pnas.1806933115","article-title":"Palmitoylation enables MAPK-dependent proteostasis of axon survival factors","volume":"115","author":"Summers","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.02.001_bb0350","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/embor.2013.64","article-title":"The DLK signalling pathway\u2014a double-edged sword in neural development and regeneration","volume":"14","author":"Tedeschi","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.nbd.2019.02.001_bb0355","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neuron.2016.09.026","article-title":"The calcium channel subunit Alpha2delta2 suppresses axon regeneration in the adult CNS","volume":"92","author":"Tedeschi","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0360","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0365","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.expneurol.2007.11.007","article-title":"Electrical stimulation of intact peripheral sensory axons in rats promotes outgrowth of their central projections","volume":"210","author":"Udina","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0370","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2015.02.014","article-title":"Cytoskeletal disruption activates the DLK\/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury","volume":"77","author":"Valakh","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.02.001_bb0375","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1089\/089771504772695986","article-title":"Peripheral and spinal motor reorganization after nerve injury and repair","volume":"21","author":"Valero-Cabr\u00e9","year":"2004","journal-title":"J. Neurotrauma"},{"issue":"10","key":"10.1016\/j.nbd.2019.02.001_bb0380","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/dneu.22605","article-title":"Developmental chromatin restriction of pro-growth gene networks acts as an epigenetic barrier to axon regeneration in cortical neurons","volume":"78","author":"Venkatesh","year":"2018","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0385","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0006-8993(95)00762-F","article-title":"The effect of aging on efferent nerve fibers regeneration in mice","volume":"696","author":"Verdu","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2019.02.001_bb0390","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the neuropathic pain phenotype to reveal neural mechanisms","volume":"73","author":"von Hehn","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0395","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201108111","article-title":"Axon degeneration: molecular mechanisms of a self-destruction pathway","volume":"196","author":"Wang","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0400","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.celrep.2018.03.071","article-title":"Sarm1\/Myd88-5 regulates neuronal intrinsic immune response to traumatic axonal injuries","volume":"23","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2019.02.001_bb0405","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1073\/pnas.1211074110","article-title":"DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury","volume":"110","author":"Watkins","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.02.001_bb0410","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1073\/pnas.1211284110","article-title":"Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death","volume":"110","author":"Welsbie","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.02.001_bb0415","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.33910","article-title":"Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury","volume":"7","author":"Wlaschin","year":"2018","journal-title":"elife"},{"key":"10.1016\/j.nbd.2019.02.001_bb0420","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.201006039","article-title":"Protein turnover of the Wallenda\/DLK kinase regulates a retrograde response to axonal injury","volume":"191","author":"Xiong","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2019.02.001_bb0425","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cell.2009.06.023","article-title":"The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration","volume":"138","author":"Yan","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2019.02.001_bb0430","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuron.2008.05.029","article-title":"Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve","volume":"59","author":"Yudin","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.001_bb0435","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/hmg\/ddu493","article-title":"Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration","volume":"24","author":"Zhan","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.02.001_bb0440","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1523\/JNEUROSCI.5290-05.2006","article-title":"A peptide c-Jun N-terminal Kinase (JNK) inhibitor blocks mechanical allodynia after spinal Nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance","volume":"26","author":"Zhuang","year":"2006","journal-title":"J. Neurosci."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118305370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996118305370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:15:44Z","timestamp":1760850944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996118305370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":88,"alternative-id":["S0969996118305370"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.02.001","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}