{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:16:16Z","timestamp":1790090176877,"version":"4.0.1"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01ES024183"],"award-info":[{"award-number":["5R01ES024183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.nbd.2019.02.020","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T05:28:35Z","timestamp":1551072515000},"page":"193-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Genetic suppression of IKK2\/NF-\u03baB in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease"],"prefix":"10.1016","volume":"127","author":[{"given":"Kelly S.","family":"Kirkley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katriana A.","family":"Popichak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean L.","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Tjalkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2019.02.020_bb0005","first-page":"505","article-title":"The use of astrocytes in culture as model systems for evaluating neurotoxic-induced-injury","volume":"12","author":"Aschner","year":"1991","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.nbd.2019.02.020_bb0010","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.it.2004.03.008","article-title":"The two NF-\u03baB activation pathways and their role in innate and adaptive immunity","volume":"25","author":"Bonizzi","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.nbd.2019.02.020_bb0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1084\/jem.20041918","article-title":"Inhibition of astroglial nuclear factor B reduces inflammation and improves functional recovery after spinal cord injury","volume":"202","author":"Brambilla","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2019.02.020_bb0020","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.4049\/jimmunol.0802954","article-title":"Transgenic inhibition of Astroglial NF- B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation","volume":"182","author":"Brambilla","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2019.02.020_bb0025","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive gliosis and the multicellular response to CNS damage and disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.020_bb0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1124\/mol.108.050781","article-title":"Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel Diindolylmethane Analog protects striatal neurons against apoptosis","volume":"75","author":"Carbone","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.nbd.2019.02.020_bb0035","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.mcn.2005.12.006","article-title":"GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS","volume":"31","author":"Casper","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.020_bb0040","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/dvg.20287","article-title":"Characterization of astrocyte-specific conditional knockouts","volume":"45","author":"Casper","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.nbd.2019.02.020_bb0045","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1073\/pnas.0813361106","article-title":"Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte","volume":"106","author":"Chen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2019.02.020_bb0050","article-title":"MInocycline reduces neuroinflammation but does not ameliorate neuronal loss in a mouse model of neurodegeneration","volume":"5","author":"Cheng","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2019.02.020_bb0055","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1093\/brain\/awn230","article-title":"Role of microglial IKK in kainic acid-induced hippocampal neuronal cell death","volume":"131","author":"Cho","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2019.02.020_bb0060","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s11248-008-9185-4","article-title":"Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells","volume":"17","author":"Chow","year":"2008","journal-title":"Transgenic Res."},{"key":"10.1016\/j.nbd.2019.02.020_bb0065","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Da Wei Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2019.02.020_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(93)90175-F","article-title":"Glutathione peroxidase, glial cells and Parkinson's disease","volume":"52","author":"Damier","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2019.02.020_bb0075","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1124\/jpet.112.201558","article-title":"Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory Para-phenyl substituted Diindolylmethanes in a mouse model of Parkinson's disease","volume":"345","author":"De Miranda","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2019.02.020_bb0080","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1046\/j.1471-4159.2000.0742213.x","article-title":"Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo","volume":"74","author":"Dehmer","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.02.020_bb0085","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1046\/j.1471-4159.2003.02210.x","article-title":"Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I\u03baB\u03b1 induction and block of NF\u03baB and iNOS activation","volume":"88","author":"Dehmer","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.02.020_bb0090","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.molmet.2017.01.010","article-title":"Astrocyte IKKbeta\/NF-kappaB signaling is required for diet-induced obesity and hypothalamic inflammation","volume":"6","author":"Douglass","year":"2017","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.nbd.2019.02.020_bb0095","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00702-014-1293-0","article-title":"Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study","volume":"122","author":"Durrenberger","year":"2014","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nbd.2019.02.020_bb0100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1460-9568.2009.06814.x","article-title":"Inactivation of astroglial NF-\u03baB promotes survival of retinal neurons following ischemic injury","volume":"30","author":"Dvoriantchikova","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.020_bb0105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2014.10.028","article-title":"Inflammation is genetically implicated in Parkinson's disease","volume":"302","author":"Dzamko","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2019.02.020_bb0110","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1750-1326-4-47","article-title":"Does neuroinflammation fan the flame in neurodegenerative diseases?","volume":"4","author":"Frank-Cannon","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2019.02.020_bb0115","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1600-0773.1990.tb00833.x","article-title":"MPTP-induced hypoactivity in mice: reversal by L-dopa","volume":"67","author":"Fredriksson","year":"1990","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.nbd.2019.02.020_bb0120","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1124\/pr.114.010397","article-title":"Regulation of the dopamine and vesicular monoamine transporters: pharmacological targets and implications for disease","volume":"67","author":"German","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.nbd.2019.02.020_bb0125","doi-asserted-by":"crossref","first-page":"18754","DOI":"10.1073\/pnas.0704908104","article-title":"Selective inhibition of NF-\u03baB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease","volume":"104","author":"Ghosh","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.02.020_bb0130","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","article-title":"Mechanisms underlying inflammation in Neurodegeneration","volume":"140","author":"Glass","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2019.02.020_bb0135","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jneumeth.2010.11.001","article-title":"A simple magnetic separation method for high-yield isolation of pure primary microglia","volume":"194","author":"Gordon","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2019.02.020_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-2952(98)00214-7","article-title":"Nuclear factor-\u03baB\/Rel proteins","volume":"57","author":"Grilli","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2019.02.020_bb0145","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1124\/jpet.117.246389","article-title":"The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)methane, modulates glial reactivity and is Neuroprotective in MPTP-induced parkinsonism","volume":"365","author":"Hammond","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2019.02.020_bb0150","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/nm1323","article-title":"IKK mediates ischemia-induced neuronal death","volume":"11","author":"Herrmann","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2019.02.020_bb0155","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S1474-4422(09)70062-6","article-title":"Neuroinflammation in Parkinson's disease: a target for neuroprotection?","volume":"8","author":"Hirsch","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2019.02.020_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acid Res."},{"key":"10.1016\/j.nbd.2019.02.020_bb0165","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1073\/pnas.94.14.7531","article-title":"Nuclear translocation of NF-\u03baB is increased in dopaminergic neurons of patients with Parkinson disease","volume":"95","author":"Hunot","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.02.020_bb0170","first-page":"1","article-title":"The role of the IkB kinase (IKK) complex","author":"Karin","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.nbd.2019.02.020_bb0175","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1513\/pats.200504-034SR","article-title":"Inflammation-activated protein kinases as targets for drug development","volume":"2","author":"Karin","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.nbd.2019.02.020_bb0180","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1093\/nar\/gkn508","article-title":"Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation","volume":"36","author":"Kaufman","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2019.02.020_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-017-0871-0","article-title":"Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity","volume":"14","author":"Kirkley","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2019.02.020_bb0190","first-page":"407","article-title":"Spontaneous development of cutaneous squamous cell carcinoma in mice with cell-specific deletion of inhibitor of kappaB kinase 2","volume":"67","author":"Kirkley","year":"2017","journal-title":"Comp. Med."},{"key":"10.1016\/j.nbd.2019.02.020_bb0195","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.brainresbull.2011.11.016","article-title":"Gene expression in the Parkinson's disease brain","volume":"88","author":"Lewis","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2019.02.020_bb0200","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.4049\/jimmunol.170.9.4630","article-title":"IKK beta is required for peripheral B cell survival and proliferation","volume":"170","author":"Li","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2019.02.020_bb0210","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2019.02.020_bb0215","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/toxsci\/kfj150","article-title":"Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration","volume":"91","author":"Liu","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.nbd.2019.02.020_bb0220","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0896-6273(03)00116-8","article-title":"Neuronal or glial progeny: regional differences in radial glia fate","volume":"37","author":"Malatesta","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.02.020_bb0225","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1172\/JCI11916","article-title":"NF-\u03baB in neuronal plasticity and neurodegenerative disorders","volume":"107","author":"Mattson","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2019.02.020_bb0230","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.mehy.2006.01.013","article-title":"Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders","volume":"67","author":"McCarty","year":"2006","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.nbd.2019.02.020_bb0235","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1096\/fj.201700826R","article-title":"IKK2\/NF-\u03baB signaling protects neurons after traumatic brain injury","volume":"32","author":"Mettang","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2019.02.020_bb0240","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/jnr.22549","article-title":"Low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor-\u03baB reporter mice prior to loss of dopaminergic neurons","volume":"89","author":"Miller","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2019.02.020_bb0245","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s11481-012-9377-9","article-title":"Testing NF-\u03baB-based therapy in Hemiparkinsonian monkeys","volume":"7","author":"Mondal","year":"2012","journal-title":"J. NeuroImmune. Pharm."},{"key":"10.1016\/j.nbd.2019.02.020_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/952375","article-title":"Cellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson's disease","volume":"2013","author":"More","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.nbd.2019.02.020_bb0255","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1002\/jnr.21640","article-title":"Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways","volume":"86","author":"Moreno","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2019.02.020_bb0260","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/toxsci\/kfp220","article-title":"Age-dependent susceptibility to manganese-induced neurological dysfunction","volume":"112","author":"Moreno","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.nbd.2019.02.020_bb0265","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2174\/1381612053381620","article-title":"Inflammatory process in Parkinson's disease: role for cytokines","volume":"11","author":"Nagatsu","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.nbd.2019.02.020_bb0270","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bbadis.2017.11.004","article-title":"Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration","volume":"1864","author":"Neal","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2019.02.020_bb0275","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1601-1848.2001.00013.x","article-title":"The ultimate chip shot: can microarray technology deliver for neuroscience?","volume":"1","author":"Nisenbaum","year":"2002","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2019.02.020_bb0280","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.nbd.2012.06.010","article-title":"Astrocyte-specific IKK2 activation in mice is sufficient to induce neuroinflammation but does not increase susceptibility to MPTP","volume":"48","author":"Oeckl","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"Suppl. 3","key":"10.1016\/j.nbd.2019.02.020_bb0285","doi-asserted-by":"crossref","first-page":"S200","DOI":"10.1016\/S1353-8020(09)70814-4","article-title":"Neuroinflammation in the living brain of Parkinson's disease","volume":"15","author":"Ouchi","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2019.02.020_bb0290","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1073\/pnas.0409598102","article-title":"Parkin-deficient mice are not a robust model of parkinsonism","volume":"102","author":"Perez","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.02.020_bb0295","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s12974-018-1349-4","article-title":"Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese","volume":"15","author":"Popichak","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2019.02.020_bb0300","first-page":"135","article-title":"The parkinsonian toxin MPTP: action and mechanism","volume":"16","author":"Przedborski","year":"2000","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.020_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40478-016-0350-3","article-title":"Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia","volume":"4","author":"Saggu","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2019.02.020_bb0310","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2009.01.038","article-title":"A Nurr1\/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death","volume":"137","author":"Saijo","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2019.02.020_bb0315","first-page":"1","article-title":"NSAIDs: how they work and their prospects as therapeutics in Alzheimer's disease","volume":"2","author":"Sastre","year":"2010","journal-title":"Front Ag Neurosci"},{"key":"10.1016\/j.nbd.2019.02.020_bb0320","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0166-4328(01)00309-6","article-title":"Behavioral phenotyping of the MPTP mouse model of Parkinson's disease","volume":"125","author":"Sedelis","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2019.02.020_bb0325","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1523\/JNEUROSCI.0877-17.2017","article-title":"Calcineurin\/NFAT Signaling in activated astrocytes drives network Hyperexcitability in Abeta-bearing mice","volume":"37","author":"Sompol","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.02.020_bb0330","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/toxsci\/kfr335","article-title":"Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice","volume":"126","author":"Streifel","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.nbd.2019.02.020_bb0335","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0006-8993(02)04085-4","article-title":"Age-related microglial activation in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL\/6 mice","volume":"964","author":"Sugama","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2019.02.020_bb0340","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.nbd.2009.11.004","article-title":"Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention","volume":"37","author":"Tansey","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.02.020_bb0345","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"SAM significance analysis of Microarraysapplied to transcriptional responses to ionizing radiation","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.02.020_bb0350","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/ni1372","article-title":"Inhibition of transcription factor NF-\u03baB in the central nervous system ameliorates autoimmune encephalomyelitis in mice","volume":"7","author":"Van Loo","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.nbd.2019.02.020_bb0355","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009365","article-title":"Programmed cell death in Parkinson's disease","volume":"2","author":"Venderova","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.nbd.2019.02.020_bb0360","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.cmet.2017.04.002","article-title":"Astrocytic process plasticity and IKKbeta;\/NF-&kappaB in central control of blood glucose, blood pressure, and body weight","volume":"25","author":"Zhang","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2019.02.020_bb0365","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/gene.10008","article-title":"hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo","volume":"31","author":"Zhuo","year":"2001","journal-title":"Genesis"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119300506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119300506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:15:53Z","timestamp":1760850953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996119300506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":72,"alternative-id":["S0969996119300506"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.02.020","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic suppression of IKK2\/NF-\u03baB in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}