{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:33:42Z","timestamp":1773927222791,"version":"3.50.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"am","delay-in-days":302,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005191","name":"Craig H. Neilsen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.nbd.2019.04.014","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T21:05:50Z","timestamp":1556139950000},"page":"591-604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function"],"prefix":"10.1016","volume":"127","author":[{"given":"Biswarup","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Nong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhicheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W.","family":"Urban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolette M.","family":"Heinsinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria A.","family":"Trovillion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan C.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo C.","family":"Lepore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.nbd.2019.04.014_bb0005","doi-asserted-by":"crossref","first-page":"14014","DOI":"10.1073\/pnas.93.24.14014","article-title":"A novel mechanism of action of tetracyclines: effects on nitric oxide synthases","volume":"93","author":"Amin","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.nbd.2019.04.014_bb0010","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nrn1964","article-title":"Spinal cord repair strategies: why do they work?","volume":"7","author":"Bradbury","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"Pt 4","key":"10.1016\/j.nbd.2019.04.014_bb0015","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/brain\/aws072","article-title":"Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury","volume":"135","author":"Casha","year":"2012","journal-title":"Brain"},{"issue":"18","key":"10.1016\/j.nbd.2019.04.014_bb0020","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1523\/JNEUROSCI.5135-04.2005","article-title":"Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats","volume":"25","author":"Choi","year":"2005","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.nbd.2019.04.014_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012021","article-title":"Spatio-temporal progression of grey and white matter damage following contusion injury in rat spinal cord","volume":"5","author":"Ek","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.nbd.2019.04.014_bb0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bcp.2009.07.028","article-title":"Mitochondria and calcium flux as targets of neuroprotection caused by minocycline in cerebellar granule cells","volume":"79","author":"Garcia-Martinez","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.nbd.2019.04.014_bb0035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/bph.12139","article-title":"Minocycline: far beyond an antibiotic","volume":"169","author":"Garrido-Mesa","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"26","key":"10.1016\/j.nbd.2019.04.014_bb0040","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.1523\/JNEUROSCI.3084-17.2018","article-title":"Local BDNF delivery to the injured cervical spinal cord using an engineered hydrogel enhances diaphragmatic respiratory function","volume":"38","author":"Ghosh","year":"2018","journal-title":"J. Neurosci."},{"issue":"1\u20134","key":"10.1016\/j.nbd.2019.04.014_bb0045","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1152\/advan.00039.2002","article-title":"Recent advances in pathophysiology and treatment of spinal cord injury","volume":"26","author":"Hulsebosch","year":"2002","journal-title":"Adv. Physiol. Educ."},{"issue":"4","key":"10.1016\/j.nbd.2019.04.014_bb0050","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s13233-010-0412-5","article-title":"Thermosensitive polymer-based hydrogel mixed with the anti-inflammatory agent minocycline induces axonal regeneration in hemisected spinal cord","volume":"18","author":"Kang","year":"2010","journal-title":"Macromol. Res."},{"issue":"43","key":"10.1016\/j.nbd.2019.04.014_bb0055","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2019.04.014_bb0060","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbr.2008.09.040","article-title":"Minocycline and neurodegenerative diseases","volume":"196","author":"Kim","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2019.04.014_bb0065","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1038\/cddis.2013.54","article-title":"Minocycline selectively inhibits M1 polarization of microglia","volume":"4","author":"Kobayashi","year":"2013","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.nbd.2019.04.014_bb0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1191\/0267659105pf788oa","article-title":"Dextran sulfate as a leukocyte-endothelium adhesion molecule inhibitor of lung injury in pediatric open-heart surgery","volume":"20","author":"Komai","year":"2005","journal-title":"Perfusion"},{"issue":"3","key":"10.1016\/j.nbd.2019.04.014_bb0075","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1471-4159.2005.03219.x","article-title":"Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity","volume":"94","author":"Kraus","year":"2005","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.nbd.2019.04.014_bb0080","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.neuron.2014.07.027","article-title":"TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord","volume":"83","author":"Kroner","year":"2014","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.nbd.2019.04.014_bb0085","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1089\/neu.2009.1149","article-title":"A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury","volume":"28","author":"Kwon","year":"2011","journal-title":"J. Neurotrauma"},{"issue":"10","key":"10.1016\/j.nbd.2019.04.014_bb0090","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tins.2008.07.002","article-title":"Respiratory neuroplasticity and cervical spinal cord injury: translational perspectives","volume":"31","author":"Lane","year":"2008","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2019.04.014_bb0095","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.expneurol.2011.09.024","article-title":"Respiratory function following bilateral mid-cervical contusion injury in the adult rat","volume":"235","author":"Lane","year":"2012","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2019.04.014_bb0100","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1523\/JNEUROSCI.07-01-00252.1987","article-title":"Topographic mapping of motor pools onto skeletal muscles","volume":"7","author":"Laskowski","year":"1987","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.nbd.2019.04.014_bb0105","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1089\/089771503770195867","article-title":"Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat","volume":"20","author":"Lee","year":"2003","journal-title":"J. Neurotrauma"},{"issue":"8","key":"10.1016\/j.nbd.2019.04.014_bb0110","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1073\/pnas.0905437106","article-title":"Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury","volume":"107","author":"Lee","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.nbd.2019.04.014_bb0115","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/nn.2210","article-title":"Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease","volume":"11","author":"Lepore","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2019.04.014_bb0120","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.nbd.2010.03.021","article-title":"Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats","volume":"39","author":"Lepore","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"22","key":"10.1016\/j.nbd.2019.04.014_bb0125","doi-asserted-by":"crossref","first-page":"7622","DOI":"10.1523\/JNEUROSCI.4690-13.2014","article-title":"Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury","volume":"34","author":"Li","year":"2014","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2019.04.014_bb0130","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/mt.2014.236","article-title":"Transplantation of glial progenitors that overexpress glutamate transporter GLT1 preserves diaphragm function following cervical SCI","volume":"23","author":"Li","year":"2015","journal-title":"Mol. Ther."},{"key":"10.1016\/j.nbd.2019.04.014_bb0135","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.expneurol.2015.07.020","article-title":"Human iPS cell-derived astrocyte transplants preserve respiratory function after spinal cord injury","volume":"271","author":"Li","year":"2015","journal-title":"Exp. Neurol."},{"issue":"14","key":"10.1016\/j.nbd.2019.04.014_bb0140","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1523\/JNEUROSCI.17-14-05395.1997","article-title":"Neuronal and glial apoptosis after traumatic spinal cord injury","volume":"17","author":"Liu","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.04.014_bb0145","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.expneurol.2013.04.002","article-title":"Motoneuron BDNF\/TrkB signaling enhances functional recovery after cervical spinal cord injury","volume":"247","author":"Mantilla","year":"2013","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2019.04.014_bb0150","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.expneurol.2007.03.029","article-title":"Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3","volume":"209","author":"Massey","year":"2008","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.nbd.2019.04.014_bb0155","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1517\/13543784.2015.1009629","article-title":"Investigational drugs for the treatment of spinal cord injury: review of preclinical studies and evaluation of clinical trials from phase I to II","volume":"24","author":"Nagoshi","year":"2015","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"6","key":"10.1016\/j.nbd.2019.04.014_bb0160","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/jid.2015.30","article-title":"Relative expression of Proinflammatory and Antiinflammatory genes reveals differences between healing and nonhealing human chronic diabetic foot ulcers","volume":"135","author":"Nassiri","year":"2015","journal-title":"J Invest Dermatol"},{"issue":"45","key":"10.1016\/j.nbd.2019.04.014_bb0165","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1016\/j.vaccine.2014.08.057","article-title":"Evaluation of safety and efficacy as an adjuvant for the chitosan-based vaccine delivery vehicle ViscoGel in a single-blind randomised phase I\/IIa clinical trial","volume":"32","author":"Neimert-Andersson","year":"2014","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.nbd.2019.04.014_bb0170","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.expneurol.2012.03.007","article-title":"Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury","volume":"235","author":"Nicaise","year":"2012","journal-title":"Exp. Neurol."},{"issue":"18","key":"10.1016\/j.nbd.2019.04.014_bb0175","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1089\/neu.2012.2467","article-title":"Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice","volume":"29","author":"Nicaise","year":"2012","journal-title":"J. Neurotrauma"},{"issue":"12","key":"10.1016\/j.nbd.2019.04.014_bb0180","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1089\/neu.2012.2728","article-title":"Early phrenic motor neuron loss and transient respiratory abnormalities after unilateral cervical spinal cord contusion","volume":"30","author":"Nicaise","year":"2013","journal-title":"J. Neurotrauma"},{"issue":"11","key":"10.1016\/j.nbd.2019.04.014_bb0185","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/S0003-9993(99)90247-2","article-title":"Recent demographic and injury trends in people served by the model spinal cord injury care systems","volume":"80","author":"Nobunaga","year":"1999","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"2","key":"10.1016\/j.nbd.2019.04.014_bb0190","doi-asserted-by":"crossref","first-page":"281","DOI":"10.55782\/ane-2011-1848","article-title":"Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade","volume":"71","author":"Oyinbo","year":"2011","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"issue":"4","key":"10.1016\/j.nbd.2019.04.014_bb0195","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbagen.2012.01.011","article-title":"Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition","volume":"1820","author":"Pang","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"24","key":"10.1016\/j.nbd.2019.04.014_bb0200","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.2174\/13816128113199990341","article-title":"Modulation of the intrinsic properties of motoneurons by serotonin","volume":"19","author":"Perrier","year":"2013","journal-title":"Curr. Pharm. Des."},{"issue":"5","key":"10.1016\/j.nbd.2019.04.014_bb0205","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/j.1471-4159.2004.02796.x","article-title":"Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways","volume":"91","author":"Pi","year":"2004","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.nbd.2019.04.014_bb0210","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.tripleo.2009.04.025","article-title":"Lip augmentation with a new filler (agarose gel): a 3-year follow-up study","volume":"108","author":"Scarano","year":"2009","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"issue":"4","key":"10.1016\/j.nbd.2019.04.014_bb0215","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3174\/ajnr.A0916","article-title":"Diffusion tensor MR imaging in cervical spine trauma","volume":"29","author":"Shanmuganathan","year":"2008","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nbd.2019.04.014_bb0220","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0079-6123(06)61027-3","article-title":"Intrathecal drug delivery strategy is safe and efficacious for localized delivery to the spinal cord","volume":"161","author":"Shoichet","year":"2007","journal-title":"Prog. Brain Res."},{"issue":"5","key":"10.1016\/j.nbd.2019.04.014_bb0225","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4103\/1673-5374.206633","article-title":"Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury","volume":"12","author":"Shultz","year":"2017","journal-title":"Neural Regen. Res."},{"issue":"9","key":"10.1016\/j.nbd.2019.04.014_bb0230","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1523\/JNEUROSCI.5275-03.2004","article-title":"Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury","volume":"24","author":"Stirling","year":"2004","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.nbd.2019.04.014_bb0235","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/1073858405275175","article-title":"Minocycline as a neuroprotective agent","volume":"11","author":"Stirling","year":"2005","journal-title":"Neuroscientist"},{"issue":"3","key":"10.1016\/j.nbd.2019.04.014_bb0240","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1189\/jlb.0504272","article-title":"Functional plasticity of macrophages: reversible adaptation to changing microenvironments","volume":"76","author":"Stout","year":"2004","journal-title":"J. Leukoc. Biol."},{"issue":"23","key":"10.1016\/j.nbd.2019.04.014_bb0245","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1097\/BRS.0b013e3181ffda29","article-title":"Effects of minocycline on hind-limb motor function and gray and white matter injury after spinal cord ischemia in rats","volume":"36","author":"Takeda","year":"2011","journal-title":"Spine (Phila Pa 1976)"},{"issue":"9","key":"10.1016\/j.nbd.2019.04.014_bb0250","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1073\/pnas.0306239101","article-title":"Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury","volume":"101","author":"Teng","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2019.04.014_bb0255","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.expneurol.2018.02.007","article-title":"Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI","volume":"303","author":"Urban","year":"2018","journal-title":"Exp. Neurol."},{"issue":"18","key":"10.1016\/j.nbd.2019.04.014_bb0260","doi-asserted-by":"crossref","first-page":"10483","DOI":"10.1073\/pnas.1832501100","article-title":"Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease","volume":"100","author":"Wang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.nbd.2019.04.014_bb0265","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/glia.22774","article-title":"Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris","volume":"63","author":"Wang","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2019.04.014_bb0270","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.biomaterials.2016.10.002","article-title":"Local delivery of minocycline from metal ion-assisted self-assembled complexes promotes neuroprotection and functional recovery after spinal cord injury","volume":"112","author":"Wang","year":"2017","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.nbd.2019.04.014_bb0275","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.expneurol.2007.06.025","article-title":"Minocycline protects the blood-brain barrier and reduces edema following intracerebral hemorrhage in the rat","volume":"207","author":"Wasserman","year":"2007","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2019.04.014_bb0280","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.expneurol.2007.03.011","article-title":"Ciliary neurotrophic factor is not required for terminal sprouting and compensatory reinnervation of neuromuscular synapses: re-evaluation of CNTF null mice","volume":"205","author":"Wright","year":"2007","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2019.04.014_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.21439","article-title":"Distinct patterns of motor nerve terminal sprouting induced by ciliary neurotrophic factor vs. botulinum toxin","volume":"504","author":"Wright","year":"2007","journal-title":"J. Comp. Neurol."},{"issue":"47","key":"10.1016\/j.nbd.2019.04.014_bb0290","doi-asserted-by":"crossref","first-page":"14942","DOI":"10.1523\/JNEUROSCI.2276-09.2009","article-title":"Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses","volume":"29","author":"Wright","year":"2009","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.nbd.2019.04.014_bb0295","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1523\/JNEUROSCI.3822-13.2014","article-title":"Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration","volume":"34","author":"Wright","year":"2014","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2019.04.014_bb0300","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2353\/ajpath.2010.090361","article-title":"Improving outcomes of neuroprotection by minocycline: guides from cell culture and intracerebral hemorrhage in mice","volume":"176","author":"Xue","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2019.04.014_bb0305","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/1756-3305-7-372","article-title":"Activated microglia contribute to neuronal apoptosis in Toxoplasmic encephalitis","volume":"7","author":"Zhang","year":"2014","journal-title":"Parasit. Vectors"},{"issue":"1","key":"10.1016\/j.nbd.2019.04.014_bb0310","doi-asserted-by":"crossref","first-page":"015006","DOI":"10.1088\/1758-5090\/7\/1\/015006","article-title":"Metal ion-assisted self-assembly of complexes for controlled and sustained release of minocycline for biomedical applications","volume":"7","author":"Zhang","year":"2015","journal-title":"Biofabrication"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119301032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119301032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:20:55Z","timestamp":1760851255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996119301032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":62,"alternative-id":["S0969996119301032"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.04.014","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}