{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T21:58:49Z","timestamp":1778191129189,"version":"3.51.4"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"crossref","award":["# C26A14RMK5"],"award-info":[{"award-number":["# C26A14RMK5"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.nbd.2019.104531","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T11:25:33Z","timestamp":1562844333000},"page":"104531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["The endocannabinoid system is affected by cholesterol dyshomeostasis: Insights from a murine model of Niemann Pick type C disease"],"prefix":"10.1016","volume":"130","author":[{"given":"Sergio","family":"Oddi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Caporali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Dragotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Totaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Maiolati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Scipioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clotilde Beatrice","family":"Angelucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Orsini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Canterini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Rapino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Maccarrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-4019","authenticated-orcid":false,"given":"Maria Teresa","family":"Fiorenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2019.104531_bb0005","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1126\/science.1068886","article-title":"A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains","volume":"296","author":"Anderson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.nbd.2019.104531_bb0010","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1037\/a0034686","article-title":"Immediate response strategy and shift to place strategy in submerged T-maze","volume":"127","author":"Asem","year":"2013","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2019.104531_bb0015","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/14734220410019011","article-title":"Immunohistochemical localization of cannabinoid CB 1 receptor in inhibitory interneurons in the cerebellum","volume":"3","author":"Ashton","year":"2004","journal-title":"Cerebellum"},{"key":"10.1016\/j.nbd.2019.104531_bb0020","doi-asserted-by":"crossref","first-page":"12212","DOI":"10.1074\/jbc.M411642200","article-title":"Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis","volume":"280","author":"Bari","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2019.104531_bb0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/jnr.20546","article-title":"Cholesterol-dependent modulation of type 1 cannabinoid receptors in nerve cells","volume":"81","author":"Bari","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2019.104531_bb0030","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.4049\/jimmunol.177.8.4971","article-title":"Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells","volume":"177","author":"Bari","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2019.104531_bb0035","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0014-4886(03)00345-5","article-title":"Postnatal development of inflammation in a murine model of Niemann-Pick type C disease: immunohistochemical observations of microglia and astroglia","volume":"184","author":"Baudry","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2019.104531_bb0040","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bbr.2014.10.009","article-title":"Evidence for the involvement of extinction-associated inhibitory learning in the forced swimming test","volume":"278","author":"Campus","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2019.104531_bb0045","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1093\/hmg\/ddx118","article-title":"Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease","volume":"26","author":"Canterini","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.104531_bb0050","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s40478-016-0370-z","article-title":"Developmental delay in motor skill acquisition in Niemann-Pick C1 mice reveals abnormal cerebellar morphogenesis","volume":"4","author":"Caporali","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2019.104531_bb0055","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1093\/brain\/awm160","article-title":"The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis","volume":"130","author":"Centonze","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2019.104531_bb0060","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pneurobio.2017.10.007","article-title":"The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: clues for other neuroinflammatory diseases","volume":"160","author":"Chiurchi\u00f9","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2019.104531_bb0065","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1601-183X.2010.00604.x","article-title":"Strain-specific proportion of the two isoforms of the dopamine D2 receptor in the mouse striatum: associated neural and behavioral phenotypes","volume":"9","author":"Colelli","year":"2010","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2019.104531_bb0070","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.2174\/092986707782023235","article-title":"Modulation of the endocannabinoid system by lipid rafts","volume":"14","author":"Dainese","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.nbd.2019.104531_bb0075","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2174\/092986710790980087","article-title":"Interaction of endocannabinoid receptors with biological membranes","volume":"17","author":"Dainese","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.nbd.2019.104531_bb0080","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/BJ20130960","article-title":"Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH","volume":"457","author":"Dainese","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2019.104531_bb5000","doi-asserted-by":"crossref","first-page":"18932","DOI":"10.1073\/pnas.1110439108","article-title":"Niemann\u2013Pick type C function requires luminal domain residues that mediate cholesterol-dependent NPC2 binding","volume":"108","author":"Deffieu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2019.104531_bb0085","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0031-9384(89)90261-8","article-title":"Learned immobility explains the behavior of rats in the forced swimming test","volume":"46","author":"De Pablo","year":"1989","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.nbd.2019.104531_bb0090","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1136\/jnnp.2007.139071","article-title":"Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis","volume":"79","author":"Di Filippo","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2019.104531_bb0095","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrd2553","article-title":"Targeting the endocannabinoid system: to enhance or reduce?","volume":"7","author":"Di Marzo","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.nbd.2019.104531_bb0100","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrn3876","article-title":"Endocannabinoid signalling and the deteriorating brain","volume":"16","author":"Di Marzo","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2019.104531_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/srep28781","article-title":"Common molecular mechanism of amyloid pore formation by Alzheimer's \u03b2-amyloid peptide and \u03b1-synuclein","volume":"6","author":"Di Scala","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2019.104531_bb0110","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.bbamem.2009.08.016","article-title":"Sphingolipid\/cholesterol regulation of neurotransmitter receptor conformation and function","volume":"1788","author":"Fantini","year":"2009","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.nbd.2019.104531_bb0115","doi-asserted-by":"crossref","first-page":"17078","DOI":"10.3390\/molecules191117078","article-title":"Endocannabinoids, related compounds and their metabolic routes","volume":"19","author":"Fezza","year":"2014","journal-title":"Molecules"},{"issue":"2 Suppl","key":"10.1016\/j.nbd.2019.104531_bb0120","first-page":"23","article-title":"Cholesterol metabolism-associated molecules in late onset Alzheimer's disease","volume":"27","author":"Fiorenza","year":"2013","journal-title":"J. Biol. Regul. Homeost. Agents"},{"issue":"R2","key":"10.1016\/j.nbd.2019.104531_bb0125","doi-asserted-by":"crossref","first-page":"R119","DOI":"10.1093\/hmg\/ddy155","article-title":"The pathogenesis of lysosomal storage disorders: beyond the engorgement of lysosomes to abnormal development and neuroinflammation","volume":"27","author":"Fiorenza","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.104531_bb0130","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1038\/s41598-018-24925-8","article-title":"Endocannabinoids in Caenorhabditis elegans are essential for the mobilization of cholesterol from internal reserves","volume":"8","author":"Galles","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2019.104531_bb0135","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13023-017-0714-1","article-title":"Cognitive impairment profile in adult patients with Niemann pick type C disease","volume":"12","author":"Heitz","year":"2017","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.nbd.2019.104531_bb0140","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00227765","article-title":"Cerebellar degeneration in the Niemann\u2013Pick type C mouse","volume":"85","author":"Higashi","year":"1993","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2019.104531_bb0145","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1194\/jlr.D058438","article-title":"Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors","volume":"57","author":"Iglesias","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.nbd.2019.104531_bb0150","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bbrc.2010.12.031","article-title":"Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors","volume":"404","author":"Jafurulla","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2019.104531_bb4000","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cell.2009.03.049","article-title":"Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol","volume":"137","author":"Kwon","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2019.104531_bb0155","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1021\/bi060163l","article-title":"Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids","volume":"45","author":"Leung","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.nbd.2019.104531_bb0160","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fnmol.2017.00166","article-title":"Metabolism of the endocannabinoid anandamide: open questions after 25 years","volume":"10","author":"Maccarrone","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2019.104531_bb0165","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1471-4159.2009.05948.x","article-title":"Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum","volume":"109","author":"Maccarrone","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.104531_bb0170","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.tibs.2010.05.008","article-title":"Intracellular trafficking of anandamide: new concepts for signaling","volume":"35","author":"Maccarrone","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.nbd.2019.104531_bb0175","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.phrs.2018.02.009","article-title":"Early alteration of distribution and activity of hippocampal type-1 cannabinoid receptor in Alzheimer's disease-like mice overexpressing the human mutant amyloid precursor protein","volume":"130","author":"Maccarrone","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.nbd.2019.104531_bb0180","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12311-014-0629-5","article-title":"Cerebellar endocannabinoids: retrograde signaling from purkinje cells","volume":"14","author":"Marcaggi","year":"2015","journal-title":"Cerebellum"},{"key":"10.1016\/j.nbd.2019.104531_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137034","article-title":"Potential therapeutic value of a novel FAAH inhibitor for the treatment of anxiety","volume":"10","author":"Marco","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2019.104531_bb0190","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/hmg\/ddr505","article-title":"A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations","volume":"21","author":"Maue","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.104531_bb0195","doi-asserted-by":"crossref","first-page":"41991","DOI":"10.1074\/jbc.M407250200","article-title":"A role for caveolae\/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide","volume":"279","author":"McFarland","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2019.104531_bb0200","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-psych-113011-143739","article-title":"The endocannabinoid system and the brain","volume":"64","author":"Mechoulam","year":"2013","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.nbd.2019.104531_bb0205","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1037\/0735-7044.105.6.798","article-title":"Effects of corticosterone on response consolidation and retrieval in the forced swim test","volume":"105","author":"Mitchell","year":"1991","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2019.104531_bb0210","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.nbd.2014.06.012","article-title":"A marked paucity of granule cells in the developing cerebellum of the Npc1(\u2212\/\u2212) mouse is corrected by a single injection of hydroxypropyl-beta-cyclodextrin","volume":"70","author":"Nusca","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104531_bb0215","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s00018-004-4446-8","article-title":"Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes","volume":"62","author":"Oddi","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2019.104531_bb0220","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s00018-008-7494-7","article-title":"Evidence for the intracellular accumulation of anandamide in adiposomes","volume":"65","author":"Oddi","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2019.104531_bb0225","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.chembiol.2009.05.004","article-title":"Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins","volume":"16","author":"Oddi","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.nbd.2019.104531_bb0230","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1471-4159.2010.07041.x","article-title":"Functional characterization of putative cholesterol binding sequence (CRAC) in human type-1 cannabinoid receptor","volume":"116","author":"Oddi","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.104531_bb0235","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1111\/j.1476-5381.2011.01658.x","article-title":"Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling","volume":"165","author":"Oddi","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2019.104531_bb0240","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S1074-7427(03)00075-3","article-title":"Selective improvement of strain-dependent performances of cognitive tasks by food restriction","volume":"81","author":"Orsini","year":"2004","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.nbd.2019.104531_bb2000","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13023-015-0348-0","article-title":"Visual evoked potentials of Niemann-Pick type C1 mice reveal an impairment of the visual pathway that is rescued by 2-hydroxypropyl-\u00df-cyclodextrin","volume":"10","author":"Palladino","year":"2015","journal-title":"Orphanet. J. Rare. Dis."},{"key":"10.1016\/j.nbd.2019.104531_bb6000","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1016\/j.febslet.2010.04.047","article-title":"Defective cholesterol trafficking in Niemann-Pick C-deficient cells","volume":"584","author":"Peake","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2019.104531_bb0245","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","article-title":"The molecular logic of endocannabinoid signalling","volume":"4","author":"Piomelli","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2019.104531_bb0250","first-page":"5","article-title":"Making memories of stessful events: a journey along epigenetic, gene transcription, and signaling pathways","volume":"5","author":"Raul","year":"2014","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.nbd.2019.104531_bb0255","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/sj.bjp.0707561","article-title":"Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line","volume":"153","author":"Rimmerman","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2019.104531_bb0260","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/brain\/awl260","article-title":"The adult form of Niemann-Pick disease type C","volume":"130","author":"Sevin","year":"2007","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.nbd.2019.104531_bb8000","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0166-4328(94)90008-6","article-title":"Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions","volume":"61","author":"Simon","year":"1994","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2019.104531_bb0265","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1039\/c000237b","article-title":"Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo","volume":"6","author":"Simon","year":"2010","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.nbd.2019.104531_bb0270","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.nbd.2019.104531_bb0275","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1113\/JP271106","article-title":"Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia?","volume":"594","author":"Stephens","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2019.104531_bb0280","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1208\/s12248-010-9180-6","article-title":"Assessment of a spectrophotometric assay for monoacylglycerol lipase activity","volume":"12","author":"Ulloa","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.nbd.2019.104531_bb3000","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1750-1172-5-16","article-title":"Niemann-Pick disease type C","volume":"5","author":"Vanier","year":"2010","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.nbd.2019.104531_bb0285","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1007\/s00018-006-6037-3","article-title":"Endocannabinoids and \u03b2-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels","volume":"63","author":"Van Der Stelt","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2019.104531_bb0290","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3389\/fnins.2018.00440","article-title":"Chemical proteomic analysis of serine hydrolase activity in Niemann-Pick type C mouse brain","volume":"12","author":"Van Rooden","year":"2018","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2019.104531_bb7000","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2019.104531_bb0295","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0278-5846(90)90073-P","article-title":"Neurobehavioral studies of forced swimming: the role of learning and memory in the forced swim test","volume":"14","author":"West","year":"1990","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2019.104531_bb0300","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1111\/j.1471-4159.2004.02544.x","article-title":"Endocannabinoids accumulate in spinal cord of SOD1G93Atransgenic mice","volume":"89","author":"Witting","year":"2004","journal-title":"J. Neurochem."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119301998?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119301998?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:21:53Z","timestamp":1760851313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996119301998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":67,"alternative-id":["S0969996119301998"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.104531","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The endocannabinoid system is affected by cholesterol dyshomeostasis: Insights from a murine model of Niemann Pick type C disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.104531","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104531"}}