{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:23:39Z","timestamp":1762899819034,"version":"build-2065373602"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2017-01080"],"award-info":[{"award-number":["2017-01080"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Olle Engkvist Foundation"},{"name":"Royal Physiographic Society"},{"name":"Kocks foundation and P\u00e5hlsson foundation"},{"DOI":"10.13039\/501100003792","name":"Swedish Brain Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2018-02532"],"award-info":[{"award-number":["2018-02532"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["681712"],"award-info":[{"award-number":["681712"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish State Support for Clinical Research","award":["ALFGBG-720931"],"award-info":[{"award-number":["ALFGBG-720931"]}]},{"name":"UK Dementia Research Institute at UCL"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.nbd.2019.104560","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T19:25:20Z","timestamp":1565724320000},"page":"104560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Leptin deficiency reverses high metabolic state and weight loss without affecting central pathology in the R6\/2 mouse model of Huntington's disease"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3443-4539","authenticated-orcid":false,"given":"Marie","family":"Sj\u00f6gren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Soylu-Kucharz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Unali","family":"Dandunna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiberiu Loredan","family":"Stan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Cavalera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Sandelius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bj\u00f6rkqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2019.104560_bb0005","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1210\/endo.140.6.6774","article-title":"Regulation of neuronal and glial proteins by leptin: implications for brain development","volume":"140","author":"Ahima","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.nbd.2019.104560_bb0010","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/nbdi.2001.0406","article-title":"Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease","volume":"8","author":"Andreassen","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104560_bb0015","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1006\/nbdi.2002.0562","article-title":"Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression","volume":"11","author":"Andreassen","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104560_bb0020","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1136\/jnnp.2009.191833","article-title":"Systemic energy homeostasis in Huntington's disease patients","volume":"81","author":"Aziz","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2019.104560_bb0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrendo.2013.204","article-title":"Adipose tissue browning and metabolic health","volume":"10","author":"Bartelt","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.nbd.2019.104560_bb0030","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.nbd.2019.104560_bb0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0006-8993(79)90557-2","article-title":"Altered neuroanatomical organization in the central nervous system of the genetically obese (ob\/ob) mouse","volume":"165","author":"Bereiter","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2019.104560_bb0040","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/hmg\/ddi053","article-title":"The R6\/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis","volume":"14","author":"Bjorkqvist","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.104560_bb0045","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/hmg\/ddl094","article-title":"Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6\/2 transgenic mouse model of Huntington's disease","volume":"15","author":"Bjorkqvist","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.104560_bb0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2007.07.029","article-title":"Increased metabolism in the R6\/2 mouse model of Huntington's disease","volume":"29","author":"van der Burg","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104560_bb0055","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(09)70178-4","article-title":"Beyond the brain: widespread pathology in Huntington's disease","volume":"8","author":"van der Burg","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2019.104560_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2011.05.006","article-title":"Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice","volume":"44","author":"van der Burg","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104560_bb0065","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/ana.25007","article-title":"Body weight is a robust predictor of clinical progression in Huntington disease","volume":"82","author":"van der Burg","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2019.104560_bb0070","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S1474-4422(17)30124-2","article-title":"Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis","volume":"16","author":"Byrne","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2019.104560_bb0075","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S1474-4422(15)00177-5","article-title":"Treating the whole body in Huntington's disease","volume":"14","author":"Carroll","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2019.104560_bb0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00429772","article-title":"Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice","volume":"14","author":"Coleman","year":"1978","journal-title":"Diabetologia"},{"key":"10.1016\/j.nbd.2019.104560_bb0085","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1242\/dmm.024786","article-title":"A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6\/J mice","volume":"9","author":"Coughlan","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.nbd.2019.104560_bb0090","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2019.104560_bb0095","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nprot.2006.170","article-title":"Assessing nest building in mice","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2019.104560_bb0100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nprot.2006.20","article-title":"Digging and marble burying in mice: simple methods for in vivo identification of biological impacts","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2019.104560_bb0105","first-page":"e2607","article-title":"Assessing burrowing, nest construction, and hoarding in mice","author":"Deacon","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.nbd.2019.104560_bb0110","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbr.2007.12.024","article-title":"Age-dependent and -independent behavioral deficits in Tg2576 mice","volume":"189","author":"Deacon","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2019.104560_bb0115","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1046\/j.1471-4159.2003.01706.x","article-title":"Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice","volume":"85","author":"Dedeoglu","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.104560_bb0120","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1471-4159.2005.03588.x","article-title":"Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease","volume":"96","author":"Desplats","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.104560_bb0125","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nbd.2019.104560_bb0130","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/0026-0495(76)90109-8","article-title":"The development of obesity, hyperinsulinemia, and hyperglycemia in ob\/ob mice","volume":"25","author":"Dubuc","year":"1976","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.nbd.2019.104560_bb0135","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1474-4422(10)70224-6","article-title":"Energy metabolism in amyotrophic lateral sclerosis","volume":"10","author":"Dupuis","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2019.104560_bb0140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.baga.2013.01.085","article-title":"Impact of cognitive and behavioural changes on quality of life in Huntington's disease","volume":"3","author":"Eddy","year":"2013","journal-title":"Basal Ganglia"},{"key":"10.1016\/j.nbd.2019.104560_bb0145","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1176\/appi.ajp.2015.14121551","article-title":"Longitudinal psychiatric symptoms in prodromal Huntington's disease: a decade of data","volume":"173","author":"Epping","year":"2016","journal-title":"Am. J. Psychiatry"},{"year":"2008","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","key":"10.1016\/j.nbd.2019.104560_bb0150"},{"key":"10.1016\/j.nbd.2019.104560_bb0155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000080056","article-title":"Cytochemical analysis of pancreatic islet hypercytolipidemia following diabetes (db\/db) and obese (ob\/ob) mutation expression: influence of genomic background","volume":"71","author":"Garris","year":"2004","journal-title":"Pathobiology"},{"key":"10.1016\/j.nbd.2019.104560_bb0160","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1210\/endo-107-3-671","article-title":"A longitudinal hormonal profile of the genetically obese mouse","volume":"107","author":"Garthwaite","year":"1980","journal-title":"Endocrinology"},{"key":"10.1016\/j.nbd.2019.104560_bb0165","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1210\/endo-88-5-1230","article-title":"Insulin resistance in genetically obese, hyperglycemic mice","volume":"88","author":"Genuth","year":"1971","journal-title":"Endocrinology"},{"key":"10.1016\/j.nbd.2019.104560_bb0170","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.expneurol.2007.12.026","article-title":"The metabolic profile of early Huntington's disease--a combined human and transgenic mouse study","volume":"210","author":"Goodman","year":"2008","journal-title":"Exp. Neurol."},{"year":"2009","series-title":"The Open Field Test. Springer Links","author":"Gould","key":"10.1016\/j.nbd.2019.104560_bb0175"},{"key":"10.1016\/j.nbd.2019.104560_bb0180","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"Group THsDCR","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2019.104560_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2005.01.024","article-title":"Early behavioral deficits in R6\/2 mice suitable for use in preclinical drug testing","volume":"20","author":"Hickey","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104560_bb0190","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/j.1550-8528.1996.tb00519.x","article-title":"Obese, a new mutation in the house mouse","volume":"4","author":"Ingalls","year":"1996","journal-title":"Obes. Res."},{"key":"10.1016\/j.nbd.2019.104560_bb0195","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0026-0495(74)90030-4","article-title":"Growth pattern and behavioral traits associated with the development of the obese-hyperglycemic syndrome in mice (ob-ob)","volume":"23","author":"Joosten","year":"1974","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.nbd.2019.104560_bb0200","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neulet.2011.03.025","article-title":"Whole body cholesterol metabolism is impaired in Huntington's disease","volume":"494","author":"Leoni","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2019.104560_bb0205","doi-asserted-by":"crossref","first-page":"8473","DOI":"10.1523\/JNEUROSCI.21-21-08473.2001","article-title":"Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice","volume":"21","author":"Li","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.104560_bb0210","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1602\/neurorx.2.3.447","article-title":"The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies","volume":"2","author":"Li","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.nbd.2019.104560_bb0215","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.1093\/hmg\/ddu214","article-title":"Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis","volume":"23","author":"Lim","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.104560_bb0220","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nm1195-1155","article-title":"Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight- reduced subjects","volume":"11","author":"Maffei","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2019.104560_bb0225","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.nbd.2019.104560_bb0230","first-page":"9","article-title":"Metabolic, nutritional and endocrine studies of the hereditary obesity-diabetes syndrome of mice and mechanism of its development","volume":"2","author":"Mayer","year":"1953","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.nbd.2019.104560_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159870","article-title":"White adipose tissue browning in the R6\/2 mouse model of Huntington's disease","volume":"11","author":"McCourt","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2019.104560_bb0240","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/cne.10295","article-title":"Cellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6\/2 transgenic mice","volume":"449","author":"Meade","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2019.104560_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099520","article-title":"Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6\/2 and zQ175 mouse models of Huntington's disease","volume":"9","author":"Menalled","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2019.104560_bb0250","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/ejhg.2010.72","article-title":"Dietary anaplerotic therapy improves peripheral tissue energy metabolism in patients with Huntington's disease","volume":"18","author":"Mochel","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2019.104560_bb0255","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.nbd.2008.11.015","article-title":"Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6\/2 mice","volume":"33","author":"Morton","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104560_bb0260","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0006-8993(03)03219-0","article-title":"Elevated neurofilament levels in neurological diseases","volume":"987","author":"Norgren","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2019.104560_bb0265","doi-asserted-by":"crossref","first-page":"c3109","DOI":"10.1136\/bmj.c3109","article-title":"Huntington's disease","volume":"340","author":"Novak","year":"2010","journal-title":"Bmj"},{"key":"10.1016\/j.nbd.2019.104560_bb0270","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2008.04.045","article-title":"Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro","volume":"438","author":"Oldreive","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2019.104560_bb0275","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.metabol.2016.05.002","article-title":"Endoplasmic reticulum stress in obesity and obesity-related disorders: an expanded view","volume":"65","author":"Pagliassotti","year":"2016","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.nbd.2019.104560_bb0280","first-page":"351982","article-title":"Rodent models for metabolic syndrome research","volume":"2011","author":"Panchal","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.nbd.2019.104560_bb0285","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neulet.2006.11.058","article-title":"Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model","volume":"413","author":"Park","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2019.104560_bb0290","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1093\/hmg\/9.14.2175","article-title":"Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis","volume":"9","author":"Passani","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.104560_bb0295","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/B978-0-12-801893-4.00006-7","article-title":"Cognitive and behavioral changes in Huntington disease before diagnosis","volume":"144","author":"Paulsen","year":"2017","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.nbd.2019.104560_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070274","article-title":"Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease","volume":"8","author":"Paumier","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2019.104560_bb0305","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1460-9568.2006.04985.x","article-title":"Hypothalamic-endocrine aspects in Huntington's disease","volume":"24","author":"Petersen","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2019.104560_bb0310","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3233\/JHD-2012-120006","article-title":"Hypothalamic and limbic system changes in Huntington's disease","volume":"1","author":"Petersen","year":"2012","journal-title":"J. Huntington's Dis."},{"key":"10.1016\/j.nbd.2019.104560_bb0315","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.nbd.2014.12.009","article-title":"Longitudinal change in white matter microstructure in Huntington's disease: the IMAGE-HD study","volume":"74","author":"Poudel","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104560_bb0320","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1212\/WNL.0000000000003154","article-title":"Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia","volume":"87","author":"Rohrer","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2019.104560_bb0325","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.neuroimage.2009.10.015","article-title":"Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical \"disconnection\"","volume":"49","author":"Rosas","year":"2010","journal-title":"NeuroImage"},{"key":"10.1016\/j.nbd.2019.104560_bb0330","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington's disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2019.104560_bb0335","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.2337\/diabetes.53.2007.S130","article-title":"The biology of mitochondrial uncoupling proteins","volume":"53","author":"Rousset","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.nbd.2019.104560_bb0340","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/hmg\/8.5.813","article-title":"Formation of polyglutamine inclusions in non-CNS tissue","volume":"8","author":"Sathasivam","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.104560_bb0345","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0022-510X(85)90104-2","article-title":"Brain myelin of genetically obese mice","volume":"68","author":"Sena","year":"1985","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2019.104560_bb0350","doi-asserted-by":"crossref","first-page":"E49","DOI":"10.1152\/ajpendo.00630.2010","article-title":"Molecular characterization of skeletal muscle atrophy in the R6\/2 mouse model of Huntington's disease","volume":"301","author":"She","year":"2011","journal-title":"Am. J. Phys. Endocrinol. Metab."},{"key":"10.1016\/j.nbd.2019.104560_bb0355","doi-asserted-by":"crossref","first-page":"13896","DOI":"10.1038\/s41598-017-13713-5","article-title":"Ghrelin rescues skeletal muscle catabolic profile in the R6\/2 mouse model of Huntington's disease","volume":"7","author":"Sj\u00f6gren","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2019.104560_bb0360","doi-asserted-by":"crossref","first-page":"14114","DOI":"10.1038\/s41598-017-14179-1","article-title":"Neurofilament light protein in CSF and blood is associated with neurodegeneration and disease severity in Huntington's disease R6\/2 mice","volume":"7","author":"Soylu-Kucharz","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2019.104560_bb0365","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/hmg\/ddi192","article-title":"Gene expression in Huntington's disease skeletal muscle: a potential biomarker","volume":"14","author":"Strand","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.104560_bb0370","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/75484","article-title":"Dopamine is required for hyperphagia in Lep(ob\/ob) mice","volume":"25","author":"Szczypka","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2019.104560_bb0375","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1741-4520.2007.00150.x","article-title":"Roles of leptin in prenatal and perinatal brain development","volume":"47","author":"Udagawa","year":"2007","journal-title":"Congenit Anom (Kyoto)"},{"key":"10.1016\/j.nbd.2019.104560_bb0380","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1093\/hmg\/ddm170","article-title":"Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation","volume":"16","author":"Valenza","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2019.104560_bb0385","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00401-018-1835-x","article-title":"Energy metabolism in ALS: an underappreciated opportunity?","volume":"135","author":"Vandoorne","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2019.104560_bb0390","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.nbd.2015.04.008","article-title":"The role of type 2 diabetes in neurodegeneration","volume":"84","author":"Verdile","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104560_bb0395","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00401-007-0306-6","article-title":"Huntington disease models and human neuropathology: similarities and differences","volume":"115","author":"Vonsattel","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2019.104560_bb0400","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington's disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2019.104560_bb0405","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","article-title":"Use and abuse of HOMA modeling","volume":"6","author":"Wallace","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nbd.2019.104560_bb0410","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ana.25309","article-title":"In vivo characterization of white matter pathology in premanifest huntington's disease","volume":"84","author":"Zhang","year":"2018","journal-title":"Ann. Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119302281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119302281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:16:30Z","timestamp":1760850990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996119302281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":82,"alternative-id":["S0969996119302281"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.104560","relation":{},"ISSN":["0969-9961"],"issn-type":[{"type":"print","value":"0969-9961"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leptin deficiency reverses high metabolic state and weight loss without affecting central pathology in the R6\/2 mouse model of Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.104560","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104560"}}