{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:03:01Z","timestamp":1769839381875,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.nbd.2019.104677","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T02:25:13Z","timestamp":1573611913000},"page":"104677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Elemental fingerprint: Reassessment of a cerebrospinal fluid biomarker for Parkinson's disease"],"prefix":"10.1016","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-2852","authenticated-orcid":false,"given":"Fabian","family":"Maass","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-2588","authenticated-orcid":false,"given":"Bernhard","family":"Michalke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiree","family":"Willkommen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Leha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"T\u00f6nges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brit","family":"Mollenhauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Trenkwalder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"R\u00fcckamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"B\u00f6rger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Zerr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"B\u00e4hr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9362-7096","authenticated-orcid":false,"given":"Paul","family":"Lingor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2019.104677_bb0005","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1212\/WNL.0000000000000641","article-title":"Low clinical diagnostic accuracy of early vs advanced Parkinson disease","volume":"83","author":"Adler","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2019.104677_bb0010","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jtemb.2007.05.001","article-title":"Elemental profile of cerebrospinal fluid in patients with Parkinson's disease","volume":"21","author":"Alimonti","year":"2007","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.nbd.2019.104677_bb0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1326-6-8","article-title":"Glutathione peroxidase 4 is associated with neuromelanin in substantia nigra and dystrophic axons in putamen of Parkinson's brain","volume":"6","author":"Bellinger","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2019.104677_bb0020","first-page":"115","article-title":"Changes in selenoprotein P in substantia nigra and putamen in Parkinson's disease","volume":"2","author":"Bellinger","year":"2012","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.nbd.2019.104677_bb0025","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1309\/L241WUER8831GLWB","article-title":"Comparison of sample preservation methods for clinical trace element analysis by inductively coupled plasma mass spectrometry","volume":"123","author":"Bornhorst","year":"2005","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.nbd.2019.104677_bb0030","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.neurobiolaging.2007.10.018","article-title":"CSF mg and ca as diagnostic markers for dementia with Lewy bodies","volume":"30","author":"Bostr\u00f6m","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2019.104677_bb0035","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/ars.2015.6478","article-title":"Selenoprotein T exerts an essential oxidoreductase activity that protects dopaminergic neurons in mouse models of Parkinson's disease","volume":"24","author":"Boukhzar","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2019.104677_bb0040","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jtemb.2011.08.144","article-title":"Role of manganese in neurodegenerative diseases","volume":"25","author":"Bowman","year":"2011","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.nbd.2019.104677_bb0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/toxsci\/kfw117","article-title":"Arsenic induces accumulation of \u03b1-synuclein: implications for synucleinopathies and neurodegeneration","volume":"153","author":"Cholanians","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.nbd.2019.104677_bb0050","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neurobiolaging.2013.09.034","article-title":"Copper pathology in vulnerable brain regions in Parkinson's disease","volume":"35","author":"Davies","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2019.104677_bb0055","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/ars.2013.5593","article-title":"Targeting Chelatable Iron as a therapeutic modality in Parkinson's disease","volume":"21","author":"Devos","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2019.104677_bb0060","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1111\/j.1471-4159.1989.tb07264.x","article-title":"Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease","volume":"52","author":"Dexter","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.104677_bb0065","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an Iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2019.104677_bb0070","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1590\/0001-3765201620150595","article-title":"Biological functions of selenium and its potential influence on Parkinson's disease","volume":"88","author":"Ellwanger","year":"2016","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.nbd.2019.104677_bb0075","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00702-004-0124-0","article-title":"Trace and major elements in whole blood, serum, cerebrospinal fluid and urine of patients with Parkinson's disease","volume":"111","author":"Forte","year":"2004","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nbd.2019.104677_bb0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF02224396","article-title":"A case control study of CSF copper, iron and manganese in Parkinson disease","volume":"13","author":"Gazzaniga","year":"1992","journal-title":"Ital. J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2019.104677_bb0085","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fnagi.2013.00034","article-title":"A delicate balance: Iron metabolism and diseases of the brain","volume":"5","author":"Hare","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2019.104677_bb0090","series-title":"Nondetects and Data Analysis : Statistics for Censored Environmental Data","author":"Helsel","year":"2005"},{"key":"10.1016\/j.nbd.2019.104677_bb0095","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/ageing\/afp223","article-title":"Ageing, neurodegeneration and Parkinson's disease","volume":"39","author":"Hindle","year":"2010","journal-title":"Age Ageing"},{"key":"10.1016\/j.nbd.2019.104677_bb0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jns.2011.01.003","article-title":"Patterns of levels of biological metals in CSF differ among neurodegenerative diseases","volume":"303","author":"Hozumi","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2019.104677_bb0105","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s007020050073","article-title":"Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease","volume":"105","author":"Jim\u00e9nez-Jim\u00e9nez","year":"1998","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nbd.2019.104677_bb0110","first-page":"369","article-title":"Cerebrospinal fluid biochemical studies in patients with Parkinson's disease: toward a potential search for biomarkers for this disease","volume":"8","author":"Jim\u00e9nez-Jim\u00e9nez","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2019.104677_bb0115","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s10822-011-9431-3","article-title":"Effect of training data size and noise level on support vector machines virtual screening of genotoxic compounds from large compound libraries","volume":"25","author":"Kumar","year":"2011","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.nbd.2019.104677_bb0120","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/mds.26498","article-title":"Validation of conversion between mini-mental state examination and Montreal cognitive assessment","volume":"31","author":"Lawton","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2019.104677_bb0125","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13195-018-0418-3","article-title":"Interlaboratory proficiency processing scheme in CSF aliquoting: implementation and assessment based on biomarkers of Alzheimer's disease","volume":"10","author":"Lewczuk","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nbd.2019.104677_bb0130","doi-asserted-by":"crossref","first-page":"e1461","DOI":"10.1212\/WNL.0000000000005353","article-title":"White matter abnormalities and cognition in patients with conflicting diagnoses and CSF profiles","volume":"90","author":"Lindemer","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2019.104677_bb0135","first-page":"3218","article-title":"Elemental fingerprint as a cerebrospinal fluid biomarker for the diagnosis of Parkinson's disease","volume":"12","author":"Maass","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.104677_bb0140","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.neurobiolaging.2012.05.015","article-title":"Fe and cu do not differ in Parkinson's disease: a replication study plus meta-analysis","volume":"34","author":"Mariani","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2019.104677_bb0145","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/mds.25189","article-title":"Applying bioinformatics to proteomics: is machine learning the answer to biomarker discovery for PD and MSA?","volume":"27","author":"Mattison","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2019.104677_bb0150","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1515\/CCLM.2010.131","article-title":"Inter-laboratory variation in cerebrospinal fluid biomarkers for Alzheimer's disease: united we stand, divided we fall","volume":"48","author":"Mattsson","year":"2010","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.nbd.2019.104677_bb0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4155\/fmc.09.140","article-title":"Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders","volume":"2","author":"Mills","year":"2010","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.nbd.2019.104677_bb0160","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S1474-4422(11)70014-X","article-title":"Alpha-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study","volume":"10","author":"Mollenhauer","year":"2011","journal-title":"Lancet Neurol."},{"issue":"Suppl","key":"10.1016\/j.nbd.2019.104677_bb0165","first-page":"290","article-title":"Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders","volume":"139","author":"Mollenhauer","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2019.104677_bb0170","first-page":"303","article-title":"Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms","volume":"5","author":"Morris","year":"1992","journal-title":"Magnes. Res."},{"key":"10.1016\/j.nbd.2019.104677_bb0175","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1212\/WNL.0b013e3182698ced","article-title":"Associations of welding and manganese exposure with Parkinson disease; review and meta-analysis","volume":"79","author":"Mortimer","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2019.104677_bb0180","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jb\/mvy043","article-title":"Rapid increase of \u2018brain-type\u2019 transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery","volume":"164","author":"Murakami","year":"2018","journal-title":"J. Biochem."},{"key":"10.1016\/j.nbd.2019.104677_bb0185","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.aca.2008.08.018","article-title":"Speciation analysis of selected metals and determination of their total contents in paired serum and cerebrospinal fluid samples: an approach to investigate the permeability of the human blood-cerebrospinal fluid-barrier","volume":"627","author":"Nischwitz","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.nbd.2019.104677_bb0190","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.chemolab.2015.02.019","article-title":"zCompositions \u2014 R package for multivariate imputation of left-censored data under a compositional approach","volume":"143","author":"Palarea-Albaladejo","year":"2015","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"10.1016\/j.nbd.2019.104677_bb0195","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0140-6736(87)90827-0","article-title":"Raised cerebrospinal-fluid copper concentration in Parkinson's disease","volume":"2","author":"Pall","year":"1987","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.nbd.2019.104677_bb0200","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2019.104677_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/srep35097","article-title":"Metallomic biomarkers in cerebrospinal fluid and serum in patients with Parkinson's disease in Indian population","volume":"6","author":"Sanyal","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2019.104677_bb0210","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.brainresbull.2011.09.017","article-title":"Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo","volume":"86","author":"Slotkin","year":"2011","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2019.104677_bb0215","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s00216-012-6294-y","article-title":"Selenium speciation in paired serum and cerebrospinal fluid samples","volume":"405","author":"Solovyev","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.nbd.2019.104677_bb0220","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10653-017-9915-8","article-title":"Association of soil selenium, strontium, and magnesium concentrations with Parkinson's disease mortality rates in the USA","volume":"40","author":"Sun","year":"2018","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.nbd.2019.104677_bb0225","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2019.104677_bb0230","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1212\/WNL.0b013e3181c47cc2","article-title":"A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking","volume":"73","author":"Teunissen","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2019.104677_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2018.05.043","article-title":"Assessing the stability of cd, Mn, Pb, se, and total hg in whole human blood by ICP-DRC-MS as a function of temperature and time","volume":"485","author":"Tevis","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.nbd.2019.104677_bb0240","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson's disease","volume":"25","author":"Tomlinson","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2019.104677_bb0245","doi-asserted-by":"crossref","first-page":"44284","DOI":"10.1074\/jbc.M105343200","article-title":"Metal-triggered structural transformations, aggregation, and fibrillation of human ??-synuclein: a possible molecular link between parkinson's disease and heavy metal exposure","volume":"276","author":"Uversky","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2019.104677_bb0250","series-title":"Inorganic Chemistry","author":"Wiberg","year":"2001"},{"key":"10.1016\/j.nbd.2019.104677_bb0255","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jtemb.2018.01.005","article-title":"Species fractionation in a case-control study concerning Parkinson's disease: Cu-amino acids discriminate CSF of PD from controls","volume":"49","author":"Willkommen","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.nbd.2019.104677_bb0260","first-page":"325","article-title":"Pathways of arsenic uptake and efflux","author":"Yang","year":"2012","journal-title":"Curr. Top. Membr."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119303523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119303523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:22:11Z","timestamp":1760851331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996119303523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":52,"alternative-id":["S0969996119303523"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.104677","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elemental fingerprint: Reassessment of a cerebrospinal fluid biomarker for Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.104677","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104677"}}