{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:12:40Z","timestamp":1790003560741,"version":"4.0.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30 AG058458"],"award-info":[{"award-number":["F30 AG058458"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50NS108675"],"award-info":[{"award-number":["P50NS108675"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS102257"],"award-info":[{"award-number":["R01 NS102257"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PD150032"],"award-info":[{"award-number":["PD150032"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","award":["P30 NS47466"],"award-info":[{"award-number":["P30 NS47466"]}],"id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.nbd.2019.104708","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T07:08:06Z","timestamp":1576480086000},"page":"104708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"special_numbering":"C","title":["Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded \u03b1-synuclein inclusions"],"prefix":"10.1016","volume":"134","author":[{"given":"Lindsay E.","family":"Stoyka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Arrant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drake R.","family":"Thrasher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dreson L.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey L.","family":"Mahoney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseel G.","family":"Dib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Standaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8934-4018","authenticated-orcid":false,"given":"Laura A.","family":"Volpicelli-Daley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2019.104708_bb0005","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.nbd.2017.05.014","article-title":"alpha-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic neurodegeneration","volume":"105","author":"Abdelmotilib","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104708_bb0010","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/mds.26605","article-title":"Neuropathological basis of nonmotor manifestations of Parkinson\u2019s disease","volume":"31","author":"Adler","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2019.104708_bb0015","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/gbb.12300","article-title":"Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test","volume":"15","author":"Arrant","year":"2016","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2019.104708_bb0020","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02095-16","article-title":"Robust central nervous system pathology in transgenic mice following peripheral injection of alpha-Synuclein fibrils","volume":"91","author":"Ayers","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.nbd.2019.104708_bb0025","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00401-009-0538-8","article-title":"Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction","volume":"117","author":"Beach","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2019.104708_bb0030","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nn.3601","article-title":"CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses","volume":"17","author":"Bemben","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0035","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2017.03.007","article-title":"Internalization, axonal transport and release of fibrillar forms of alpha-synuclein","volume":"109","author":"Bieri","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104708_bb0040","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1037\/h0026779","article-title":"Crouching as an index of fear","volume":"67","author":"Blanchard","year":"1969","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.nbd.2019.104708_bb0045","doi-asserted-by":"crossref","first-page":"716","DOI":"10.15252\/emmm.201607305","article-title":"Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex","volume":"9","author":"Blumenstock","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2019.104708_bb0050","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1523\/JNEUROSCI.2898-12.2013","article-title":"Mapping the subcellular distribution of alpha-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson\u2019s disease pathogenesis","volume":"33","author":"Boassa","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0055","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2818.2006.01706.x","article-title":"A guided tour into subcellular colocalization analysis in light microscopy","volume":"224","author":"Bolte","year":"2006","journal-title":"J. Microsc."},{"key":"10.1016\/j.nbd.2019.104708_bb0060","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1038\/ncomms3575","article-title":"Structural and functional characterization of two alpha-synuclein strains","volume":"4","author":"Bousset","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2019.104708_bb0065","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1093\/brain\/awl301","article-title":"Startling facts about emotion in Parkinson\u2019s disease: blunted reactivity to aversive stimuli","volume":"129","author":"Bowers","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2019.104708_bb0070","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF00296485","article-title":"Amygdala pathology in Parkinson's disease","volume":"88","author":"Braak","year":"1994","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2019.104708_bb0075","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2019.104708_bb0080","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00401-016-1538-0","article-title":"Axonal transport and secretion of fibrillar forms of alpha-synuclein, Abeta42 peptide and HTTExon 1","volume":"131","author":"Brahic","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2019.104708_bb0085","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s13311-012-0104-2","article-title":"A progressive mouse model of Parkinson\u2019s disease: the Thy1-aSyn (\u201cLine 61\u201d) mice","volume":"9","author":"Chesselet","year":"2012","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2019.104708_bb0090","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature09559","article-title":"Encoding of conditioned fear in central amygdala inhibitory circuits","volume":"468","author":"Ciocchi","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2019.104708_bb0095","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/jnnp.74.7.852","article-title":"Lewy body cortical involvement may not always predict dementia in Parkinson\u2019s disease","volume":"74","author":"Colosimo","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2019.104708_bb0100","series-title":"Methods of Behavior Analysis in Neuroscience","article-title":"Cued and contextual fear conditioning for rodents","author":"Curzon","year":"2009"},{"key":"10.1016\/j.nbd.2019.104708_bb0105","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1002\/cne.24468","article-title":"Sensitivity and specificity of phospho-Ser129 alpha-synuclein monoclonal antibodies","volume":"526","author":"Delic","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2019.104708_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184731","article-title":"A novel panel of alpha-synuclein antibodies reveal distinctive staining profiles in synucleinopathies","volume":"12","author":"Dhillon","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2019.104708_bb0115","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.2353\/ajpath.2007.061232","article-title":"Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation","volume":"170","author":"Dufty","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2019.104708_bb0120","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3758\/BF03205285","article-title":"Factors governing one-trial contextual conditioning","volume":"18","author":"Fanselow","year":"1990","journal-title":"Anim. Learn. Behav."},{"key":"10.1016\/j.nbd.2019.104708_bb0125","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1523\/JNEUROSCI.6103-11.2013","article-title":"Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice","volume":"33","author":"Filiano","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40478-018-0537-x","article-title":"alpha-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons","volume":"6","author":"Froula","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2019.104708_bb0135","doi-asserted-by":"crossref","first-page":"10392","DOI":"10.1074\/jbc.RA119.007743","article-title":"Defining \u03b1-synuclein species responsible for Parkinson\u2019s disease phenotypes in mice","volume":"294","author":"Froula","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2019.104708_bb0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41593-018-0298-7","article-title":"A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology","volume":"22","author":"Fu","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0145","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb748","article-title":"alpha-Synuclein is phosphorylated in synucleinopathy lesions","volume":"4","author":"Fujiwara","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2019.104708_bb0150","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s004010000270","article-title":"Cortical neurons expressing calcium binding proteins are spared in dementia with Lewy bodies","volume":"101","author":"Gomez-Tortosa","year":"2001","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2019.104708_bb0155","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/mds.25857","article-title":"The neurobiological basis of cognitive impairment in Parkinson\u2019s disease","volume":"29","author":"Halliday","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2019.104708_bb0160","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/ar.22656","article-title":"Expression of transcription factor Satb2 in adult mouse brain","volume":"296","author":"Huang","year":"2013","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.nbd.2019.104708_bb0165","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19103","article-title":"A comprehensive excitatory input map of the striatum reveals novel functional organization","volume":"5","author":"Hunnicutt","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2019.104708_bb0170","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1212\/WNL.54.10.1916","article-title":"Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson\u2019s disease","volume":"54","author":"Hurtig","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2019.104708_bb0175","doi-asserted-by":"crossref","DOI":"10.4172\/2161-0460.1000444","article-title":"The contribution of Tau, amyloid-beta and alpha-synuclein pathology to dementia in Lewy body disorders","volume":"8","author":"Irwin","year":"2018","journal-title":"J. Alzheimers Dis. Parkinsonism."},{"key":"10.1016\/j.nbd.2019.104708_bb0180","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/ana.23659","article-title":"Neuropathologic substrates of Parkinson disease dementia","volume":"72","author":"Irwin","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2019.104708_bb0185","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrn3549","article-title":"Parkinson\u2019s disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies","volume":"14","author":"Irwin","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0190","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1474-4422(16)30291-5","article-title":"Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis","volume":"16","author":"Irwin","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2019.104708_bb0195","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1586\/ern.12.131","article-title":"Neurobiology of cognitive impairment in Parkinson\u2019s disease","volume":"12","author":"Jellinger","year":"2012","journal-title":"Expert. Rev. Neurother."},{"key":"10.1016\/j.nbd.2019.104708_bb0200","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00702-017-1821-9","article-title":"Dementia with Lewy bodies and Parkinson\u2019s disease-dementia: current concepts and controversies","volume":"125","author":"Jellinger","year":"2018","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.nbd.2019.104708_bb0205","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1037\/h0030808","article-title":"Alterations in social behavior following septal and amygdaloid lesions in the rat","volume":"75","author":"Jonason","year":"1971","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.nbd.2019.104708_bb0210","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2019.104708_bb0215","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1093\/brain\/awq059","article-title":"Relationships between age and late progression of Parkinson\u2019s disease: a clinico-pathological study","volume":"133","author":"Kempster","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2019.104708_bb0220","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1385\/JMN:17:2:225","article-title":"Lewy body pathology in Alzheimer\u2019s disease","volume":"17","author":"Kotzbauer","year":"2001","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0225","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1358\/mf.2007.29.5.1117557","article-title":"Elevated zero maze: a paradigm to evaluate antianxiety effects of drugs","volume":"29","author":"Kulkarni","year":"2007","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.nbd.2019.104708_bb0230","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00429-011-0305-1","article-title":"Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer\u2019s disease","volume":"216","author":"Lemmens","year":"2011","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.nbd.2019.104708_bb0235","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/ana.23894","article-title":"G51D alpha-synuclein mutation causes a novel parkinsonian-pyramidal syndrome","volume":"73","author":"Lesage","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2019.104708_bb0240","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/191474a0","article-title":"Social dominance in inbred mouse strains","volume":"191","author":"Lindzey","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2019.104708_bb0245","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.nbd.2019.104708_bb0250","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1084\/jem.20112457","article-title":"Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice","volume":"209","author":"Luk","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2019.104708_bb0255","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1460-9568.2012.08012.x","article-title":"Cognitive deficits in a mouse model of pre-manifest Parkinson\u2019s disease","volume":"35","author":"Magen","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0260","first-page":"669","article-title":"Social cognition impairments in mice overexpressing alpha-synuclein under the Thy1 promoter, a model of pre-manifest Parkinson\u2019s disease","volume":"5","author":"Magen","year":"2015","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.nbd.2019.104708_bb0265","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/brain\/awt037","article-title":"Prion-like spreading of pathological alpha-synuclein in brain","volume":"136","author":"Masuda-Suzukake","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2019.104708_bb0270","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-014-0088-8","article-title":"Pathological alpha-synuclein propagates through neural networks","volume":"2","author":"Masuda-Suzukake","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2019.104708_bb0275","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s004019900168","article-title":"Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson\u2019s disease","volume":"100","author":"Mattila","year":"2000","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2019.104708_bb0280","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1037\/0735-7044.111.4.683","article-title":"Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli","volume":"111","author":"Muller","year":"1997","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0285","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.celrep.2015.01.060","article-title":"Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism","volume":"10","author":"Osterberg","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2019.104708_bb0290","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ana.20321","article-title":"Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia","volume":"57","author":"Parkkinen","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2019.104708_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104525","article-title":"Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal alpha-synuclein preformed fibrils","volume":"130","author":"Patterson","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104708_bb0300","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.nbd.2015.06.003","article-title":"Intrastriatal injection of pre-formed mouse alpha-synuclein fibrils into rats triggers alpha-synuclein pathology and bilateral nigrostriatal degeneration","volume":"82","author":"Paumier","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2019.104708_bb0305","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1037\/0735-7044.108.4.810","article-title":"DBA\/2 and C57BL\/6 mice differ in contextual fear but not auditory fear conditioning","volume":"108","author":"Paylor","year":"1994","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0310","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1037\/0735-7044.106.2.274","article-title":"Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning","volume":"106","author":"Phillips","year":"1992","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0315","first-page":"303","article-title":"Best practices for generating and using alpha-Synuclein pre-formed fibrils to model Parkinson\u2019s disease in rodents","volume":"8","author":"Polinski","year":"2018","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.nbd.2019.104708_bb0320","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nbd.2019.104708_bb0325","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00401-017-1792-9","article-title":"Spread of aggregates after olfactory bulb injection of alpha-synuclein fibrils is associated with early neuronal loss and is reduced long term","volume":"135","author":"Rey","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2019.104708_bb0330","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/gbb.12181","article-title":"Prefrontal neuronal circuits of contextual fear conditioning","volume":"14","author":"Rozeske","year":"2015","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2019.104708_bb0335","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.2174\/1871527313666140917122739","article-title":"The impact of dementia development concurrent with Parkinson\u2019s disease: a new perspective","volume":"13","author":"Russell","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.nbd.2019.104708_bb0340","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-016-0357-9","article-title":"Novel antibodies to phosphorylated alpha-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes","volume":"4","author":"Rutherford","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2019.104708_bb0345","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/2051-5960-1-38","article-title":"Induction of CNS alpha-synuclein pathology by fibrillar and non-amyloidogenic recombinant alpha-synuclein","volume":"1","author":"Sacino","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2019.104708_bb0350","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s004290050191","article-title":"Variation of fractionator estimates and its prediction","volume":"198","author":"Schmitz","year":"1998","journal-title":"Anat. Embryol. (Berl)"},{"key":"10.1016\/j.nbd.2019.104708_bb0355","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuropsychologia.2017.09.035","article-title":"Human lesion studies of ventromedial prefrontal cortex","volume":"107","author":"Schneider","year":"2017","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.nbd.2019.104708_bb0360","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1090278","article-title":"alpha-Synuclein locus triplication causes Parkinson\u2019s disease","volume":"302","author":"Singleton","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.nbd.2019.104708_bb0365","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0306-4522(02)00063-5","article-title":"NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern","volume":"112","author":"Sugita","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2019.104708_bb0370","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/cne.23901","article-title":"Brain region-dependent differential expression of alpha-synuclein","volume":"524","author":"Taguchi","year":"2016","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2019.104708_bb0375","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B978-0-444-53860-4.00009-X","article-title":"Human prefrontal cortex: evolution, development, and pathology","volume":"195","author":"Teffer","year":"2012","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2019.104708_bb0380","first-page":"105","article-title":"Amygdala and emotionality in Parkinson\u2019s disease: an integrative review of the neuropsychological evidence","volume":"39","author":"Trnka","year":"2018","journal-title":"Neuro Endocrinol Lett."},{"key":"10.1016\/j.nbd.2019.104708_bb0385","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fnbeh.2017.00013","article-title":"Behavior of male and female C57BL\/6J mice is more consistent with repeated trials in the elevated zero maze than in the elevated plus maze","volume":"11","author":"Tucker","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0390","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/01.jnen.0000225908.90052.07","article-title":"Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy","volume":"65","author":"Uchikado","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2019.104708_bb0395","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.celrep.2016.12.023","article-title":"Synucleins have multiple effects on presynaptic architecture","volume":"18","author":"Vargas","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2019.104708_bb0400","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuron.2011.08.033","article-title":"Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death","volume":"72","author":"Volpicelli-Daley","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2019.104708_bb0405","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1091\/mbc.e14-02-0741","article-title":"Formation of alpha-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes","volume":"25","author":"Volpicelli-Daley","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.nbd.2019.104708_bb0410","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.1209951","article-title":"Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex","volume":"334","author":"Wang","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.nbd.2019.104708_bb0415","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.tins.2014.07.005","article-title":"The mouse that roared: neural mechanisms of social hierarchy","volume":"37","author":"Wang","year":"2014","journal-title":"Trends Neurosci."},{"issue":"26","key":"10.1016\/j.nbd.2019.104708_bb0420","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1523\/JNEUROSCI.0060-19.2019","article-title":"Alpha-synuclein (alphaSyn) preformed fibrils induce endogenous alphaSyn aggregation, compromise synaptic activity and enhance synapse loss in cultured excitatory hippocampal neurons","volume":"39","author":"Wu","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2019.104708_bb0425","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/ana.10795","article-title":"The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia","volume":"55","author":"Zarranz","year":"2004","journal-title":"Ann. Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119303833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996119303833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:24:59Z","timestamp":1760851499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996119303833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":85,"alternative-id":["S0969996119303833"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2019.104708","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded \u03b1-synuclein inclusions","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2019.104708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104708"}}