{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:50:56Z","timestamp":1790700656398,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013326","name":"University Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004726","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004726","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.nbd.2020.104846","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T12:31:33Z","timestamp":1584707493000},"page":"104846","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson's disease"],"prefix":"10.1016","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5683-2709","authenticated-orcid":false,"given":"Caroline","family":"Moreau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Sophie","family":"Rolland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Pioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Odou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Barthelemy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Lannoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Demailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Carta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Deramecourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Auger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kuchcinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Laloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Defebvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis","family":"Bordet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Duce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Christophe","family":"Devedjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Bezard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Fisichella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Devos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2020.104846_bb0005","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1046\/j.1460-9568.1999.00627.x","article-title":"Involvement of the subthalamic nucleus in glutamatergic compensatory mechanisms","volume":"11","author":"Bezard","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104846_bb0010","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S1474-4422(09)70068-7","article-title":"Non-motor symptoms of Parkinson\u2019s disease: dopaminergic pathophysiology and treatment","volume":"8","author":"Chaudhuri","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2020.104846_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122708","article-title":"Carbidopa-based modulation of the functional effect of the AAV2-hAADC gene therapy in 6-OHDA lesioned rats","volume":"10","author":"Ciesielska","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2020.104846_bb0020","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/brain\/awu195","article-title":"The modern pre-levodopa era of Parkinson\u2019s disease: insights into motor complications from sub-Saharan Africa","volume":"137","author":"Cilia","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2020.104846_bb0025","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/14767050701227992","article-title":"Toxicity of corticosteroids and catecholamines for mice neuronal cell cultures: role of preservatives","volume":"20","author":"Dani","year":"2007","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.nbd.2020.104846_bb0030","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"5","author":"De Lau","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2020.104846_bb0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/mds.870020302","article-title":"Continuous intracerebroventricular infusion of dopamine and dopamine agonists through a totally implanted drug delivery system in animal models of Parkinson\u2019s disease","volume":"2","author":"De Yebenes","year":"1987","journal-title":"Mov. Disord."},{"issue":"52 Suppl 4","key":"10.1016\/j.nbd.2020.104846_bb0040","first-page":"IV37","article-title":"Does levodopa slow or hasten the rate of progression of Parkinson\u2019s disease?","volume":"2","author":"Fahn","year":"2005","journal-title":"J. Neurol"},{"issue":"27","key":"10.1016\/j.nbd.2020.104846_bb0045","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1002\/mds.25133","article-title":"A critique of available scales and presentation of the Non-Human Primate Dyskinesia Rating Scale","volume":"15","author":"Fox","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2020.104846_bb0050","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1111\/j.1468-1331.2011.03593.x","article-title":"Moving from continuous dopaminergic stimulation to continuous drug delivery in the treatment of Parkinson\u2019s disease","volume":"19","author":"Gershanik","year":"2012","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2020.104846_bb0055","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/ana.410260620","article-title":"Intraventricular infusion of dopamine in Parkinson\u2019s disease","volume":"26","author":"Horne","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2020.104846_bb0060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0165-0270(99)00184-3","article-title":"Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the macaque monkey","volume":"96","author":"Imbert","year":"2000","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2020.104846_bb0065","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.nbd.2017.03.013","article-title":"Continuous cerebroventricular administration of dopamine: a new treatment for severe dyskinesia in Parkinson\u2019s disease?","volume":"103","author":"Laloux","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2020.104846_bb0070","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/nimg.1996.0036","article-title":"A stereotaxic template atlas of the macaque brain for digital imaging and quantitative neuroanatomy","volume":"4","author":"Martin","year":"1996","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2020.104846_bb0075","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.2169\/internalmedicine.0994-18","article-title":"The relationship between the intrarenal dopamine system and intrarenal renin-angiotensin system depending on the renal function","volume":"57","author":"Matsuyama","year":"2018","journal-title":"Intern. Med."},{"key":"10.1016\/j.nbd.2020.104846_bb0080","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1385\/MN:28:3:209","article-title":"Time-course of nigrostriatal degeneration in a progressive MPTP-lesioned macaque model of Parkinson\u2019s disease","volume":"28","author":"Meissner","year":"2003","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2020.104846_bb0085","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ncpneuro0222","article-title":"Drug insight: continuous dopaminergic stimulation in the treatment of Parkinson\u2019s disease","volume":"2","author":"Olanow","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.nbd.2020.104846_bb0090","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/mds.26078","article-title":"Novel formulations and modes of delivery of levodopa","volume":"30","author":"Poewe","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2020.104846_bb0095","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1093\/brain\/awz176","article-title":"Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson\u2019s disease","volume":"142","author":"Rosenblad","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2020.104846_bb0100","first-page":"369465","article-title":"L-Dopa pharmacokinetic profile with effervescent Melevodopa\/Carbidopa versus standard-release levodopa\/Carbidopa tablets in Parkinson\u2019s disease: a randomised study","volume":"2015","author":"Stocchi","year":"2015","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.nbd.2020.104846_bb0105","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/WCO.0000000000000354","article-title":"Continuous dopaminergic stimulation therapy for Parkinson\u2019s disease - recent advances","volume":"29","author":"Timpka","year":"2016","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.nbd.2020.104846_bb0110","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.3233\/JPD-181476","article-title":"Continuous drug delivery aiming continuous dopaminergic stimulation in Parkinson\u2019s disease","volume":"8","author":"van Wamelen","year":"2018","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nbd.2020.104846_bb0115","first-page":"62","article-title":"Treatment of severe Parkinson\u2019s disease by intraventricular injection of dopamine","volume":"47","author":"Venna","year":"1984","journal-title":"Appl. Neurophysiol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996120301212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996120301212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:18:23Z","timestamp":1760851103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996120301212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":23,"alternative-id":["S0969996120301212"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2020.104846","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2020.104846","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104846"}}