{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:27:24Z","timestamp":1787236044973,"version":"build-2736575974"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001454","name":"American Epilepsy Society","doi-asserted-by":"publisher","award":["NS090076"],"award-info":[{"award-number":["NS090076"]}],"id":[{"id":"10.13039\/100001454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Edward and Irene Pimley Research Fund"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.nbd.2020.104949","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T13:02:41Z","timestamp":1589893361000},"page":"104949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury"],"prefix":"10.1016","volume":"142","author":[{"given":"Maria-Belen","family":"Perez-Ramirez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Prince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2020.104949_bb0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.nbd.2014.08.022","article-title":"Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation","volume":"71","author":"Andresen","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2020.104949_bb0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1152\/jn.1970.33.1.73","article-title":"Excitability changes and inhibitory mechanisms in neocortical neurons during seizures","volume":"33","author":"Ayala","year":"1970","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2020.104949_bb0015","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.brainres.2008.06.044","article-title":"Generalization of seizures parallels the formation of \u201cdark\u201d neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat","volume":"1228","author":"Baracskay","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2020.104949_bb0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0987-7053(99)80063-X","article-title":"Development of focal chronic epilepsy following focal status epilepticus in adult patients","volume":"29","author":"Bartolomei","year":"1999","journal-title":"Neurophysiol. Clin."},{"key":"10.1016\/j.nbd.2020.104949_bb0025","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1523\/JNEUROSCI.0356-09.2009","article-title":"The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin","volume":"29","author":"Bauer","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104949_bb0030","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.yebeh.2005.07.019","article-title":"Axonal sprouting of GABAergic interneurons in temporal lobe epilepsy","volume":"7","author":"Bausch","year":"2005","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2020.104949_bb0035","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1080\/07853890500407520","article-title":"Inhibition of Nogo: a key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system","volume":"37","author":"Buchli","year":"2005","journal-title":"Ann. Med."},{"key":"10.1016\/j.nbd.2020.104949_bb0040","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1002\/cne.24226","article-title":"Seizure frequency correlates with loss of dentate gyrus GABAergic neurons in a mouse model of temporal lobe epilepsy","volume":"525","author":"Buckmaster","year":"2017","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2020.104949_bb0045","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1523\/JNEUROSCI.14-05-03106.1994","article-title":"Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures","volume":"14","author":"Cavazos","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104949_bb0050","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s004010050715","article-title":"Characterization of a prolonged regenerative attempt by diffusely injured axons following traumatic brain injury in adult cat: a light and electron microscopic immunocytochemical study","volume":"94","author":"Christman","year":"1997","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.nbd.2020.104949_bb0055","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2004.12.020","article-title":"Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis","volume":"120","author":"Christopherson","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2020.104949_bb0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.7123229","article-title":"Focal cortical seizures cause distant thalamic lesions","volume":"218","author":"Collins","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.nbd.2020.104949_bb0065","doi-asserted-by":"crossref","first-page":"10167","DOI":"10.1523\/JNEUROSCI.3256-05.2005","article-title":"Extensive cortical rewiring after brain injury","volume":"25","author":"Dancause","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104949_bb0070","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/368737a0","article-title":"Axonal sprouting accompanies functional reorganization in adult cat striate cortex","volume":"368","author":"Darian-Smith","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2020.104949_bb0075","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0006-8993(89)90234-5","article-title":"Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy","volume":"495","author":"de Lanerolle","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2020.104949_bb0080","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1046\/j.1460-9568.2000.00140.x","article-title":"Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus","volume":"12","author":"De Simoni","year":"2000","journal-title":"Eur. J. Neurosci."},{"issue":"Pt 10","key":"10.1016\/j.nbd.2020.104949_bb0085","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1093\/brain\/122.10.1807","article-title":"Chandelier cells and epilepsy","volume":"122","author":"DeFelipe","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2020.104949_bb0090","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00004691-199512040-00003","article-title":"Epidemiology of status epilepticus","volume":"12","author":"DeLorenzo","year":"1995","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.nbd.2020.104949_bb0095","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0920-1211(93)90083-J","article-title":"Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy","volume":"16","author":"Du","year":"1993","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2020.104949_bb0100","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.1523\/JNEUROSCI.15-10-06301.1995","article-title":"Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy","volume":"15","author":"Du","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104949_bb0105","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cell.2009.09.025","article-title":"Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis","volume":"139","author":"Eroglu","year":"2009","journal-title":"Cell"},{"issue":"428\u2013445","key":"10.1016\/j.nbd.2020.104949_bb0110","article-title":"Astrocyte-secreted Glypican 4 regulates release of neuronal Pentraxin 1 from axons to induce functional synapse formation","volume":"96","author":"Farhy-Tselnicker","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2020.104949_bb0115","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1152\/jn.00351.2010","article-title":"Presynaptic inhibitory terminals are functionally abnormal in a rat model of posttraumatic epilepsy","volume":"104","author":"Faria","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2020.104949_bb0120","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nbd.2017.01.009","article-title":"Epileptiform activity and behavioral arrests in mice overexpressing the calcium channel subunit alpha2delta-1","volume":"102","author":"Faria","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2020.104949_bb0125","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12264-016-0054-5","article-title":"Generation of febrile seizures and subsequent Epileptogenesis","volume":"32","author":"Feng","year":"2016","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.nbd.2020.104949_bb0130","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"1997"},{"key":"10.1016\/j.nbd.2020.104949_bb0135","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.eplepsyres.2009.03.005","article-title":"Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy","volume":"85","author":"Friedman","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2020.104949_bb0140","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1528-1157.2000.tb00283.x","article-title":"Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy","volume":"41","author":"Fujikawa","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2020.104949_bb0145","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1213\/00000539-199801000-00022","article-title":"Gabapentin reverses the allodynia produced by the administration of anti-GD2 ganglioside, an immunotherapeutic drug","volume":"86","author":"Gillin","year":"1998","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.nbd.2020.104949_bb0150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yebeh.2015.04.047","article-title":"Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis","volume":"49","author":"Gorter","year":"2015","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2020.104949_bb0155","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/ana.20124","article-title":"A critical period for prevention of posttraumatic neocortical hyperexcitability in rats","volume":"55","author":"Graber","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2020.104949_bb0160","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.nbd.2017.08.008","article-title":"Structural alterations in fast-spiking GABAergic interneurons in a model of posttraumatic neocortical epileptogenesis","volume":"108","author":"Gu","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2020.104949_bb0165","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1208\/s12248-017-0096-2","article-title":"Breaking bad: the structure and function of the blood-brain barrier in epilepsy","volume":"19","author":"Han","year":"2017","journal-title":"AAPS J."},{"key":"10.1016\/j.nbd.2020.104949_bb0170","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/ana.410440609","article-title":"Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus","volume":"44","author":"Hesdorffer","year":"1998","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.nbd.2020.104949_bb0175","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/epi.13376","article-title":"Hilar somatostatin interneuron loss reduces dentate gyrus inhibition in a mouse model of temporal lobe epilepsy","volume":"57","author":"Hofmann","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2020.104949_bb0180","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/jnnp.2004.041947","article-title":"Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit","volume":"76","author":"Holtkamp","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2020.104949_bb0185","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.coph.2015.11.002","article-title":"Modulation of neuronal excitability by immune mediators in epilepsy","volume":"26","author":"Iori","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2020.104949_bb0190","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/brain\/awl317","article-title":"TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis","volume":"130","author":"Ivens","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2020.104949_bb0195","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1152\/jn.00854.2013","article-title":"Excitatory and inhibitory synaptic connectivity to layer V fast-spiking interneurons in the freeze lesion model of cortical microgyria","volume":"112","author":"Jin","year":"2014","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2020.104949_bb0200","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1023\/A:1024126110356","article-title":"Parvalbumin, somatostatin and cholecystokinin as chemical markers for specific GABAergic interneuron types in the rat frontal cortex","volume":"31","author":"Kawaguchi","year":"2002","journal-title":"J. Neurocytol."},{"issue":"3","key":"10.1016\/j.nbd.2020.104949_bb5000","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/epi.16450","article-title":"Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?","volume":"61","author":"Klein","year":"2020","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2020.104949_bb0205","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1523\/JNEUROSCI.23-06-02440.2003","article-title":"Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy","volume":"23","author":"Kobayashi","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104949_bb0210","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/jn.1987.57.1.325","article-title":"Epileptiform burst activity induced by potassium in the hippocampus and its regulation by GABA-mediated inhibition","volume":"57","author":"Korn","year":"1987","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2020.104949_bb0215","doi-asserted-by":"crossref","first-page":"E440","DOI":"10.1073\/pnas.1104977108","article-title":"Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC","volume":"108","author":"Kucukdereli","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2020.104949_bb0220","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neuroscience.2014.09.079","article-title":"Changes in long-range connectivity and neuronal reorganization in partial cortical deafferentation model of epileptogenesis","volume":"284","author":"Kusmierczak","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2020.104949_bb0225","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0316-17.2017","article-title":"alpha2delta-1 signaling drives cell death, synaptogenesis, circuit reorganization, and gabapentin-mediated neuroprotection in a model of insult-induced cortical malformation","volume":"4","author":"Lau","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.nbd.2020.104949_bb0230","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.nbd.2012.06.019","article-title":"Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma","volume":"48","author":"Li","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2020.104949_bb0235","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.eplepsyres.2010.01.002","article-title":"Sprouting in human temporal lobe epilepsy: excitatory pathways and axons of interneurons","volume":"89","author":"Magloczky","year":"2010","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2020.104949_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/PL00005608","article-title":"Altered synaptic circuitry in the human temporal neocortex removed from epileptic patients","volume":"114","author":"Marco","year":"1997","journal-title":"Exp. Brain Res."},{"issue":"Pt 4","key":"10.1016\/j.nbd.2020.104949_bb0245","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/brain\/119.4.1327","article-title":"Inhibitory neurons in the human epileptogenic temporal neocortex. An immunocytochemical study","volume":"119","author":"Marco","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2020.104949_bb0250","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/epi.13405","article-title":"Different parvalbumin and GABA expression in human epileptogenic focal cortical dysplasia","volume":"57","author":"Medici","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2020.104949_bb0255","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0006-8993(72)90190-4","article-title":"Neuronal loss and gliosis in the hippocampus following repetitive epileptic seizures induced in adolescent baboons by allylglycine","volume":"48","author":"Meldrum","year":"1972","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2020.104949_bb0260","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.neuron.2014.12.058","article-title":"Decreased subcortical cholinergic arousal in focal seizures","volume":"85","author":"Motelow","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2020.104949_bb0265","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s13311-014-0263-4","article-title":"Origins of temporal lobe epilepsy: febrile seizures and febrile status epilepticus","volume":"11","author":"Patterson","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2020.104949_bb0270","doi-asserted-by":"crossref","first-page":"14392","DOI":"10.1523\/JNEUROSCI.2045-13.2013","article-title":"A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons","volume":"33","author":"Peng","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104949_bb0275","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1152\/jn.1993.69.4.1276","article-title":"Epileptogenesis in chronically injured cortex: in vitro studies","volume":"69","author":"Prince","year":"1993","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2020.104949_bb0280","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.brainres.2009.11.063","article-title":"Albumin activates astrocytes and microglia through mitogen-activated protein kinase pathways","volume":"1313","author":"Ralay Ranaivo","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2020.104949_bb0285","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.matbio.2012.01.004","article-title":"Thrombospondins as key regulators of synaptogenesis in the central nervous system","volume":"31","author":"Risher","year":"2012","journal-title":"Matrix Biol."},{"key":"10.1016\/j.nbd.2020.104949_bb0290","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1083\/jcb.201802057","article-title":"Thrombospondin receptor alpha2delta-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1","volume":"217","author":"Risher","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2020.104949_bb0295","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/cercor\/8.8.753","article-title":"Effects of neonatal freeze lesions on expression of parvalbumin in rat neocortex","volume":"8","author":"Rosen","year":"1998","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2020.104949_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078516","article-title":"Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus","volume":"8","author":"Rossi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2020.104949_bb0305","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/ph10040093","article-title":"Early gabapentin treatment during the latency period increases convulsive threshold, reduces microglial activation and macrophage infiltration in the lithium-pilocarpine model of epilepsy","volume":"10","author":"Rossi","year":"2017","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.nbd.2020.104949_bb0310","doi-asserted-by":"crossref","first-page":"8234","DOI":"10.1523\/JNEUROSCI.15-12-08234.1995","article-title":"Axonal sprouting in layer V pyramidal neurons of chronically injured cerebral cortex","volume":"15","author":"Salin","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104949_bb0315","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yebeh.2015.04.059","article-title":"Prognosis of status epilepticus (SE): relationship between SE duration and subsequent development of epilepsy","volume":"49","author":"Santamarina","year":"2015","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2020.104949_bb0320","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1523\/JNEUROSCI.1751-04.2004","article-title":"Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex","volume":"24","author":"Seiffert","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104949_bb0325","doi-asserted-by":"crossref","first-page":"443","DOI":"10.21470\/1678-9741-2018-0061","article-title":"Mid-term results of peripheral cannulation after robotic cardiac surgery","volume":"33","author":"Sen","year":"2018","journal-title":"Braz. J. Cardiovasc. Surg."},{"key":"10.1016\/j.nbd.2020.104949_bb0330","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1152\/jn.00131.2004","article-title":"Increased excitatory synaptic activity and local connectivity of hippocampal CA1 pyramidal cells in rats with Kainate-induced epilepsy","volume":"92","author":"Shao","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2020.104949_bb0335","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1528-1167.2005.31604.x","article-title":"Neocortical and hippocampal changes after multiple pilocarpine-induced status epilepticus in rats","volume":"46","author":"Silva","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2020.104949_bb0340","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1126\/science.2879352","article-title":"Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy","volume":"235","author":"Sloviter","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.nbd.2020.104949_bb0345","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.nbd.2016.03.003","article-title":"Aberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma","volume":"91","author":"Takahashi","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2020.104949_bb0350","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/cercor\/bhx152","article-title":"Gabapentin prevents progressive increases in excitatory connectivity and Epileptogenesis following neocortical trauma","volume":"28","author":"Takahashi","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2020.104949_bb0355","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1523\/JNEUROSCI.05-04-01016.1985","article-title":"Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats","volume":"5","author":"Tauck","year":"1985","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104949_bb0360","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/cercor\/9.7.675","article-title":"Sex differences in cortical plasticity and behavior following anterior cortical kindling in rats","volume":"9","author":"Teskey","year":"1999","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2020.104949_bb0365","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.nbd.2006.10.006","article-title":"Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex","volume":"25","author":"Tomkins","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2020.104949_bb0370","doi-asserted-by":"crossref","first-page":"26954","DOI":"10.18632\/oncotarget.25485","article-title":"Astroglial role in the pathophysiology of status epilepticus: an overview","volume":"9","author":"Vargas-Sanchez","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.nbd.2020.104949_bb0375","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00401-015-1481-5","article-title":"Infections, inflammation and epilepsy","volume":"131","author":"Vezzani","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2020.104949_bb0380","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neulet.2016.12.044","article-title":"Pathophysiology of status epilepticus","volume":"667","author":"Walker","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2020.104949_bb0385","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/ana.1021","article-title":"Focal cooling rapidly terminates experimental neocortical seizures","volume":"49","author":"Yang","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2020.104949_bb0390","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1756-6606-5-18","article-title":"Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats","volume":"5","author":"Yang","year":"2012","journal-title":"Mol. Brain"},{"key":"10.1016\/j.nbd.2020.104949_bb0395","doi-asserted-by":"crossref","first-page":"7846","DOI":"10.1523\/JNEUROSCI.6199-08.2009","article-title":"Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy","volume":"29","author":"Zhang","year":"2009","journal-title":"J. Neurosci."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996120302242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996120302242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:20:30Z","timestamp":1760851230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996120302242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":80,"alternative-id":["S0969996120302242"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2020.104949","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2020.104949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104949"}}