{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:02:46Z","timestamp":1793156566980,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.nbd.2020.104956","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T07:52:59Z","timestamp":1590825179000},"page":"104956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":158,"special_numbering":"C","title":["Microglia depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9328-9728","authenticated-orcid":false,"given":"Brad T.","family":"Casali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn P.","family":"MacPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-0347","authenticated-orcid":false,"given":"Erin G.","family":"Reed-Geaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Landreth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2020.104956_bb0005","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2015.06.012","article-title":"Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system","volume":"43","author":"Bruttger","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2020.104956_bb0010","doi-asserted-by":"crossref","first-page":"15112","DOI":"10.1523\/JNEUROSCI.1729-12.2012","article-title":"Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer\u2019s disease","volume":"32","author":"Cameron","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104956_bb0015","article-title":"A\u03b2 extraction from murine brain homogenates","volume":"6","author":"Casali","year":"2016","journal-title":"BIO-Protoc."},{"key":"10.1016\/j.nbd.2020.104956_bb0020","doi-asserted-by":"crossref","first-page":"9173","DOI":"10.1523\/JNEUROSCI.1000-15.2015","article-title":"Omega-3 fatty acids augment the actions of nuclear receptor agonists in a mouse model of Alzheimer\u2019s disease","volume":"35","author":"Casali","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104956_bb0025","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-018-0262-8","article-title":"The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer\u2019s disease","volume":"13","author":"Cheng-Hathaway","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2020.104956_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2017.00680","article-title":"Alzheimer\u2019s disease: the role of microglia in brain homeostasis and proteopathy","volume":"11","author":"Clayton","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2020.104956_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7176","article-title":"Microglia constitute a barrier that prevents neurotoxic protofibrillar A\u03b242 hotspots around plaques","volume":"6","author":"Condello","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2020.104956_bb0040","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.biopsych.2017.10.007","article-title":"Microglia-mediated neuroprotection, TREM2, and Alzheimer\u2019s disease: evidence from optical imaging","volume":"83","author":"Condello","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2020.104956_bb0045","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0366-9","article-title":"Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice","volume":"12","author":"Dagher","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2020.104956_bb0050","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-017-0184-x","article-title":"Late onset Alzheimer\u2019s disease genetics implicates microglial pathways in disease risk","volume":"12","author":"Efthymiou","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2020.104956_bb0055","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","article-title":"CSF1 receptor signaling is necessary for microglia viability, which unmasks a cell that rapidly repopulates the microglia-depleted adult brain","volume":"82","author":"Elmore","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2020.104956_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122912","article-title":"Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation","volume":"10","author":"Elmore","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2020.104956_bb0065","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1084\/jem.20171831","article-title":"BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions","volume":"215","author":"Hu","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2020.104956_bb0070","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41593-018-0090-8","article-title":"Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion","volume":"21","author":"Huang","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2020.104956_bb0075","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer\u2019s disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2020.104956_bb0080","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2020.104956_bb0085","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41586-019-0924-x","article-title":"Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution","volume":"566","author":"Masuda","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2020.104956_bb0090","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.15252\/embr.201743922","article-title":"TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury","volume":"18","author":"Mazaheri","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/j.nbd.2020.104956_bb0095","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.104956_bb0100","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1093\/brain\/awv379","article-title":"Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer\u2019s-like pathology","volume":"139","author":"Olmos-Alonso","year":"2016","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nbd.2020.104956_bb0105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41593-018-0296-9","article-title":"Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE","volume":"22","author":"Parhizkar","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2020.104956_bb0110","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/glia.23135","article-title":"Microglial repopulation resolves inflammation and promotes brain recovery after injury","volume":"65","author":"Rice","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2020.104956_bb0115","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1084\/jem.20190980","article-title":"Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model","volume":"216","author":"Shi","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2020.104956_bb0120","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/s41590-018-0212-1","article-title":"The identity and function of microglia in neurodegeneration","volume":"19","author":"Song","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.nbd.2020.104956_bb0125","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13024-018-0244-x","article-title":"Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer\u2019s disease","volume":"13","author":"Sosna","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2020.104956_bb0130","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/brain\/aww016","article-title":"Eliminating microglia in Alzheimer\u2019s mice prevents neuronal loss without modulating amyloid-\u03b2 pathology","volume":"139","author":"Spangenberg","year":"2016","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nbd.2020.104956_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11674-z","article-title":"Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer\u2019s disease model","volume":"10","author":"Spangenberg","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2020.104956_bb0140","article-title":"Microglial regional heterogeneity and its role in the brain","volume":"25","author":"Tan","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2020.104956_bb0145","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature25158","article-title":"Microglia-derived ASC specks cross-seed amyloid-\u03b2 in Alzheimer\u2019s disease","volume":"552","author":"Venegas","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2020.104956_bb0150","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.it.2015.08.005","article-title":"Homeostasis of microglia in the adult brain: review of novel microglia depletion systems","volume":"36","author":"Waisman","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.nbd.2020.104956_bb0155","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.neuron.2016.05.003","article-title":"TREM2 Haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy","volume":"90","author":"Yuan","year":"2016","journal-title":"Neuron"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999612030231X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999612030231X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:19:23Z","timestamp":1760851163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096999612030231X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":31,"alternative-id":["S096999612030231X"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2020.104956","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglia depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2020.104956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104956"}}