{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:19:22Z","timestamp":1769501962339,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.nbd.2020.105084","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T11:49:21Z","timestamp":1600084161000},"page":"105084","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Mechanical injury and blood are drivers of spatial memory deficits after rapid intraventricular hemorrhage"],"prefix":"10.1016","volume":"145","author":[{"given":"Kimia","family":"Kamal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet A.","family":"Keiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar R.","family":"Binyamin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce N.","family":"de la Cruz Dapula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey R.","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron W.","family":"Hawk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Izadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Lyeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene G.","family":"Gurkoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank R.","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Waldau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2020.105084_bb0005","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.110.581975","article-title":"Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage","volume":"41","author":"Al-Khindi","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2020.105084_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.325","article-title":"Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis","volume":"4","author":"Azevedo","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2020.105084_bb0015","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1115\/1.1324667","article-title":"Tissue-level thresholds for axonal damage in an experimental model of central nervous system white matter injury","volume":"122","author":"Bain","year":"2000","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.nbd.2020.105084_bb0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/svn-2015-000003","article-title":"Mechanisms of hydrocephalus after intraventricular haemorrhage in adults","volume":"1","author":"Bu","year":"2016","journal-title":"Stroke Vasc. Neurol."},{"key":"10.1016\/j.nbd.2020.105084_bb0025","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1101\/pdb.prot073411","article-title":"Manual hematoxylin and eosin staining of mouse tissue sections","volume":"2014","author":"Cardiff","year":"2014","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1016\/j.nbd.2020.105084_bb0030","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/STROKEAHA.110.602755","article-title":"Role of iron in brain injury after intraventricular hemorrhage","volume":"42","author":"Chen","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2020.105084_bb0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12975-014-0367-5","article-title":"Chronic hydrocephalus and perihematomal tissue injury developed in a rat model of intracerebral hemorrhage with ventricular extension","volume":"6","author":"Chen","year":"2015","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.nbd.2020.105084_bb0040","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1161\/STROKEAHA.115.009713","article-title":"Intracerebral hematoma contributes to hydrocephalus after intraventricular hemorrhage via aggravating iron accumulation","volume":"46","author":"Chen","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2020.105084_bb0045","first-page":"381","article-title":"Role of oxidative stress as physiopathologic factor in the preterm infant","volume":"56","author":"Dani","year":"2004","journal-title":"Minerva Pediatr."},{"key":"10.1016\/j.nbd.2020.105084_bb0050","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/02699052.2011.635362","article-title":"Mild traumatic brain injury (MTBI) leads to spatial learning deficits","volume":"26","author":"Darwish","year":"2012","journal-title":"Brain Inj."},{"key":"10.1016\/j.nbd.2020.105084_bb0055","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fnagi.2017.00208","article-title":"Microglial activation in traumatic brain injury","volume":"9","author":"Donat","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2020.105084_bb0060","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12832","article-title":"Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice","volume":"17","author":"Elmore","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.nbd.2020.105084_bb0065","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/jcbfm.2014.56","article-title":"Role of red blood cell lysis and iron in hydrocephalus after intraventricular hemorrhage","volume":"34","author":"Gao","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2020.105084_bb0070","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/jcbfm.2013.225","article-title":"Hydrocephalus after intraventricular hemorrhage: the role of thrombin","volume":"34","author":"Gao","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2020.105084_bb0075","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.brainres.2015.12.060","article-title":"Hemoglobin-induced neuronal degeneration in the hippocampus after neonatal intraventricular hemorrhage","volume":"1635","author":"Garton","year":"2016","journal-title":"Brain Res."},{"issue":"Suppl. 2","key":"10.1016\/j.nbd.2020.105084_bb0080","first-page":"91","article-title":"Brain and ventricular volume in hydrocephalus","volume":"39","author":"Jackson","year":"1984","journal-title":"Z. Kinderchir."},{"key":"10.1016\/j.nbd.2020.105084_bb0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fncel.2013.00003","article-title":"Quantitating the subtleties of microglial morphology with fractal analysis","volume":"7","author":"Karperien","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2020.105084_bb0090","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuropsychologia.2015.11.013","article-title":"Impairments in precision, rather than spatial strategy, characterize performance on the virtual Morris water maze: a case study","volume":"80","author":"Kolarik","year":"2016","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.nbd.2020.105084_bb0095","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/hs0102.101080","article-title":"Predictors of cognitive dysfunction after subarachnoid hemorrhage","volume":"33","author":"Kreiter","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2020.105084_bb0100","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/ana.21924","article-title":"Blood-brain barrier breakdown and repair by Src after thrombin-induced injury","volume":"67","author":"Liu","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2020.105084_bb0105","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1177\/0271678X16666291","article-title":"Inhibition of Src family kinases improves cognitive function after intraventricular hemorrhage or intraventricular thrombin","volume":"37","author":"Liu","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2020.105084_bb0110","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial activation and chronic neurodegeneration","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2020.105084_bb0115","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1179\/016164103771953934","article-title":"Temporal changes of neurogenesis in the mouse hippocampus after experimental subarachnoid hemorrhage","volume":"25","author":"Mino","year":"2003","journal-title":"Neurol. Res."},{"key":"10.1016\/j.nbd.2020.105084_bb0120","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bbi.2016.01.009","article-title":"Cognitive deficits develop 1month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge","volume":"54","author":"Muccigrosso","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2020.105084_bb0125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2045-8118-9-19","article-title":"The relationship between ventricular dilatation, neuropathological and neurobehavioural changes in hydrocephalic rats","volume":"9","author":"Olopade","year":"2012","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.nbd.2020.105084_bb0130","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ana.22455","article-title":"Inflammation after trauma: microglial activation and traumatic brain injury","volume":"70","author":"Ramlackhansingh","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2020.105084_bb0135","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1093\/brain\/awx191","article-title":"Glymphatic MRI in idiopathic normal pressure hydrocephalus","volume":"140","author":"Ringstad","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2020.105084_bb0140","doi-asserted-by":"crossref","first-page":"104713","DOI":"10.1016\/j.nbd.2019.104713","article-title":"Sustained neuronal and microglial alterations are associated with diverse neurobehavioral dysfunction long after experimental brain injury","volume":"136","author":"Ritzel","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2020.105084_bb0145","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00401-015-1440-1","article-title":"Microglia inflict delayed brain injury after subarachnoid hemorrhage","volume":"130","author":"Schneider","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2020.105084_bb0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12975-012-0182-9","article-title":"Mechanisms of hydrocephalus after neonatal and adult intraventricular hemorrhage","volume":"3","author":"Strahle","year":"2012","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.nbd.2020.105084_bb0155","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1227\/NEU.0000000000000524","article-title":"Role of hemoglobin and iron in hydrocephalus after neonatal intraventricular hemorrhage","volume":"75","author":"Strahle","year":"2014","journal-title":"Neurosurgery"},{"key":"10.1016\/j.nbd.2020.105084_bb0160","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1096\/fj.09-142844","article-title":"Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration","volume":"24","author":"Tang-Schomer","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2020.105084_bb0165","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1101\/lm.33000","article-title":"Fornix and hippocampal atrophy in traumatic brain injury","volume":"7","author":"Tate","year":"2000","journal-title":"Learn. Mem."},{"key":"10.1016\/j.nbd.2020.105084_bb0170","doi-asserted-by":"crossref","first-page":"21970","DOI":"10.1038\/srep21970","article-title":"A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2020.105084_bb0175","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2340\/16501977-1145","article-title":"Neural reorganization following bilateral injury of the fornix crus in a patient with traumatic brain injury","volume":"45","author":"Yeo","year":"2013","journal-title":"J. Rehabil. Med."},{"key":"10.1016\/j.nbd.2020.105084_bb0180","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1152\/jn.00775.2009","article-title":"Experimental mild traumatic brain injury induces functional alteration of the developing hippocampus","volume":"103","author":"Yu","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2020.105084_bb0185","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.clineuro.2018.04.032","article-title":"Intraventricular extension of an aneurysmal subarachnoid hemorrhage is an independent predictor of a worse functional outcome","volume":"170","author":"Zanaty","year":"2018","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.nbd.2020.105084_bb0190","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/jmri.24292","article-title":"Cerebral perfusion measured by dynamic susceptibility contrast MRI is reduced in patients with idiopathic normal pressure hydrocephalus","volume":"39","author":"Ziegelitz","year":"2014","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.nbd.2020.105084_bb0195","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.expneurol.2018.10.011","article-title":"Neurogenesis changes and the fate of progenitor cells after subarachnoid hemorrhage in rats","volume":"311","author":"Zuo","year":"2019","journal-title":"Exp. Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996120303594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996120303594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:27:02Z","timestamp":1760851622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996120303594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":39,"alternative-id":["S0969996120303594"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2020.105084","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical injury and blood are drivers of spatial memory deficits after rapid intraventricular hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2020.105084","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105084"}}