{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:24:04Z","timestamp":1786994644661,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.nbd.2020.105145","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T22:25:20Z","timestamp":1603837520000},"page":"105145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases"],"prefix":"10.1016","volume":"147","author":[{"given":"Orjon","family":"Rroji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravanan S.","family":"Karuppagounder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv R.","family":"Ratan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2020.105145_bb0005","doi-asserted-by":"crossref","first-page":"104725","DOI":"10.1016\/j.nbd.2019.104725","article-title":"The drug adaptaquin blocks ATF4\/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson\u2019s disease","volume":"136","author":"Aime","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"1262\u20131279","key":"10.1016\/j.nbd.2020.105145_bb0010","article-title":"Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke","volume":"177","author":"Alim","year":"2019","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2020.105145_bb0015","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1074\/jbc.M409223200","article-title":"Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line","volume":"280","author":"Aminova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2020.105145_bb0020","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1089\/ars.2008.2039","article-title":"Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line","volume":"10","author":"Aminova","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2020.105145_bb0025","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798896","article-title":"A high-throughput method to identify trans-activation domains within transcription factor sequences","volume":"37","author":"Arnold","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2020.105145_bb0030","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/S0021-9258(17)35926-4","article-title":"Exchange of cystine and glutamate across plasma membrane of human fibroblasts","volume":"261","author":"Bannai","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2020.105145_bb0035","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/jcbfm.2013.53","article-title":"Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block","volume":"33","author":"Basso","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2020.105145_bb0040","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.1523\/JNEUROSCI.3353-11.2012","article-title":"Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation","volume":"32","author":"Basso","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.105145_bb0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2016.02.009","article-title":"Butyrate, neuroepigenetics and the gut microbiome: can a high fiber diet improve brain health?","volume":"625","author":"Bourassa","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2020.105145_bb0055","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1126\/science.1066373","article-title":"A conserved family of prolyl-4-hydroxylases that modify HIF","volume":"294","author":"Bruick","year":"2001","journal-title":"Science."},{"key":"10.1016\/j.nbd.2020.105145_bb0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jneuroim.2005.02.022","article-title":"Transcriptional therapy with the histone deacetylase inhibitor trichostatin a ameliorates experimental autoimmune encephalomyelitis","volume":"164","author":"Camelo","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2020.105145_bb0065","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.brainres.2005.05.060","article-title":"Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1G93A transgenic mice","volume":"1050","author":"Chung","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2020.105145_bb0070","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1471-4159.1999.0720889.x","article-title":"Pathogenesis of inclusion bodies in (CAG)n\/Qn-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability","volume":"72","author":"Cooper","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2020.105145_bb0075","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2020.105145_bb0080","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1523\/JNEUROSCI.19-02-00562.1999","article-title":"Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione","volume":"19","author":"Dringen","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.105145_bb0085","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/01.mlg.0000197630.85208.36","article-title":"The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in Guinea pigs","volume":"116","author":"Drottar","year":"2006","journal-title":"Laryngoscope."},{"key":"10.1016\/j.nbd.2020.105145_bb0090","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1126\/science.1072613","article-title":"Sp1 and TAFII130 transcriptional activity disrupted in early Huntington\u2019s disease","volume":"296","author":"Dunah","year":"2002","journal-title":"Science."},{"key":"10.1016\/j.nbd.2020.105145_bb0095","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41586-019-1024-7","article-title":"Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3","volume":"567","author":"Farrelly","year":"2019","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2020.105145_bb0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3233\/JAD-131076","article-title":"Decrease of ERK\/MAPK overactivation in prefrontal cortex reverses early memory deficit in a mouse model of Alzheimer\u2019s disease","volume":"40","author":"Feld","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2020.105145_bb0105","doi-asserted-by":"crossref","first-page":"9418","DOI":"10.1523\/JNEUROSCI.23-28-09418.2003","article-title":"Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington\u2019s disease mice","volume":"23","author":"Ferrante","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.105145_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3233(08)60217-X","article-title":"The epsilon-(gamma-glutamyl)lysine crosslink and the catalytic role of transglutaminases","volume":"31","author":"Folk","year":"1977","journal-title":"Adv. Protein Chem."},{"key":"10.1016\/j.nbd.2020.105145_bb0115","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pnpbp.2009.11.005","article-title":"Cystamine prevents MPTP-induced toxicity in young adult mice via the up-regulation of the brain-derived neurotrophic factor","volume":"34","author":"Gibrat","year":"2010","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2020.105145_bb0120","doi-asserted-by":"crossref","first-page":"756","DOI":"10.4161\/cbt.20558","article-title":"Selenium-containing histone deacetylase inhibitors for melanoma management","volume":"13","author":"Gowda","year":"2012","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.nbd.2020.105145_bb0130","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2020.105145_bb0135","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/jcbfm.2012.28","article-title":"Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?","volume":"32","author":"Karuppagounder","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2020.105145_bb0140","doi-asserted-by":"crossref","first-page":"328ra29","DOI":"10.1126\/scitranslmed.aac6008","article-title":"Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models","volume":"8","author":"Karuppagounder","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2020.105145_bb0145","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/JHD-160205","article-title":"Oxidative stress and huntington\u2019s disease: the good, the bad, and the ugly","volume":"5","author":"Kumar","year":"2016","journal-title":"J. Huntingtons Dis."},{"key":"10.1016\/j.nbd.2020.105145_bb0150","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1084\/jem.20071460","article-title":"ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo","volume":"205","author":"Lange","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2020.105145_bb0155","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1523\/JNEUROSCI.3200-07.2008","article-title":"Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1\/cip1) in cell cycle-independent neuroprotection","volume":"28","author":"Langley","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.105145_bb0160","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1126\/science.aaw8806","article-title":"Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking","volume":"368","author":"Lepack","year":"2020","journal-title":"Science."},{"key":"10.1016\/j.nbd.2020.105145_bb0165","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jns.2017.08.3235","article-title":"Sodium butyrate exerts protective effect against Parkinson\u2019s disease in mice via stimulation of glucagon like peptide-1","volume":"381","author":"Liu","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2020.105145_bb0170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00240602","article-title":"Transglutaminases","volume":"58","author":"Lorand","year":"1984","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.nbd.2020.105145_bb0175","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/sj.cdd.4401093","article-title":"Tissue\u2019 transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington\u2019s disease","volume":"9","author":"Mastroberardino","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.nbd.2020.105145_bb0180","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/emmm.201000084","article-title":"Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease","volume":"2","author":"McConoughey","year":"2010","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2020.105145_bb0185","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1128\/MCB.01231-07","article-title":"The von Hippel-Lindau tumor suppressor protein and Egl-9-type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress","volume":"28","author":"Mikhaylova","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2020.105145_bb0190","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/0896-6273(89)90043-3","article-title":"Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress","volume":"2","author":"Murphy","year":"1989","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2020.105145_bb0195","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cmet.2011.08.015","article-title":"Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2","volume":"14","author":"Nandal","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2020.105145_bb0200","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.brainres.2008.10.035","article-title":"Tissue-type transglutaminase and the effects of cystamine on intracerebral hemorrhage-induced brain edema and neurological deficits","volume":"1249","author":"Okauchi","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2020.105145_bb0205","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.tips.2016.06.007","article-title":"Targeting oxidative stress in central nervous system disorders","volume":"37","author":"Patel","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.nbd.2020.105145_bb0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0169-328X(02)00488-6","article-title":"Up-regulation of mitogen-activated protein kinases ERK1\/2 and MEK1\/2 is associated with the progression of neurofibrillary degeneration in Alzheimer\u2019s disease","volume":"109","author":"Pei","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2020.105145_bb0215","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.chembiol.2020.03.007","article-title":"The chemical biology of ferroptosis in the central nervous system","volume":"27","author":"Ratan","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.nbd.2020.105145_bb0220","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1046\/j.1471-4159.1994.62010376.x","article-title":"Oxidative stress induces apoptosis in embryonic cortical neurons","volume":"62","author":"Ratan","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2020.105145_bb0225","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/emm.1999.9","article-title":"Redox signaling: hydrogen peroxide as intracellular messenger","volume":"31","author":"Rhee","year":"1999","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.nbd.2020.105145_bb0230","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1073\/pnas.0737363100","article-title":"Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway","volume":"100","author":"Ryu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2020.105145_bb0235","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1523\/JNEUROSCI.23-09-03597.2003","article-title":"Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons","volume":"23","author":"Ryu","year":"2003","journal-title":"J. Neurosci."},{"issue":"39","key":"10.1016\/j.nbd.2020.105145_bb0240","doi-asserted-by":"crossref","first-page":"13915","DOI":"10.1073\/pnas.0502878102","article-title":"Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons","volume":"102","author":"Ryu","year":"2005","journal-title":"PNAS"},{"key":"10.1016\/j.nbd.2020.105145_bb0245","doi-asserted-by":"crossref","first-page":"e12322","DOI":"10.1371\/journal.pone.0012322","article-title":"Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia","volume":"5","author":"Santini","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2020.105145_bb5050","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2008.07.005","article-title":"Glutathione peroxidase 4 senses and translates oxidative stress into 12\/15-lipoxygenase dependent- and AIF-mediated cell death","volume":"8","author":"Seiler","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2020.105145_bb0250","doi-asserted-by":"crossref","first-page":"41732","DOI":"10.1074\/jbc.M504963200","article-title":"Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system","volume":"280","author":"Siddiq","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2020.105145_bb0255","doi-asserted-by":"crossref","first-page":"8828","DOI":"10.1523\/JNEUROSCI.1779-09.2009","article-title":"Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways","volume":"29","author":"Siddiq","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.105145_bb0260","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3390\/ph4081183","article-title":"Histone deacetylase inhibitors and mithramycin a impact a similar neuroprotective pathway at a crossroad between cancer and neurodegeneration","volume":"4","author":"Sleiman","year":"2011","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.nbd.2020.105145_bb0265","doi-asserted-by":"crossref","first-page":"14328","DOI":"10.1523\/JNEUROSCI.1010-14.2014","article-title":"Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition","volume":"34","author":"Sleiman","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.105145_bb0270","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.chembiol.2010.03.008","article-title":"Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation","volume":"17","author":"Smirnova","year":"2010","journal-title":"Chem. Biol."},{"key":"10.1016\/j.nbd.2020.105145_bb0280","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature05859","article-title":"RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2020.105145_bb0285","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal2029","article-title":"Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy","volume":"9","author":"Yanamandra","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2020.105145_bb0290","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1523\/JNEUROSCI.4424-03.2004","article-title":"Calmodulin regulates transglutaminase 2 cross-linking of huntingtin","volume":"24","author":"Zainelli","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.105145_bb0295","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1523\/JNEUROSCI.19-22-09821.1999","volume":"19","author":"Zaman","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.105145_bb0300","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1161\/STROKEAHA.116.015609","article-title":"Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis","volume":"48","author":"Zille","year":"2017","journal-title":"Stroke."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996120304204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996120304204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:22:29Z","timestamp":1760851349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996120304204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":58,"alternative-id":["S0969996120304204"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2020.105145","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2020.105145","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105145"}}