{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:13:05Z","timestamp":1784563985246,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.nbd.2020.105200","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T20:13:20Z","timestamp":1606335200000},"page":"105200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury"],"prefix":"10.1016","volume":"148","author":[{"given":"Chia-Yi","family":"Kuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ru","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Min","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianer","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa M.","family":"Kinkaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erding","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Yo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2020.105200_bb0005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/FJC.0b013e3181e2bfef","article-title":"Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat","volume":"56","author":"Bao","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.nbd.2020.105200_bb0010","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/1531-8249(200009)48:3<285::AID-ANA2>3.0.CO;2-8","article-title":"Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain","volume":"48","author":"Bergeron","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2020.105200_bb0015","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.nbd.2008.05.020","article-title":"HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model","volume":"31","author":"Chen","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2020.105200_bb0020","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMoa1901713","article-title":"Roxadustat treatment for Anemia in patients undergoing long-term dialysis","volume":"381","author":"Chen","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2020.105200_bb0025","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature19795","article-title":"On-target efficacy of a HIF-2alpha antagonist in preclinical kidney cancer models","volume":"539","author":"Cho","year":"2016","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2020.105200_bb0030","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/jps.21924","article-title":"Intranasal delivery to the central nervous system: mechanisms and experimental considerations","volume":"99","author":"Dhuria","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.nbd.2020.105200_bb0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.brainresrev.2009.09.006","article-title":"The role and regulation of hypoxia-inducible factor-1alpha expression in brain development and neonatal hypoxic-ischemic brain injury","volume":"62","author":"Fan","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.nbd.2020.105200_bb0040","doi-asserted-by":"crossref","unstructured":"Forristal, C. E., Nowlan, B., Jacobsen, R. N,. Barbier, V., Walkinshaw, G., Walkley, C. R., Winkler, I. G., Levesque, J. P., 2015. HIF-1alpha is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1alpha. Leukemia. 29, 1366\u20131378.","DOI":"10.1038\/leu.2015.8"},{"key":"10.1016\/j.nbd.2020.105200_bb0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrd2761","article-title":"Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease","volume":"8","author":"Fraisl","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.nbd.2020.105200_bb0050","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba3512","article-title":"Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity","volume":"370","author":"Hammarlund","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.nbd.2020.105200_bb0055","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science."},{"key":"10.1016\/j.nbd.2020.105200_bb0060","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science."},{"key":"10.1016\/j.nbd.2020.105200_bb0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1056\/NEJMoa1907423","article-title":"A randomized trial of erythropoietin for neuroprotection in preterm infants","volume":"382","author":"Juul","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2020.105200_bb0070","article-title":"Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent modelsx","volume":"370","author":"Karuppagounder","year":"2016","journal-title":"Science"},{"issue":"Pt 1","key":"10.1016\/j.nbd.2020.105200_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2015.10.007","article-title":"Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal rats","volume":"275","author":"Li","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2020.105200_bb0080","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0253-16.2016","article-title":"Osteopontin is a blood biomarker for microglial activation and brain injury in experimental hypoxic-ischemic encephalopathy","volume":"4","author":"Li","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.nbd.2020.105200_bb0085","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1159\/000495879","article-title":"HIF1\u03b1 Signaling in the endogenous protective responses after neonatal brain hypoxia-ischemia","volume":"40","author":"Liang","year":"2018","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.nbd.2020.105200_bb0090","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1535-6108(03)00077-1","article-title":"2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF","volume":"3","author":"Mabjeesh","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.nbd.2020.105200_bb0095","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00418-003-0539-y","article-title":"Perfusion-Perls and -Turnbull methods supplemented by DAB intensification for nonheme iron histochemistry: demonstration of the superior sensitivity of the methods in the liver, spleen, and stomach of the rat","volume":"120","author":"Meguro","year":"2003","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.nbd.2020.105200_bb0100","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/sj.jp.7211750","article-title":"Elevated total peripheral leukocyte count may identify risk for neurological disability in asphyxiated term neonates","volume":"27","author":"Morkos","year":"2007","journal-title":"J. Perinatol."},{"key":"10.1016\/j.nbd.2020.105200_bb0105","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.nbd.2011.10.020","article-title":"Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1alpha","volume":"45","author":"Ogle","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2020.105200_bb0110","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3390\/ijms21041487","article-title":"Treatment of neonatal hypoxic-ischemic encephalopathy with erythropoietin alone, and erythropoietin combined with hypothermia: history, current status, and future research","volume":"21","author":"Oorschot","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2020.105200_bb0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jpeds.2017.08.031","article-title":"Neuroprotective strategies in neonatal brain injury","volume":"192","author":"Parikh","year":"2018","journal-title":"J. Pediatr."},{"key":"10.1016\/j.nbd.2020.105200_bb0120","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.jpeds.2013.07.007","article-title":"Reference ranges for regional cerebral tissue oxygen saturation and fractional oxygen extraction in neonates during immediate transition after birth","volume":"163","author":"Pichler","year":"2013","journal-title":"J. Pediatr."},{"key":"10.1016\/j.nbd.2020.105200_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084767","article-title":"Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke","volume":"9","author":"Reischl","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2020.105200_bb0130","article-title":"Neuroprotective role of lactate in rat neonatal hypoxia-ischemia","author":"Roumes","year":"2020","journal-title":"J Cereb blood flow"},{"key":"10.1016\/j.nbd.2020.105200_bb0135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1073\/pnas.0509459103","article-title":"Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production","volume":"103","author":"Safran","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2020.105200_bb0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pathol-012513-104720","article-title":"Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology","volume":"9","author":"Semenza","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.nbd.2020.105200_bb0145","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1159\/000232563","article-title":"HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemia","volume":"31","author":"Sheldon","year":"2009","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.nbd.2020.105200_bb0150","doi-asserted-by":"crossref","first-page":"9621","DOI":"10.1523\/JNEUROSCI.2295-10.2010","article-title":"Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1alpha in a cell-type-specific manner","volume":"30","author":"Sun","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.105200_bb0155","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1161\/STROKEAHA.115.009162","article-title":"Prophylactic Edaravone prevents transient hypoxic-ischemic brain injury: implications for perioperative neuroprotection","volume":"46","author":"Sun","year":"2015","journal-title":"Stroke."},{"key":"10.1016\/j.nbd.2020.105200_bb0160","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1046\/j.1471-4159.1996.67031014.x","article-title":"Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stress","volume":"67","author":"Thorburne","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2020.105200_bb0165","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances","volume":"8","author":"Volpe","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2020.105200_bb0170","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1074\/jbc.270.3.1230","article-title":"Purification and characterization of hypoxia-inducible factor 1","volume":"270","author":"Wang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2020.105200_bb0175","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0191","article-title":"High-dose erythropoietin and hypothermia for hypoxic-ischemic encephalopathy: a phase II trial","volume":"137","author":"Wu","year":"2016","journal-title":"Pediatrics."},{"key":"10.1016\/j.nbd.2020.105200_bb0180","doi-asserted-by":"crossref","first-page":"8669","DOI":"10.1523\/JNEUROSCI.1117-09.2009","article-title":"Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns","volume":"29","author":"Yang","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2020.105200_bb0185","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.expneurol.2013.01.015","article-title":"Intranasal delivery of cell-penetrating anti-NF-kappaB peptides (tat-NBD) alleviates infection-sensitized hypoxic-ischemic brain injury","volume":"247","author":"Yang","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2020.105200_bb0190","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1161\/STROKEAHA.113.001233","article-title":"Taming neonatal hypoxic-ischemic brain injury by intranasal delivery of plasminogen activator inhibitor-1","volume":"44","author":"Yang","year":"2013","journal-title":"Stroke."},{"key":"10.1016\/j.nbd.2020.105200_bb0195","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/cercor\/bhs115","article-title":"Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia","volume":"23","author":"Yang","year":"2013","journal-title":"Cereb. Cortex"},{"issue":"11","key":"10.1016\/j.nbd.2020.105200_bb0200","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1177\/0271678X19891839","article-title":"Early neutrophil infiltration is critical for inflammation-sensitized hypoxic-ischemic brain injury in newborns","volume":"40","author":"Yao","year":"2020","journal-title":"J. Cereb. Blood flow. Metab."},{"key":"10.1016\/j.nbd.2020.105200_bb0205","doi-asserted-by":"crossref","unstructured":"Yeh, T. L., Leissing, T. M., Abboud, M. I., Thinnes, C. C., Atasoylu, O., Holt-Martyn, J. P., Zhang, D., Tumber, A., Lippl, K,. Lohans, C. T., Leung, I. K. H., Morcrette, H., Clifton, I. J., Claridge, T. D. W., Kawamura, A., Flashman, E., Lu, X., Ratcliffe, P. J., Chowdhury, R., Pugh, C. W., Schofield, C. J 2017. Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem. Sci. 8, 7651\u20137668.","DOI":"10.1039\/C7SC02103H"},{"key":"10.1016\/j.nbd.2020.105200_bb0210","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1161\/STROKEAHA.109.574418","article-title":"Combination of tissue-plasminogen activator with erythropoietin induces blood-brain barrier permeability, extracellular matrix disaggregation, and DNA fragmentation after focal cerebral ischemia in mice","volume":"41","author":"Zechariah","year":"2010","journal-title":"Stroke."},{"key":"10.1016\/j.nbd.2020.105200_bb0215","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1161\/STROKEAHA.111.647420","article-title":"Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury","volume":"43","author":"Zhang","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2020.105200_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184049","article-title":"The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits","volume":"12","author":"Zhou","year":"2017","journal-title":"PLoS One"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996120304757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996120304757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:24:48Z","timestamp":1760851488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996120304757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":44,"alternative-id":["S0969996120304757"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2020.105200","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2020.105200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105200"}}