{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:38:09Z","timestamp":1793140689604,"version":"4.5.0"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1286"],"award-info":[{"award-number":["SFB1286"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2067\/1 - 390729940"],"award-info":[{"award-number":["EXC 2067\/1 - 390729940"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/25029-4"],"award-info":[{"award-number":["2014\/25029-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED481B 2017\/053"],"award-info":[{"award-number":["ED481B 2017\/053"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008211","name":"Association France Parkinson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["821522"],"award-info":[{"award-number":["821522"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000304","name":"Parkinson's UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.nbd.2021.105256","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T03:11:53Z","timestamp":1610421113000},"page":"105256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Doxycycline inhibits \u03b1-synuclein-associated pathologies in vitro and in vivo"],"prefix":"10.1016","volume":"151","author":[{"given":"Antonio","family":"Dominguez-Meijide","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Parrales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eftychia","family":"Vasili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Gonz\u00e1lez-Liz\u00e1rraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annekatrin","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana F.","family":"L\u00e1zaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Lannuzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Haik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Del Bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana","family":"Cheh\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Raisman-Vozari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick P.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bizat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Fleming","family":"Outeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2021.105256_bb0005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0896-6273(00)80886-7","article-title":"Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system","volume":"25","author":"Abeliovich","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2021.105256_bb0010","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/j.1460-2075.1984.tb01957.x","article-title":"Localization of the ribosomal genes in Caenorhabditis elegans chromosomes by in situ hybridization using biotin-labeled probes","volume":"3","author":"Albertson","year":"1984","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2021.105256_bb0015","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3389\/fgene.2014.00279","article-title":"Use of Caenorhabditis elegans as a model to study Alzheimer\u2019s disease and other neurodegenerative diseases","volume":"5","author":"Alexander","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.nbd.2021.105256_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039465","article-title":"Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo","volume":"7","author":"Angot","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105256_bb0025","doi-asserted-by":"crossref","first-page":"13838","DOI":"10.1074\/jbc.M113.544288","article-title":"Structural characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase protofibrils preventing \u03b1-synuclein oligomeric species toxicity","volume":"289","author":"\u00c1vila","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105256_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/biom9010003","article-title":"Cyclodextrins in Parkinson\u2019s disease","volume":"9","author":"Barros","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.nbd.2021.105256_bb0035","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1523\/JNEUROSCI.5831-09.2010","article-title":"Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans","volume":"30","author":"Bizat","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105256_bb0040","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cell.2005.10.017","article-title":"Snaring the function of alpha-synuclein","volume":"123","author":"Bonini","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105256_bb0045","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s00702-018-1913-1","article-title":"Tetracycline repurposing in neurodegeneration: focus on Parkinson\u2019s disease","volume":"125","author":"Bortolanza","year":"2018","journal-title":"J. Neural Trans. (Vienna, Austria\u202f: 1996)"},{"key":"10.1016\/j.nbd.2021.105256_bb0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/bs.pbr.2019.10.005","article-title":"Mechanisms of alpha-synuclein toxicity: an update and outlook","volume":"252","author":"Br\u00e1s","year":"2020","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2021.105256_bb0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.nbd.2021.105256_bb0060","doi-asserted-by":"crossref","first-page":"E4274","DOI":"10.1073\/pnas.1416598111","article-title":"\u03b1-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation","volume":"111","author":"Burr\u00e9","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105256_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013700","article-title":"Synphilin-1 enhances alpha-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner","volume":"5","author":"B\u00fcttner","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105256_bb0070","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/ana.25446","article-title":"Seeding variability of different alpha synuclein strains in synucleinopathies","volume":"85","author":"Candelise","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2021.105256_bb0075","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40035-019-0181-9","article-title":"Effect of the micro-environment on \u03b1-synuclein conversion and implication in seeded conversion assays","volume":"9","author":"Candelise","year":"2020","journal-title":"Transl. Neurodegen."},{"key":"10.1016\/j.nbd.2021.105256_bb0080","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1523\/JNEUROSCI.5157-04.2005","article-title":"Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans","volume":"25","author":"Cao","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105256_bb0085","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1042\/BJ20111924","article-title":"Toxic prefibrillar \u03b1-synuclein amyloid oligomers adopt a distinctive antiparallel \u03b2-sheet structure","volume":"443","author":"Celej","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2021.105256_bb0090","first-page":"9","article-title":"Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans","author":"Cermak","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.nbd.2021.105256_bb0095","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s12640-009-9078-1","article-title":"Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3","volume":"16","author":"Cho","year":"2009","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.nbd.2021.105256_bb0100","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/JPD-171258","article-title":"Modeling Parkinson\u2019s disease in C. elegans","volume":"8","author":"Cooper","year":"2018","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nbd.2021.105256_bb0110","doi-asserted-by":"crossref","first-page":"41647","DOI":"10.1074\/jbc.M111.274548","article-title":"Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease","volume":"286","author":"Costa","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105256_bb0115","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1128\/IAI.70.8.4705-4707.2002","article-title":"Diverse bacteria are pathogens of Caenorhabditis elegans","volume":"70","author":"Couillault","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.nbd.2021.105256_bb0120","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuroscience.2017.10.018","article-title":"Neuroprotective and neuro-restorative effects of minocycline and rasagiline in a zebrafish 6-hydroxydopamine model of Parkinson\u2019s disease","volume":"367","author":"Cronin","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2021.105256_bb0125","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jinorgbio.2017.02.020","article-title":"A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson\u2019s disease: therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies","volume":"170","author":"Cukierman","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.nbd.2021.105256_bb0130","doi-asserted-by":"crossref","first-page":"16252","DOI":"10.1039\/D0DT01138J","article-title":"X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(i)\/copper(ii)-\u03b1-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy","volume":"49","author":"Cukierman","year":"2020","journal-title":"Dalton Trans. (Cambridge, England\u202f: 2003)"},{"key":"10.1016\/j.nbd.2021.105256_bb0135","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4364","article-title":"Novel self-replicating \u03b1-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons","volume":"6","author":"De Giorgi","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.nbd.2021.105256_bb0140","doi-asserted-by":"crossref","first-page":"13010","DOI":"10.1073\/pnas.0903691106","article-title":"Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein","volume":"106","author":"Desplats","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105256_bb0145","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s13311-012-0109-x","article-title":"A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders","volume":"9","author":"Dexter","year":"2012","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2021.105256_bb0150","doi-asserted-by":"crossref","first-page":"12827","DOI":"10.1038\/s41598-020-69744-y","article-title":"Effects of pharmacological modulators of \u03b1-synuclein and tau aggregation and internalization","volume":"10","author":"Dominguez-Meijide","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105256_bb0155","doi-asserted-by":"crossref","first-page":"14669","DOI":"10.1073\/pnas.251341998","article-title":"Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson\u2019s disease","volume":"98","author":"Du","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105256_bb0160","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/8820","article-title":"Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions","volume":"22","author":"Engelender","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105256_bb0165","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56498-5","article-title":"C. elegans expressing D76N \u03b2(2)-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis","volume":"9","author":"Faravelli","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105256_bb0170","first-page":"9","article-title":"Found in translation: the utility of C. elegans alpha-synuclein models of Parkinson\u2019s disease","author":"Gaeta","year":"2019","journal-title":"Brain Sci."},{"key":"10.1016\/j.nbd.2021.105256_bb0175","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bcp.2009.07.028","article-title":"Mitochondria and calcium flux as targets of neuroprotection caused by minocycline in cerebellar granule cells","volume":"79","author":"Garcia-Martinez","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2021.105256_bb0180","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1074\/jbc.M110.178376","article-title":"Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils","volume":"286","author":"Giorgetti","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105256_bb0185","doi-asserted-by":"crossref","first-page":"41755","DOI":"10.1038\/srep41755","article-title":"Repurposing doxycycline for synucleinopathies: remodelling of \u03b1-synuclein oligomers towards non-toxic parallel beta-sheet structured species","volume":"7","author":"Gonz\u00e1lez-Liz\u00e1rraga","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105256_bb0190","doi-asserted-by":"crossref","first-page":"E2634","DOI":"10.1073\/pnas.1713849115","article-title":"Identification of a highly neurotoxic \u03b1-synuclein species inducing mitochondrial damage and mitophagy in Parkinson\u2019s disease","volume":"115","author":"Grassi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105256_bb0195","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1073\/pnas.0711018105","article-title":"Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson\u2019s disease model","volume":"105","author":"Hamamichi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105256_bb0200","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/jnc.13532","article-title":"Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models","volume":"137","author":"Hannan","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105256_bb0205","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/infdis\/jit623","article-title":"Cycline efficacy on the propagation of human prions in primary cultured neurons is strain-specific","volume":"209","author":"Hannaoui","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.nbd.2021.105256_bb0210","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1046\/j.1471-4159.1997.69062620.x","article-title":"Tetracycline-regulated transgene expression in hippocampal neurones following transfection with adenoviral vectors","volume":"69","author":"Harding","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105256_bb0215","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0166-2236(02)02236-1","article-title":"Teaching old drugs new tricks. Meeting of the neurodegeneration drug screening consortium, 7-8 April 2002, Washington, DC, USA","volume":"25","author":"Heemskerk","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2021.105256_bb0220","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.parkreldis.2019.01.002","article-title":"The next chapter in symptomatic Parkinson disease treatments","volume":"59","author":"Hengartner","year":"2019","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2021.105256_bb0225","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/WNR.0000000000000740","article-title":"Montelukast treatment protects nigral dopaminergic neurons against microglial activation in the 6-hydroxydopamine mouse model of Parkinson\u2019s disease","volume":"28","author":"Jang","year":"2017","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2021.105256_bb0230","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s12035-020-02124-9","article-title":"Haloperidol interactions with the dop-3 receptor in Caenorhabditis elegans","volume":"58","author":"Krum","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2021.105256_bb0235","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1074\/jbc.M504860200","article-title":"Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans","volume":"281","author":"Kuwahara","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105256_bb0240","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/hmg\/ddn198","article-title":"A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans","volume":"17","author":"Kuwahara","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2021.105256_bb0245","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1471-4159.2003.01809.x","article-title":"Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein","volume":"86","author":"Lakso","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105256_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004741","article-title":"Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation","volume":"10","author":"L\u00e1zaro","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2021.105256_bb0255","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s40478-016-0402-8","article-title":"The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation","volume":"4","author":"L\u00e1zaro","year":"2016","journal-title":"Acta Neuropahtol. Commun."},{"key":"10.1016\/j.nbd.2021.105256_bb0260","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/glia.22496","article-title":"Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model","volume":"61","author":"Lazzarini","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2021.105256_bb0265","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41378-018-0003-8","article-title":"Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution","volume":"4","author":"Letizia","year":"2018","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.nbd.2021.105256_bb0270","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/pro.5560020312","article-title":"Thioflavine T interaction with synthetic Alzheimer\u2019s disease beta-amyloid peptides: detection of amyloid aggregation in solution","volume":"2","author":"LeVine","year":"1993","journal-title":"Protein Sci."},{"key":"10.1016\/j.nbd.2021.105256_bb0275","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pnmrs.2018.02.001","article-title":"Solution NMR of SNAREs, complexin and \u03b1-synuclein in association with membrane-mimetics","volume":"105","author":"Liang","year":"2018","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"key":"10.1016\/j.nbd.2021.105256_bb0280","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105256_bb0285","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mcn.2017.04.009","article-title":"Extensive uptake of \u03b1-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage","volume":"82","author":"Lindstr\u00f6m","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2021.105256_bb0290","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1242\/dev.126.24.5819","article-title":"Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox gene","volume":"126","author":"Lints","year":"1999","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.nbd.2021.105256_bb0295","doi-asserted-by":"crossref","first-page":"20051","DOI":"10.1073\/pnas.0908005106","article-title":"Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells","volume":"106","author":"Luk","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105256_bb0300","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s40478-018-0578-1","article-title":"Membrane binding, internalization, and sorting of alpha-synuclein in the cell","volume":"6","author":"Masaracchia","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2021.105256_bb0305","doi-asserted-by":"crossref","first-page":"140298","DOI":"10.1016\/j.bbapap.2019.140298","article-title":"Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies","volume":"1868","author":"Masaracchia","year":"2020","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2021.105256_bb0310","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0306-4522(01)00113-0","article-title":"Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons","volume":"104","author":"McLean","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2021.105256_bb0315","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.bbapap.2019.03.001","article-title":"\u03b1-Synuclein misfolding and aggregation: implications in Parkinson\u2019s disease pathogenesis","volume":"1867","author":"Mehra","year":"2019","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2021.105256_bb0320","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0091-679X(08)61399-0","article-title":"DNA transformation","volume":"48","author":"Mello","year":"1995","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.nbd.2021.105256_bb0325","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.3923\/pjbs.2007.3853.3858","article-title":"Effects of aspirin and celecoxib on rigidity in a rat model of Parkinson\u2019s disease","volume":"10","author":"Moghaddam","year":"2007","journal-title":"Pak. J. Biol. Sci."},{"key":"10.1016\/j.nbd.2021.105256_bb0330","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cmet.2020.01.011","article-title":"A conserved mito-cytosolic translational balance links two longevity pathways","volume":"31","author":"Molenaars","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2021.105256_bb0335","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1523\/JNEUROSCI.20-09-03214.2000","article-title":"Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons","volume":"20","author":"Murphy","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105256_bb0340","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-6632.2011.06354.x","article-title":"The history of the tetracyclines","volume":"1241","author":"Nelson","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2021.105256_bb0345","first-page":"52321","article-title":"Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegans","author":"Nussbaum-Krammer","year":"2015","journal-title":"J. Visual. Exp."},{"key":"10.1016\/j.nbd.2021.105256_bb0350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2018.01.015","article-title":"Prion-like seeding and nucleation of intracellular amyloid-\u03b2","volume":"113","author":"Olsson","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105256_bb0355","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/9282f173-df82-4b70-9120-b4e62b3dacb1","article-title":"Formation of toxic oligomeric alpha-synuclein species in living cells","volume":"3","author":"Outeiro","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105256_bb0360","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-019-0306-8","article-title":"Dementia with Lewy bodies: an update and outlook","volume":"14","author":"Outeiro","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2021.105256_bb0365","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s12035-019-01847-8","article-title":"Neuroprotective effects of doxycycline in the R6\/2 mouse model of Huntington\u2019s disease","volume":"57","author":"Paldino","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2021.105256_bb0370","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-019-0349-x","article-title":"Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway","volume":"15","author":"Park","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2021.105256_bb0375","first-page":"e59758","article-title":"Generation of alpha-synuclein preformed fibrils from monomers and use in vivo","volume":"148","author":"Patterson","year":"2019","journal-title":"J. Visual. Exp."},{"key":"10.1016\/j.nbd.2021.105256_bb0380","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41582-020-0333-7","article-title":"Protein transmission in neurodegenerative disease","volume":"16","author":"Peng","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2021.105256_bb0385","doi-asserted-by":"crossref","first-page":"E1009","DOI":"10.1073\/pnas.1610586114","article-title":"A natural product inhibits the initiation of \u03b1-synuclein aggregation and suppresses its toxicity","volume":"114","author":"Perni","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105256_bb0390","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0304-3940(03)00781-X","article-title":"Epitope mapping and specificity of the anti-alpha-synuclein monoclonal antibody Syn-1 in mouse brain and cultured cell lines","volume":"349","author":"Perrin","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2021.105256_bb0395","first-page":"9","article-title":"Mitochondrial dysfunction, oxidative stress, and neuroinflammation: intertwined roads to neurodegeneration","author":"Picca","year":"2020","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.nbd.2021.105256_bb0400","doi-asserted-by":"crossref","first-page":"46711","DOI":"10.1038\/srep46711","article-title":"A specific nanobody prevents amyloidogenesis of D76N \u03b2(2)-microglobulin in vitro and modifies its tissue distribution in vivo","volume":"7","author":"Raimondi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105256_bb0405","series-title":"C. elegans II","article-title":"Synaptic transmission","author":"Rand","year":"1997"},{"key":"10.1016\/j.nbd.2021.105256_bb0410","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuint.2018.05.013","article-title":"Blockade and reversal of swimming-induced paralysis in C. elegans by the antipsychotic and D2-type dopamine receptor antagonist azaperone","volume":"123","author":"Refai","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2021.105256_bb0415","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pneurobio.2015.10.004","article-title":"Novel tactics for neuroprotection in Parkinson\u2019s disease: role of antibiotics, polyphenols and neuropeptides","volume":"155","author":"Reglodi","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2021.105256_bb0420","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s13311-018-0646-z","article-title":"Angiotensin type 1 receptor antagonists protect against alpha-synuclein-induced neuroinflammation and dopaminergic neuron death","volume":"15","author":"Rodriguez-Perez","year":"2018","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2021.105256_bb0425","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12640-015-9592-2","article-title":"Doxycycline suppresses microglial activation by inhibiting the p38 MAPK and NF-kB signaling pathways","volume":"29","author":"Santa-Cec\u00edlia","year":"2016","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.nbd.2021.105256_bb0430","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s12640-019-00015-z","article-title":"The neuroprotective effect of doxycycline on neurodegenerative diseases","volume":"35","author":"Santa-Cec\u00edlia","year":"2019","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.nbd.2021.105256_bb0435","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1111\/febs.15364","article-title":"Protein trapping leads to altered synaptic proteostasis in synucleinopathies","volume":"287","author":"Santos","year":"2020","journal-title":"FEBS J."},{"key":"10.1016\/j.nbd.2021.105256_bb0440","doi-asserted-by":"crossref","first-page":"28711","DOI":"10.1038\/srep28711","article-title":"Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie","volume":"6","author":"Schmitz","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105256_bb0445","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1523\/JNEUROSCI.0482-05.2005","article-title":"Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y","volume":"25","author":"Smith","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105256_bb0450","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pneurobio.2017.12.002","article-title":"Exploiting the therapeutic potential of ready-to-use drugs: repurposing antibiotics against amyloid aggregation in neurodegenerative diseases","volume":"162","author":"Socias","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2021.105256_bb0455","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson\u2019s disease and dementia with lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105256_bb0460","series-title":"WormBook\u202f: The Online Review of C elegans Biology","first-page":"1","article-title":"Maintenance of C. elegans","author":"Stiernagle","year":"2006"},{"key":"10.1016\/j.nbd.2021.105256_bb0465","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1021\/jm400161p","article-title":"A new face for old antibiotics: tetracyclines in treatment of amyloidoses","volume":"56","author":"Stoilova","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.nbd.2021.105256_bb0470","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/cne.901630207","article-title":"Dopaminergic neurons in the nematode Caenorhabditis elegans","volume":"163","author":"Sulston","year":"1975","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2021.105256_bb0475","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.celrep.2019.06.009","article-title":"Cytosolic trapping of a mitochondrial heat shock protein is an early pathological event in synucleinopathies","volume":"28","author":"Szeg\u0151","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2021.105256_bb0480","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1460-9568.2007.05736.x","article-title":"Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D","volume":"26","author":"Takahashi","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105256_bb0485","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"124","author":"Tysnes","year":"2017","journal-title":"J. Neural Trans. (Vienna, Austria\u202f: 1996)"},{"key":"10.1016\/j.nbd.2021.105256_bb0490","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1038\/s41598-017-07383-6","article-title":"Novel animal model defines genetic contributions for neuron-to-neuron transfer of alpha-synuclein","volume":"7","author":"Tyson","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105256_bb0495","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000027","article-title":"C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging","volume":"4","author":"van Ham","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2021.105256_bb0500","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3233\/JAD-180610","article-title":"An inducible alpha-synuclein expressing neuronal cell line model for Parkinson\u2019s disease","volume":"66","author":"Vasquez","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.nbd.2021.105256_bb0505","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/j.1471-4159.2009.06054.x","article-title":"Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death","volume":"109","author":"Vekrellis","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105256_bb0510","doi-asserted-by":"crossref","first-page":"17504","DOI":"10.1073\/pnas.1108673108","article-title":"Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin","volume":"108","author":"Vidal-Gadea","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105256_bb0515","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/nprot.2014.143","article-title":"Addition of exogenous \u03b1-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous \u03b1-synuclein to Lewy body and Lewy neurite-like aggregates","volume":"9","author":"Volpicelli-Daley","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2021.105256_bb0520","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00401-013-1114-9","article-title":"Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson\u2019s disease","volume":"125","author":"Wagner","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105256_bb0525","first-page":"12","article-title":"Selective neuronal vulnerability to oxidative stress in the brain","volume":"2","author":"Wang","year":"2010","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2021.105256_bb0530","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40478-019-0696-4","article-title":"Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration","volume":"7","author":"Wang","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2021.105256_bb0535","first-page":"1","article-title":"The structure of the nervous system of the nematode Caenorhabditis elegans","volume":"314","author":"White","year":"1986","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.nbd.2021.105256_bb0540","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001217","article-title":"Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays","volume":"6","author":"Wilham","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.nbd.2021.105256_bb0545","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.1252884","article-title":"Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins","volume":"344","author":"Wilhelm","year":"2014","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.nbd.2021.105256_bb0550","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.201003122","article-title":"\u03b1-Synuclein impairs macroautophagy: implications for Parkinson\u2019s disease","volume":"190","author":"Winslow","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2021.105256_bb0555","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jmb.2009.09.056","article-title":"Binding modes of thioflavin-T to the single-layer beta-sheet of the peptide self-assembly mimics","volume":"394","author":"Wu","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.nbd.2021.105256_bb0560","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1084-9521(02)00018-6","article-title":"Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling","volume":"13","author":"Zhu","year":"2002","journal-title":"Semin. Cell Dev. Biol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999612100005X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999612100005X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:00:20Z","timestamp":1778792420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096999612100005X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":111,"alternative-id":["S096999612100005X"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105256","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.11.06.371229","asserted-by":"object"}]},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Doxycycline inhibits \u03b1-synuclein-associated pathologies in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105256","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105256"}}