{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:27:40Z","timestamp":1792016860275,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01 AG054753"],"award-info":[{"award-number":["K01 AG054753"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R03 AG063250"],"award-info":[{"award-number":["R03 AG063250"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U54 AG054345"],"award-info":[{"award-number":["U54 AG054345"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG050597"],"award-info":[{"award-number":["RF1 AG050597"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG051495"],"award-info":[{"award-number":["RF1 AG051495"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K?N"],"award-info":[{"award-number":["K?N"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NLM R01 LM012535"],"award-info":[{"award-number":["NLM R01 LM012535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.nbd.2021.105303","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T19:54:46Z","timestamp":1614023686000},"page":"105303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"special_numbering":"C","title":["INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia"],"prefix":"10.1016","volume":"153","author":[{"given":"Andy P.","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Bor-Chian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanpeng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Moutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad T.","family":"Casali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce T.","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Landreth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian L.","family":"Oblak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangsik","family":"Nho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2021.105303_bb0005","doi-asserted-by":"crossref","first-page":"160089","DOI":"10.1038\/sdata.2016.89","article-title":"Human whole genome genotype and transcriptome data for Alzheimer\u2019s and other neurodegenerative diseases","volume":"3","author":"Allen","year":"2016","journal-title":"Sci Data"},{"key":"10.1016\/j.nbd.2021.105303_bb0010","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1038\/s41467-020-17405-z","article-title":"Multiscale causal networks identify VGF as a key regulator of Alzheimer\u2019s disease","volume":"11","author":"Beckmann","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105303_bb0015","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-179939","article-title":"Religious orders study and rush memory and aging project","volume":"64","author":"Bennett","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2021.105303_bb0020","doi-asserted-by":"crossref","first-page":"104956","DOI":"10.1016\/j.nbd.2020.104956","article-title":"Microglia depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies","volume":"142","author":"Casali","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105303_bb0025","doi-asserted-by":"crossref","first-page":"180142","DOI":"10.1038\/sdata.2018.142","article-title":"A multi-omic atlas of the human frontal cortex for aging and Alzheimer\u2019s disease research","volume":"5","author":"De Jager","year":"2018","journal-title":"Sci Data"},{"key":"10.1016\/j.nbd.2021.105303_bb0030","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1212\/WNL.0000000000002909","article-title":"Relation of genomic variants for Alzheimer disease dementia to common neuropathologies","volume":"87","author":"Farfel","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2021.105303_bb0035","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1001\/archneur.55.9.1185","article-title":"Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease","volume":"55","author":"Haroutunian","year":"1998","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2021.105303_bb0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/mp.2017.246","article-title":"Markers of microglia in post-mortem brain samples from patients with Alzheimer\u2019s disease: a systematic review","volume":"23","author":"Hopperton","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2021.105303_bb0045","doi-asserted-by":"crossref","first-page":"69225","DOI":"10.18632\/oncotarget.12648","article-title":"INPP5D rs35349669 polymorphism with late-onset Alzheimer\u2019s disease: a replication study and meta-analysis","volume":"7","author":"Jing","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.nbd.2021.105303_bb0050","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0448-18.2019","article-title":"Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and manipulating microglia","volume":"6","author":"Kaiser","year":"2019","journal-title":"eNeuro"},{"key":"10.1016\/j.nbd.2021.105303_bb0055","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopsych.2014.05.006","article-title":"Alzheimer\u2019s disease risk genes and mechanisms of disease pathogenesis","volume":"77","author":"Karch","year":"2015","journal-title":"Biol. Psychiatry"},{"issue":"566\u2013581","key":"10.1016\/j.nbd.2021.105303_bb0060","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2021.105303_bb0065","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer\u2019s disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105303_bb0070","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105303_bb0075","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00702-010-0433-4","article-title":"The role of microglia in amyloid clearance from the AD brain","volume":"117","author":"Lee","year":"2010","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.nbd.2021.105303_bb0080","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2174\/187152710791012071","article-title":"Microglia and inflammation in Alzheimer\u2019s disease","volume":"9","author":"Mandrekar-Colucci","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.nbd.2021.105303_bb0085","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The clinical dementia rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2021.105303_bb0090","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.238030","article-title":"Pan-SHIP1\/2 inhibitors promote microglia effector functions essential for CNS homeostasis","volume":"133","author":"Pedicone","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2021.105303_bb0095","doi-asserted-by":"crossref","first-page":"ra38","DOI":"10.1126\/scisignal.2000500","article-title":"TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1","volume":"3","author":"Peng","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.nbd.2021.105303_bb0100","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/sj.embor.7400784","article-title":"Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology","volume":"7","author":"Radde","year":"2006","journal-title":"EMBO Rep."},{"issue":"64\u201382","key":"10.1016\/j.nbd.2021.105303_bb0105","article-title":"Multiscale analysis of independent Alzheimer\u2019s cohorts finds disruption of molecular, genetic, and clinical networks by human Herpesvirus","volume":"99","author":"Readhead","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2021.105303_bb0110","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2021.105303_bb0115","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1101\/gad.14.5.505","article-title":"Structure, function, and biology of SHIP proteins","volume":"14","author":"Rohrschneider","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.nbd.2021.105303_bb0120","doi-asserted-by":"crossref","first-page":"fcz022","DOI":"10.1093\/braincomms\/fcz022","article-title":"Genetic variability in response to amyloid beta deposition influences Alzheimer\u2019s disease risk","volume":"1","author":"Salih","year":"2019","journal-title":"Brain Commun"},{"key":"10.1016\/j.nbd.2021.105303_bb0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/neup.12235","article-title":"TMEM119 marks a subset of microglia in the human brain","volume":"36","author":"Satoh","year":"2016","journal-title":"Neuropathology"},{"key":"10.1016\/j.nbd.2021.105303_bb0130","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/ng.3916","article-title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer\u2019s disease","volume":"49","author":"Sims","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105303_bb0135","article-title":"<em>PLCG2<\/em> as a risk factor for Alzheimer\u2019s disease","author":"Tsai","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2021.105303_bb0140","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/med.21305","article-title":"Discovery and development of small molecule SHIP phosphatase modulators","volume":"34","author":"Viernes","year":"2014","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.nbd.2021.105303_bb0145","doi-asserted-by":"crossref","first-page":"180185","DOI":"10.1038\/sdata.2018.185","article-title":"The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer\u2019s disease","volume":"5","author":"Wang","year":"2018","journal-title":"Sci Data"},{"key":"10.1016\/j.nbd.2021.105303_bb0150","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neurobiolaging.2019.06.003","article-title":"Targeted genetic analysis of cerebral blood flow imaging phenotypes implicates the INPP5D gene","volume":"81","author":"Yao","year":"2019","journal-title":"Neurobiol. Aging"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121000528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121000528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:00:03Z","timestamp":1778792403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996121000528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":30,"alternative-id":["S0969996121000528"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105303","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.08.31.276444","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-69967\/v1","asserted-by":"object"}]},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105303"}}