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Osmond, M., Payen, J.-F., Perlbarg, V., Persona, P., Pichon, N., Piippo-Karjalainen, A., Pili-Floury, S., Pirinen, M., Ple, H., Poca, M.A., Posti, J., Praag, D.V., Ptito, A., Radoi, A., Ragauskas, A., Raj, R., Real, R.G.L., Reed, N., Rhodes, J., Robertson, C., Rocka, S., R\u00f8e, C., R\u00f8ise, O., Roks, G., Rosand, J., Rosenfeld, J.V., Rosenlund, C., Rosenthal, G., Rossi, S., Rueckert, D., de Ruiter, G.C.W., Sacchi, M., Sahakian, B.J., Sahuquillo, J., Sakowitz, O., Salvato, G., S\u00e1nchez-Porras, R., S\u00e1ndor, J., Sangha, G., Sch\u00e4fer, N., Schmidt, S., Schneider, K.J., Schnyer, D., Sch\u00f6hl, H., Schoonman, G.G., Schou, R.F., Sir, \u00d6., Skandsen, T., Smeets, D., Sorinola, A., Stamatakis, E., Stevanovic, A., Stevens, R.D., Sundstr\u00f6m, N., Taccone, F.S., Takala, R., Tanskanen, P., Taylor, M.S., Telgmann, R., Temkin, N., Teodorani, G., Thomas, M., Tolias, C.M., Trapani, T., Turgeon, A., Vajkoczy, P., Valadka, A.B., Valeinis, E., Vallance, S., V\u00e1mos, Z., Vargiolu, 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Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 16, 987\u20131048. doi:https:\/\/doi.org\/10.1016\/S1474-4422(17)30371-X.","DOI":"10.1016\/S1474-4422(17)30371-X"},{"key":"10.1016\/j.nbd.2021.105330_bb0135","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1038\/nprot.2006.281","article-title":"Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay","volume":"1","author":"Mahoney","year":"2006","journal-title":"Nat. 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