{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:24:18Z","timestamp":1789043058284,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.nbd.2021.105332","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T11:46:33Z","timestamp":1616067993000},"page":"105332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Dermal and cardiac autonomic fiber involvement in Parkinson's disease and multiple system atrophy"],"prefix":"10.1016","volume":"153","author":[{"given":"Joachim","family":"Brumberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Kuzkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Lapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Mammadova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Volkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis U.","family":"Isaias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Doppler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2021.105332_bb0005","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","article-title":"The genetic architecture of Parkinson's disease","volume":"19","author":"Blauwendraat","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2021.105332_bb0010","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1007\/s00259-010-1545-7","article-title":"131I\/123I-metaiodobenzylguanidine (mIBG) scintigraphy: procedure guidelines for tumour imaging","volume":"37","author":"Bombardieri","year":"2010","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.nbd.2021.105332_bb0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/mds.27138","article-title":"How does parkinson\u2019s disease begin? Perspectives on neuroanatomical pathways, prions, and histology","volume":"33","author":"Borghammer","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105332_bb0020","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40658-019-0250-2","article-title":"Imaging cardiac sympathetic innervation with MIBG: linear conversion of the heart-to-mediastinum ratio between different collimators","volume":"6","author":"Brumberg","year":"2019","journal-title":"EJNMMI Phys."},{"key":"10.1016\/j.nbd.2021.105332_bb0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.expneurol.2006.01.023","article-title":"Tyrosine hydroxylase is expressed in a subpopulation of small dorsal root ganglion neurons in the adult mouse","volume":"200","author":"Brumovsky","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105332_bb0030","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a024091","article-title":"Cell biology and pathophysiology of alpha-synuclein","volume":"8","author":"Burre","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.nbd.2021.105332_bb0035","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0002-9440(10)65226-1","article-title":"Widespread alterations of \u03b1-synuclein in multiple system atrophy","volume":"155","author":"Dickson","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2021.105332_bb0040","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S1474-4422(09)70238-8","article-title":"Neuropathological assessment of Parkinson\u2019s disease: refining the diagnostic criteria","volume":"8","author":"Dickson","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2021.105332_bb0045","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1212\/WNL.0000000000000316","article-title":"Skin nerve alpha-synuclein deposits: a biomarker for idiopathic Parkinson disease","volume":"82","author":"Donadio","year":"2014","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2021.105332_bb0050","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1212\/WNL.0000000000004146","article-title":"A new potential biomarker for dementia with Lewy bodies: skin nerve alpha-synuclein deposits","volume":"89","author":"Donadio","year":"2017","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2021.105332_bb0055","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/jnen\/nly074","article-title":"Skin nerve phosphorylated alpha-synuclein deposits in Parkinson disease with orthostatic hypotension","volume":"77","author":"Donadio","year":"2018","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105332_bb0060","doi-asserted-by":"crossref","first-page":"14246","DOI":"10.1038\/s41598-018-32588-8","article-title":"Skin alpha-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study","volume":"8","author":"Donadio","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105332_bb0065","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/mds.28126","article-title":"Skin biopsy may help to distinguish multiple system atrophy-Parkinsonism from Parkinson\u2019s disease with orthostatic hypotension","volume":"35","author":"Donadio","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105332_bb0070","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00401-014-1284-0","article-title":"Cutaneous neuropathy in Parkinson's disease: a window into brain pathology","volume":"128","author":"Doppler","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105332_bb0075","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/mds.26293","article-title":"Distinctive distribution of phospho-alpha-synuclein in dermal nerves in multiple system atrophy","volume":"30","author":"Doppler","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105332_bb0080","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00401-017-1684-z","article-title":"Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease","volume":"133","author":"Doppler","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105332_bb0085","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.3389\/fneur.2018.01094","article-title":"Dermal phospho-alpha-synuclein deposition in patients with Parkinson\u2019s disease and mutation of the glucocerebrosidase gene","volume":"9","author":"Doppler","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2021.105332_bb0090","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s00259-010-1491-4","article-title":"Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology","volume":"37","author":"Flotats","year":"2010","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.nbd.2021.105332_bb0095","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.parkreldis.2020.10.016","article-title":"Comparison of 123I-MIBG scintigraphy and phosphorylated alpha-synuclein skin deposits in synucleinopathies","volume":"81","author":"Giannoccaro","year":"2020","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2021.105332_bb0100","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","article-title":"Second consensus statement on the diagnosis of multiple system atrophy","volume":"71","author":"Gilman","year":"2008","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2021.105332_bb0105","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s12350-015-0387-x","article-title":"ASNC imaging guidelines for SPECT nuclear cardiology procedures: stress, protocols, and tracers","volume":"23","author":"Henzlova","year":"2016","journal-title":"J. Nucl. Cardiol."},{"key":"10.1016\/j.nbd.2021.105332_bb0110","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/brain\/awf080","article-title":"The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service","volume":"125","author":"Hughes","year":"2002","journal-title":"Brain."},{"key":"10.1016\/j.nbd.2021.105332_bb0115","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1212\/WNL.52.6.1269","article-title":"Lewy body-type degeneration in cardiac plexus in Parkinson\u2019s and incidental Lewy body diseases","volume":"52","author":"Iwanaga","year":"1999","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2021.105332_bb0120","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.jacc.2010.01.014","article-title":"Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study","volume":"55","author":"Jacobson","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.nbd.2021.105332_bb0125","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/jnnp-2019-322338","article-title":"Parkinson\u2019s disease: etiopathogenesis and treatment","volume":"91","author":"Jankovic","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2021.105332_bb0130","series-title":"Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice","author":"Kimura","year":"2013"},{"key":"10.1016\/j.nbd.2021.105332_bb0135","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.parkreldis.2014.05.005","article-title":"Multiple system atrophy as emerging template for accelerated drug discovery in alpha-synucleinopathies","volume":"20","author":"Krismer","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2021.105332_bb0140","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/mds.27669","article-title":"Morphometric MRI profiles of multiple system atrophy variants and implications for differential diagnosis","volume":"34","author":"Krismer","year":"2019","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105332_bb0145","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1468-1331.2005.01260.x","article-title":"EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy","volume":"12","author":"Lauria","year":"2005","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2021.105332_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012728","article-title":"Colonic biopsies to assess the neuropathology of Parkinson\u2019s disease and its relationship with symptoms","volume":"5","author":"Lebouvier","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105332_bb0155","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1001\/archneur.1997.00550200007003","article-title":"What is the accuracy of the clinical diagnosis of multiple system atrophy? A clinicopathologic study","volume":"54","author":"Litvan","year":"1997","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2021.105332_bb0160","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.2967\/jnumed.116.186403","article-title":"(18)F-FDG PET in Parkinsonism: differential diagnosis and evaluation of cognitive impairment","volume":"58","author":"Meyer","year":"2017","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nbd.2021.105332_bb0165","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/mds.23338","article-title":"Abnormal cardiac [(123)I]-meta-iodobenzylguanidine uptake in multiple system atrophy","volume":"25","author":"Nagayama","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105332_bb0170","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1440-1827.2004.01680.x","article-title":"Lewy bodies in the sinoatrial nodal ganglion: clinicopathological studies","volume":"54","author":"Okada","year":"2004","journal-title":"Pathol. Int."},{"key":"10.1016\/j.nbd.2021.105332_bb0175","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/jnnp.67.2.189","article-title":"(123)I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson\u2019s disease","volume":"67","author":"Orimo","year":"1999","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2021.105332_bb0180","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/brain\/awm302","article-title":"Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson\u2019s disease","volume":"131","author":"Orimo","year":"2008","journal-title":"Brain."},{"key":"10.1016\/j.nbd.2021.105332_bb0185","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.parkreldis.2012.01.009","article-title":"123I-MIBG myocardial scintigraphy for differentiating Parkinson\u2019s disease from other neurodegenerative parkinsonism: a systematic review and meta-analysis","volume":"18","author":"Orimo","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2021.105332_bb0190","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105332_bb0195","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.nbd.2017.04.004","article-title":"Alpha-synuclein: pathology, mitochondrial dysfunction and neuroinflammation in Parkinson\u2019s disease","volume":"109","author":"Rocha","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105332_bb0200","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2021.105332_bb0205","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00401-005-1013-9","article-title":"alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy","volume":"110","author":"Sone","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105332_bb0210","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1353-8020(99)00031-0","article-title":"Parkinson\u2019s disease, dementia with Lewy bodies and multiple system atrophy are alpha-synucleinopathies","volume":"5","author":"Spillantini","year":"1999","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2021.105332_bb0215","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10286-011-0135-5","article-title":"MIBG scintigraphy in differential diagnosis of Parkinsonism: a meta-analysis","volume":"22","author":"Treglia","year":"2012","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.nbd.2021.105332_bb0220","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S1474-4422(16)00080-6","article-title":"Assessment of \u03b1-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study","volume":"15","author":"Vilas","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2021.105332_bb0225","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrn.2016.13","article-title":"A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration","volume":"17","author":"Walsh","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2021.105332_bb0230","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1093\/brain\/awv138","article-title":"Phosphorylated alpha-synuclein in skin nerve fibres differentiates Parkinson\u2019s disease from multiple system atrophy","volume":"138","author":"Zange","year":"2015","journal-title":"Brain."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121000814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121000814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:25:41Z","timestamp":1760851541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996121000814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":46,"alternative-id":["S0969996121000814"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105332","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dermal and cardiac autonomic fiber involvement in Parkinson's disease and multiple system atrophy","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105332","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105332"}}