{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:44:14Z","timestamp":1787136254116,"version":"build-2736575974"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002334","name":"R\u00e9gion Alsace","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["13-JSV4-0003-01"],"award-info":[{"award-number":["13-JSV4-0003-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004562","name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Superieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.nbd.2021.105363","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:08:16Z","timestamp":1618790896000},"page":"105363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain"],"prefix":"10.1016","volume":"155","author":[{"given":"Dhanasak","family":"Dhanasobhon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Carmen","family":"Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a J.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunuen","family":"Moreno-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehrazat","family":"Kavraal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Bichara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Schlichter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Inquimbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipek","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Cordero-Erausquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"295\u2013310","key":"10.1016\/j.nbd.2021.105363_bb0005","article-title":"The cellular and synaptic architecture of the mechanosensory dorsal horn","volume":"168","author":"Abraira","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105363_bb0010","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1097\/j.pain.0000000000000221","article-title":"Subpopulations of PKCgamma interneurons within the medullary dorsal horn revealed by electrophysiologic and morphologic approach","volume":"156","author":"Alba-Delgado","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2021.105363_bb0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cne.902290305","article-title":"The morphology and distribution of neurons containing choline acetyltransferase in the adult rat spinal cord: an immunocytochemical study","volume":"229","author":"Barber","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2021.105363_bb0020","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ejpain.2007.10.002","article-title":"Sciatic nerve cuffing in mice: a model of sustained neuropathic pain","volume":"12","author":"Benbouzid","year":"2008","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.nbd.2021.105363_bb0025","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.nbd.2021.105363_bb0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0006-8993(02)04123-9","article-title":"Spinal GABAB receptors mediate antinociceptive actions of cholinergic agents in normal and diabetic rats","volume":"965","author":"Chen","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105363_bb0035","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuroscience.2004.01.015","article-title":"Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors","volume":"125","author":"Chen","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2021.105363_bb0040","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nn.4549","article-title":"Identification of spinal circuits involved in touch-evoked dynamic mechanical pain","volume":"20","author":"Cheng","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2021.105363_bb0045","doi-asserted-by":"crossref","first-page":"7342","DOI":"10.1523\/JNEUROSCI.19-17-07342.1999","article-title":"Junctional versus extrajunctional glycine and GABA(A) receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord","volume":"19","author":"Chery","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105363_bb0050","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1097\/00000542-199911000-00038","article-title":"Sex differences in cholinergic analgesia I: a supplemental nicotinic mechanism in normal females","volume":"91","author":"Chiari","year":"1999","journal-title":"Anesthesiology"},{"issue":"16","key":"10.1016\/j.nbd.2021.105363_bb0055","first-page":"30421","article-title":"Neuronal networks and nociceptive processing in the dorsal horn of the spinal cord","volume":"S0306-4522","author":"Cordero-Erausquin","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2021.105363_bb0060","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1213\/ane.0b013e3181a891c2","article-title":"Epidural neostigmine: will it replace lipid soluble opioids for postoperative and labor analgesia?","volume":"109","author":"Eisenach","year":"2009","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.nbd.2021.105363_bb0065","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1213\/00000539-199603000-00034","article-title":"Cerebrospinal fluid norepinephrine and acetylcholine concentrations during acute pain","volume":"82","author":"Eisenach","year":"1996","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.nbd.2021.105363_bb0070","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jneumeth.2011.06.017","article-title":"A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord","volume":"200","author":"Flynn","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2021.105363_bb0075","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.neuron.2015.02.028","article-title":"Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch","volume":"85","author":"Foster","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2021.105363_bb0080","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/j.1532-2149.2013.00294.x","article-title":"Properties of spinal lamina III GABAergic neurons in naive and in neuropathic mice","volume":"17","author":"Gassner","year":"2013","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.nbd.2021.105363_bb0085","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0006-8993(00)03022-5","article-title":"Antagonist of nicotinic acetylcholine receptors (nAChR) enhances formalin-induced nociception in rats: tonic role of nAChRs in the control of pain following injury","volume":"888","author":"Hama","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105363_bb0090","first-page":"75","article-title":"Cholinergic mechanisms in pain and analgesia","author":"Hartvig","year":"1989","journal-title":"Trends Pharmacol. Sci. Suppl."},{"key":"10.1016\/j.nbd.2021.105363_bb0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3940(02)00073-3","article-title":"Intrathecal alpha2 adrenoceptor agonist clonidine inhibits mechanical transmission in mouse spinal cord via activation of muscarinic M1 receptors","volume":"322","author":"Honda","year":"2002","journal-title":"Neurosci.Lett."},{"key":"10.1016\/j.nbd.2021.105363_bb0100","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/00000542-199902000-00025","article-title":"The antiallodynic effects of intrathecal cholinesterase inhibitors in a rat model of neuropathic pain","volume":"90","author":"Hwang","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nbd.2021.105363_bb0105","doi-asserted-by":"crossref","first-page":"37104","DOI":"10.1038\/srep37104","article-title":"Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain","volume":"6","author":"Imlach","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105363_bb0110","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1016\/j.celrep.2018.04.107","article-title":"NMDA receptor activation underlies the loss of spinal dorsal horn neurons and the transition to persistent pain after peripheral nerve injury","volume":"23","author":"Inquimbert","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2021.105363_bb0115","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/ejp.891","article-title":"Reductions in tonic GABAergic current in substantia gelatinosa neurons and GABAA receptor delta subunit expression after chronic constriction injury of the sciatic nerve in mice","volume":"20","author":"Iura","year":"2016","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.nbd.2021.105363_bb0120","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pain.2004.12.032","article-title":"Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition","volume":"114","author":"Julien","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2021.105363_bb0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/ALN.0b013e318277a81c","article-title":"Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and gamma-aminobutyric acid mechanisms","volume":"118","author":"Kimura","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nbd.2021.105363_bb0130","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1097\/00000542-199911000-00039","article-title":"Sex differences in cholinergic analgesia II: differing mechanisms in two models of allodynia","volume":"91","author":"Lavand\u2019homme","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nbd.2021.105363_bb0135","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/00000542-199808000-00027","article-title":"Intrathecal neostigmine, but not sympathectomy, relieves mechanical allodynia in a rat model of neuropathic pain","volume":"89","author":"Lavand\u2019homme","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nbd.2021.105363_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073370","article-title":"Impaired excitatory drive to spinal GABAergic neurons of neuropathic mice","volume":"8","author":"Leitner","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105363_bb0145","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1172\/JCI70026","article-title":"A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia","volume":"123","author":"Lu","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2021.105363_bb0150","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0091-3057(94)00372-P","article-title":"A study of the N-methyl-D-aspartate antagonistic properties of anticholinergic drugs","volume":"51","author":"McDonough","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nbd.2021.105363_bb0155","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1097\/j.pain.0000000000000538","article-title":"Loss of inhibitory tone on spinal cord dorsal horn spontaneously and nonspontaneously active neurons in a mouse model of neuropathic pain","volume":"157","author":"Medrano","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2021.105363_bb0160","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1002\/cne.22668","article-title":"Morphological and functional characterization of cholinergic interneurons of the dorsal horn of the mouse spinal cord","volume":"519","author":"Mesnage","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2021.105363_bb0165","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1073\/pnas.0611134104","article-title":"Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion","volume":"104","author":"Miles","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105363_bb0170","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/sj.bjp.0704599","article-title":"Neostigmine interactions with non steroidal anti-inflammatory drugs","volume":"135","author":"Miranda","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2021.105363_bb0175","doi-asserted-by":"crossref","first-page":"6724","DOI":"10.1523\/JNEUROSCI.22-15-06724.2002","article-title":"Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord","volume":"22","author":"Moore","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105363_bb0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0304-3959(95)00077-1","article-title":"Fixed-diameter polyethylene cuffs applied to the rat sciatic nerve induce a painful neuropathy: ultrastructural morphometric analysis of axonal alterations","volume":"64","author":"Mosconi","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2021.105363_bb0185","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1471-4159.2007.04498.x","article-title":"Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures","volume":"102","author":"Moser","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105363_bb0190","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1097\/00000542-199406000-00022","article-title":"Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with mu and alpha 2 receptor systems","volume":"80","author":"Naguib","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nbd.2021.105363_bb0195","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1124\/mol.63.2.332","article-title":"Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors","volume":"63","author":"Nelson","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.nbd.2021.105363_bb0200","doi-asserted-by":"crossref","first-page":"23","DOI":"10.18637\/jss.v050.i12","article-title":"nparLD: an R software package for the nonparametric analysis of longitudinal data in factorial experiments","volume":"50","author":"Noguchi","year":"2012","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.nbd.2021.105363_bb0205","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0304-3940(88)90276-5","article-title":"Mecamylamine is a selective non-competitive antagonist of N-methyl-D-aspartate- and aspartate-induced currents in horizontal cells dissociated from the catfish retina","volume":"94","author":"O\u2019Dell","year":"1988","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2021.105363_bb0210","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s00221-002-1142-5","article-title":"Myelinated and unmyelinated primary afferent axons form contacts with cholinergic interneurons in the spinal dorsal horn","volume":"145","author":"Olave","year":"2002","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nbd.2021.105363_bb0215","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0022-3565(24)29581-1","article-title":"Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes","volume":"297","author":"Papke","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2021.105363_bb0220","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00000542-200307000-00030","article-title":"Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury","volume":"99","author":"Paqueron","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nbd.2021.105363_bb0225","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1523\/JNEUROSCI.3954-12.2013","article-title":"A novel population of cholinergic neurons in the macaque spinal dorsal horn of potential clinical relevance for pain therapy","volume":"33","author":"Pawlowski","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105363_bb0230","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.neuron.2015.07.029","article-title":"Dorsal horn circuits for persistent mechanical pain","volume":"87","author":"Peirs","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2021.105363_bb0235","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.celrep.2015.09.080","article-title":"Dorsal horn parvalbumin neurons are gate-keepers of touch-evoked pain after nerve injury","volume":"13","author":"Petitjean","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2021.105363_bb0240","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/374065a0","article-title":"Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain","volume":"374","author":"Picciotto","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105363_bb0245","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pain.2004.06.011","article-title":"Lack of evidence for significant neuronal loss in laminae I-III of the spinal dorsal horn of the rat in the chronic constriction injury model","volume":"111","author":"Polgar","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2021.105363_bb0250","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1113\/jphysiol.2001.013437","article-title":"Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat","volume":"539","author":"Prescott","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2021.105363_bb0255","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0006-8993(02)03270-5","article-title":"Neuropathy-specific analgesic action of intrathecal nicotinic agonists and its spinal GABA-mediated mechanism","volume":"953","author":"Rashid","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105363_bb0260","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pain.2006.05.011","article-title":"Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice","volume":"125","author":"Rashid","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2021.105363_bb0265","series-title":"The Rat Nervous System","first-page":"129","article-title":"Substantia gelatinosa of the spinal cord","author":"Ribeiro-da-Silva","year":"2004"},{"key":"10.1016\/j.nbd.2021.105363_bb0270","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1046\/j.1460-9568.1998.00246.x","article-title":"A population of cholinergic neurons is present in the macaque monkey thalamus","volume":"10","author":"Rico","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105363_bb0275","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2021.105363_bb0280","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1113\/jphysiol.2006.118034","article-title":"Physiological properties of spinal lamina II GABAergic neurons in mice following peripheral nerve injury","volume":"577","author":"Schoffnegger","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2021.105363_bb0285","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1523\/JNEUROSCI.1526-05.2005","article-title":"Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury","volume":"25","author":"Scholz","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105363_bb0290","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/sj.bjp.0706731","article-title":"Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury","volume":"148","author":"Takasu","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2021.105363_bb0295","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/jnc.14001","article-title":"Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex","volume":"141","author":"Tsuda","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105363_bb0300","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.1523\/JNEUROSCI.4647-06.2007","article-title":"Functional characterization of intrinsic cholinergic interneurons in the cortex","volume":"27","author":"von Engelhardt","year":"2007","journal-title":"J.Neurosci."},{"key":"10.1016\/j.nbd.2021.105363_bb0305","series-title":"The Spinal Cord","first-page":"308","article-title":"Atlas of the mouse spinal cord","author":"Watson","year":"2009"},{"key":"10.1016\/j.nbd.2021.105363_bb0310","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009986","article-title":"The nicotinic alpha6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2\/3 receptors","volume":"7","author":"Wieskopf","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2021.105363_bb0315","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.expneurol.2009.10.008","article-title":"Chronic treatment with agonists of beta(2)-adrenergic receptors in neuropathic pain","volume":"221","author":"Yalcin","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105363_bb0320","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.biopsych.2011.07.017","article-title":"A time-dependent history of mood disorders in a murine model of neuropathic pain","volume":"70","author":"Yalcin","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2021.105363_bb0325","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.pain.2011.05.022","article-title":"Nociceptive thresholds are controlled through spinal beta(2)-subunit-containing nicotinic acetylcholine receptors","volume":"152","author":"Yalcin","year":"2011","journal-title":"Pain"},{"issue":"89","key":"10.1016\/j.nbd.2021.105363_bb0330","first-page":"51608","article-title":"The sciatic nerve cuffing model of neuropathic pain in mice","author":"Yalcin","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.nbd.2021.105363_bb0335","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.0953-816X.2004.03121.x","article-title":"Peripheral nerve injury induces trans-synaptic modification of channels, receptors and signal pathways in rat dorsal spinal cord","volume":"19","author":"Yang","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105363_bb0340","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/ACO.0b013e32833c348b","article-title":"Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states","volume":"23","author":"Yarnitsky","year":"2010","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"10.1016\/j.nbd.2021.105363_bb0345","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.brainres.2008.06.086","article-title":"Spinal alpha3beta2* nicotinic acetylcholine receptors tonically inhibit the transmission of nociceptive mechanical stimuli","volume":"1229","author":"Young","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105363_bb0350","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0304-3959(91)90078-C","article-title":"Tonic cholinergic inhibition of spinal mechanical transmission","volume":"46","author":"Zhuo","year":"1991","journal-title":"Pain"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121001121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121001121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:35:01Z","timestamp":1777602901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996121001121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":70,"alternative-id":["S0969996121001121"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105363","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105363","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105363"}}