{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:35:33Z","timestamp":1782124533153,"version":"3.54.5"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.nbd.2021.105373","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T13:28:42Z","timestamp":1619616522000},"page":"105373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats"],"prefix":"10.1016","volume":"155","author":[{"given":"Ilona","family":"Har-Paz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elor","family":"Arieli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anan","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2021.105373_bb0005","first-page":"219","article-title":"Clinical benefits of Tramiprosate in Alzheimer\u2019s disease are associated with higher number of APOE4 alleles: the \u201c APOE4 gene- dose effect \u201d","volume":"33","author":"Abushakra","year":"2016","journal-title":"J Prev Alz Dis"},{"key":"10.1016\/j.nbd.2021.105373_bb0010","doi-asserted-by":"crossref","first-page":"13707","DOI":"10.1523\/JNEUROSCI.4040-10.2010","article-title":"Apolipoprotein E4 causes age- and tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice","volume":"30","author":"Andrews-Zwilling","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0015","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1113\/JP280213","article-title":"Temporally-precise basolateral amygdala activation is required for the formation of taste memories in gustatory cortex","volume":"598","author":"Arieli","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2021.105373_bb0020","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1037\/0735-7044.119.4.983","article-title":"Temporal and qualitative dynamics of conditioned taste aversion processing: combined generalization testing and licking microstructure analysis","volume":"119","author":"Baird","year":"2005","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0025","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0197-4580(03)00006-X","article-title":"Apolipoprotein E epsilon 4 affects new learning in cognitively normal individuals at risk for Alzheimer\u2019s disease","volume":"24","author":"Baxter","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2021.105373_bb0030","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/aje\/kwt135","article-title":"Is obesity associated with a decline in intelligence quotient during the first half of the life course?","volume":"178","author":"Belsky","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.nbd.2021.105373_bb0035","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJM200008173430701","article-title":"Patterns of brain activation in people at risk for Alzheimer\u2019s disease","volume":"343","author":"Bookheimer","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2021.105373_bb0040","doi-asserted-by":"crossref","first-page":"12011","DOI":"10.1073\/pnas.0914984107","article-title":"ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105373_bb0045","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbr.2016.03.038","article-title":"Differential involvement of glutamatergic and catecholaminergic activity within the amygdala during taste aversion retrieval on memory expression and updating","volume":"307","author":"Daniel","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2021.105373_bb0050","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.2174\/1567205013666160401115127","article-title":"Alzheimer\u2019s disease genetic risk factor APOE-\u03b54 also affects Normal brain function","volume":"13","author":"Di Battista","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.nbd.2021.105373_bb0055","doi-asserted-by":"crossref","first-page":"15317","DOI":"10.1523\/JNEUROSCI.4026-09.2009","article-title":"ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo","volume":"29","author":"Dumanis","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0060","article-title":"The role of apoE4 in disrupting the homeostatic functions of astrocytes and microglia in aging and Alzheimer\u2019s disease","volume":"10","author":"Fernandez","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0065","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1073\/pnas.0811879106","article-title":"Distinct patterns of brain activity in young carriers of the APOE-\u03b54 allele","volume":"106","author":"Filippini","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105373_bb0070","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1523\/JNEUROSCI.4063-07.2008","article-title":"Learning-related plasticity of temporal coding in simultaneously recorded amygdala-cortical ensembles","volume":"28","author":"Grossman","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0075","first-page":"1","article-title":"Extra-hippocampal learning deficits in young Apolipoprotein E4 mice and their synaptic underpinning","author":"Har-Paz","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2021.105373_bb0080","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1042\/BST0390924","article-title":"Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer\u2019s disease: lessons from ApoE mouse models","volume":"39","author":"Huang","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.nbd.2021.105373_bb0085","doi-asserted-by":"crossref","first-page":"18772","DOI":"10.1073\/pnas.0705546104","article-title":"Natural stimuli evoke dynamic sequences of states in sensory cortical ensembles","volume":"104","author":"Jones","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105373_bb0090","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1523\/JNEUROSCI.21-12-04478.2001","article-title":"Dynamic and multimodal responses of gustatory cortical neurons in awake rats","volume":"21","author":"Katz","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00275","article-title":"An algorithm for preclinical diagnosis of Alzheimer\u2019s disease","volume":"12","author":"Khan","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0100","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3233\/JAD-170556","article-title":"The impact of APOE \u03f54 in Alzheimer\u2019s disease differs according to age","volume":"61","author":"Kim","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2021.105373_bb0105","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.neurobiolaging.2014.02.019","article-title":"Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice","volume":"35","author":"Klein","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2021.105373_bb0110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tem.2016.12.001","article-title":"ApoE, ApoE receptors, and the synapse in Alzheimer\u2019s disease","volume":"28","author":"Lane-Donovan","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.nbd.2021.105373_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053569","article-title":"Apolipoprotein E4 causes age- and sex-dependent impairments of Hilar GABAergic interneurons and learning and memory deficits in mice","volume":"7","author":"Leung","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105373_bb0120","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.physbeh.2012.03.029","article-title":"Taste neophobia and palatability: the pleasure of drinking","volume":"106","author":"Lin","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.nbd.2021.105373_bb0125","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1750-1326-8-16","article-title":"ApoE4 induces Abeta42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice","volume":"8","author":"Liraz","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2021.105373_bib292","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF02477711","article-title":"The limiting information capacity of a neuronal link","volume":"14","author":"MacKay","year":"1952","journal-title":"Bull. Math. Biophys."},{"key":"10.1016\/j.nbd.2021.105373_bb0130","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/jcbfm.2010.99","article-title":"Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice","volume":"31","author":"Mannix","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2021.105373_bb0135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroimage.2013.11.042","article-title":"Differential effects of the ApoE4 genotype on brain structure and function","volume":"89","author":"Matura","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2021.105373_bb0140","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jalz.2014.06.015","article-title":"APOE \u03b54: the most prevalent yet understudied risk factor for Alzheimer\u2019s disease","volume":"10","author":"Michaelson","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2021.105373_bb0145","doi-asserted-by":"crossref","first-page":"11417","DOI":"10.1073\/pnas.182200499","article-title":"Glutamatergic activity in the amygdala signals visceral input during taste memory formation","volume":"99","author":"Miranda","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105373_bb0150","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuron.2007.06.018","article-title":"Differential attention-dependent response modulation across cell classes in macaque visual area V4","volume":"55","author":"Mitchell","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2021.105373_bb0155","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1523\/JNEUROSCI.3331-13.2014","article-title":"Sensory cortical population dynamics uniquely track behavior across learning and extinction","volume":"34","author":"Moran","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0165","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-019-0324-6","article-title":"Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer\u2019s disease","volume":"14","author":"Najm","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2021.105373_bb0170","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1037\/a0019505","article-title":"Increased liking for a solution is not necessary for the attenuation of neophobia in rats","volume":"124","author":"Neath","year":"2010","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01444-0","article-title":"Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer\u2019s disease-like pathology","volume":"8","author":"Nuriel","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105373_bb0180","article-title":"Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study","volume":"7","author":"O\u2019Dwyer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105373_bb0185","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3758\/BF03211020","article-title":"A rapid method for permanent implantation of an intraoral fistula in rats","volume":"2","author":"Phillips","year":"1970","journal-title":"Behav. Res. Methods Instrum."},{"key":"10.1016\/j.nbd.2021.105373_bb0190","doi-asserted-by":"crossref","first-page":"9981","DOI":"10.1523\/JNEUROSCI.0669-12.2012","article-title":"Inactivation of Basolateral amygdala specifically eliminates palatability-related information in cortical sensory responses","volume":"32","author":"Piette","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bib291","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nn.4268","article-title":"Spike sorting for large, dense electrode arrays","volume":"19","author":"Rossant","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0195","doi-asserted-by":"crossref","first-page":"9999","DOI":"10.1523\/JNEUROSCI.6059-11.2012","article-title":"Sodium concentration coding gives way to evaluative coding in cortex and amygdala","volume":"32","author":"Sadacca","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0200","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.neuron.2012.02.031","article-title":"Effects of Cue-triggered expectation on cortical processing of taste","volume":"74","author":"Samuelsen","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2021.105373_bb0205","doi-asserted-by":"crossref","first-page":"172932","DOI":"10.1016\/j.pbb.2020.172932","article-title":"Administration of low doses of the 5-HT1A receptor agonist 8-OH-DPAT attenuates the discriminative signal of amphetamine in the conditioned taste aversion procedure","author":"Sandoval-S\u00e1nchez","year":"2020","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.nbd.2021.105373_bb0210","series-title":"Advances in Neural Information Processing Systems","article-title":"Information capacity and robustness of stochastic neuron models","author":"Schneidman","year":"2000"},{"key":"10.1016\/j.nbd.2021.105373_bb0225","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1385\/JMN:23:3:167","article-title":"ApoE-dependent plasticity in Alzheimer\u2019s disease","volume":"23","author":"Teter","year":"2004","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0230","doi-asserted-by":"crossref","first-page":"9506","DOI":"10.1523\/JNEUROSCI.0693-14.2014","article-title":"Inhibitory interneuron progenitor transplantation restores Normal learning and memory in ApoE4 Knock-in mice without or with a accumulation","volume":"34","author":"Tong","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0235","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1523\/JNEUROSCI.3815-15.2016","article-title":"Enhancing GABA signaling during middle adulthood prevents age-dependent GABAergic interneuron decline and learning and memory deficits in ApoE4 mice","volume":"36","author":"Tong","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0240","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.neuropsychologia.2007.11.035","article-title":"fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer\u2019s disease","volume":"46","author":"Trivedi","year":"2008","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.nbd.2021.105373_bb0245","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1097\/00001756-200412030-00020","article-title":"ApoE isoform affects LTP in human targeted replacement mice","volume":"15","author":"Trommer","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2021.105373_bb0250","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0006-8993(98)00884-1","article-title":"Role of glutamate in the amygdala and lateral hypothalamus in conditioned taste aversion","volume":"813","author":"Tucci","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105373_bb0255","doi-asserted-by":"crossref","first-page":"E1807","DOI":"10.1073\/pnas.1220484110","article-title":"ApoE influences amyloid-\u03b2 (A\u03b2) clearance despite minimal apoE\/a association in physiological conditions","volume":"110","author":"Verghese","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2021.105373_bb0260","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.nbd.2004.10.013","article-title":"Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology","volume":"18","author":"Wang","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105373_bb0265","doi-asserted-by":"crossref","first-page":"9708","DOI":"10.1523\/JNEUROSCI.22-22-09708.2002","article-title":"Limit on the role of activity in controlling the release-ready supply of synaptic vesicles","volume":"22","author":"Wesseling","year":"2002","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2021.105373_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(97)00636-2","article-title":"Short-term and long-term excitability changes of the insular cortical neurons after the acquisition of taste aversion learning in behaving rats","volume":"84","author":"Yasoshima","year":"1998","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2021.105373_bb0275","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3233\/JAD-2011-110479","article-title":"Deficits in spatial learning and memory is associated with hippocampal volume loss in aged apolipoprotein e4 mice","volume":"27","author":"Yin","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2021.105373_bb0280","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/cercor\/bhq126","article-title":"Functional properties of putative pyramidal neurons and inhibitory interneurons in the rat gustatory cortex","volume":"21","author":"Yokota","year":"2011","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2021.105373_bb0285","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2019.00074","article-title":"Identifying changepoints in biomarkers during the preclinical phase of Alzheimer\u2019s disease","volume":"11","author":"Younes","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2021.105373_bb0290","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.biopsych.2017.03.003","article-title":"Apolipoprotein E, receptors, and modulation of Alzheimer\u2019s disease","volume":"83","author":"Zhao","year":"2018","journal-title":"Biol. Psychiatry"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121001224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121001224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:26:46Z","timestamp":1760851606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996121001224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":57,"alternative-id":["S0969996121001224"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105373","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.01.14.426651","asserted-by":"object"}]},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105373","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105373"}}