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Biotechnol."},{"key":"10.1016\/j.nbd.2021.105403_bb0365","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/S0735-1097(16)31933-7","article-title":"A phase 1 randomized, double-blind, placebo-controlled, multiple ascending dose study to evaluate safety, tolerability and pharmacokinetics of the liver-selective TR-BETA agonist VK2809 (MB07811) in hypercholesterolemic subjects","volume":"67","author":"Lian","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.nbd.2021.105403_bb0370","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1471-4159.2009.06364.x","article-title":"Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons","volume":"111","author":"Lin","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105403_bb0375","article-title":"Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105403_bb0380","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.1016\/S0021-9258(18)53289-0","article-title":"Protein-DNA interactions at a dioxin-responsive enhancer Analysis of six bona fide DNA-binding sites for the liganded Ah receptor","volume":"268","author":"Lusska","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105403_bb0385","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cbi.2018.04.020","article-title":"6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression","volume":"288","author":"Ma","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.nbd.2021.105403_bb0390","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.phrs.2017.12.009","article-title":"Alzheimer\u2019s disease and gut microbiota modifications: the long way between preclinical studies and clinical evidence","volume":"129","author":"Mancuso","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.nbd.2021.105403_bb0395","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1091\/mbc.e09-08-0689","article-title":"Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)\u03b1 protein degradation in breast cancer cells disrupting an ER\u03b1GATA3 transcriptional cross-regulatory loop","volume":"21","author":"Marconett","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.nbd.2021.105403_bb0400","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3233\/JAD-171145","article-title":"Alzheimer\u2019s disease: a journey from amyloid peptides and oxidative stress, to biomarker technologies and disease prevention strategies-gains from AIBL and DIAN cohort studies","volume":"62","author":"Martins","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2021.105403_bb0405","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.1471-4159.2003.01654.x","article-title":"Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer\u2019s disease","volume":"85","author":"Matsubara","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105403_bb0410","first-page":"926","article-title":"Gut\/brain axis and the microbiota","volume":"125","author":"Mayer","year":"2015","journal-title":"Review Series: Enteric Nervous System"},{"key":"10.1016\/j.nbd.2021.105403_bb0415","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2005.05.007","article-title":"An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system","volume":"122","author":"Mazmanian","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105403_bb0420","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1080\/19490976.2019.1586038","article-title":"Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity","volume":"10","author":"Menni","year":"2019","journal-title":"Gut Microbes"},{"key":"10.1016\/j.nbd.2021.105403_bb0425","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1128\/MCB.18.2.978","article-title":"Hepatitis B virus X-associated protein 2 is a subunit of the Unliganded aryl hydrocarbon receptor Core complex and exhibits transcriptional enhancer activity","volume":"18","author":"Meyer","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2021.105403_bb0430","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.nbd.2021.105403_bb0435","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0304-4165(97)00039-1","article-title":"Comparative studies of enhanced iron-mediated production of hydroxyl radical by glutathione, cysteine, ascorbic acid, and selected catechols","volume":"1336","author":"Nappi","year":"1997","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.nbd.2021.105403_bb0440","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/18715273113126660147","article-title":"Role of gut microbiota in obesity, type 2 diabetes and Alzheimer\u2019s disease","volume":"13","author":"Naseer","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.nbd.2021.105403_bb0445","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1523\/JNEUROSCI.19-06-01959.1999","article-title":"RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer\u2019s disease","volume":"19","author":"Nunomura","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105403_bb0450","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/jnen\/59.11.1011","article-title":"Neuronal oxidative stress precedes amyloid-\u03b2 deposition in down syndrome","volume":"59","author":"Nunomura","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105403_bb0455","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/00005072-199605000-00127","article-title":"Imunohistochemical evidence of oxidative stress in Parkinson\u2019s disease","volume":"55","author":"Omar","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105403_bb0460","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13024-015-0027-6","article-title":"Prophylactic melatonin significantly reduces Alzheimer\u2019s neuropathology and associated cognitive deficits independent of antioxidant pathways in A\u03b2PP(swe)\/PS1 mice","volume":"10","author":"O\u2019Neal-Moffitt","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2021.105403_bb0465","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0050177","article-title":"Development of the human infant intestinal microbiota","volume":"5","author":"Palmer","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2021.105403_bb0470","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/00019442-200508000-00002","article-title":"Current epidemiology of mild cognitive impairment and other predementia syndromes","volume":"13","author":"Panza","year":"2005","journal-title":"Am. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.nbd.2021.105403_bb0475","article-title":"mTOR as a central regulator of lifespan and aging. F1000Research 8","author":"Papadopoli","year":"2019","journal-title":"F1000 Faculty Rev. 1998"},{"key":"10.1016\/j.nbd.2021.105403_bb0480","first-page":"621","article-title":"Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer\u2019s disease","volume":"140","author":"Pappolla","year":"1992","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2021.105403_bb0485","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1523\/JNEUROSCI.17-05-01683.1997","article-title":"Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide","volume":"17","author":"Pappolla","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105403_bb0490","doi-asserted-by":"crossref","first-page":"7185","DOI":"10.1074\/jbc.273.13.7185","article-title":"Inhibition of Alzheimer \u03b2-fibrillogenesis by melatonin","volume":"273","author":"Pappolla","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105403_bb0495","first-page":"871","article-title":"Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer\u2019s disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo","volume":"152","author":"Pappolla","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2021.105403_bb0500","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0891-5849(02)00841-9","article-title":"Cholesterol, oxidative stress, and Alzheimer\u2019s disease: expanding the horizons of pathogenesis","volume":"33","author":"Pappolla","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2021.105403_bb0505","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2174\/1567205015666180411092551","article-title":"Melatonin treatment enhances A\u03b2 lymphatic clearance in a transgenic mouse model of amyloidosis","volume":"15","author":"Pappolla","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.nbd.2021.105403_bb0510","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2015.00085","article-title":"Interleukin-22 signaling in the regulation of intestinal health and disease","volume":"3","author":"Parks","year":"2016","journal-title":"Front. Cell Developmental Biol."},{"key":"10.1016\/j.nbd.2021.105403_bb0515","doi-asserted-by":"crossref","first-page":"13802","DOI":"10.1016\/S0021-9258(18)68314-0","article-title":"Association of the Ah receptor with the 90-kDa heat shock protein","volume":"263","author":"Perdew","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105403_bb0520","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1001\/archneurol.2009.266","article-title":"Mild cognitive impairment: ten years later","volume":"66","author":"Petersen","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2021.105403_bb0525","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/joim.12190","article-title":"Mild cognitive impairment: a concept in evolution","volume":"275","author":"Petersen","year":"2014","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.nbd.2021.105403_bb0530","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0009-2797(02)00064-9","article-title":"The role of chaperone proteins in the aryl hydrocarbon receptor core complex","volume":"141","author":"Petrulis","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.nbd.2021.105403_bb0535","doi-asserted-by":"crossref","first-page":"14995","DOI":"10.1021\/bi0114269","article-title":"Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide","volume":"40","author":"Poeggeler","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.nbd.2021.105403_bb0540","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010206","article-title":"A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan","volume":"5","author":"Poeggeler","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2021.105403_bb0545","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1016\/S0021-9258(17)33205-2","article-title":"Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase","volume":"251","author":"Poland","year":"1976","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105403_bb0550","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.semcancer.2017.06.002","article-title":"Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K\/Akt\/mTOR signalling pathway and the aryl hydrocarbon receptor","volume":"46","author":"Popolo","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.nbd.2021.105403_bb0555","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature06880","article-title":"Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor","volume":"453","author":"Quintana","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105403_bb0560","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/10408444.2018.1493086","article-title":"The tryptophan derivative 6-formylindolo[3,2- <i>b<\/i> ]carbazole, FICZ, a dynamic mediator of endogenous aryl hydrocarbon receptor signaling, balances cell growth and differentiation","volume":"48","author":"Rannug","year":"2018","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.nbd.2021.105403_bb0565","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuron.2018.05.023","article-title":"Multiscale analysis of independent Alzheimer's cohorts finds disruption of molecular, genetic, and clinical networks by Human Herpesvirus","volume":"99","author":"Readhead","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2021.105403_bb0570","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1158\/1055-9965.EPI-06-0396","article-title":"Single-dose and multiple-dose administration of indole-3-carbinol to women: Pharmacokinetics based on 3,3\u2032-diindolylmethane","volume":"15","author":"Reed","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.nbd.2021.105403_bb0575","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ddr.430150203","article-title":"Stage-specific behavioral, cognitive, and in vivo changes in community residing subjects with age-associated memory impairment and primary degenerative dementia of the Alzheimer type","volume":"15","author":"Reisberg","year":"1988","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.nbd.2021.105403_bb0580","article-title":"Determination of indole-type phytonutrients in cruciferous vegetables","author":"Revelou","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.nbd.2021.105403_bb0585","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1126\/science.256.5060.1193","article-title":"Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor","volume":"256","author":"Reyes","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105403_bb0590","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","article-title":"Microbial tryptophan catabolites in health and disease","volume":"9","author":"Roager","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105403_bb0595","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-079X.2011.00937.x","article-title":"Alzheimer\u2019s disease: pathological mechanisms and the beneficial role of melatonin","volume":"52","author":"Rosales-Corral","year":"2012","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.nbd.2021.105403_bb0600","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s40495-014-0003-9","article-title":"The epigenetic impact of cruciferous vegetables on Cancer prevention","volume":"1","author":"Royston","year":"2015","journal-title":"Curr. Pharmacol. Rep."},{"key":"10.1016\/j.nbd.2021.105403_bb0605","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1007\/s12035-015-9471-0","article-title":"Selective Aryl Hydrocarbon receptor modulator 3, 3 \u2032 -Diindolylmethane impairs AhR and ARNT signaling and protects mouse neuronal cells against Hypoxia","volume":"53","author":"Rzemieniec","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2021.105403_bb0610","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10495-019-01522-2","article-title":"The neuroprotective action of 3,3\u2032-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR\/CYP1A1 but not ER\u03b1\/CYP19A1 signaling","volume":"24","author":"Rzemieniec","year":"2019","journal-title":"Apoptosis"},{"key":"10.1016\/j.nbd.2021.105403_bb0615","doi-asserted-by":"crossref","first-page":"33","DOI":"10.21775\/cimb.036.033","article-title":"Microbiome: Effects of ageing and diet","volume":"36","author":"Salazar","year":"2020","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.nbd.2021.105403_bb0620","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson\u2019s disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105403_bb0625","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/art.38892","article-title":"Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease","volume":"67","author":"Scher","year":"2015","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.nbd.2021.105403_bb0630","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature21080","article-title":"Feedback control of AHR signalling regulates intestinal immunity","volume":"542","author":"Schiering","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105403_bb0635","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1021\/bi901786x","article-title":"The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor","volume":"49","author":"Schroeder","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.nbd.2021.105403_bb0640","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2021.105403_bb0645","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.lfs.2012.01.013","article-title":"Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-\u03baB, p53, ERK, and JNK in proximal tubular cells","volume":"90","author":"Shimizu","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.nbd.2021.105403_bb0650","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1046\/j.1471-4159.1998.70052212.x","article-title":"Amyloid-\u03b2 deposition in Alzheimer transgenic mice is associated with oxidative stress","volume":"70","author":"Smith","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105403_bb0655","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF02736852","article-title":"Melatonin alters the metabolism of the beta-amyloid precursor protein in the neuroendocrine cell line PC12","volume":"9","author":"Song","year":"1997","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2021.105403_bb0660","doi-asserted-by":"crossref","first-page":"14694","DOI":"10.1073\/pnas.232562899","article-title":"A ligand for the aryl hydrocarbon receptor isolated from lung","volume":"99","author":"Song","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105403_bb0665","doi-asserted-by":"crossref","first-page":"E7506","DOI":"10.1073\/pnas.1706464114","article-title":"Indoles from commensal bacteria extend healthspan","volume":"114","author":"Sonowal","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105403_bb0670","doi-asserted-by":"crossref","first-page":"35275","DOI":"10.1074\/jbc.M111.246439","article-title":"Ligand displaces heat shock protein 90 from overlapping binding sites within the aryl hydrocarbon receptor ligandbinding domain","volume":"286","author":"Soshilov","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105403_bb0675","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.bmcl.2017.02.001","article-title":"Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of \u03b2-amyloid-42 aggregation for the treatment of Alzheimer's disease","volume":"27","author":"Sreenivasachary","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.nbd.2021.105403_bb0680","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.ne.19.030196.000413","article-title":"Apolipoprotein E and Alzheimer\u2019s disease","volume":"19","author":"Strittmatter","year":"1996","journal-title":"Annu. Rev. 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