{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:57:31Z","timestamp":1787497051638,"version":"build-2736575974"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.nbd.2021.105468","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T03:09:18Z","timestamp":1628046558000},"page":"105468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["CXCL1-CXCR1\/2 signaling is induced in human temporal lobe epilepsy and contributes to seizures in a murine model of acquired epilepsy"],"prefix":"10.1016","volume":"158","author":[{"given":"Rossella","family":"Di Sapia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till S.","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Kebede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Balosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ravizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Sorrentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Alejandro Montano","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Porcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Cattani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ruocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Aronica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Allegretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Brandolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Vezzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2021.105468_bb0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/bpa.12661","article-title":"Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence","volume":"29","author":"Arena","year":"2019","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2021.105468_bb0010","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/33340","article-title":"Chemokines and leukocyte traffic","volume":"392","author":"Baggiolini","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105468_bb0015","doi-asserted-by":"crossref","first-page":"834","DOI":"10.3389\/fneur.2018.00834","article-title":"Detection of HHV-6 and EBV and cytokine levels in saliva from children with seizures: results of a multi-center Cross-sectional study","volume":"9","author":"Bartolini","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2021.105468_bb0020","doi-asserted-by":"crossref","first-page":"11791","DOI":"10.1073\/pnas.0402090101","article-title":"Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury","volume":"101","author":"Bertini","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105468_bb0025","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/epi.12220","article-title":"International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a task force report from the ILAE commission on diagnostic methods","volume":"54","author":"Blumcke","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105468_bb0030","doi-asserted-by":"crossref","first-page":"43375","DOI":"10.18632\/oncotarget.6234","article-title":"Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling","volume":"6","author":"Brandolini","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.nbd.2021.105468_bb0035","doi-asserted-by":"crossref","first-page":"23188","DOI":"10.18632\/oncotarget.15533","article-title":"CXCR1\/2 pathways in paclitaxel-induced neuropathic pain","volume":"8","author":"Brandolini","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.nbd.2021.105468_bb0040","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.expneurol.2014.05.014","article-title":"Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2","volume":"261","author":"Cao","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105468_bb0045","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/039463200501800307","article-title":"Neutrophil recruitment in the reperfused-injured rat liver was effectively attenuated by repertaxin, a novel allosteric noncompetitive inhibitor of CXCL8 receptors: a therapeutic approach for the treatment of post-ischemic hepatic syndromes","volume":"18","author":"Cavalieri","year":"2005","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.nbd.2021.105468_bb0050","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1523\/JNEUROSCI.0451-15.2016","article-title":"The chemokine CCL2 mediates the seizure-enhancing effects of systemic inflammation","volume":"36","author":"Cerri","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105468_bb0055","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.eplepsyres.2017.07.016","article-title":"Chemokines as new inflammatory players in the pathogenesis of epilepsy","volume":"136","author":"Cerri","year":"2017","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2021.105468_bb0060","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1742-2094-6-38","article-title":"Cellular injury and neuroinflammation in children with chronic intractable epilepsy","volume":"6","author":"Choi","year":"2009","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2021.105468_bb0065","doi-asserted-by":"crossref","first-page":"a022434","DOI":"10.1101\/cshperspect.a022434","article-title":"Role of astrocytes in epilepsy","volume":"5","author":"Coulter","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.nbd.2021.105468_bb0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1744-8069-8-11","article-title":"Elevated interleukin-8 enhances prefrontal synaptic transmission in mice with persistent inflammatory pain","volume":"8","author":"Cui","year":"2012","journal-title":"Mol. Pain"},{"key":"10.1016\/j.nbd.2021.105468_bb0075","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jneuroim.2009.06.008","article-title":"Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy","volume":"214","author":"De Herdt","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2021.105468_bb0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neubiorev.2016.02.007","article-title":"Inflammatory mediators in human epilepsy: a systematic review and meta-analysis","volume":"63","author":"de Vries","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nbd.2021.105468_bb0085","doi-asserted-by":"crossref","unstructured":"Deftu, A.F., Filippi, A., Gheorghe, R.O., Ristoiu, V., 2018. CXCL1 activates TRPV1 via Gi\/o protein and actin filaments. Life Sci. 193, 282\u2013291.","DOI":"10.1016\/j.lfs.2017.09.041"},{"key":"10.1016\/j.nbd.2021.105468_bb0090","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tins.2012.11.008","article-title":"Glia and epilepsy: excitability and inflammation","volume":"36","author":"Devinsky","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2021.105468_bb0095","doi-asserted-by":"crossref","DOI":"10.1111\/epi.16956","article-title":"Microglia proliferation plays distinct roles in acquired epilepsy depending on disease stages","author":"Di Nunzio","year":"2021","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2021.105468_bb0105","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"2008"},{"key":"10.1016\/j.nbd.2021.105468_bb0110","doi-asserted-by":"crossref","unstructured":"Frigerio, F., Flynn, C., Han, Y., Lyman, K., Lugo, J.N., Ravizza, T., Ghestem, A., Pitsch, J., Becker, A., Anderson, A.E., Vezzani, A., Chetkovich, D., Bernard, C., 2018a. Neuroinflammation alters integrative properties of rat hippocampal pyramidal cells. Mol. Neurobiol. 55, 7500\u20137511.","DOI":"10.1007\/s12035-018-0915-1"},{"key":"10.1016\/j.nbd.2021.105468_bb0115","first-page":"3130","article-title":"N-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis","volume":"141","author":"Frigerio","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2021.105468_bb0120","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/epi.13750","article-title":"Plasma cytokines associated with febrile status epilepticus in children: a potential biomarker for acute hippocampal injury","volume":"58","author":"Gallentine","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105468_bb0125","doi-asserted-by":"crossref","unstructured":"Garau, A., Bertini, R., Colotta, F., Casilli, F., Bigini, P., Cagnotto, A., Mennini, T., Ghezzi, P., Villa, P. 2005. Neuroprotection with the CXCL8 inhibitor repertaxin in transient brain ischemia. Cytokine 30, 125\u201331.","DOI":"10.1016\/j.cyto.2004.12.014"},{"key":"10.1016\/j.nbd.2021.105468_bb0130","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13058-019-1243-8","article-title":"A window-of-opportunity trial of the CXCR1\/2 inhibitor reparixin in operable HER-2-negative breast cancer","volume":"22","author":"Goldstein","year":"2020","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.nbd.2021.105468_bb0135","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3390\/biom10030464","article-title":"Ionotropic glutamate receptors in epilepsy: a review focusing on AMPA and NMDA receptors","volume":"10","author":"Hanada","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.nbd.2021.105468_bb0140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.expneurol.2016.05.003","article-title":"Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy","volume":"283","author":"Hubbard","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105468_bb0145","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/ilar.46.2.148","article-title":"Environmental enrichment for laboratory rodents","volume":"46","author":"Hutchinson","year":"2005","journal-title":"ILAR J."},{"key":"10.1016\/j.nbd.2021.105468_bb0150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nbd.2016.12.007","article-title":"Blockade of the IL-1R1\/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy","volume":"99","author":"Iori","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105468_bb0155","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/ajt.14116","article-title":"A novel xenogeneic graft-versus-host disease model for investigating the pathological role of human CD4(+) or CD8(+) T cells using Immunodeficient NOG mice","volume":"17","author":"Ito","year":"2017","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.nbd.2021.105468_bb0160","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/ana.24806","article-title":"Febrile infection-related epilepsy syndrome treated with anakinra","volume":"80","author":"Kenney-Jung","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2021.105468_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Perspective improving bioscience research reporting: The ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2021.105468_bb5555","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0165-5728(02)00178-9","article-title":"Chemokine receptor CXCR2 regulates the functional properties of AMPA-type glutamate receptor GluR1 in HEK cells","volume":"129","author":"Lax","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2021.105468_bb0170","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20180992","article-title":"Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1\/CXCR2-mediated reactive astrogliosis","volume":"217","author":"Liu","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2021.105468_bb0175","doi-asserted-by":"crossref","unstructured":"Louboutin, J.-P., Chekmasova, A., Marusich, E., Agrawal, L., Strayer, D.S., 2011. Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage. FASEB J. 25, 737\u2013753.","DOI":"10.1096\/fj.10-161851"},{"key":"10.1016\/j.nbd.2021.105468_bb6655","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3390\/ijms21020591","article-title":"Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?","volume":"21","author":"L\u00f6scher","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2021.105468_bb0180","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2337\/dc19-1480","article-title":"Targeting CXCR1\/2 does not improve insulin secretion after pancreatic islet transplantation: a phase 3, double-blind, randomized, placebo-controlled trial in type 1 diabetes","volume":"43","author":"Maffi","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nbd.2021.105468_bb0185","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1093\/brain\/awy276","article-title":"Microglial phenotypes in the human epileptic temporal lobe","volume":"141","author":"Morin-Brureau","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2021.105468_bb0190","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainres.2008.03.061","article-title":"Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice","volume":"1213","author":"Mouri","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105468_bb0195","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/cei.12488","article-title":"A pilot study on reparixin, a CXCR1\/2 antagonist, to assess safety and efficacy in attenuating ischaemia-reperfusion injury and inflammation after on-pump coronary artery bypass graft surgery","volume":"180","author":"Opfermann","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.nbd.2021.105468_bb0200","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.nbd.2016.05.001","article-title":"Cognitive deficits and brain myo-inositol are early biomarkers of epileptogenesis in a rat model of epilepsy","volume":"93","author":"Pascente","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105468_bb0205","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1523\/JNEUROSCI.2462-16.2016","article-title":"Targeting extracellular Cyclophilin a reduces Neuroinflammation and extends survival in a mouse model of amyotrophic lateral sclerosis","volume":"37","author":"Pasetto","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105468_bb0210","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.seizure.2013.04.023","article-title":"TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue","volume":"22","author":"Pernhorst","year":"2013","journal-title":"Seizure"},{"key":"10.1016\/j.nbd.2021.105468_bb0215","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/epi4.12239","article-title":"From clinical trials of antiepileptic drugs to treatment","volume":"3","author":"Perucca","year":"2018","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.nbd.2021.105468_bb0220","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fneur.2012.00181","article-title":"The TARC\/sICAM5 ratio in patient plasma is a candidate biomarker for drug resistant epilepsy","volume":"3","author":"Pollard","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2021.105468_bb0225","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/jnr.20612","article-title":"CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons","volume":"82","author":"Qin","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2021.105468_bb0230","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cyto.2016.08.032","article-title":"Immunohistochemical expression and localization of cytokines\/chemokines\/growth factors in gastric cancer","volume":"89","author":"Raja","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.nbd.2021.105468_bb0235","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ygeno.2019.01.017","article-title":"Peripheral blood gene expression signatures associated with epilepsy and its etiologic classification","volume":"112","author":"Rawat","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/j.nbd.2021.105468_bb0240","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/epi.12354","article-title":"Fractalkine\/CX3CL1 modulates GABAA currents in human temporal lobe epilepsy","volume":"54","author":"Roseti","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105468_bb0245","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1093\/brain\/awy242","article-title":"Evidence for peri-ictal blood-brain barrier dysfunction in patients with epilepsy","volume":"141","author":"R\u00fcber","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2021.105468_bb0250","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1136\/jnnp-2014-309388","article-title":"Intrathecal overproduction of proinflammatory cytokines and chemokines in febrile infection-related refractory status epilepticus","volume":"86","author":"Sakuma","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2021.105468_bb0255","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/sj.bjp.0705862","article-title":"Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury","volume":"143","author":"Souza","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2021.105468_bb0260","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12974-016-0727-z","article-title":"Brain region and epilepsy-associated differences in inflammatory mediator levels in medically refractory mesial temporal lobe epilepsy","volume":"13","author":"Strauss","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2021.105468_bb0265","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3390\/brainsci9120332","article-title":"Cannabis influences the putative cytokines-related pathway of epilepsy among Egyptian epileptic patients","volume":"9","author":"Taalab","year":"2019","journal-title":"Brain Sci"},{"key":"10.1016\/j.nbd.2021.105468_bb0270","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/epi.13950","article-title":"Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet","volume":"59","author":"Terrone","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105468_bb0275","doi-asserted-by":"crossref","first-page":"7878","DOI":"10.1523\/JNEUROSCI.0315-17.2017","article-title":"Chemokine CCL2-CCR2 signaling induces neuronal cell death via STAT3 activation and IL-1\u03b2 production after status Epilepticus","volume":"37","author":"Tian","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105468_bb0280","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/nan.12444","article-title":"Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies","volume":"44","author":"van Vliet","year":"2018","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.nbd.2021.105468_bb0285","doi-asserted-by":"crossref","first-page":"E5665","DOI":"10.1073\/pnas.1604263113","article-title":"Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus","volume":"113","author":"Varvel","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105468_bb0290","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1523\/JNEUROSCI.2040-20.2020","article-title":"Peripheral myeloid cell EP2 activation contributes to the deleterious consequences of status Epilepticus","volume":"41","author":"Varvel","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105468_bb0295","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuropharm.2014.10.027","article-title":"Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability","volume":"96","author":"Vezzani","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2021.105468_bb0300","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41582-019-0217-x","article-title":"Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy","volume":"15","author":"Vezzani","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2021.105468_bb0305","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1744-8069-4-38","article-title":"The chemokine CXCL1\/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons","volume":"4","author":"Wang","year":"2008","journal-title":"Mol. Pain"},{"key":"10.1016\/j.nbd.2021.105468_bb0310","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainresbull.2017.07.003","article-title":"The effect of CXCR2 inhibition on seizure activity in the pilocarpine epilepsy mouse model","volume":"134","author":"Xu","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2021.105468_bb0315","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neulet.2015.12.044","article-title":"Up-regulation of CXCL1 and CXCR2 contributes to remifentanil-induced hypernociception via modulating spinal NMDA receptor expression and phosphorylation in rats","volume":"626","author":"Yang","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2021.105468_bb0325","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/bjp.2008.270","article-title":"Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury in mice","volume":"155","author":"Zarbock","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2021.105468_bb0330","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1523\/JNEUROSCI.6210-10.2011","article-title":"Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy","volume":"31","author":"Zattoni","year":"2011","journal-title":"J. Neurosci."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121002175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121002175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:27:52Z","timestamp":1760851672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996121002175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":66,"alternative-id":["S0969996121002175"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105468","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CXCL1-CXCR1\/2 signaling is induced in human temporal lobe epilepsy and contributes to seizures in a murine model of acquired epilepsy","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105468"}}