{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:01:30Z","timestamp":1780358490589,"version":"3.54.1"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.nbd.2021.105469","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T11:54:49Z","timestamp":1628164489000},"page":"105469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Glial contribution to cyclodextrin-mediated reversal of cholesterol accumulation in murine NPC1-deficient neurons in vivo"],"prefix":"10.1016","volume":"158","author":[{"given":"Am\u00e9lie","family":"Barthelemy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Demais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela-Cristina","family":"Stancu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeniu","family":"Vasile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Houben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Reber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pallottini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Perraut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Reibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.","family":"Pfrieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2021.105469_bb0005","doi-asserted-by":"crossref","first-page":"19316","DOI":"10.1073\/pnas.0910916106","article-title":"Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells","volume":"106","author":"Abi-Mosleh","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105469_bb0010","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1055\/s-0028-1091741","article-title":"Niemann-Pick disease type-C - case report with ultrastructural findings","volume":"4","author":"Anzil","year":"1973","journal-title":"Neuropadiatrie."},{"key":"10.1016\/j.nbd.2021.105469_bb0015","doi-asserted-by":"crossref","first-page":"9404","DOI":"10.1523\/JNEUROSCI.1317-11.2011","article-title":"Unesterified cholesterol accumulation in late endosomes\/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment","volume":"31","author":"Aqul","year":"2011","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.nbd.2021.105469_bib646","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.3390\/ijms22084220","article-title":"Genistein activates transcription factor EB and corrects Niemann-Pick C phenotype","volume":"22","author":"Arg\u00fcello","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2021.105469_bb0020","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1124\/jpet.119.260497","article-title":"Modest blood-brain barrier permeability of the cyclodextrin kleptose: modification by efflux and luminal surface binding","volume":"371","author":"Banks","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2021.105469_bb0025","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0014-4886(03)00345-5","article-title":"Postnatal development of inflammation in a murine model of Niemann-Pick type C disease: immunohistochemical observations of microglia and astroglia","volume":"184","author":"Baudry","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105469_bb0030","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pediatrneurol.2017.12.014","article-title":"Long-term treatment of Niemann-Pick type C1 disease with intrathecal 2-hydroxypropyl-\u03b2-cyclodextrin","volume":"80","author":"Berry-Kravis","year":"2018","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.nbd.2021.105469_bb0035","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/glia.22966","article-title":"Dark microglia: a new phenotype predominantly associated with pathological states","volume":"64","author":"Bisht","year":"2016","journal-title":"Glia."},{"key":"10.1016\/j.nbd.2021.105469_bb0040","article-title":"NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse mode of Niemann-Pick disease type C","volume":"147","author":"Boyle","year":"2020","journal-title":"Development."},{"key":"10.1016\/j.nbd.2021.105469_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184392","article-title":"Current challenges in understanding the cellular and molecular mechanisms in Niemann-Pick disease type C1","volume":"20","author":"Br\u00e4uer","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2021.105469_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072566","article-title":"Mechanism of secondary ganglioside and lipid accumulation in lysosomal disease","volume":"21","author":"Breiden","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2021.105469_bb0055","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/02713680701231857","article-title":"Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina","volume":"32","author":"Bretillon","year":"2007","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0060","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mcn.2014.06.003","article-title":"Relevance of neuronal and glial NPC1 for synaptic input to cerebellar Purkinje cells","volume":"61","author":"Buard","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2021.105469_bb0065","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0024-3205(01)01384-4","article-title":"Cyclodextrins in the treatment of a mouse model of Niemann-Pick C disease","volume":"70","author":"Camargo","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.nbd.2021.105469_bb0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.semcdb.2020.08.001","article-title":"Microglia and lipids: how metabolism controls brain innate immunity","volume":"112","author":"Chausse","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.nbd.2021.105469_bb0075","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jneumeth.2008.03.013","article-title":"NS21: re-defined and modified supplement B27 for neuronal cultures","volume":"171","author":"Chen","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2021.105469_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015054","article-title":"Cyclodextrin induces calcium-dependent lysosomal exocytosis","volume":"5","author":"Chen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105469_bb0085","author":"Clarke"},{"key":"10.1016\/j.nbd.2021.105469_bb0090","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.mcn.2009.10.007","article-title":"Lack of Niemann Pick type C1 induces age-related degeneration in the mouse retina","volume":"43","author":"Claudepierre","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2021.105469_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21121748","article-title":"Cyclodextrins as emerging therapeutic tools in the treatment of cholesterol-associated vascular and neurodegenerative diseases","volume":"21","author":"Coisne","year":"2016","journal-title":"Molecules."},{"key":"10.1016\/j.nbd.2021.105469_bb0100","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10545-013-9610-6","article-title":"Human and mouse neuroinflammation markers in Niemann-Pick disease, type C1","volume":"37","author":"Cologna","year":"2014","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0105","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/s41467-021-21428-5","article-title":"Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia","volume":"12","author":"Colombo","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105469_bb0115","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1093\/hmg\/ddy112","article-title":"Microglia activation in Niemann-Pick disease, type C1 is amendable to therapeutic intervention","volume":"27","author":"Cougnoux","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2021.105469_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155368","article-title":"Single cell transcriptome analysis of Niemann-Pick disease, Type C1 Cerebella","volume":"21","author":"Cougnoux","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2021.105469_bb0125","doi-asserted-by":"crossref","first-page":"10940","DOI":"10.1021\/cr500081p","article-title":"Review: a history of cyclodextrins","volume":"114","author":"Crini","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.nbd.2021.105469_bb0130","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.ijpharm.2017.06.080","article-title":"Cyclodextrin-modified inorganic materials for the construction of nanocarriers","volume":"531","author":"Cutrone","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.nbd.2021.105469_bb0135","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2017.1329081","article-title":"Methyl-beta-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK","volume":"13","author":"Dai","year":"2017","journal-title":"Autophagy."},{"key":"10.1016\/j.nbd.2021.105469_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006951","article-title":"Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression","volume":"4","author":"Davidson","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105469_bb0145","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.preteyeres.2016.12.001","article-title":"Pharmacokinetic aspects of retinal drug delivery","volume":"57","author":"Del Amo","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0150","doi-asserted-by":"crossref","first-page":"8012","DOI":"10.1523\/JNEUROSCI.0900-16.2016","article-title":"Reversal of pathologic lipid accumulation in NPC1-deficient neurons by drug-promoted release of LAMP1-coated lamellar inclusions","volume":"36","author":"Demais","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105469_bb0155","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/jimd.12210","article-title":"Nanoparticles containing beta-cyclodextrin potentially useful for the treatment of Niemann-pick C","volume":"43","author":"Donida","year":"2020","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0160","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/art.41078","article-title":"Neutrophil extracellular traps in tissue and periphery in juvenile dermatomyositis","volume":"72","author":"Duvvuri","year":"2020","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.nbd.2021.105469_bb0165","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s40263-019-00642-2","article-title":"Long-term neuropsychological outcomes from an open-label phase I\/IIa trial of 2-hydroxypropyl-beta-cyclodextrins (VTS-270) in Niemann-Pick disease, type C1","volume":"33","author":"Farmer","year":"2019","journal-title":"CNS Drugs."},{"key":"10.1016\/j.nbd.2021.105469_bb0170","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1194\/jlr.RA119000571","article-title":"Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick type C1-deficient cells after cyclodextrin treatment","volume":"61","author":"Feltes","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0175","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3390\/ijms22010452","article-title":"Intracerebroventricular treatment with 2-hydroxypropyl-\u03b2-cyclodextrin decreased cerebellar and hepatic glycoprotein nonmetastatic melanoma protein B (GPNMB) expression in Niemann-Pick disease type C model mice","volume":"22","author":"Fukaura","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2021.105469_bb0180","doi-asserted-by":"crossref","first-page":"e99553","DOI":"10.15252\/embj.201899553","article-title":"Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders","volume":"38","author":"Gabande-Rodriguez","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2021.105469_bb0185","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3389\/fimmu.2019.00790","article-title":"Phagocytosis in the brain: homeostasis and disease","volume":"10","author":"Galloway","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2021.105469_bb0190","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13023-018-0785-7","article-title":"Consensus clinical management guidelines for Niemann-Pick disease type C","volume":"13","author":"Geberhiwot","year":"2018","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0195","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0306-4522(01)00517-6","article-title":"Neurodegeneration in the Niemann-Pick C mouse: glial involvement","volume":"109","author":"German","year":"2002","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2021.105469_bb0200","doi-asserted-by":"crossref","first-page":"105142","DOI":"10.1016\/j.nbd.2020.105142","article-title":"Deregulation of signalling in genetic conditions affecting the lysosomal metabolism of cholesterol and galactosyl-sphingolipids","volume":"146","author":"Gowrishankar","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0205","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nm1073","article-title":"Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone","volume":"10","author":"Griffin","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2021.105469_bb0210","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.bbalip.2019.04.002","article-title":"The complexity of a monogenic neurodegenerative disease: more than two decades of therapeutic driven research into Niemann-Pick type C disease","volume":"1864","author":"Hammond","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.nbd.2021.105469_bb0215","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00685003","article-title":"Neurovisceral lipidosis compatible with Niemann-Pick disease type C: morphological and biochemical studies of a late infantile case and enzyme and lipid assays in a prenatal case of the same family","volume":"43","author":"Harzer","year":"1978","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105469_bb0220","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1007\/s00415-020-09796-2","article-title":"Retinal axonal degeneration in Niemann-Pick type C disease","volume":"267","author":"Havla","year":"2020","journal-title":"J. Neurol."},{"key":"10.1016\/j.nbd.2021.105469_bb0225","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1038\/s41467-019-11425-0","article-title":"Lysosomal integral membrane protein-2 (LIMP-2\/SCARB2) is involved in lysosomal cholesterol export","volume":"10","author":"Heybrock","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105469_bb0230","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1046\/j.1471-4159.2002.01220.x","article-title":"Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neurons","volume":"83","author":"Karten","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105469_bb0235","doi-asserted-by":"crossref","first-page":"14722","DOI":"10.1038\/s41598-019-51246-1","article-title":"Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick type-C","volume":"9","author":"Kavetsky","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105469_bb0240","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/10084","article-title":"Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport","volume":"1","author":"Kobayashi","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2021.105469_bb0245","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijpharm.2012.06.055","article-title":"Cyclodextrins","volume":"453","author":"Kurkov","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.nbd.2021.105469_bb0250","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1750-1172-9-64","article-title":"Visualization of cholesterol deposits in lysosomes of Niemann-Pick type C fibroblasts using recombinant perfringolysin O","volume":"9","author":"Kwiatkowska","year":"2014","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0255","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cell.2009.03.049","article-title":"Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol","volume":"137","author":"Kwon","year":"2009","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2021.105469_bb0260","doi-asserted-by":"crossref","first-page":"18915","DOI":"10.1074\/jbc.273.30.18915","article-title":"Circulation of cholesterol between lysosomes and the plasma membrane","volume":"273","author":"Lange","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105469_bb0265","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.1073\/pnas.1711716114","article-title":"3.3 \u00c5 structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport","volume":"114","author":"Li","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105469_bb0270","doi-asserted-by":"crossref","first-page":"11796","DOI":"10.1016\/S0021-9258(18)80136-3","article-title":"The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one","volume":"264","author":"Liscum","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105469_bb0275","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1083\/jcb.108.5.1625","article-title":"The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts","volume":"108","author":"Liscum","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2021.105469_bb0280","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1021\/cm0342041","article-title":"Control of the size and distribution of gold nanoparticles by unmodified cyclodextrins","volume":"15","author":"Liu","year":"2003","journal-title":"Chem. Mater."},{"key":"10.1016\/j.nbd.2021.105469_bb0285","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1194\/jlr.M700525-JLR200","article-title":"Genetic variations and treatments that affect the lifespan of the NPC1 mouse","volume":"49","author":"Liu","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0290","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1073\/pnas.0810895106","article-title":"Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1\u2212\/\u2212 mouse","volume":"106","author":"Liu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105469_bb0295","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/nm.1876","article-title":"Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium","volume":"14","author":"Lloyd-Evans","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2021.105469_bb0300","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1126\/science.277.5323.232","article-title":"Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene","volume":"277","author":"Loftus","year":"1997","journal-title":"Science."},{"key":"10.1016\/j.nbd.2021.105469_bb0305","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1523\/JNEUROSCI.5981-10.2011","article-title":"Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder","volume":"31","author":"Lopez","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105469_bb0310","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/brain\/118.1.119","article-title":"Neurofibrillary tangles in Niemann-Pick disease type C","volume":"118","author":"Love","year":"1995","journal-title":"Brain."},{"key":"10.1016\/j.nbd.2021.105469_bb0315","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fphys.2020.00393","article-title":"Lipid and lipoprotein metabolism in microglia","volume":"11","author":"Loving","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.nbd.2021.105469_bb0320","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF00334507","article-title":"Feline sphingolipidosis resembling Niemann-Pick disease type C","volume":"81","author":"Lowenthal","year":"1990","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105469_bb0325","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12177","article-title":"Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection","volume":"4","author":"Lu","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2021.105469_bb0330","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jns.2007.11.018","article-title":"Brainstem neuropathology in a mouse model of Niemann-Pick disease type C","volume":"268","author":"Luan","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2021.105469_bb0335","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1073\/pnas.96.13.7238","article-title":"cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain","volume":"96","author":"Lund","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105469_bb0340","doi-asserted-by":"crossref","first-page":"9799","DOI":"10.1073\/pnas.93.18.9799","article-title":"Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation","volume":"93","author":"Lutjohann","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105469_bb0345","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3389\/fimmu.2020.00506","article-title":"Microglial corpse clearance: lessons from macrophages","volume":"11","author":"M\u00e1rquez-Ropero","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2021.105469_bb0350","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/med.21509","article-title":"Gold nanoparticles in ophthalmology","volume":"39","author":"Masse","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.nbd.2021.105469_bb0355","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/hmg\/ddr505","article-title":"A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations","volume":"21","author":"Maue","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2021.105469_bb0360","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1093\/hmg\/dds322","article-title":"Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a beta-cyclodextrin","volume":"21","author":"Maulik","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2021.105469_bb0365","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.nbd.2013.12.018","article-title":"The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability","volume":"64","author":"Meske","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0370","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnint.2018.00035","article-title":"Olfactory performance as an indicator for protective treatment effects in an animal model of neurodegeneration","volume":"12","author":"Meyer","year":"2018","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.nbd.2021.105469_bb0375","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1124\/jpet.104.067512","article-title":"Behavior of \u03b1-, \u03b2-, and \u03b3-cyclodextrins and their derivatives on an in vitro model of blood-brain barrier","volume":"310","author":"Monnaert","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2021.105469_bb0380","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1126\/science.290.5500.2298","article-title":"Identification of HE1 as the second gene of Niemann-Pick C disease","volume":"290","author":"Naureckiene","year":"2000","journal-title":"Science."},{"key":"10.1016\/j.nbd.2021.105469_bb0385","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1471-4159.2009.05917.x","article-title":"Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats","volume":"109","author":"Nieweg","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105469_bb0390","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1016\/S0021-9258(19)45558-0","article-title":"Studies on the biological properties of polyene antibiotics. Evidence for the direct interaction of filipin with cholesterol","volume":"247","author":"Norman","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105469_bb0395","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/S0140-6736(17)31465-4","article-title":"Intrathecal 2-hydroxypropyl-\u03b2-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial","volume":"390","author":"Ory","year":"2017","journal-title":"Lancet."},{"key":"10.1016\/j.nbd.2021.105469_bb0400","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13023-015-0348-0","article-title":"Visual evoked potentials of Niemann-Pick type C1 mice reveal an impairment of the visual pathway that is rescued by 2-hydroxypropyl-\u00df-cyclodextrin","volume":"10","author":"Palladino","year":"2015","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0405","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.3390\/ijms21238979","article-title":"Understanding and treating Niemann-Pick type C disease: models matter","volume":"21","author":"Pallottini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2021.105469_bb0410","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/archopht.1985.01050060077030","article-title":"Niemann-pick disease\u2013type C. Ocular histopathologic and electron microscopic studies","volume":"103","author":"Palmer","year":"1985","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.nbd.2021.105469_bb0415","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.ymthe.2019.05.008","article-title":"Characterization of the subventricular-thalamo-cortical circuit in the NP-C mouse brain, and new insights regarding treatment","volume":"27","author":"Park","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.nbd.2021.105469_bb0420","doi-asserted-by":"crossref","first-page":"9290","DOI":"10.1074\/jbc.M111.326405","article-title":"Normalization of cholesterol homeostasis by 2-hydroxypropyl-beta-cyclodextrin in neurons and glia from Niemann-Pick C1 (NPC1)-deficient mice","volume":"287","author":"Peake","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105469_bb0425","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.bbadis.2011.06.003","article-title":"Niemann-Pick type C1 deficiency in microglia does not cause neuron death in vitro","volume":"1812","author":"Peake","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2021.105469_bb0430","doi-asserted-by":"crossref","first-page":"8247","DOI":"10.1073\/pnas.82.23.8247","article-title":"A defect in cholesterol esterification in Niemann-Pick disease (type C) patients","volume":"82","author":"Pentchev","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105469_bb0435","series-title":"The Fine Structure of the Nervous System: The Neurons and Supporting Cells","author":"Peters","year":"1991"},{"key":"10.1016\/j.nbd.2021.105469_bb0440","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1074\/jbc.TM118.004165","article-title":"NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes","volume":"294","author":"Pfeffer","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105469_bb0445","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.plipres.2011.06.002","article-title":"Cholesterol metabolism in neurons and astrocytes","volume":"50","author":"Pfrieger","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0450","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1523\/JNEUROSCI.5529-07.2008","article-title":"Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration","volume":"28","author":"Phillips","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105469_bb0455","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.preteyeres.2014.03.002","article-title":"Cholesterol in the retina: the best is yet to come","volume":"41","author":"Pikuleva","year":"2014","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0460","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.chemphyslip.2012.03.007","article-title":"Uptake of a fluorescent methyl-\u03b2-cyclodextrin via clathrin-dependent endocytosis","volume":"165","author":"Plazzo","year":"2012","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.nbd.2021.105469_bb0465","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10545-012-9583-x","article-title":"Cyclodextrin alleviates neuronal storage of cholesterol in Niemann-Pick C disease without evidence of detectable blood-brain barrier permeability","volume":"36","author":"Pontikis","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0470","doi-asserted-by":"crossref","first-page":"8091","DOI":"10.1523\/JNEUROSCI.4173-14.2015","article-title":"A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele","volume":"35","author":"Praggastis","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105469_bb0475","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.nbd.2011.12.027","article-title":"Early glial activation, synaptic changes and axonal pathology in the thalamocortical system of Niemann-Pick type C1 mice","volume":"45","author":"Pressey","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0480","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","article-title":"Microglia biology: one century of evolving concepts","volume":"179","author":"Prinz","year":"2019","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2021.105469_bb0485","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cell.2020.05.020","article-title":"Structural basis of low-pH-dependent lysosomal cholesterol egress by NPC1 and NPC2","volume":"182","author":"Qian","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105469_bb0110","series-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"10.1016\/j.nbd.2021.105469_bb0490","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/0042-6989(95)00322-3","article-title":"Structural specializations of human retinal glial cells","volume":"36","author":"Ram\u00edrez","year":"1996","journal-title":"Vis. Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0495","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1203\/PDR.0b013e3181ee4dd2","article-title":"Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life","volume":"68","author":"Ramirez","year":"2010","journal-title":"Pediatr.Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0500","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1194\/jlr.D300032-JLR200","article-title":"A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain","volume":"45","author":"Reid","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0505","doi-asserted-by":"crossref","first-page":"14470","DOI":"10.1523\/JNEUROSCI.4823-07.2007","article-title":"Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse","volume":"27","author":"Repa","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105469_bb0510","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1073\/pnas.0914309107","article-title":"Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells","volume":"107","author":"Rosenbaum","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105469_bb0515","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ajpath.2018.10.013","article-title":"Retinal vascular abnormalities and microglia activation in mice with deficiency in cytochrome P450 46A1-mediated cholesterol removal","volume":"189","author":"Saadane","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2021.105469_bb0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e01293","article-title":"Hepatic and neuronal phenotype of NPC1(\u2212\/\u2212) mice","volume":"5","author":"Santiago-Mujica","year":"2019","journal-title":"Heliyon."},{"key":"10.1016\/j.nbd.2021.105469_bb0525","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1021\/acs.molpharmaceut.9b00679","article-title":"Intravitreal pharmacokinetics in mice: SPECT\/CT imaging and scaling to rabbits and humans","volume":"16","author":"Schmitt","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.nbd.2021.105469_bb0530","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/npp.2013.284","article-title":"Simvastatin treatment highlights a new role for the isoprenoid\/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats","volume":"39","author":"Segatto","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2021.105469_bb0535","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.bbadis.2014.08.005","article-title":"Excessive microglial activation aggravates olfactory dysfunction by impeding the survival of newborn neurons in the olfactory bulb of Niemann-Pick disease type C1 mice","volume":"1842","author":"Seo","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2021.105469_bb0540","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/S0021-9258(18)69086-6","article-title":"Type C Niemann-pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol","volume":"263","author":"Sokol","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2021.105469_bb0545","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/NEN.0b013e31825414a6","article-title":"Miglustat improves purkinje cell survival and alters microglial phenotype in feline niemann-pick disease type C","volume":"71","author":"Stein","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105469_bb0550","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00005072-198805000-00008","article-title":"Cerebellar involvement in murine sphingomyelinosis: a new model of Niemann-Pick disease","volume":"47","author":"Tanaka","year":"1988","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105469_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107851","article-title":"Addressing neurodegeneration in lysosomal storage disorders: advances in Niemann Pick diseases","volume":"171","author":"Toledano-Zaragoza","year":"2020","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.nbd.2021.105469_bb0560","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13024-019-0314-8","article-title":"Glial phagocytic clearance in Parkinson\u2019s disease","volume":"14","author":"Tremblay","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2021.105469_bb0565","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1194\/jlr.M089979","article-title":"Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells","volume":"60","author":"Vacca","year":"2019","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0570","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1194\/jlr.R047837","article-title":"Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin","volume":"55","author":"Vance","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0575","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1750-1172-5-16","article-title":"Niemann-Pick disease type C","volume":"5","author":"Vanier","year":"2010","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0580","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/bs.mcb.2014.10.028","article-title":"Laboratory diagnosis of Niemann-Pick disease type C: the filipin staining test","volume":"126","author":"Vanier","year":"2015","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.nbd.2021.105469_bb0585","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3390\/biom9100509","article-title":"Pharmacokinetic properties of fluorescently labelled hydroxypropyl-beta-cyclodextrin","volume":"9","author":"Varadi","year":"2019","journal-title":"Biomolecules."},{"key":"10.1016\/j.nbd.2021.105469_bb0590","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","article-title":"Glia-neuron interactions in the mammalian retina","volume":"51","author":"Vecino","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.nbd.2021.105469_bb0595","doi-asserted-by":"crossref","first-page":"276ra26","DOI":"10.1126\/scitranslmed.3010101","article-title":"Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease","volume":"7","author":"Vite","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2021.105469_bb0600","doi-asserted-by":"crossref","first-page":"e1716","DOI":"10.1212\/WNL.0000000000009287","article-title":"Imaging of neuroinflammation in adult Niemann-Pick type C disease: a cross-sectional study","volume":"94","author":"Walterfang","year":"2020","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2021.105469_bb0605","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/jnc.14895","article-title":"Niemann-Pick type C disease: cellular pathology and pharmacotherapy","volume":"153","author":"Wheeler","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105469_bb0610","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.nbd.2021.105469_bb0615","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2019.08.038","article-title":"Structural insight into eukaryotic sterol transport through Niemann-Pick type C proteins","volume":"179","author":"Winkler","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105469_bb0620","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12868-014-0126-2","article-title":"Defects in the retina of Niemann-pick type C 1 mutant mice","volume":"15","author":"Yan","year":"2014","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.nbd.2021.105469_bb0625","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/glia.22659","article-title":"Hyperactive glial cells contribute to axonal pathologies in the spinal cord of Npc1 mutant mice","volume":"62","author":"Yan","year":"2014","journal-title":"Glia."},{"key":"10.1016\/j.nbd.2021.105469_bb0630","doi-asserted-by":"crossref","first-page":"105290","DOI":"10.1016\/j.nbd.2021.105290","article-title":"Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system","volume":"152","author":"Yang","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105469_bb0635","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nm.2847","article-title":"Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo","volume":"18","author":"Yipp","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2021.105469_bb0640","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/jnen\/60.1.49","article-title":"Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations","volume":"60","author":"Zervas","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105469_bb0645","article-title":"Spatial distribution of the pathways of cholesterol homeostasis in human retina","volume":"7","author":"Zheng","year":"2012","journal-title":"PLoS One"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121002187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121002187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:28:38Z","timestamp":1760851718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996121002187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":130,"alternative-id":["S0969996121002187"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105469","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.04.08.438990","asserted-by":"object"}]},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glial contribution to cyclodextrin-mediated reversal of cholesterol accumulation in murine NPC1-deficient neurons in vivo","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105469"}}