{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:19:50Z","timestamp":1782299990898,"version":"3.54.5"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.nbd.2021.105540","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T04:20:06Z","timestamp":1635481206000},"page":"105540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Quantitative detection of grey and white matter amyloid pathology using a combination of K114 and CRANAD-3 fluorescence"],"prefix":"10.1016","volume":"161","author":[{"given":"Anastasiia A.","family":"Stepanchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Barber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammaryn","family":"Lashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey T.","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Stys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2021.105540_bb0005","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrev.9b00404","article-title":"Interrogating amyloid aggregates using fluorescent probes","author":"Aliyan","year":"2019","journal-title":"Chem. Rev."},{"issue":"490","key":"10.1016\/j.nbd.2021.105540_bb0010","doi-asserted-by":"crossref","first-page":"eaat8462","DOI":"10.1126\/scitranslmed.aat8462","article-title":"A\u03b2 and tau prion-like activities decline with longevity in the Alzheimer\u2019s disease human brain","volume":"11","author":"Aoyagi","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.nbd.2021.105540_bb0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/neur.1996.0005","article-title":"A comparison of \u03b2-amyloid deposition in the medial temporal lobe in sporadic Alzheimer\u2019s disease, Down\u2019s syndrome and normal elderly brains","volume":"5","author":"Armstrong","year":"1996","journal-title":"Neurodegeneration"},{"issue":"1","key":"10.1016\/j.nbd.2021.105540_bb0020","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/cercor\/1.1.103","article-title":"The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer\u2019s disease","volume":"1","author":"Arnold","year":"1991","journal-title":"Cereb. Cortex"},{"issue":"8","key":"10.1016\/j.nbd.2021.105540_bb0025","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1021\/cb900112v","article-title":"Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses","volume":"4","author":"Aslund","year":"2009","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.nbd.2021.105540_bb0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00401-020-02255-2","article-title":"Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-Centre study","volume":"141","author":"Attems","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105540_bb0035","first-page":"1537","article-title":"Eine spezifische Amyloidfarbung mit Kongorot","volume":"69","author":"Bennhold","year":"1922","journal-title":"Muenchener Medizinische Wochenschrift"},{"issue":"7","key":"10.1016\/j.nbd.2021.105540_bb0040","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.bbapap.2010.04.001","article-title":"Molecular mechanism of Thioflavin-T binding to amyloid fibrils","volume":"1804","author":"Biancalana","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.nbd.2021.105540_bb0045","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105540_bb0050","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3389\/fnins.2015.00184","article-title":"The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice","volume":"9","author":"Brelstaff","year":"2015","journal-title":"Front. Neurosci."},{"issue":"13","key":"10.1016\/j.nbd.2021.105540_bb0055","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.4650-14.2015","article-title":"Definition of a molecular pathway mediating \u03b1-synuclein neurotoxicity","volume":"35","author":"Burr\u00e9","year":"2015","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2021.105540_bb0060","first-page":"1","article-title":"Solvation-guided design of fluorescent probes for discrimination of amyloids","volume":"8","author":"Cao","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.nbd.2021.105540_bb0065","doi-asserted-by":"crossref","first-page":"e0188218","DOI":"10.1371\/journal.pone.0188218","article-title":"Axonal and myelinic pathology in 5xFAD Alzheimer\u2019s mouse spinal cord","volume":"12","author":"Chu","year":"2017","journal-title":"PLoS One"},{"issue":"s1","key":"10.1016\/j.nbd.2021.105540_bb0070","doi-asserted-by":"crossref","first-page":"S567","DOI":"10.3233\/JAD-179941","article-title":"The amyloid-\u03b2 oligomer hypothesis: beginning of the third decade","volume":"64","author":"Cline","year":"2018","journal-title":"J. Alzheimers Dis."},{"issue":"4669","key":"10.1016\/j.nbd.2021.105540_bb0075","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/1831202a0","article-title":"Electron microscopic observations on a fibrous component in amyloid of diverse origins","volume":"183","author":"Cohen","year":"1959","journal-title":"Nature"},{"issue":"Pt 4","key":"10.1016\/j.nbd.2021.105540_bb0080","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/brain\/awv006","article-title":"Rapidly progressive Alzheimer\u2019s disease features distinct structures of amyloid-\u03b2","volume":"138","author":"Cohen","year":"2015","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.nbd.2021.105540_bb0085","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/19336896.2015.1123371","article-title":"Distinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer\u2019s disease","volume":"10","author":"Cohen","year":"2016","journal-title":"Prion"},{"key":"10.1016\/j.nbd.2021.105540_bb0090","first-page":"83","article-title":"Soluble amyloid beta levels are elevated in the white matter of Alzheimer\u2019s patients, independent of cortical plaque severity","volume":"2","author":"Collins-Praino","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"issue":"4","key":"10.1016\/j.nbd.2021.105540_bb0095","doi-asserted-by":"crossref","first-page":"E782","DOI":"10.1073\/pnas.1714966115","article-title":"Structural heterogeneity and intersubject variability of A\u03b2 in familial and sporadic Alzheimer\u2019s disease","volume":"115","author":"Condello","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.nbd.2021.105540_bb0100","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1046\/j.1471-4159.2003.01949.x","article-title":"A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114","volume":"86","author":"Crystal","year":"2003","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.nbd.2021.105540_bb0105","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/ana.410250506","article-title":"Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer\u2019s disease","volume":"25","author":"de la Monte","year":"1989","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2021.105540_bb0110","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0197-4580(92)90027-U","article-title":"Identification of normal and pathological aging in prospectively studied nondemented elderly humans","volume":"13","author":"Dickson","year":"1992","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.nbd.2021.105540_bb0115","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/ana.23748","article-title":"Amyloid- beta oligomerization in Alzheimer dementia versus high-pathology controls","volume":"73","author":"Esparza","year":"2013","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2021.105540_bb0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/joim.12732","article-title":"Amyloid fibril polymorphism: a challenge for molecular imaging and therapy","volume":"283","author":"F\u00e4ndrich","year":"2018","journal-title":"J. Intern. Med."},{"issue":"2","key":"10.1016\/j.nbd.2021.105540_bb0125","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.expneurol.2009.09.001","article-title":"Oligomers of \u03b2-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model","volume":"223","author":"Gaspar","year":"2010","journal-title":"Exp. Neurol."},{"issue":"Pt 12","key":"10.1016\/j.nbd.2021.105540_bb0130","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1093\/brain\/awn265","article-title":"Heterogeneity of white matter hyperintensities in Alzheimer\u2019s disease: post-mortem quantitative MRI and neuropathology","volume":"131","author":"Gouw","year":"2008","journal-title":"Brain"},{"issue":"13","key":"10.1016\/j.nbd.2021.105540_bb0135","doi-asserted-by":"crossref","first-page":"7013","DOI":"10.1074\/jbc.270.13.7013","article-title":"Amyloid beta protein (A beta) in Alzheimer\u2019s disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)","volume":"270","author":"Gravina","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.nbd.2021.105540_bb0140","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways","volume":"16","author":"Greenberg","year":"2020","journal-title":"Nat. Rev. Neurol."},{"issue":"32","key":"10.1016\/j.nbd.2021.105540_bb0145","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1021\/bi100922r","article-title":"A fluorescent pentameric thiophene derivative detects in vitro-formed prefibrillar protein aggregates","volume":"49","author":"Hammarstr\u00f6m","year":"2010","journal-title":"Biochemistry"},{"issue":"29","key":"10.1016\/j.nbd.2021.105540_bb0150","doi-asserted-by":"crossref","first-page":"19855","DOI":"10.1074\/jbc.R114.549295","article-title":"Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target","volume":"289","author":"Holmes","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.nbd.2021.105540_bb0155","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.micron.2008.10.002","article-title":"Optical properties of amyloid stained by Congo red: history and mechanisms","volume":"40","author":"Howie","year":"2009","journal-title":"Micron."},{"issue":"3\u20134","key":"10.1016\/j.nbd.2021.105540_bb0160","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/13506129.2010.527448","article-title":"Discrepancies between descriptions and illustrations of colours in Congo red-stained amyloid, and explanation of discrepant colours","volume":"17","author":"Howie","year":"2010","journal-title":"Amyloid"},{"issue":"3","key":"10.1016\/j.nbd.2021.105540_bb0165","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/labinvest.3700714","article-title":"Physical basis of colors seen in Congo red-stained amyloid in polarized light","volume":"88","author":"Howie","year":"2008","journal-title":"Lab. Investig."},{"issue":"4","key":"10.1016\/j.nbd.2021.105540_bb0170","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s004010050624","article-title":"Distribution of amyloid deposits in the cerebral white matter of the Alzheimer\u2019s disease brain: relationship to blood vessels","volume":"93","author":"Iwamoto","year":"1997","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.nbd.2021.105540_bb0175","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00401-016-1537-1","article-title":"Updated TDP-43 in Alzheimer\u2019s disease staging scheme","volume":"131","author":"Josephs","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"10","key":"10.1016\/j.nbd.2021.105540_bb0180","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/s41593-018-0238-6","article-title":"Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases","volume":"21","author":"Jucker","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2021.105540_bb0185","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jsb.2005.06.006","article-title":"Mechanism of thioflavin T binding to amyloid fibrils","volume":"151","author":"Khurana","year":"2005","journal-title":"J. Struct. Biol."},{"issue":"1","key":"10.1016\/j.nbd.2021.105540_bb0190","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1038\/s41467-019-12683-8","article-title":"Cryo-EM structure and polymorphism of A\u03b2 amyloid fibrils purified from Alzheimer\u2019s brain tissue","volume":"10","author":"Kollmer","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.nbd.2021.105540_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt155","article-title":"Clinical, imaging, and pathological heterogeneity of the Alzheimer\u2019s disease syndrome","volume":"5","author":"Lam","year":"2013","journal-title":"Alzheimers Res. Ther."},{"issue":"41","key":"10.1016\/j.nbd.2021.105540_bb0200","doi-asserted-by":"crossref","first-page":"14488","DOI":"10.1523\/JNEUROSCI.3088-11.2011","article-title":"Soluble A\u03b2 seeds are potent inducers of cerebral \u03b2-amyloid deposition","volume":"31","author":"Langer","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105540_bb0205","first-page":"339","article-title":"Discriminating strains of self-propagating protein aggregates using a conformational stability assay","volume":"2018","author":"Lau","year":"1777","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.nbd.2021.105540_bb0210","article-title":"The existence of A\u03b2 strains and their potential for driving phenotypic heterogeneity in Alzheimer\u2019s disease","author":"Lau","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105540_bb0215","series-title":"Mechanism of A (1\u201340) Fibril-Induced Fluorescence of (trans, trans)-1-Bromo-2, 5-bis (4-hydroxystyryl) Benzene (K114)","first-page":"15937","author":"Levine","year":"2005"},{"issue":"4","key":"10.1016\/j.nbd.2021.105540_bb0220","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4161\/pri.29239","article-title":"Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands","volume":"8","author":"Magnusson","year":"2014","journal-title":"Prion"},{"issue":"5794","key":"10.1016\/j.nbd.2021.105540_bb0225","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1126\/science.1131864","article-title":"Exogenous induction of cerebral \u03b2-amyloidogenesis is governed by agent and host","volume":"313","author":"Meyer-Luehmann","year":"2006","journal-title":"Science"},{"issue":"34","key":"10.1016\/j.nbd.2021.105540_bb0230","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1002\/anie.200500845","article-title":"In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers","volume":"44","author":"Nesterov","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.nbd.2021.105540_bb0235","series-title":"Luminescent-Conjugated Oligothiophene Probe Applications for Fluorescence Imaging of Pure Amyloid Fibrils and Protein Aggregates in Tissues BT - Amyloid Proteins: Methods and Protocols","first-page":"485","author":"Nilsson","year":"2018"},{"issue":"40","key":"10.1016\/j.nbd.2021.105540_bb0240","doi-asserted-by":"crossref","first-page":"34186","DOI":"10.1074\/jbc.M501694200","article-title":"\u03b2-Amyloid is different in normal aging and in Alzheimer disease","volume":"280","author":"Piccini","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.nbd.2021.105540_bb0245","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","article-title":"Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer\u2019s disease","volume":"45","author":"Price","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2021.105540_bb0250","series-title":"Science","first-page":"1511","article-title":"A unifying role for prions in neurodegenerative diseases","volume":"336","author":"Prusiner","year":"2012"},{"issue":"3","key":"10.1016\/j.nbd.2021.105540_bb0255","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11307-011-0501-7","article-title":"Spectral unmixing imaging of wavelength-responsive fluorescent probes: an application for the real-time report of amyloid Beta species in Alzheimer\u2019s disease","volume":"14","author":"Ran","year":"2012","journal-title":"Mol. Imaging Biol."},{"issue":"6","key":"10.1016\/j.nbd.2021.105540_bb0260","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1747-0285.2011.01110.x","article-title":"Insight into amyloid structure using chemical probes","volume":"77","author":"Reinke","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.nbd.2021.105540_bb0265","first-page":"369808","article-title":"Alzheimer\u2019s disease and the amyloid cascade hypothesis: a critical review","volume":"2012","author":"Reitz","year":"2012","journal-title":"Int. J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.nbd.2021.105540_bb0270","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s11065-009-9118-x","article-title":"Beta-amyloid deposition and the aging brain","volume":"19","author":"Rodrigue","year":"2009","journal-title":"Neuropsychol. Rev."},{"issue":"2","key":"10.1016\/j.nbd.2021.105540_bb0275","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.neurobiolaging.2008.03.013","article-title":"White matter pathology isolates the hippocampal formation in Alzheimer\u2019s disease","volume":"31","author":"Salat","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2021.105540_bb0280","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ebiom.2016.03.035","article-title":"The role of amyloid-\u03b2 oligomers in toxicity, propagation, and immunotherapy","volume":"6","author":"Sengupta","year":"2016","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.nbd.2021.105540_bb0285","doi-asserted-by":"crossref","first-page":"a006189","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"19","key":"10.1016\/j.nbd.2021.105540_bb0290","doi-asserted-by":"crossref","first-page":"16533","DOI":"10.1074\/jbc.R111.227108","article-title":"Structural insights into functional and pathological amyloid","volume":"286","author":"Shewmaker","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.nbd.2021.105540_bb0295","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nmeth1131","article-title":"Prion strain discrimination using luminescent conjugated polymers","volume":"4","author":"Sigurdson","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2021.105540_bb0300","article-title":"Early detection of prion protein aggregation with a fluorescent pentameric oligothiophene probe using spectral confocal microscopy","author":"Stepanchuk","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105540_bb0305","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.1c00101","article-title":"Complex photophysical properties of K114 make for a versatile fluorescent probe for amyloid detection","author":"Stepanchuk","year":"2021","journal-title":"ACS Chem. Neurosci."},{"issue":"9","key":"10.1016\/j.nbd.2021.105540_bb0310","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1177\/002215540004800906","article-title":"X-34, a fluorescent derivative of congo red: a novel histochemical stain for Alzheimer\u2019s disease pathology","volume":"48","author":"Styren","year":"2000","journal-title":"J. Histochem. Cytochem."},{"issue":"12","key":"10.1016\/j.nbd.2021.105540_bb0315","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.nbd.2021.105540_bb0320","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/bpa.12842","article-title":"Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer\u2019s disease","volume":"30","author":"Toomey","year":"2020","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2021.105540_bb0325","doi-asserted-by":"crossref","first-page":"173554","DOI":"10.1016\/j.ejphar.2020.173554","article-title":"Alzheimer\u2019s disease: recent treatment strategies","volume":"887","author":"Vaz","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.nbd.2021.105540_bb0330","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1039\/C7CS00706J","article-title":"Shedding light on tau protein aggregation: the progress in developing highly selective fluorophores","volume":"47","author":"Verwilst","year":"2018","journal-title":"Chem. Soc. Rev."},{"issue":"2","key":"10.1016\/j.nbd.2021.105540_bb0335","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0039-1681041","article-title":"Alzheimer\u2019s disease including focal presentations","volume":"39","author":"Villain","year":"2019","journal-title":"Semin. Neurol."},{"issue":"28","key":"10.1016\/j.nbd.2021.105540_bb0340","doi-asserted-by":"crossref","first-page":"10323","DOI":"10.1073\/pnas.1408900111","article-title":"Serial propagation of distinct strains of A\u03b2 prions from Alzheimer\u2019s disease patients","volume":"111","author":"Watts","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"44","key":"10.1016\/j.nbd.2021.105540_bb0345","doi-asserted-by":"crossref","first-page":"16397","DOI":"10.1021\/ja405239v","article-title":"Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer\u2019s disease","volume":"135","author":"Zhang","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"31","key":"10.1016\/j.nbd.2021.105540_bb0350","doi-asserted-by":"crossref","first-page":"9734","DOI":"10.1073\/pnas.1505420112","article-title":"Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer\u2019s disease","volume":"112","author":"Zhang","year":"2015","journal-title":"PNAS"},{"issue":"28","key":"10.1016\/j.nbd.2021.105540_bb0355","doi-asserted-by":"crossref","first-page":"7210","DOI":"10.1002\/chem.201800501","article-title":"Detection and imaging of A\u03b21-42 and tau fibrils by redesigned fluorescent X-34 analogues","volume":"24","author":"Zhang","year":"2018","journal-title":"Chemistry"},{"issue":"14","key":"10.1016\/j.nbd.2021.105540_bb0360","doi-asserted-by":"crossref","first-page":"6694","DOI":"10.1021\/acs.jmedchem.9b00672","article-title":"Environment-sensitive near- infrared probe for fluorescent discrimination of A\u03b2 and tau fibrils in AD brain","volume":"62","author":"Zhou","year":"2019","journal-title":"J. Med. Chem."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121002898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121002898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:28:04Z","timestamp":1760851684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996121002898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":72,"alternative-id":["S0969996121002898"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105540","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative detection of grey and white matter amyloid pathology using a combination of K114 and CRANAD-3 fluorescence","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105540","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105540"}}