{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:30:30Z","timestamp":1791995430891,"version":"4.4.0"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.nbd.2021.105546","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T23:30:58Z","timestamp":1635982258000},"page":"105546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Sex differences in the developing brain impact stress-induced epileptogenicity following hyperthermia-induced seizures"],"prefix":"10.1016","volume":"161","author":[{"given":"Daniele C.","family":"Wolf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Desgent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie T.","family":"Sanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Shu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior M.","family":"Elkaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian M.","family":"Bosoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia N.","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexe","family":"Simard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad T.","family":"Salam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume-Alexandre","family":"Bilodeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Duss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Sawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan C.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Weil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2021.105546_bb0005","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/dev.20555","article-title":"Predator and restraint stress during gestation facilitates pilocarpine-induced seizures in prepubertal rats","volume":"53","author":"Ahmadzadeh","year":"2011","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.nbd.2021.105546_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.wneu.2016.12.074","article-title":"Prevalence and incidence of drug-resistant mesial temporal lobe epilepsy in the United States","author":"Asadi-Pooya","year":"2017","journal-title":"World Neurosurg."},{"key":"10.1016\/j.nbd.2021.105546_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2016.02.014","article-title":"Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures","volume":"91","author":"Awad","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105546_bb0020","article-title":"Sex-specific consequences of neonatal stress on cardio-respiratory inhibition following laryngeal stimulation in rat pups","volume":"4","author":"Baldy","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.nbd.2021.105546_bb0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.eplepsyres.2016.10.016","article-title":"TRPV1 deletion exacerbates hyperthermic seizures in an age-dependent manner in mice","volume":"128","author":"Barrett","year":"2016","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2021.105546_bb0030","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.nbd.2018.08.004","article-title":"Vagal TRPV1 activation exacerbates thermal hyperpnea and increases susceptibility to experimental febrile seizures in immature rats","volume":"119","author":"Barrett","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105546_bb0035","doi-asserted-by":"crossref","DOI":"10.1097\/WCO.0b013e3282f36ccd","article-title":"The natural history of mesial temporal lobe epilepsy","author":"Berg","year":"2008","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.nbd.2021.105546_bb0040","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1528-1157.1996.tb00003.x","article-title":"Complex Febrile Seizures","volume":"37","author":"Berg","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105546_bb0045","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11760-013-0502-x","article-title":"Body temperature measurement of an animal by tracking in biomedical experiments","volume":"9","author":"Bilodeau","year":"2015","journal-title":"Signal, Image Video Process."},{"key":"10.1016\/j.nbd.2021.105546_bb0050","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1212\/01.WNL.0000044055.73747.9F","article-title":"The pathological basis of temporal lobe epilepsy in childhood","volume":"60","author":"Bocti","year":"2003","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.nbd.2021.105546_bb0055","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/2661","article-title":"Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy","volume":"410","author":"Brooks-Kayal","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2021.105546_bb0060","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuroscience.2010.04.023","article-title":"Chronic high corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats","volume":"168","author":"Brummelte","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2021.105546_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046044","article-title":"Impact of corticosterone treatment on spontaneous seizure frequency and epileptiform activity in mice with chronic epilepsy","volume":"7","author":"Castro","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105546_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2017.05.010","article-title":"Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods","author":"Claflin","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.nbd.2021.105546_bb0075","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1046\/j.1460-9568.2003.02597.x","article-title":"Dentate granule cell GABA(a) receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology","volume":"17","author":"Cohen","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105546_bb0080","first-page":"4490","article-title":"Expression of type 2 11\u03b2-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life","volume":"83","author":"Condon","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.nbd.2021.105546_bb0085","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2307\/1131187","article-title":"Sex differences in neonatal stress reactivity","volume":"66","author":"Davis","year":"1995","journal-title":"Child Dev."},{"key":"10.1016\/j.nbd.2021.105546_bb0090","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1210\/endo.141.5.7455","article-title":"Rapid induction of Corticotropin-releasing hormone gene transcription in the paraventricular nucleus of the developing rat 1","volume":"141","author":"Dent","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.nbd.2021.105546_bb0095","first-page":"7","article-title":"Early-life stress is associated with gender-based vulnerability to epileptogenesis in rat pups","author":"Desgent","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105546_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.braindev.2008.11.010","article-title":"Febrile seizures: mechanisms and relationship to epilepsy","author":"Dub\u00e9","year":"2009","journal-title":"Brain and Development"},{"key":"10.1016\/j.nbd.2021.105546_bb0105","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0006-8993(99)01619-4","article-title":"Steroid hormones affect limbic afterdischarge thresholds and kindling rates in adult female rats","volume":"838","author":"Edwards","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105546_bb0110","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0006-8993(00)03147-4","article-title":"Gonadectomy unmasks an inhibitory effect of progesterone on amygdala kindling in male rats","volume":"889","author":"Edwards","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105546_bb0115","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1006\/hbeh.2002.1839","article-title":"Prenatal stress alters seizure thresholds and the development of kindled seizures in infant and adult rats","volume":"42","author":"Edwards","year":"2002","journal-title":"Horm. Behav."},{"key":"10.1016\/j.nbd.2021.105546_bb0120","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/exnr.2002.7874","article-title":"The effects of ACTH and adrenocorticosteroids on seizure susceptibility in 15-day-old male rats","volume":"175","author":"Edwards","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105546_bb0125","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/107385840100700410","article-title":"Mesial temporal lobe epilepsy: what have we learned?","volume":"7","author":"Engel","year":"2001","journal-title":"Neuroscientist"},{"key":"10.1016\/j.nbd.2021.105546_bb0130","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.conb.2007.01.002","article-title":"Role of activity-dependent regulation of neuronal chloride homeostasis in development","volume":"17","author":"Fiumelli","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.nbd.2021.105546_bb0135","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.neuron.2005.10.025","article-title":"Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 function","volume":"48","author":"Fiumelli","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2021.105546_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/S0074-7742(08)00003-2","article-title":"Chapter 3 hormonal influences on seizures. Basic neurobiology","author":"Frye","year":"2008","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.nbd.2021.105546_bb0145","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0014-4886(03)00387-X","article-title":"Role of sex hormones in the sexually dimorphic expression of KCC2 in rat substantia nigra","volume":"184","author":"Galanopoulou","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105546_bb0150","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1528-1157.1984.tb03477.x","article-title":"Pituitary and adrenal function in epileptic patients","volume":"25","author":"Gallagher","year":"1984","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105546_bb0155","series-title":"Differential epilepsy-associated alterations in postsynaptic GABAA receptor function in dentate granule and CA1 neurons","first-page":"1924","author":"Gibbs","year":"1997"},{"key":"10.1016\/j.nbd.2021.105546_bb0160","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1037\/a0014730","article-title":"Postnatal epigenetic influences on seizure susceptibility in seizure-prone versus seizure-resistant rat strains","volume":"123","author":"Gilby","year":"2009","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2021.105546_bb0165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2826.2009.01843.x","article-title":"Examining the intersection of sex and stress in modelling neuropsychiatric disorders","volume":"21","author":"Goel","year":"2009","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.nbd.2021.105546_bb0170","series-title":"Comprehensive Physiology","first-page":"1121","article-title":"Sex differences in the HPA Axis","author":"Goel","year":"2014"},{"key":"10.1016\/j.nbd.2021.105546_bb0175","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1528-1157.1993.tb00433.x","article-title":"Commission on epidemiology and prognosis, international league against epilepsy","volume":"34","author":"Guidelines for Epidemiologic Studies on Epilepsy","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105546_bb0180","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1212\/WNL.50.4.917","article-title":"Epilepsy diagnosis and localization in patients with antecedent childhood febrile convulsions","volume":"50","author":"Hamati-Haddad","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2021.105546_bb0185","doi-asserted-by":"crossref","DOI":"10.1097\/NRL.0b013e3181618ada","article-title":"Neuroendocrine hormonal conditions in epilepsy: relationship to reproductive and sexual functions","author":"Hamed","year":"2008","journal-title":"Neurologist."},{"key":"10.1016\/j.nbd.2021.105546_bb0190","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000124264","article-title":"Effects of castration and testosterone on the pituitary and adrenal responses of the newborn rat to ether inhalation","volume":"42","author":"Hary","year":"1986","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.nbd.2021.105546_bb0195","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1528-1157.1994.tb05932.x","article-title":"The prevalence and incidence of convulsive disorders in children","volume":"35","author":"Hauser","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105546_bb0200","author":"Health Canada"},{"key":"10.1016\/j.nbd.2021.105546_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-018-0167-9","article-title":"Sex differences in the hypothalamic\u2013pituitary\u2013adrenal axis\u2019 response to stress: an important role for gonadal hormones","author":"Heck","year":"2019","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.nbd.2021.105546_bb0210","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/867531","article-title":"Sex differences in mechanisms and outcome of neonatal hypoxia-ischemia in rodent models: implications for sex-specific neuroprotection in clinical neonatal practice","author":"Hill","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.nbd.2021.105546_bb0215","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1046\/j.1528-1157.2002.14602.x","article-title":"Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures","volume":"43","author":"Huang","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105546_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2007.04.001","article-title":"Chronic stress: implications for neuronal morphology, function and neurogenesis","author":"Jo\u00ebls","year":"2007","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.nbd.2021.105546_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/S0079-6123(07)67001-0","article-title":"Stress-induced changes in hippocampal function","author":"Jo\u00ebls","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2021.105546_bb9089","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1528-1167.2008.01902.x","article-title":"Stress, the hippocampus, and epilepsy","volume":"50","author":"Jo\u00ebls","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105546_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2012.09.002","article-title":"Stress, epilepsy, and psychiatric comorbidity: how can animal models inform the clinic?","author":"Jones","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2021.105546_bb0235","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbr.2009.04.023","article-title":"Anxiolytic effects of rapid amygdala kindling, and the influence of early life experience in rats","volume":"203","author":"Jones","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2021.105546_bb0240","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.psyneuen.2012.06.005","article-title":"Repeatedly stressed rats have enhanced vulnerability to amygdala kindling epileptogenesis","volume":"38","author":"Jones","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nbd.2021.105546_bb0245","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1460-9568.1999.00495.x","article-title":"Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long-term changes in hippocampal CA1 cells, in the fully kindled state","volume":"11","author":"Karst","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105546_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2014.05.027","article-title":"Using sex differences in the developing brain to identify nodes of influence for seizure susceptibility and epileptogenesis","author":"Kight","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105546_bb0255","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.psyneuen.2014.01.009","article-title":"Early life maternal separation stress augmentation of limbic epileptogenesis: the role of corticosterone and HPA axis programming","volume":"42","author":"Koe","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nbd.2021.105546_bb0260","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuroscience.2015.11.006","article-title":"Effectiveness of different corticosterone administration methods to elevate corticosterone serum levels, induce depressive-like behavior, and affect neurogenesis levels in female rats","volume":"312","author":"Kott","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2021.105546_bb0265","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.psyneuen.2007.05.011","article-title":"The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors","volume":"32","author":"Kumar","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nbd.2021.105546_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024033","article-title":"Early life stress enhancement of limbic epileptogenesis in adult rats: mechanistic insights","volume":"6","author":"Kumar","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105546_bb0275","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.eplepsyres.2005.10.005","article-title":"Effect of neonatal isolation on outcome following neonatal seizures in rats - the role of corticosterone","volume":"68","author":"Lai","year":"2006","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2021.105546_bb0280","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pedhc.2006.10.006","article-title":"Febrile Seizures","volume":"21","author":"Leung","year":"2007","journal-title":"J. Pediatr. Heal. Care"},{"key":"10.1016\/j.nbd.2021.105546_bb0285","series-title":"Annals of the New York Academy of Sciences","first-page":"275","article-title":"The ontogeny of the hypothalamic-pituitary-adrenal axis. The influence of maternal factors","author":"Levine","year":"1994"},{"key":"10.1016\/j.nbd.2021.105546_bb0290","series-title":"Evaluation and Treatment of the Child with Febrile Seizure","author":"Millar","year":"2006"},{"key":"10.1016\/j.nbd.2021.105546_bb0295","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jchemneu.2009.05.009","article-title":"Morphological reorganization after repeated corticosterone administration in the hippocampus, nucleus accumbens and amygdala in the rat","volume":"38","author":"Morales-Medina","year":"2009","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.nbd.2021.105546_bb0300","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1210\/edrv-5-1-25","article-title":"Physiological functions of glucocorticoids in stress and their relation to pharmacological actions","volume":"5","author":"Munck","year":"1984","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.nbd.2021.105546_bb0305","author":"National Institutes of Health"},{"key":"10.1016\/j.nbd.2021.105546_bb0310","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM197611042951901","article-title":"Predictors of epilepsy in children who have experienced febrile seizures","volume":"295","author":"Nelson","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2021.105546_bb0315","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1460-9568.2010.07159.x","article-title":"N-methyl-d-aspartate, hyperpolarization-activated cation current (I h) and -aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus","volume":"31","author":"Ouardouz","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105546_bb0320","doi-asserted-by":"crossref","DOI":"10.1080\/10253890.2017.1369523","article-title":"Hypothalamic\u2013pituitary\u2013adrenal and hypothalamic\u2013pituitary\u2013gonadal axes: sex differences in regulation of stress responsivity","author":"Oyola","year":"2017","journal-title":"Stress."},{"key":"10.1016\/j.nbd.2021.105546_bb0325","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11011-012-9300-3","article-title":"Exposure to prenatal stress enhances the development of seizures in young rats","volume":"27","author":"Qulu","year":"2012","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.nbd.2021.105546_bb0330","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.brainres.2015.07.040","article-title":"Exposure to prenatal stress has deleterious effects on hippocampal function in a febrile seizure rat model","volume":"1624","author":"Qulu","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105546_bb0335","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation: II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"issue":"9","key":"10.1016\/j.nbd.2021.105546_bb9090","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/0028-3908(94)90147-3","article-title":"Sensitivity of the circadian rhythm of kainic acid-induced convulsion susceptibility to manipulations of corticosterone levels and mineralocorticoid receptor binding","volume":"33","author":"Roberts","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2021.105546_bb0340","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.yebeh.2010.04.016","article-title":"Prenatal stress potentiates pilocarpine-induced epileptic behaviors in infant rats both time and sex dependently","volume":"18","author":"Sadaghiani","year":"2010","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2021.105546_bb0345","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1111\/j.1528-1167.2007.01246.x","article-title":"Early postnatal stress confers enduring vulnerability to limbic Epileptogenesis","volume":"48","author":"Salzberg","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105546_bb0350","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1111\/j.1528-1167.2010.02689.x","article-title":"Interneuron subtype specific activation of mGluR15 during epileptiform activity in hippocampus","volume":"51","author":"Sanon","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105546_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/342928","article-title":"Atypical febrile seizures, mesial temporal lobe epilepsy, and dual pathology","volume":"2012","author":"Sanon","year":"2012","journal-title":"Epilepsy Res. Treat."},{"key":"10.1016\/j.nbd.2021.105546_bb0360","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/B978-0-12-804066-9.00045-6","article-title":"Poststatus epilepticus models: hyperthermia","author":"Sanon","year":"2017","journal-title":"Model. Seizures Epilepsy"},{"key":"10.1016\/j.nbd.2021.105546_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/0165-0173(86)90010-X","article-title":"Maturation of the adrenocortical stress response: neuroendocrine control mechanisms and the stress hyporesponsive period","author":"Sapolsky","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105546_bb0370","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.0013-9580.2004.51503.x","article-title":"Freeze lesion\u2013induced focal cortical dysplasia predisposes to atypical Hyperthermic seizures in the immature rat","volume":"45","author":"Scantlebury","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105546_bb0375","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ana.20512","article-title":"Febrile seizures in the predisposed brain: a new model of temporal lobe epilepsy","volume":"58","author":"Scantlebury","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2021.105546_bb0380","doi-asserted-by":"crossref","DOI":"10.1007\/s11910-007-0053-z","article-title":"The neurobiology of epilepsy","author":"Scharfman","year":"2007","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.nbd.2021.105546_bb0385","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000123058","article-title":"Maturation of adrenal stress responsiveness in the rat","volume":"31","author":"Schoenfeld","year":"1980","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.nbd.2021.105546_bb0390","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pbb.2004.04.012","article-title":"Corticosterone increases spike-wave discharges in a dose- and time-dependent manner in WAG\/Rij rats","volume":"78","author":"Schridde","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nbd.2021.105546_bb0395","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/j.1471-4159.2011.07630.x","article-title":"Sex differences in microglial colonization of the developing rat brain","volume":"120","author":"Schwarz","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105546_bb0400","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1113\/jphysiol.2004.078212","article-title":"Postnatal masculinization alters the HPA axis phenotype in the adult female rat","volume":"563","author":"Seale","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2021.105546_bb0405","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0165-3806(94)90130-9","article-title":"Sex differences in hypothalamic-pituitary-adrenal responding to endotoxin challenge in the neonate: reversal by gonadectomy","volume":"79","author":"Shanks","year":"1994","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.nbd.2021.105546_bb0410","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.psych.57.102904.190205","article-title":"Stressful experience and learning across the llFESPAN","author":"Shors","year":"2006","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.nbd.2021.105546_bb0415","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1177\/0883073814533004","article-title":"Symptomatic neonatal seizures followed by febrile status epilepticus: the two-hit hypothesis for the subsequent development of epilepsy","volume":"30","author":"Spagnoli","year":"2015","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.nbd.2021.105546_bb0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.2040-4603.2021.tb00175.x","article-title":"Sex-specific effects of stress on respiratory control: plasticity, adaptation, and dysfunction","volume":"11","author":"Tenorio-Lopes","year":"2021","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.nbd.2021.105546_bb0425","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2018.00003","article-title":"Stress and corticosteroids aggravate morphological changes in the dentate gyrus after early-life experimental febrile seizures in mice","volume":"9","author":"van Campen","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.nbd.2021.105546_bb0430","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1210\/endo-128-3-1385","article-title":"The pituitary-adrenocortical system of neonatal rats is responsive to stress throughout development in a time- dependent and stressor-specific fashion","volume":"128","author":"Walker","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.nbd.2021.105546_bb9088","article-title":"Sex and inhibition: role of sex hormones during the development of the hippocampal GABAergic network","author":"Wolf","year":"2019","journal-title":"Society for Neuroscience. Chicago, IL, USA"},{"key":"10.1016\/j.nbd.2021.105546_bb0435","doi-asserted-by":"crossref","DOI":"10.1097\/01.mop.0000140997.24408.53","article-title":"Pediatric stress-related seizures: conceptualization, evaluation, and treatment of nonepileptic seizures in children and adolescents","author":"Wood","year":"2004","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.nbd.2021.105546_bb0440","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/10253890.2010.532576","article-title":"Early life infection alters adult BALB\/c hippocampal gene expression in a sex specific manner","volume":"14","author":"Wynne","year":"2011","journal-title":"Stress"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121002953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121002953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:30:29Z","timestamp":1760851829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996121002953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":91,"alternative-id":["S0969996121002953"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105546","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in the developing brain impact stress-induced epileptogenicity following hyperthermia-induced seizures","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105546","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105546"}}