{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:17:19Z","timestamp":1793492239015,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE17-0023-01"],"award-info":[{"award-number":["ANR-18-CE17-0023-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007586","name":"Aix-Marseille Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003135","name":"Fondation Fyssen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003135","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.nbd.2021.105547","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T11:51:26Z","timestamp":1636199486000},"page":"105547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Substantial outcome improvement using a refined pilocarpine mouse model of temporal lobe epilepsy"],"prefix":"10.1016","volume":"161","author":[{"given":"Alexandre","family":"Vigier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Partouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois J.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Cr\u00e9pel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Marissal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2021.105547_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04557","article-title":"The evolution of the pilocarpine animal model of status epilepticus","volume":"6","author":"Ahmed Juvale","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.nbd.2021.105547_bb0010","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa4050","article-title":"Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models","volume":"7","author":"Aiba","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2021.105547_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/bs8080065","article-title":"Acute administration of caffeine: the effect on motor coordination, higher brain cognitive functions, and the social behavior of BLC57 mice","volume":"8","author":"Almosawi","year":"2018","journal-title":"Behav. Sci."},{"key":"10.1016\/j.nbd.2021.105547_bb0020","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1528-1157.1999.tb02011.x","article-title":"Correlations between granule cell dispersion, mossy fiber sprouting, and hippocampal cell loss in temporal lobe epilepsy","volume":"40","author":"Bahh","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105547_bb0025","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbr.2012.02.004","article-title":"Generation and characterization of pilocarpine-sensitive C57BL\/6 mice as a model of temporal lobe epilepsy","volume":"230","author":"Bankstahl","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa9854","article-title":"Spreading depression: Epilepsy\u2019s wave of death","volume":"7","author":"Bernard","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2021.105547_bb0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neulet.2009.02.035","article-title":"Age dependent mortality in the pilocarpine model of status epilepticus","volume":"453","author":"Blair","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2021.105547_bb0040","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.eplepsyres.2012.05.012","article-title":"Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy","volume":"102","author":"Buckmaster","year":"2012","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0045","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1523\/JNEUROSCI.22-15-06650.2002","article-title":"Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit","volume":"22","author":"Buckmaster","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105547_bb0050","series-title":"The Neuroscientist","article-title":"Seizing control: from current treatments to optogenetic interventions in epilepsy","author":"Bui","year":"2015"},{"key":"10.1016\/j.nbd.2021.105547_bb0055","first-page":"257","article-title":"The role of phosphodiesterase inhibitors in the management of pulmonary vascular diseases","volume":"2014","author":"Butrous","year":"2014","journal-title":"Glob. Cardiol. Sci. Pract."},{"key":"10.1016\/j.nbd.2021.105547_bb0060","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1528-1157.1991.tb05533.x","article-title":"Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous I recurrent seizures","volume":"32","author":"Cavalheiro","year":"1991","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105547_bb0065","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/j.1528-1157.1996.tb00541.x","article-title":"The pilocarpine model of epilepsy in mice","volume":"37","author":"Cavalheiro","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105547_bb0070","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12264-013-1310-6","article-title":"One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death","volume":"29","author":"Chen","year":"2013","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.nbd.2021.105547_bb0075","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.coph.2014.11.012","article-title":"Physiopathology of kainate receptors in epilepsy","volume":"20","author":"Cr\u00e9pel","year":"2015","journal-title":"Curr. Opin. Pharmacol. Neurosci."},{"key":"10.1016\/j.nbd.2021.105547_bb0080","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jneumeth.2008.04.019","article-title":"The pilocarpine model of temporal lobe epilepsy","volume":"172","author":"Curia","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2021.105547_bb0085","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0920-1211(01)00272-8","article-title":"Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy","volume":"46","author":"Glien","year":"2001","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0090","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/j.1460-9568.1994.tb00569.x","article-title":"Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the rat hippocampal network","volume":"6","author":"Grabs","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105547_bb0095","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.expneurol.2007.06.021","article-title":"Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice","volume":"207","author":"Gr\u00f6ticke","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105547_bb0100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.expneurol.2008.04.036","article-title":"Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate","volume":"213","author":"Gr\u00f6ticke","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105547_bb0105","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/j.1528-1167.2005.63904.x","article-title":"Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats","volume":"46","author":"Hoexter","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105547_bb0110","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jneumeth.2015.04.011","article-title":"Chemically-induced TLE models: topical application","volume":"260","author":"Jefferys","year":"2016","journal-title":"J. Neurosci. Methods Models Epilepsy Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0115","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0920-1211(02)00085-2","article-title":"Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus","volume":"50","author":"Jones","year":"2002","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms2376","article-title":"On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy","volume":"4","author":"Krook-Magnuson","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105547_bb0125","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00230647","article-title":"Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats","volume":"102","author":"Lemos","year":"1995","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jneumeth.2015.03.009","article-title":"Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration","volume":"260","author":"L\u00e9vesque","year":"2016","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2021.105547_bb0135","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1111\/j.1528-1167.2012.03584.x","article-title":"Reduction in delayed mortality and subtle improvement in retrograde memory performance in pilocarpine-treated mice with conditional neuronal deletion of cyclooxygenase-2 gene","volume":"53","author":"Levin","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105547_bb0140","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jneumeth.2015.09.007","article-title":"Opportunities for improving animal welfare in rodent models of epilepsy and seizures","volume":"260","author":"Lidster","year":"2016","journal-title":"J. Neurosci. Methods Models Epilepsy Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194552","article-title":"Clustering of spontaneous recurrent seizures separated by long seizure-free periods: an extended video-EEG monitoring study of a pilocarpine mouse model","volume":"13","author":"Lim","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105547_bb0150","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.physbeh.2009.09.005","article-title":"A revised Racine\u2019s scale for PTZ-induced seizures in rats","volume":"98","author":"L\u00fcttjohann","year":"2009","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.nbd.2021.105547_bb0155","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0179-18.2019","article-title":"Effects of single cage housing on stress, cognitive, and seizure parameters in the rat and mouse pilocarpine models of epilepsy","volume":"6","author":"Manouze","year":"2019","journal-title":"eNeuro"},{"key":"10.1016\/j.nbd.2021.105547_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurol.2021.02.390","article-title":"An inventory of basic research in temporal lobe epilepsy","author":"Marissal","year":"2021","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.nbd.2021.105547_bb0165","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/B978-0-12-801022-8.00011-8","article-title":"Adenosine receptors and epilepsy: current evidence and future potential","volume":"119","author":"Masino","year":"2014","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.nbd.2021.105547_bb0170","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.expneurol.2012.08.022","article-title":"Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization","volume":"238","author":"Mazzuferi","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105547_bb0175","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/hipo.20726","article-title":"Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy","volume":"21","author":"McAuliffe","year":"2011","journal-title":"Hippocampus"},{"key":"10.1016\/j.nbd.2021.105547_bb0180","first-page":"51","article-title":"Granule cell dispersion in relation to mossy fiber sprouting, hippocampal cell loss, silent period and seizure frequency in the pilocarpine model of epilepsy","volume":"9","author":"Mello","year":"1992","journal-title":"Epilepsy Res. Suppl."},{"key":"10.1016\/j.nbd.2021.105547_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147265","article-title":"A low mortality, high morbidity reduced intensity status epilepticus (RISE) model of epilepsy and epileptogenesis in the rat","volume":"11","author":"Modebadze","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105547_bb0190","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1601-183X.2009.00490.x","article-title":"Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL\/6 mice","volume":"8","author":"M\u00fcller","year":"2009","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2021.105547_bb0195","doi-asserted-by":"crossref","first-page":"107728","DOI":"10.1016\/j.neuropharm.2019.107728","article-title":"Changes in excitatory and inhibitory receptor expression and network activity during induction and establishment of epilepsy in the rat reduced intensity status epilepticus (RISE) model","volume":"158","author":"Needs","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2021.105547_bb0200","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.celrep.2014.06.032","article-title":"Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy","volume":"8","author":"Peret","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2021.105547_bb0205","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.eplepsyres.2015.09.008","article-title":"Pilocarpine-induced status epilepticus in mice: a comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale","volume":"117","author":"Phelan","year":"2015","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0210","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0014-4886(78)90133-4","article-title":"Experimental epileptogenesis: kindling-induced epilepsy in rats","volume":"58","author":"Pinel","year":"1978","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2021.105547_bb0215","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation: II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.nbd.2021.105547_bb0220","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0006-8993(97)01285-7","article-title":"NMDA receptor activation during status epilepticus is required for the development of epilepsy","volume":"782","author":"Rice","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0225","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.1528-1157.2003.50502.x","article-title":"Prolonged low-dose caffeine exposure protects against hippocampal damage but not against the occurrence of epilepsy in the lithium-pilocarpine model in the rat","volume":"44","author":"Rigoulot","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105547_bb0230","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1111\/j.1528-1167.2010.02554.x","article-title":"Increased seizure severity and seizure-related death in mice lacking HCN1 channels","volume":"51","author":"Santoro","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105547_bb0235","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/hipo.20914","article-title":"Drebrin a expression is altered after pilocarpine-induced seizures: time course of changes is consistent for a role in the integrity and stability of dendritic spines of hippocampal granule cells","volume":"22","author":"Sbai","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.nbd.2021.105547_bb0240","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/cne.10449","article-title":"Structural and functional asymmetry in the normal and epileptic rat dentate gyrus","volume":"454","author":"Scharfman","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2021.105547_bb0245","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.nbd.2011.08.013","article-title":"Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus","volume":"45","author":"Schauwecker","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105547_bb0250","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1528-1167.2009.02248.x","article-title":"A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance","volume":"51","author":"Shen","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2021.105547_bb0255","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0920-1211(02)00012-8","article-title":"Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL\/6 and CD-1 mice","volume":"49","author":"Shibley","year":"2002","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0260","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/cne.10371","article-title":"Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons","volume":"452","author":"Singec","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2021.105547_bb0265","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0166-4328(83)90136-5","article-title":"Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study","volume":"9","author":"Turski","year":"1983","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2021.105547_bb0270","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1073\/pnas.1814185115","article-title":"Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration","volume":"116","author":"Upadhya","year":"2019","journal-title":"PNAS"},{"key":"10.1016\/j.nbd.2021.105547_bb0275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.yebeh.2019.02.029","article-title":"PTZ-induced seizures in mice require a revised Racine scale","volume":"95","author":"Van Erum","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2021.105547_bb0280","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2019.00971","article-title":"FK506 attenuated pilocarpine-induced epilepsy by reducing inflammation in rats","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2021.105547_bb0285","doi-asserted-by":"crossref","first-page":"12676","DOI":"10.1073\/pnas.94.23.12676","article-title":"Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey","volume":"94","author":"Wenzel","year":"1997","journal-title":"PNAS"},{"key":"10.1016\/j.nbd.2021.105547_bb0290","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.neuroscience.2007.06.009","article-title":"Acute and chronic responses to the convulsant pilocarpine in DBA\/2J and A\/J mice","volume":"149","author":"Winawer","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2021.105547_bb0295","article-title":"Points of view: color blindness [WWW document]","author":"Wong","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2021.105547_bb0300","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s002130050037","article-title":"The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A 2A adenosine receptor antagonists","volume":"148","author":"Yacoubi","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nbd.2021.105547_bb0305","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1476-5381.2009.00185.x","article-title":"cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies","volume":"158","author":"Zaccolo","year":"2009","journal-title":"Br. J. Pharmacol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121002965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121002965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:29:37Z","timestamp":1760851777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996121002965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":61,"alternative-id":["S0969996121002965"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105547","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Substantial outcome improvement using a refined pilocarpine mouse model of temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105547"}}