{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:05:41Z","timestamp":1790996741740,"version":"4.1.0"},"reference-count":230,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.nbd.2021.105580","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T21:30:03Z","timestamp":1638567003000},"page":"105580","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Multi-omic insights into Parkinson's Disease: From genetic associations to functional mechanisms"],"prefix":"10.1016","volume":"163","author":[{"given":"Brian M.","family":"Schilder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Towfique","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2021.105580_bb0005","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.cell.2016.11.048","article-title":"A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response","volume":"167","author":"Adamson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105580_bb0010","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1038\/s41467-018-04252-2","article-title":"The CRISPR tool kit for genome editing and beyond","volume":"9","author":"Adli","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0015","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1038\/s41467-020-17876-0","article-title":"A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders","volume":"11","author":"Agarwal","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41431-021-00813-0","article-title":"Polygenic risk modeling with latent trait-related genetic components","author":"Aguirre","year":"2021","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.devcel.2018.09.013","article-title":"Combining developmental and perturbation-Seq uncovers transcriptional modules orchestrating neuronal remodeling","volume":"47","author":"Alyagor","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.nbd.2021.105580_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/ana.26032","article-title":"Heritability enrichment implicates microglia in Parkinson\u2019s disease pathogenesis","author":"Andersen","year":"2021","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0035","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1242\/dmm.025684","article-title":"Immortalized Parkinson\u2019s disease lymphocytes have enhanced mitochondrial respiratory activity","volume":"9","author":"Annesley","year":"2016","journal-title":"Dis. Model. Mech."},{"issue":"6","key":"10.1016\/j.nbd.2021.105580_bb0040","first-page":"673","article-title":"Inflammation and infection in Parkinson`s disease","volume":"21","author":"Arai","year":"2006","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.nbd.2021.105580_bb0045","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41587-019-0140-0","article-title":"The Kipoi repository accelerates community exchange and reuse of predictive models for genomics","volume":"37","author":"Avsec","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.nbd.2021.105580_bb0050","first-page":"1196","article-title":"Effective gene expression prediction from sequence by integrating long-range interactions","volume":"18","author":"Avsec","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2021.105580_bb0055","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.3390\/ijms22094676","article-title":"The contribution of microglia to neuroinflammation in Parkinson\u2019s Disease","volume":"22","author":"Badanjak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2021.105580_bb0060","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/mds.870130205","article-title":"Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson\u2019s disease","volume":"13","author":"Banati","year":"1998","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105580_bb0065","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/mds.27614","article-title":"The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson\u2019s disease","volume":"34","author":"Bandres-Ciga","year":"2019","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105580_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104782","article-title":"Genetics of Parkinson\u2019s disease: an introspection of its journey towards precision medicine","volume":"137","author":"Bandres-Ciga","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0075","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-020-02181-3","article-title":"Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease","author":"Bandres-Ciga","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105580_bb0080","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/bioinformatics\/btw018","article-title":"FINEMAP: efficient variable selection using summary data from genome-wide association studies","volume":"32","author":"Benner","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2021.105580_bb0085","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ajhg.2017.08.012","article-title":"Prospects of fine-mapping trait-associated genomic regions by using summary statistics from genome-wide association studies","volume":"101","author":"Benner","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0090","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1038\/s41467-019-11950-y","article-title":"Identification of significant chromatin contacts from HiChIP data by FitHiChIP","volume":"10","author":"Bhattacharyya","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0095","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41531-019-0080-x","article-title":"Mitochondria function associated genes contribute to Parkinson\u2019s Disease risk and later age at onset","volume":"5","author":"Billingsley","year":"2019","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0100","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.228114","article-title":"Autophagy and endocytosis \u2013 interconnections and interdependencies","volume":"133","author":"Birgisdottir","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2021.105580_bb0105","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","article-title":"The genetic architecture of Parkinson\u2019s disease","volume":"19","author":"Blauwendraat","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0110","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf5759","article-title":"The coding and long noncoding single-cell atlas of the developing human fetal striatum","volume":"372","author":"Bocchi","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0115","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41586-020-03145-z","article-title":"Regulatory genomic circuitry of human disease loci by integrative epigenomics","volume":"590","author":"Boix","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105580_bb0120","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.3233\/JPD-179001","article-title":"Neuropathological staging of brain pathology in sporadic Parkinson\u2019s disease: separating the wheat from the chaff","volume":"7","author":"Braak","year":"2017","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0125","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2021.105580_bb0130","article-title":"The foundational data initiative for Parkinsons disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanism","author":"Bressan","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2021.105580_bb0135","first-page":"182","article-title":"Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease","volume":"119","author":"Brochard","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2021.105580_bb0140","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.190221","article-title":"A practical view of fine-mapping and gene prioritization in the post-genome-wide association era","volume":"10","author":"Broekema","year":"2020","journal-title":"Open Biol."},{"key":"10.1016\/j.nbd.2021.105580_bb0145","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41588-020-0610-9","article-title":"Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson\u2019s disease","volume":"52","author":"Bryois","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0150","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.aam9080","article-title":"Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson\u2019s disease","volume":"357","author":"Burbulla","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0155","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105580_bb0160","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba7721","article-title":"A human cell atlas of fetal gene expression","volume":"370","author":"Cao","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0165","doi-asserted-by":"crossref","first-page":"D1056","DOI":"10.1093\/nar\/gky1133","article-title":"Open targets platform: new developments and updates two years on","volume":"47","author":"Carvalho-Silva","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2021.105580_bb0170","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/ng.3955","article-title":"A meta-analysis of genome-wide association studies identifies 17 new Parkinson\u2019s disease risk loci","volume":"49","author":"Chang","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0175","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.molcel.2017.09.014","article-title":"Randomized CRISPR-Cas transcriptional perturbation screening reveals protective genes against alpha-Synuclein toxicity","volume":"68","author":"Chen","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2021.105580_bb0180","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1017\/S0317167100012695","article-title":"Cytokine gene polymorphisms and Parkinson\u2019s disease: a meta-analysis","volume":"39","author":"Chu","year":"2012","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2021.105580_bb0185","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-021-02326-5","article-title":"Towards physiologically relevant human pluripotent stem cell (hPSC) models of Parkinson\u2019s disease","volume":"12","author":"Coccia","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.nbd.2021.105580_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/srep30509","article-title":"Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson\u2019s disease etiology","volume":"6","author":"Coetzee","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105580_bb0195","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0200","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41531-017-0010-8","article-title":"LRRK2 levels in immune cells are increased in Parkinson\u2019s disease","volume":"3","author":"Cook","year":"2017","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0205","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/s41588-020-00721-x","article-title":"Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"52","author":"Corces","year":"2020","journal-title":"Nat. Genet."},{"issue":"Pt 8","key":"10.1016\/j.nbd.2021.105580_bb0210","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/brain\/122.8.1437","article-title":"The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson\u2019s disease","volume":"122","author":"Damier","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2021.105580_bb0215","first-page":"165","article-title":"Parkinson\u2019s Disease society brain Bank, London: overview and research","volume":"39","author":"Daniel","year":"1993","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.nbd.2021.105580_bb0220","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1038\/s41467-020-18515-4","article-title":"Evaluating the informativeness of deep learning annotations for human complex diseases","volume":"11","author":"Dey","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128651","article-title":"Evidence for immune response, axonal dysfunction and reduced endocytosis in the substantia Nigra in early stage Parkinson\u2019s Disease","volume":"10","author":"Dijkstra","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105580_bb0230","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.cell.2016.11.038","article-title":"Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens","volume":"167","author":"Dixit","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105580_bb0235","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1600-0404.1999.tb00721.x","article-title":"Association of circulating TNF-\u03b1 and IL-6 with ageing and parkinsonism","volume":"100","author":"Dobbs","year":"1999","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.nbd.2021.105580_bb0240","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba7612","article-title":"A human cell atlas of fetal chromatin accessibility","volume":"370","author":"Domcke","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0245","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1212\/01.wnl.0000247740.47667.03","article-title":"Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030","volume":"68","author":"Dorsey","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2021.105580_bb0250","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1038\/s41467-019-11112-0","article-title":"Analysis of polygenic risk score usage and performance in diverse human populations","volume":"10","author":"Duncan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0255","article-title":"The MRC IEU OpenGWAS data infrastructure","author":"Elsworth","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2021.105580_bb0260","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41576-019-0122-6","article-title":"Deep learning: new computational modelling techniques for genomics","volume":"20","author":"Eraslan","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0265","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.2174\/0929867321666140601163658","article-title":"Fetal programming of the human brain: is there a link with insurgence of neurodegenerative disorders in adulthood?","volume":"21","author":"Faa","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.nbd.2021.105580_bb0270","doi-asserted-by":"crossref","first-page":"1246949","DOI":"10.1126\/science.1246949","article-title":"Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression","volume":"343","author":"Fairfax","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0275","series-title":"Introduction to Quantitative Genetics","author":"Falconer","year":"1996"},{"key":"10.1016\/j.nbd.2021.105580_bb0280","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/cr.2016.137","article-title":"Mapping of long-range chromatin interactions by proximity ligation-assisted ChIP-seq","volume":"26","author":"Fang","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.nbd.2021.105580_bb0285","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature13835","article-title":"Genetic and epigenetic fine mapping of causal autoimmune disease variants","volume":"518","author":"Farh","year":"2015","journal-title":"Nature"},{"issue":"Pt 5","key":"10.1016\/j.nbd.2021.105580_bb0290","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and Parkinson\u2019s disease: substantia nigra regional selectivity","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2021.105580_bb0295","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.15252\/emmm.201505439","article-title":"Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson\u2019s disease patients","volume":"7","author":"Fern\u00e1ndez-Santiago","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2021.105580_bb0300","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13148-019-0701-6","article-title":"Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson\u2019s disease patients","volume":"11","author":"Fern\u00e1ndez-Santiago","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.nbd.2021.105580_bb0305","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41588-020-0596-3","article-title":"Modeling the complex genetic architectures of brain disease","volume":"52","author":"Fernando","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0310","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.3404","article-title":"Partitioning heritability by functional annotation using genome-wide association summary statistics","volume":"47","author":"Finucane","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0315","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.stemcr.2013.08.001","article-title":"Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells","volume":"1","author":"Fong","year":"2013","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.nbd.2021.105580_bb0320","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/nn.4399","article-title":"Gene expression elucidates functional impact of polygenic risk for schizophrenia","volume":"19","author":"Fromer","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb0325","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/s41588-019-0538-0","article-title":"Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations","volume":"51","author":"Fulco","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0330","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/acn3.369","article-title":"Genomics implicates adaptive and innate immunity in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"3","author":"Gagliano","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0335","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3389\/fneur.2020.01005","article-title":"Patient-derived midbrain organoids to explore the molecular basis of Parkinson\u2019s Disease","volume":"11","author":"Galet","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0340","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1093\/brain\/awaa269","article-title":"CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson\u2019s disease","volume":"143","author":"Galiano-Landeira","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2021.105580_bb0345","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ng.3367","article-title":"A gene-based association method for mapping traits using reference transcriptome data","volume":"47","author":"Gamazon","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0350","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fneur.2017.00157","article-title":"Parkinson Disease: an evolutionary perspective","volume":"8","author":"Garcia-Ruiz","year":"2017","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0355","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3389\/fimmu.2019.00303","article-title":"Autoimmunity in Parkinson\u2019s Disease: the role of \u03b1-Synuclein-specific T cells","volume":"10","author":"Garretti","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2021.105580_bb0360","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41467-020-20578-2","article-title":"Identification and analysis of splicing quantitative trait loci across multiple tissues in the human genome","volume":"12","author":"Garrido-Mart\u00edn","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0365","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.abf7266","article-title":"CD4+ T cells contribute to neurodegeneration in Lewy body dementia","volume":"374","author":"Gate","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0370","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.nbd.2005.08.002","article-title":"In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson\u2019s disease","volume":"21","author":"Gerhard","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0380","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/ana.25441","article-title":"Concordance for Parkinson\u2019s disease in twins: a 20-year update","volume":"85","author":"Goldman","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0385","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal3222","article-title":"An environment-dependent transcriptional network specifies human microglia identity","volume":"356","author":"Gosselin","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0390","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ng.3259","article-title":"Understanding multicellular function and disease with human tissue-specific networks","volume":"47","author":"Greene","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0395","doi-asserted-by":"crossref","DOI":"10.1002\/mds.28197","article-title":"The Parkinson\u2019s Disease genome-wide association study locus browser","author":"Grenn","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105580_bb0400","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00401-014-1345-4","article-title":"Inflammatory dysregulation of blood monocytes in Parkinson\u2019s disease patients","volume":"128","author":"Grozdanov","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105580_bb0405","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/ana.25557","article-title":"Increased immune activation by pathologic \u03b1-Synuclein in Parkinson\u2019s Disease","volume":"86","author":"Grozdanov","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0410","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"Human genomics. The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"GTEx Consortium","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0415","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0420","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41588-018-0092-1","article-title":"Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights","volume":"50","author":"Gusev","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0425","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ng.642","article-title":"Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson\u2019s disease","volume":"42","author":"Hamza","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0430","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1008-1091","article-title":"The immunological genome project: networks of gene expression in immune cells","volume":"9","author":"Heng","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.nbd.2021.105580_bb0435","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-981-13-9913-8_13","article-title":"Microglia in Parkinson\u2019s Disease","volume":"1175","author":"Ho","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.nbd.2021.105580_bb0440","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fgene.2018.00238","article-title":"Application of causal inference to genomic analysis: advances in methodology","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0445","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/mds.21290","article-title":"Lower low-density lipoprotein cholesterol levels are associated with Parkinson\u2019s disease","volume":"22","author":"Huang","year":"2007","journal-title":"Mov. Disord."},{"issue":"5","key":"10.1016\/j.nbd.2021.105580_bb4000","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2144\/000112598","article-title":"The costs of using unauthenticated, over-passaged cell lines: how much more data do we need?","volume":"43","author":"Hughes","year":"2007","journal-title":"Biotechniques"},{"key":"10.1016\/j.nbd.2021.105580_bb0450","doi-asserted-by":"crossref","first-page":"R81","DOI":"10.1093\/hmg\/ddaa148","article-title":"Fine-mapping genetic associations","volume":"29","author":"Hutchinson","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0455","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00401-003-0766-2","article-title":"Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson\u2019s disease brains","volume":"106","author":"Imamura","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2021.105580_bb0460","series-title":"Accelerating Medicines Partnership: Parkinson\u2019s Disease","author":"Iwaki","year":"2020"},{"key":"10.1016\/j.nbd.2021.105580_bb0465","first-page":"503","article-title":"Evaluation of models of Parkinson\u2019s Disease","volume":"9","author":"Jagmag","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb0470","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-017-1147-9","article-title":"Discovery and functional prioritization of Parkinson\u2019s disease candidate genes from large-scale whole exome sequencing","volume":"18","author":"Jansen","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.nbd.2021.105580_bb0475","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz6063","article-title":"In vivo perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes","volume":"370","author":"Jin","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0480","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1006982","article-title":"MAPS: model-based analysis of long-range chromatin interactions from PLAC-seq and HiChIP experiments","volume":"15","author":"Juric","year":"2019","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.nbd.2021.105580_bb0485","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2021.105580_bb0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105028","article-title":"Microglia and astrocyte dysfunction in parkinson\u2019s disease","volume":"144","author":"Kam","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0495","article-title":"A molecular census of midbrain dopaminergic neurons in Parkinson\u2019s disease","author":"Kamath","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2021.105580_bb0500","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3233\/JPD-130250","article-title":"The role of innate and adaptive immunity in Parkinson\u2019s disease","volume":"3","author":"Kannarkat","year":"2013","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0505","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1093\/jxb\/49.327.1619","article-title":"The principles of QTL analysis (a minimal mathematics approach)","volume":"49","author":"Kearsey","year":"1998","journal-title":"J. Exp. Bot."},{"issue":"22","key":"10.1016\/j.nbd.2021.105580_bb0510","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1093\/hmg\/dds335","article-title":"Using genome-wide complex trait analysis to quantify \u201cmissing heritability\u201din Parkinson\u2019s disease","volume":"21","author":"Keller","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0515","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1101\/gr.227819.117","article-title":"Sequential regulatory activity prediction across chromosomes with convolutional neural networks","volume":"28","author":"Kelley","year":"2018","journal-title":"Genome Res."},{"key":"10.1016\/j.nbd.2021.105580_bb0520","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jamaneurol.2020.5257","article-title":"Identification of candidate Parkinson Disease genes by integrating genome-wide association study, expression, and epigenetic data sets","volume":"78","author":"Kia","year":"2021","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0525","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/bioinformatics\/btw615","article-title":"Improved methods for multi-trait fine mapping of pleiotropic risk loci","volume":"33","author":"Kichaev","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2021.105580_bb0530","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/B978-0-444-63916-5.00011-2","article-title":"Parkinson disease","volume":"159","author":"Kim","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0535","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.stemcr.2019.01.020","article-title":"Modeling G2019S-LRRK2 sporadic Parkinson\u2019s Disease in 3D midbrain organoids","volume":"12","author":"Kim","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.nbd.2021.105580_bb0540","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1038\/s41467-020-17155-y","article-title":"Deep learning for genomics using Janggu","volume":"11","author":"Kopp","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0545","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neuroscience.2014.03.045","article-title":"Linking pathways in the developing and aging brain with neurodegeneration","volume":"269","author":"Kovacs","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2021.105580_bb0560","article-title":"Association of a Common Genetic Variant with Parkinson\u2019s Disease is propagated through microglia","author":"Langston","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2021.105580_bb0565","article-title":"Association of a common genetic variant with Parkinson\u2019s Disease is propagated through microglia","author":"Langston","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2021.105580_bb0570","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: generalized gene-set analysis of GWAS data","volume":"11","author":"de Leeuw","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.nbd.2021.105580_bb0575","doi-asserted-by":"crossref","first-page":"R48","DOI":"10.1093\/hmg\/ddp012","article-title":"Parkinson\u2019s disease: from monogenic forms to genetic susceptibility factors","volume":"18","author":"Lesage","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0580","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0030098","article-title":"A genomic pathway approach to a complex disease: axon guidance and Parkinson disease","volume":"3","author":"Lesnick","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0585","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000333222","article-title":"Subsequent risks of Parkinson disease in patients with autoimmune and related disorders: a nationwide epidemiological study from Sweden","volume":"10","author":"Li","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0590","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature24267","article-title":"The impact of rare variation on gene expression across tissues","volume":"550","author":"Li","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105580_bb0595","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/s41467-019-08912-9","article-title":"Prioritizing Parkinson\u2019s disease genes using population-scale transcriptomic data","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0600","article-title":"Characterizing the expression patterns of Parkinson\u2019s Disease associated genes","volume":"15","author":"Li","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb0605","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1126\/science.1181369","article-title":"Comprehensive mapping of long-range interactions reveals folding principles of the human genome","volume":"326","author":"Lieberman-Aiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0610","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002548","article-title":"Comprehensive research synopsis and systematic meta-analyses in Parkinson\u2019s disease genetics: the PDGene database","volume":"8","author":"Lill","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0615","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00439-019-02044-2","article-title":"Identifying causal variants and genes using functional genomics in specialized cell types and contexts","volume":"139","author":"Liu","year":"2020","journal-title":"Hum. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0620","article-title":"EpiGraphDB: a database and data mining platform for health data science","author":"Liu","year":"2020","journal-title":"Bioinformatics."},{"key":"10.1016\/j.nbd.2021.105580_bb0625","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ana.26153","article-title":"Characterizing the genetic architecture of Parkinson\u2019s Disease in Latinos","volume":"90","author":"Loesch","year":"2021","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0630","series-title":"GenoML: Automated Machine Learning for Genomics. arXiv [cs.LG]","author":"Makarious","year":"2021"},{"key":"10.1016\/j.nbd.2021.105580_bb0635","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192497","article-title":"Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson\u2019s disease","volume":"13","author":"Marrone","year":"2018","journal-title":"PLoS One"},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2021.105580_bb0640","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.parkreldis.2004.01.005","article-title":"Inflammation and neurodegeneration in Parkinson\u2019s disease","volume":"10","author":"McGeer","year":"2004","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2021.105580_bb0645","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson\u2019s and Alzheimer\u2019s disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2021.105580_bb0655","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1093\/bioinformatics\/bty999","article-title":"Global biobank engine: enabling genotype-phenotype browsing for biobank summary statistics","volume":"35","author":"McInnes","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2021.105580_bb0660","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0306-4522(99)00455-8","article-title":"The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson\u2019s disease","volume":"95","author":"Mirza","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2021.105580_bb0665","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/0006-291X(89)91141-8","article-title":"Deficiencies in complex I subunits of the respiratory chain in Parkinson\u2019s disease","volume":"163","author":"Mizuno","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0670","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0304-3940(94)90746-3","article-title":"Tumor necrosis factor-\u03b1 (TNF-\u03b1) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients","volume":"165","author":"Mogi","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2021.105580_bb0675","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0304-3940(95)11686-Q","article-title":"Transforming growth factor-\u03b21 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson\u2019s disease","volume":"193","author":"Mogi","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2021.105580_bb0680","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10048-005-0020-2","article-title":"Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson\u2019s disease","volume":"7","author":"Moran","year":"2006","journal-title":"Neurogenetics"},{"key":"10.1016\/j.nbd.2021.105580_bb0685","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1212\/WNL.0b013e3181ff9685","article-title":"Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2","volume":"75","author":"Mortiboys","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2021.105580_bb0690","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biopsych.2020.06.011","article-title":"Massively parallel reporter assays: defining functional psychiatric genetic variants across biological contexts","volume":"89","author":"Mulvey","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2021.105580_bb0695","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nmeth.3999","article-title":"HiChIP: efficient and sensitive analysis of protein-directed genome architecture","volume":"13","author":"Mumbach","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2021.105580_bb0700","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1038\/ng.3963","article-title":"Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements","volume":"49","author":"Mumbach","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0705","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btab665","article-title":"MungeSumstats: a Bioconductor package for the standardisation and quality control of many GWAS summary statistics","author":"Murphy","year":"2021","journal-title":"Bioinformatics."},{"key":"10.1016\/j.nbd.2021.105580_bb0710","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/ng.3043","article-title":"Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson\u2019s disease","volume":"46","author":"Nalls","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0715","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","article-title":"Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies","volume":"18","author":"Nalls","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb0720","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41586-021-03446-x","article-title":"Genome-wide enhancer maps link risk variants to disease genes","volume":"593","author":"Nasser","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105580_bb0725","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/s43587-021-00110-x","article-title":"Dysregulation of mitochondrial and proteolysosomal genes in Parkinson\u2019s disease myeloid cells","volume":"1","author":"Navarro","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.nbd.2021.105580_bb0730","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000895","article-title":"Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations","volume":"6","author":"Nica","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0735","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1126\/science.aay0793","article-title":"Brain cell type\u2013specific enhancer\u2013promoter interactome maps and disease-risk association","volume":"366","author":"Nott","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0740","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00702-020-02184-0","article-title":"Missing heritability in Parkinson\u2019s disease: the emerging role of non-coding genetic variation","volume":"127","author":"Ohnmacht","year":"2020","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nbd.2021.105580_bb0745","doi-asserted-by":"crossref","DOI":"10.3390\/biom9080296","article-title":"The Michael J. Fox Foundation for Parkinson\u2019s Research strategy to advance therapeutic development of PINK1 and Parkin","volume":"9","author":"Padmanabhan","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.nbd.2021.105580_bb0750","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.neuron.2004.10.023","article-title":"Cloning of the gene containing mutations that cause PARK8-linked Parkinson\u2019s disease","volume":"44","author":"Pais\u00e1n-Ru\u00edz","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2021.105580_bb0755","article-title":"Atlas of genetic effects in human microglia transcriptome across brain regions, aging and disease pathologies","author":"de Paiva Lopes","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2021.105580_bb0760","article-title":"Single cell atlas of human putamen reveals disease specific changes in synucleinopathies: Parkinson\u2019s Disease and multiple system atrophy","author":"Pande","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2021.105580_bb0765","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nrg2641","article-title":"ChIP\u2013seq: advantages and challenges of a maturing technology","volume":"10","author":"Park","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0770","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.arr.2018.08.003","article-title":"Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence","volume":"47","author":"Park","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.nbd.2021.105580_bb0775","series-title":"An Essay on the Shaking Palsy","author":"Parkinson","year":"1817"},{"key":"10.1016\/j.nbd.2021.105580_bb0780","first-page":"1511","article-title":"A meta-analysis of genome-wide association studies identifies 17 new Parkinson\u2019s disease risk loci","volume":"49","author":"Parkinson\u2019s Disease Genomics","year":"2017","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2021.105580_bb0785","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrg.2016.142","article-title":"Dissecting the genetics of complex traits using summary association statistics","volume":"18","author":"Pasaniuc","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0790","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1038\/ncomms6890","article-title":"Biological interpretation of genome-wide association studies using predicted gene functions","volume":"6","author":"Pers","year":"2015","journal-title":"Nat. Commun."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2021.105580_bb0795","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1016\/S1353-8020(11)70064-5","article-title":"Neurodegeneration and inflammation in Parkinson\u2019s disease","volume":"18","author":"Phani","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2021.105580_bb0800","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, Parkin, and mitochondrial fidelity in Parkinson\u2019s Disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2021.105580_bb0805","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175882","article-title":"Parkinson\u2019s disease-associated genetic variation is linked to quantitative expression of inflammatory genes","volume":"12","author":"Pierce","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105580_bb0810","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175882","article-title":"Parkinson\u2019s disease-associated genetic variation is linked to quantitative expression of inflammatory genes","volume":"12","author":"Pierce","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105580_bb0815","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1038\/s41467-021-22648-5","article-title":"Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data","volume":"12","author":"Pintacuda","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0820","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.nbd.2021.105580_bb0825","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1038\/s41467-021-25805-y","article-title":"Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome","volume":"12","author":"Porcu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0830","article-title":"Limitations of animal models of Parkinson\u2019s disease","volume":"2011","author":"Potashkin","year":"2010","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0835","doi-asserted-by":"crossref","first-page":"E180","DOI":"10.1073\/pnas.1711023115","article-title":"Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy","volume":"115","author":"Potting","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2021.105580_bb0840","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/321275","article-title":"Linkage disequilibrium in humans: models and data","volume":"69","author":"Pritchard","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0845","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1126\/science.1249547","article-title":"Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes","volume":"344","author":"Raj","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0850","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1126\/science.1249547","article-title":"Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes","volume":"344","author":"Raj","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.nbd.2021.105580_bb0855","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/s41588-018-0238-1","article-title":"Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer\u2019s disease susceptibility","volume":"50","author":"Raj","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0860","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/nn.3801","article-title":"Genetic variability in the regulation of gene expression in ten regions of the human brain","volume":"17","author":"Ramasamy","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb0865","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008549","article-title":"Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs","volume":"16","author":"Ramdhani","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0870","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/omi.2017.0181","article-title":"From genomics to omics landscapes of Parkinson\u2019s Disease: revealing the molecular mechanisms","volume":"22","author":"Reden\u0161ek","year":"2018","journal-title":"OMICS"},{"key":"10.1016\/j.nbd.2021.105580_bb0875","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27041","article-title":"The human cell atlas","volume":"6","author":"Regev","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2021.105580_bb0880","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1600-0404.2007.00894.x","article-title":"Circulating interleukin-15 and RANTES chemokine in Parkinson\u2019s disease","volume":"116","author":"Rentzos","year":"2007","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.nbd.2021.105580_bb0885","first-page":"5","article-title":"Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson\u2019s disease heritability","author":"Reynolds","year":"2019","journal-title":"NPJ Parkinson\u2019s Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0890","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.66546","article-title":"Point of view: open science takes on Parkinson\u2019s disease","volume":"10","author":"Riley","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2021.105580_bb0895","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1093\/brain\/awx285","article-title":"Excessive burden of lysosomal storage disorder gene variants in Parkinson\u2019s disease","volume":"140","author":"Robak","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2021.105580_bb0900","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/mds.26438","article-title":"The NINDS Parkinson\u2019s disease biomarkers program","volume":"31","author":"Rosenthal","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105580_bb0905","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002367","article-title":"Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans","volume":"7","author":"Rotival","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0910","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.cell.2013.12.004","article-title":"Isogenic human iPSC Parkinson\u2019s model shows nitrosative stress-induced dysfunction in MEF2-PGC1\u03b1 transcription","volume":"155","author":"Ryan","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105580_bb0915","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/emmm.201200215","article-title":"Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson\u2019s disease: iPS cell-based model of Parkinson\u2019s disease","volume":"4","author":"S\u00e1nchez-Dan\u00e9s","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2021.105580_bb0920","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41576-018-0016-z","article-title":"From genome-wide associations to candidate causal variants by statistical fine-mapping","volume":"19","author":"Schaid","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0925","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1471-4159.1990.tb02325.x","article-title":"Mitochondrial complex I deficiency in Parkinson\u2019s disease","volume":"54","author":"Schapira","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105580_bb0930","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51167","article-title":"Coordinating a new approach to basic research into Parkinson\u2019s disease","volume":"8","author":"Schekman","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2021.105580_bb0935","article-title":"Fine-mapping of Parkinson\u2019s disease susceptibility loci identifies putative causal variants","author":"Schilder","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0940","article-title":"echolocatoR: an automated end-to-end statistical and functional genomic fine-mapping pipeline","author":"Schilder","year":"2021","journal-title":"Bioinformatics."},{"key":"10.1016\/j.nbd.2021.105580_bb0945","doi-asserted-by":"crossref","first-page":"10757","DOI":"10.1038\/s41598-018-28986-7","article-title":"A monocyte gene expression signature in the early clinical course of Parkinson\u2019s disease","volume":"8","author":"Schlachetzki","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2021.105580_bb0950","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-018-0561-x","article-title":"Sporadic Parkinson\u2019s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs","volume":"6","author":"Schulze","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb0955","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/01.STR.0000217384.03237.9c","article-title":"Reduced risk factors for vascular disorders in Parkinson disease patients: a case-control study","volume":"37","author":"Scigliano","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2021.105580_bb0960","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41593-020-0603-0","article-title":"A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles","volume":"23","author":"Sey","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb2000","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000489758","article-title":"Comprehensive Assessment of Genotype Imputation Performance","volume":"83","author":"Shi","year":"2018","journal-title":"Hum Hered"},{"key":"10.1016\/j.nbd.2021.105580_bb0965","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/ng.487","article-title":"Genome-wide association study reveals genetic risk underlying Parkinson\u2019s disease","volume":"41","author":"Simon-Sanchez","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb0970","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnins.2016.00016","article-title":"Identification of vulnerable cell types in major brain disorders using single cell transcriptomes and expression weighted cell type enrichment","volume":"10","author":"Skene","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb0975","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/mds.104","article-title":"Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson\u2019s blood cells","volume":"33","author":"Smith","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2021.105580_bb0980","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41531-019-0078-4","article-title":"Modeling Parkinson\u2019s disease in midbrain-like organoids","volume":"5","author":"Smits","year":"2019","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.nbd.2021.105580_bb0985","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.cell.2009.02.013","article-title":"Parkinson\u2019s disease patient-derived induced pluripotent stem cells free of viral reprogramming factors","volume":"136","author":"Soldner","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105580_bb0990","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cell.2011.06.019","article-title":"Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations","volume":"146","author":"Soldner","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105580_bb0995","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature17939","article-title":"Parkinson-associated risk variant in distal enhancer of \u03b1-synuclein modulates target gene expression","volume":"533","author":"Soldner","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105580_bb1000","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000097237","article-title":"Evaluation of interleukins, ACTH, cortisol and prolactin concentrations in the blood of patients with parkinson\u2019s disease","volume":"3","author":"Stypu\u0142a","year":"1996","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.nbd.2021.105580_bb1005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2021.105580_bb1010","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105580_bb1015","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1038\/s41467-019-11953-9","article-title":"Components of genetic associations across 2,138 phenotypes in the UK biobank highlight adipocyte biology","volume":"10","author":"Tanigawa","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb1020","article-title":"Immune system responses in Parkinson\u2019s disease: early and dynamic","author":"Tansey","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb1025","article-title":"Single nuclei sequencing of human putamen oligodendrocytes reveals altered heterogeneity and Disease-associated changes in Parkinson\u2019s Disease and multiple system atrophy","author":"Teeple","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2021.105580_bb1030","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3389\/fnins.2017.00737","article-title":"Parkinson\u2019s Disease skin fibroblasts display signature alterations in growth, redox homeostasis, mitochondrial function, and autophagy","volume":"11","author":"Teves","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb1035","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.cell.2018.02.021","article-title":"Direct identification of hundreds of expression-modulating variants using a multiplexed reporter assay","volume":"172","author":"Tewhey","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2021.105580_bb1040","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/mds.28494","article-title":"GP2: the global Parkinson\u2019s genetics program","volume":"36","author":"The Global Parkinson\u2019\u2019s Genetics Program","year":"2021","journal-title":"Mov. Disord."},{"issue":"13","key":"10.1016\/j.nbd.2021.105580_bb3000","doi-asserted-by":"crossref","first-page":"108189","DOI":"10.1016\/j.celrep.2020.108189","article-title":"Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans","volume":"32","author":"Thrupp","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.nbd.2021.105580_bb1045","doi-asserted-by":"crossref","DOI":"10.1038\/s41593-021-00862-0","article-title":"Genome-wide CRISPRi\/a screens in human neurons link lysosomal failure to ferroptosis","author":"Tian","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb1050","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.neurobiolaging.2018.05.032","article-title":"MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients","volume":"69","author":"Tolosa","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2021.105580_bb1055","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1136\/jnnp-2013-307307","article-title":"Bone health in Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"85","author":"Torsney","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2021.105580_bb1060","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/s41593-020-00740-1","article-title":"Massively parallel techniques for cataloguing the regulome of the human brain","volume":"23","author":"Townsley","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb1065","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1471-4159.2011.07432.x","article-title":"Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies","volume":"119","author":"Trabzuni","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2021.105580_bb1070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070724","article-title":"Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus","volume":"8","author":"Trabzuni","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2021.105580_bb1075","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41588-019-0385-z","article-title":"Opportunities and challenges for transcriptome-wide association studies","volume":"51","author":"Wainberg","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb1080","article-title":"The landscape of multiscale transcriptomic networks and key regulators in Parkinson\u2019s disease","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2021.105580_bb1085","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/s41588-020-00735-5","article-title":"Functionally informed fine-mapping and polygenic localization of complex trait heritability","volume":"52","author":"Weissbrod","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb1090","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52155","article-title":"Science forum: the single-cell eQTLGen consortium","volume":"9","author":"van der Wijst","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2021.105580_bb1095","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1136\/bmj.289.6456.1401","article-title":"MPTP parkinsonism","volume":"289","author":"Williams","year":"1984","journal-title":"Br. Med. J."},{"key":"10.1016\/j.nbd.2021.105580_bb1100","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.02.017","article-title":"Heritability of Parkinson disease in Swedish twins: a longitudinal study","volume":"32","author":"Wirdefeldt","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2021.105580_bb1105","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1001\/jamaneurol.2017.0469","article-title":"Genome-wide pleiotropy between Parkinson Disease and autoimmune diseases","volume":"74","author":"Witoelar","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2021.105580_bb1115","doi-asserted-by":"crossref","first-page":"W65","DOI":"10.1093\/nar\/gky408","article-title":"GIANT 2.0: genome-scale integrated analysis of gene networks in tissues","volume":"46","author":"Wong","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2021.105580_bb1120","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/s41593-021-00886-6","article-title":"Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders","volume":"24","author":"Yang","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2021.105580_bb1125","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41398-021-01348-0","article-title":"Mendelian randomization integrating GWAS and eQTL data revealed genes pleiotropically associated with major depressive disorder","volume":"11","author":"Yang","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2021.105580_bb1130","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1093\/schbul\/sbab023","article-title":"Epigenetic element-based transcriptome-wide association study identifies novel genes for bipolar disorder","volume":"47","author":"Yao","year":"2021","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.nbd.2021.105580_bb1135","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41531-021-00221-7","article-title":"A transcriptome-wide association study identifies susceptibility genes for Parkinson\u2019s disease","volume":"7","author":"Yao","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"issue":"12","key":"10.1016\/j.nbd.2021.105580_bb1140","first-page":"20.874099","article-title":"A map of transcriptional heterogeneity and regulatory variation in human microglia","volume":"2019","author":"Young","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb1145","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nmeth.3547","article-title":"Predicting effects of noncoding variants with deep learning\u2013based sequence model","volume":"12","author":"Zhou","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2021.105580_bb1150","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/s41588-018-0160-6","article-title":"Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk","volume":"50","author":"Zhou","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2021.105580_bb1155","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","article-title":"Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology","volume":"44","author":"Zimprich","year":"2004","journal-title":"Neuron"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121003296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996121003296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:29:38Z","timestamp":1760851778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996121003296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":230,"alternative-id":["S0969996121003296"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105580","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omic insights into Parkinson's Disease: From genetic associations to functional mechanisms","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2021.105580","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105580"}}