{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:27:04Z","timestamp":1789032424891,"version":"build-2803163510"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG061038"],"award-info":[{"award-number":["R01AG061038"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG059177"],"award-info":[{"award-number":["R21AG059177"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007859","name":"University of Kansas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007859","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.nbd.2022.105631","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T11:19:29Z","timestamp":1642245569000},"page":"105631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-A\u03b2 interaction and A\u03b2 fibrillation"],"prefix":"10.1016","volume":"164","author":[{"given":"Hee-Jung","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahram","family":"Haroutunian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2022.105631_bb0005","doi-asserted-by":"crossref","first-page":"10571","DOI":"10.1021\/bi9626362","article-title":"Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer\u2019s disease","volume":"36","author":"Aleshkov","year":"1997","journal-title":"Biochemistry."},{"key":"10.1016\/j.nbd.2022.105631_bb0010","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/01.STR.0000064320.73388.C6","article-title":"Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction","volume":"34","author":"Aoki","year":"2003","journal-title":"Stroke."},{"key":"10.1016\/j.nbd.2022.105631_bb0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/bj20020207","article-title":"Apolipoprotein E structural requirements for the formation of SDS-stable complexes with beta-amyloid-(1-40): the role of salt bridges","volume":"366","author":"Bentley","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2022.105631_bb0020","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fnagi.2018.00180","article-title":"APOE and Alzheimer\u2019s disease: neuroimaging of metabolic and cerebrovascular dysfunction","volume":"10","author":"Brandon","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0025","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrn2620","article-title":"Apolipoprotein E and its receptors in Alzheimer\u2019s disease: pathways, pathogenesis and therapy","volume":"10","author":"Bu","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0030","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2353\/ajpath.2010.090973","article-title":"Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice","volume":"177","author":"Buttini","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2022.105631_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134306","article-title":"Peripheral versus central nervous system APOE in Alzheimer\u2019s disease: interplay across the blood-brain barrier","volume":"708","author":"Chernick","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2022.105631_bb0040","doi-asserted-by":"crossref","first-page":"19053","DOI":"10.1074\/jbc.271.32.19053","article-title":"Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins","volume":"271","author":"Dong","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105631_bb0045","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nsb0896-718","article-title":"Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia","volume":"3","author":"Dong","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.nbd.2022.105631_bb0050","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12264-013-1422-z","article-title":"Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer\u2019s disease","volume":"30","author":"Dorey","year":"2014","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.nbd.2022.105631_bb0055","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-017-0184-x","article-title":"Late onset Alzheimer\u2019s disease genetics implicates microglial pathways in disease risk","volume":"12","author":"Efthymiou","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2022.105631_bb0060","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/nbdi.2002.0483","article-title":"Human and murine ApoE markedly alters a beta metabolism before and after plaque formation in a mouse model of Alzheimer\u2019s disease","volume":"9","author":"Fagan","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2022.105631_bb0065","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer disease Meta analysis consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"Jama."},{"key":"10.1016\/j.nbd.2022.105631_bb0070","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/glycob\/cwz084","article-title":"O-glycosylation on cerebrospinal fluid and plasma apolipoprotein E differs in the lipid-binding domain","volume":"30","author":"Flowers","year":"2020","journal-title":"Glycobiology."},{"key":"10.1016\/j.nbd.2022.105631_bb0075","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1172\/JCI30954","article-title":"Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine","volume":"117","author":"Galeano","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2022.105631_bb0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1385\/JMN:23:3:205","article-title":"A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity","volume":"23","author":"Guo","year":"2004","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0085","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1021\/pr300963h","article-title":"LC-MS\/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins","volume":"12","author":"Halim","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.nbd.2022.105631_bb0090","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1001\/jamaneurol.2013.396","article-title":"Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial","volume":"70","author":"Hanson","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2022.105631_bb0095","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1074\/jbc.M309475200","article-title":"Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer\u2019s disease","volume":"279","author":"Harris","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105631_bb0100","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.tibs.2006.06.008","article-title":"Apolipoprotein E structure: insights into function","volume":"31","author":"Hatters","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.nbd.2022.105631_bb0105","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.plipres.2010.09.001","article-title":"Apolipoprotein E: from lipid transport to neurobiology","volume":"50","author":"Hauser","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.nbd.2022.105631_bb0110","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-4-431-54011-3_8","article-title":"Human-specific changes in sialic acid biology","author":"Hayakawa","year":"2012","journal-title":"Post-Genome Biol. Prim."},{"key":"10.1016\/j.nbd.2022.105631_bb0115","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1093\/jnen\/nlw067","article-title":"Apolipoprotein E genotype affects size of ApoE complexes in cerebrospinal fluid","volume":"75","author":"Heinsinger","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2022.105631_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2019.00233","article-title":"Microglia in Alzheimer disease: well-known targets and new opportunities","volume":"11","author":"Hemonnot","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0125","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13024-015-0001-3","article-title":"Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and A\u03b2 metabolism in apoE4-targeted replacement mice","volume":"10","author":"Hu","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2022.105631_bb0130","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1212\/01.wnl.0000192102.41141.9e","article-title":"Apolipoprotein E and Alzheimer disease","volume":"66","author":"Huang","year":"2006","journal-title":"Neurology."},{"issue":"Pt A","key":"10.1016\/j.nbd.2022.105631_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2014.08.025","article-title":"Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer\u2019s diseases","volume":"72","author":"Huang","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2022.105631_bb0140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1385\/JMN:23:3:189","article-title":"Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer\u2019s disease","volume":"23","author":"Huang","year":"2004","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0145","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1194\/jlr.R075481","article-title":"Apolipoprotein E and Alzheimer\u2019s disease: the influence of apolipoprotein E on amyloid-beta and other amyloidogenic proteins","volume":"58","author":"Huynh","year":"2017","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.nbd.2022.105631_bb0150","doi-asserted-by":"crossref","first-page":"14720","DOI":"10.1074\/jbc.M117.784264","article-title":"Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay","volume":"292","author":"Kara","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105631_bb0155","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cca.2008.12.018","article-title":"Sialic acid moiety of apolipoprotein E and its impact on the formation of lipoprotein particles in human cerebrospinal fluid","volume":"402","author":"Kawasaki","year":"2009","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.nbd.2022.105631_bb0160","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1126\/science.284.5418.1372","article-title":"UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation","volume":"284","author":"Keppler","year":"1999","journal-title":"Science."},{"key":"10.1016\/j.nbd.2022.105631_bb0165","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","article-title":"The role of apolipoprotein E in Alzheimer's disease","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2022.105631_bb0170","doi-asserted-by":"crossref","first-page":"14069","DOI":"10.1523\/JNEUROSCI.2281-14.2014","article-title":"Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice","volume":"34","author":"Knoferle","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0175","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00109-018-1632-y","article-title":"Cell-specific production, secretion, and function of apolipoprotein E","volume":"96","author":"Kockx","year":"2018","journal-title":"J. Mol. Med. (Berl)."},{"key":"10.1016\/j.nbd.2022.105631_bb0180","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.ajpath.2013.01.034","article-title":"Blocking the interaction between apolipoprotein E and A\u03b2 reduces intraneuronal accumulation of A\u03b2 and inhibits synaptic degeneration","volume":"182","author":"Kuszczyk","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2022.105631_bb0185","doi-asserted-by":"crossref","first-page":"23403","DOI":"10.1016\/S0021-9258(17)31529-6","article-title":"Isoform-specific binding of apolipoprotein E to beta-amyloid","volume":"269","author":"LaDu","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105631_bb0190","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1074\/mcp.M900430-MCP200","article-title":"Glycosylation and sialylation of macrophage-derived human apolipoprotein E analyzed by SDS-PAGE and mass spectrometry: evidence for a novel site of glycosylation on Ser290","volume":"9","author":"Lee","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.nbd.2022.105631_bb0195","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/glycob\/cwu044","article-title":"Siglec functions of microglia","volume":"24","author":"Linnartz-Gerlach","year":"2014","journal-title":"Glycobiology."},{"key":"10.1016\/j.nbd.2022.105631_bb0200","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2022.105631_bb0205","doi-asserted-by":"crossref","first-page":"8009","DOI":"10.1038\/s41598-017-08604-8","article-title":"Targeting apolipoprotein E\/amyloid beta binding by peptoid CPO_Abeta17-21 P ameliorates Alzheimer\u2019s disease related pathology and cognitive decline","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2022.105631_bb0210","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00109-016-1427-y","article-title":"Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders","volume":"94","author":"Mahley","year":"2016","journal-title":"J. Mol. Med. (Berl)."},{"issue":"Suppl","key":"10.1016\/j.nbd.2022.105631_bb0215","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1194\/jlr.R800069-JLR200","article-title":"Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer\u2019s disease to AIDS","volume":"50","author":"Mahley","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.nbd.2022.105631_bb0220","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1385\/JMN:23:3:235","article-title":"ApoE and Abeta1-42 interactions: effects of isoform and conformation on structure and function","volume":"23","author":"Manelli","year":"2004","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0225","doi-asserted-by":"crossref","DOI":"10.5772\/45977","article-title":"Lipoproteins and apolipoproteins in Alzheimer\u2019s disease","author":"Matsubara","year":"2012","journal-title":"Lipoproteins - Role Health Dis."},{"key":"10.1016\/j.nbd.2022.105631_bb0230","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/glia.21004","article-title":"Astrocytic a beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteins","volume":"58","author":"Nielsen","year":"2010","journal-title":"Glia."},{"key":"10.1016\/j.nbd.2022.105631_bb0235","first-page":"75","article-title":"Blocking the apoE\/A\u03b2 interaction ameliorates A\u03b2-related pathology in APOE \u03b52 and \u03b54 targeted replacement Alzheimer model mice","volume":"2","author":"Pankiewicz","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2022.105631_bb0240","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3233\/JAD-151205","article-title":"Altered energy metabolism pathways in the posterior cingulate in young adult apolipoprotein E \u025b4 carriers","volume":"53","author":"Perkins","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105631_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.648617","article-title":"Sialometabolism in brain health and Alzheimer\u2019s disease","volume":"15","author":"Rawal","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0250","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1073\/pnas.2635903100","article-title":"Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer\u2019s dementia","volume":"101","author":"Reiman","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105631_bb0255","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0002-9440(10)63355-X","article-title":"A synthetic peptide blocking the apolipoprotein E\/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice","volume":"165","author":"Sadowski","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2022.105631_bb0260","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/febs.12590","article-title":"The role of protein glycosylation in Alzheimer disease","volume":"281","author":"Schedin-Weiss","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.nbd.2022.105631_bb0265","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910606","article-title":"Novel Alzheimer risk genes determine the microglia response to amyloid-\u03b2 but not to TAU pathology","volume":"12","author":"Sierksma","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2022.105631_bb0270","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a005199","article-title":"Golgi glycosylation","volume":"3","author":"Stanley","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.nbd.2022.105631_bb0275","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1073\/pnas.90.17.8098","article-title":"Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105631_bb0280","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1074\/jbc.M112.442103","article-title":"Levels of soluble apolipoprotein E\/amyloid-beta (Abeta) complex are reduced and oligomeric Abeta increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples","volume":"288","author":"Tai","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105631_bb0285","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1326-9-2","article-title":"Soluble apoE\/Abeta complex: mechanism and therapeutic target for APOE4-induced AD risk","volume":"9","author":"Tai","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2022.105631_bb0290","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0002-9440(10)64788-8","article-title":"Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord","volume":"157","author":"Tesseur","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2022.105631_bb0295","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2353\/ajpath.2006.050752","article-title":"Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice","volume":"168","author":"Van Dooren","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2022.105631_bb0300","doi-asserted-by":"crossref","first-page":"E1807","DOI":"10.1073\/pnas.1220484110","article-title":"ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE\/Abeta association in physiological conditions","volume":"110","author":"Verghese","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105631_bb0305","article-title":"Largest GWAS (N=1,126,563) of Alzheimer\u2019s disease implicates microglia and immune cells","author":"Wightman","year":"2020","journal-title":"medRxiv."},{"key":"10.1016\/j.nbd.2022.105631_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104784","article-title":"APOE-amyloid interaction: therapeutic targets","volume":"138","author":"Wisniewski","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2022.105631_bb0315","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4103\/1673-5374.179044","article-title":"ApoE2 and Alzheimer\u2019s disease: time to take a closer look","volume":"11","author":"Wu","year":"2016","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.nbd.2022.105631_bb0320","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1523\/JNEUROSCI.2262-17.2018","article-title":"Human ApoE isoforms differentially modulate brain glucose and ketone body metabolism: implications for Alzheimer\u2019s disease risk reduction and early intervention","volume":"38","author":"Wu","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0325","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0002-9440(10)65305-9","article-title":"Specific regional transcription of apolipoprotein E in human brain neurons","volume":"154","author":"Xu","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2022.105631_bb0330","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1523\/JNEUROSCI.5476-05.2006","article-title":"Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus","volume":"26","author":"Xu","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0335","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ymgme.2017.04.010","article-title":"Safety, pharmacokinetics and sialic acid production after oral administration of N-acetylmannosamine (ManNAc) to subjects with GNE myopathy","volume":"122","author":"Xu","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.nbd.2022.105631_bb0340","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1096\/fj.15-270983","article-title":"Sialylation regulates brain structure and function","volume":"29","author":"Yoo","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2022.105631_bb0345","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev-neuro-071013-014300","article-title":"Apolipoprotein E in Alzheimer\u2019s disease: an update","volume":"37","author":"Yu","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2022.105631_bb0350","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1074\/jbc.R800009200","article-title":"Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure","volume":"284","author":"Zhong","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105631_bb0355","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF03401614","article-title":"Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E","volume":"2","author":"Zhou","year":"1996","journal-title":"Mol. Med."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996122000225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996122000225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:31:16Z","timestamp":1760851876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996122000225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":71,"alternative-id":["S0969996122000225"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2022.105631","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-A\u03b2 interaction and A\u03b2 fibrillation","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2022.105631","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105631"}}