{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:56:41Z","timestamp":1793642201239,"version":"4.5.1"},"reference-count":177,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.nbd.2022.105695","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T21:39:07Z","timestamp":1647553147000},"page":"105695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Gut dysbiosis and age-related neurological diseases in females"],"prefix":"10.1016","volume":"168","author":[{"given":"Janelle M.","family":"Korf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhanu P.","family":"Ganesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise D.","family":"McCullough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2022.105695_bb0005","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.parkreldis.2019.10.019","article-title":"Sex differences in Parkinson's disease presentation and progression","volume":"69","author":"Abraham","year":"2019","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2019.103960","article-title":"The impact of sex and age on T cell immunity and ischemic stroke outcomes","author":"Ahnstedt","year":"2019","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.nbd.2022.105695_bb0015","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.bbi.2020.02.001","article-title":"Sex differences in T cell immune responses, gut permeability and outcome after ischemic stroke in aged mice","volume":"87","author":"Ahnstedt","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2022.105695_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2019.110886","article-title":"Aluminum-induced generation of lipopolysaccharide (LPS) from the human gastrointestinal (GI)-tract microbiome-resident Bacteroides fragilis","volume":"203","author":"Alexandrov","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.nbd.2022.105695_bb0025","first-page":"391","article-title":"Alzheimer\u2019s disease facts and figures","volume":"16","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.nbd.2022.105695_bb0030","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/advances\/nmy013","article-title":"Microbiome-mediated effects of the mediterranean diet on inflammation","volume":"9","author":"Bailey","year":"2018","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.nbd.2022.105695_bb0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.maturitas.2017.06.025","article-title":"Estrogen-gut microbiome axis: physiological and clinical implications","volume":"103","author":"Baker","year":"2017","journal-title":"Maturitas"},{"key":"10.1016\/j.nbd.2022.105695_bb0040","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/mds.27581","article-title":"Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism","volume":"34","author":"Barichella","year":"2019","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0045","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/lam.12882","article-title":"Shifts in gut microbiota composition in an APP\/PSS1 transgenic mouse model of Alzheimer's disease during lifespan","volume":"66","author":"B\u00e4uerl","year":"2018","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.595583","article-title":"Spatial memory and gut microbiota alterations are already present in early adulthood in a pre-clinical transgenic model of Alzheimer's Disease","volume":"15","author":"Bello-Medina","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2022.105695_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm9061757","article-title":"Fecal microbiota transplantation: screening and selection to choose the optimal donor","volume":"9","author":"Bibb\u00f2","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.nbd.2022.105695_bb0060","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-020-01833-1","article-title":"Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation","volume":"17","author":"Blasco","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2022.105695_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048220","article-title":"High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens","volume":"7","author":"Blasco-Baque","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0070","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1007\/s00018-018-2901-1","article-title":"Implication of gut microbiota metabolites in cardiovascular and metabolic diseases","volume":"2018 7521 75","author":"Brial","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2022.105695_bb0075","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.nbd.2022.105695_bb0080","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1002\/mds.28563","article-title":"Increased risk of Parkinson's disease in women after bilateral oophorectomy","volume":"36","author":"Canonico","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0085","article-title":"Alzheimer's disease and diabetes: role of diet, microbiota and inflammation in preclinical models","volume":"11","author":"Carranza-Naval","year":"2021","journal-title":"Biomol. 2021"},{"key":"10.1016\/j.nbd.2022.105695_bb0090","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.parkreldis.2015.02.004","article-title":"Increased urinary indoxyl sulfate (indican): New insights into gut dysbiosis in Parkinson's disease","volume":"21","author":"Cassani","year":"2015","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/09513590.2013.852531","article-title":"The immune system and aging: a review","volume":"30","author":"Castelo-Branco","year":"2014","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.nbd.2022.105695_bb0100","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neurobiolaging.2016.08.019","article-title":"Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly","volume":"49","author":"Cattaneo","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2022.105695_bb0105","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.parkreldis.2013.07.020","article-title":"Reproductive factors and clinical features of Parkinson's disease","volume":"19","author":"Cereda","year":"2013","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0110","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3233\/JPD-191683","article-title":"Parkinson's disease in women and men: what's the difference?","volume":"9","author":"Cerri","year":"2019","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0115","first-page":"246","article-title":"Mammalian gut immunity","volume":"37","author":"Chassaing","year":"2014","journal-title":"Biom. J."},{"key":"10.1016\/j.nbd.2022.105695_bb0120","article-title":"Irritable bowel syndrome is associated with an increased risk of dementia: a nationwide population-based study","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0125","first-page":"1002","article-title":"Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children","volume":"2016 104 10","author":"Cheng","year":"2015","journal-title":"ISME J."},{"key":"10.1016\/j.nbd.2022.105695_bb0130","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1210\/me.2014-1108","article-title":"Minireview: Gut Microbiota: The Neglected Endocrine Organ","volume":"28","author":"Clarke","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.nbd.2022.105695_bb0135","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59826","article-title":"Microbiota-derived short chain fatty acids modulate microglia and promote A\u03b2 plaque deposition","volume":"10","author":"Colombo","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2022.105695_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-54187-x","article-title":"Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice","volume":"9","author":"Cox","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2022.105695_bb0145","article-title":"Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice","volume":"8","author":"Crapser","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.nbd.2022.105695_bb0150","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1474-4422(19)30356-4","article-title":"The gut microbiome in neurological disorders","volume":"19","author":"Cryan","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2022.105695_bb0155","article-title":"Gut microbiota alterations and cognitive impairment are sexually dissociated in a transgenic mice model of Alzheimer's disease","volume":"1\u201320","author":"Cuervo-Zanatta","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0160","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI27987","article-title":"Estrogen receptors and human disease","volume":"116","author":"Deroo","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2022.105695_bb0165","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/ene.13412","article-title":"Atypical parkinsonian syndromes: a general neurologist's perspective","volume":"25","author":"Deutschl\u00e4nder","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2022.105695_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124599","article-title":"Sex, body mass index, and dietary fiber intake influence the human gut microbiome","volume":"10","author":"Dominianni","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237779","article-title":"Predictive analysis methods for human microbiome data with application to Parkinson's disease","volume":"15","author":"Dong","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0180","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/WCO.0000000000000783","article-title":"Immunological mechanisms in poststroke dementia","volume":"33","author":"Doyle","year":"2020","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.nbd.2022.105695_bb0185","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3233\/JPD-191612","article-title":"Fecal and blood microbial 16s rRNA gene alterations in chinese patients with multiple system atrophy and its subtypes","volume":"9","author":"Du","year":"2019","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0190","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Microbiology: diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science (80-.)"},{"key":"10.1016\/j.nbd.2022.105695_bb0195","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/glia.23822","article-title":"How microbiota shape microglial phenotypes and epigenetics","volume":"68","author":"Erny","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2022.105695_bb0200","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2022.105695_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108721","article-title":"Interactions between the microbiota and enteric nervous system during gut-brain disorders","volume":"197","author":"Fried","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2022.105695_bb0210","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1210\/jc.2014-2222","article-title":"Associations of the fecal microbiome with urinary estrogens and estrogen metabolites in postmenopausal women","volume":"99","author":"Fuhrman","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.nbd.2022.105695_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074963","article-title":"Commensal akkermansia muciniphila exacerbates gut inflammation in salmonella typhimurium-infected gnotobiotic mice","volume":"8","author":"Ganesh","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0220","doi-asserted-by":"crossref","DOI":"10.1161\/HYPERTENSIONAHA.118.11695","article-title":"Prebiotics, probiotics, and acetate supplementation prevent hypertension in a model of obstructive sleep apnea","volume":"72","author":"Ganesh","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.nbd.2022.105695_bb0225","first-page":"196","article-title":"Of the bugs that shape us: maternal obesity, the gut microbiome, and long-term disease risk","volume":"2015 771 77","author":"Gohir","year":"2014","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.nbd.2022.105695_bb0230","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.celrep.2019.12.078","article-title":"Probiotic bacillus subtilis protects against \u03b1-synuclein aggregation in C. elegans","volume":"30","author":"Goya","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2022.105695_bb0235","article-title":"Association between polycystic ovary syndrome and gut microbiota","volume":"11","author":"Guo","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0240","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/jcbfm.2012.141","article-title":"Sex differences in stroke","volume":"32","author":"Haast","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2022.105695_bb0245","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.immuni.2015.09.007","article-title":"Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine","volume":"43","author":"Haghikia","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2022.105695_bb0250","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1161\/ATVBAHA.118.311023","article-title":"Gut microbiota-dependent trimethylamine N-oxide predicts risk of cardiovascular events in patients with stroke and is related to proinflammatory monocytes","volume":"38","author":"Haghikia","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.nbd.2022.105695_bb0255","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-019-1536-z","article-title":"Gender specific decrease of a set of circulating N-acylphosphatidyl ethanolamines (NAPEs) in the plasma of Parkinson's disease patients","volume":"15","author":"Hamid","year":"2019","journal-title":"Metabolomics"},{"key":"10.1016\/j.nbd.2022.105695_bb0260","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00632-19","article-title":"Alzheimer\u2019s disease microbiome is associated with dysregulation of the anti-inflammatory P-glycoprotein pathway","volume":"10","author":"Haran","year":"2019","journal-title":"MBio"},{"key":"10.1016\/j.nbd.2022.105695_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154090","article-title":"Intestinal microbiota is influenced by gender and body mass index","volume":"11","author":"Haro","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2019.109436","article-title":"Bile acid abnormality induced by intestinal dysbiosis might explain lipid metabolism in Parkinson's disease","volume":"134","author":"Hasuike","year":"2020","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.nbd.2022.105695_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020376","article-title":"Interventional influence of the intestinal microbiome through dietary intervention and bowel cleansing might improve motor symptoms in Parkinson's disease","volume":"9","author":"Hegelmaier","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.nbd.2022.105695_bb0280","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/mds.27105","article-title":"The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder","volume":"33","author":"Heintz-Buschart","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0285","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.celrep.2019.10.035","article-title":"Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson's disease","volume":"29","author":"Hertel","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2022.105695_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00113","article-title":"Common miRNA patterns of Alzheimer's disease and Parkinson's disease and their putative impact on commensal gut microbiota","volume":"13","author":"Hewel","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2022.105695_bb0295","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/mds.26942","article-title":"Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome","volume":"32","author":"Hill-Burns","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0300","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40168-015-0101-x","article-title":"Structure and function of the healthy pre-adolescent pediatric gut microbiome","volume":"3","author":"Hollister","year":"2015","journal-title":"Microbiome"},{"key":"10.1016\/j.nbd.2022.105695_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051711","article-title":"Dysregulated gut homeostasis observed prior to the accumulation of the brain amyloid-\u03b2 in Tg2576 mice","volume":"21","author":"Honarpisheh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2022.105695_bb0310","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2017.04.019","article-title":"Gut microbiota in Parkinson disease in a northern German cohort","volume":"1667","author":"Hopfner","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2022.105695_bb0315","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/01616412.2019.1710416","article-title":"Increasing trimethylamine N-oxide levels as a predictor of early neurological deterioration in patients with acute ischemic stroke","volume":"42","author":"Hou","year":"2020","journal-title":"Neurol. Res."},{"key":"10.1016\/j.nbd.2022.105695_bb0320","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fgene.2019.00098","article-title":"Current understanding of gut microbiota in mood disorders: an update of human studies","volume":"0","author":"Huang","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.nbd.2022.105695_bb0325","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12866-021-02327-7","article-title":"Gut microbiota changes in preeclampsia, abnormal placental growth and healthy pregnant women","volume":"21","author":"Huang","year":"2021","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(15)00293-5","article-title":"A comprehensive repertoire of prokaryotic species identified in human beings","author":"Hugon","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0244680","article-title":"Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson's disease: A randomised controlled trial","volume":"15","author":"Ibrahim","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0340","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","article-title":"Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine","volume":"4","author":"Ivanov","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.nbd.2022.105695_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2019.100815","article-title":"You've got male: Sex and the microbiota-gut-brain axis across the lifespan","author":"Jaggar","year":"2020","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.nbd.2022.105695_bb0350","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2015.0122","article-title":"Sex differences in the gut microbiome - Brain axis across the lifespan","author":"Ja\u0161arevi\u0107","year":"2016","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.nbd.2022.105695_bb0355","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/brain\/awq033","article-title":"Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2","volume":"133","author":"Jayadev","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2022.105695_bb0360","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.3892\/mmr.2017.7227","article-title":"Analysis of intestinal microbial communities of cerebral infarction and ischemia patients based on high throughput sequencing technology and glucose and lipid metabolism","volume":"16","author":"Ji","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.nbd.2022.105695_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105027","article-title":"Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series","volume":"144","author":"Joers","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0243213","article-title":"N-Terminal pro-B-type natriuretic peptide and coronary microvascular dysfunction in women with preserved ejection fraction: A report from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) study","volume":"15","author":"Jones","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0375","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.parkreldis.2020.01.009","article-title":"Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo Parkinson's disease","volume":"72","author":"Jones","year":"2020","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0380","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2022.105695_bb0385","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neurobiolaging.2020.04.009","article-title":"Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer's disease","volume":"92","author":"Kaur","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2022.105695_bb0390","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.3389\/fphys.2018.01534","article-title":"Mouse microbiota models: comparing germ-free mice and antibiotics treatment as tools for modifying gut bacteria","volume":"0","author":"Kennedy","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0395","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5946\/ce.2019.009","article-title":"Fecal microbiota transplantation: an update on clinical practice","volume":"52","author":"Kim","year":"2019","journal-title":"Clin. Endosc."},{"key":"10.1016\/j.nbd.2022.105695_bb0400","doi-asserted-by":"crossref","DOI":"10.5534\/wjmh.190009","article-title":"Sex differences in gut microbiota","author":"Kim","year":"2020","journal-title":"World J. Mens. Health."},{"key":"10.1016\/j.nbd.2022.105695_bb0405","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"2016 1610 16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.nbd.2022.105695_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2018.09.001","article-title":"Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease","volume":"135","author":"Kong","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0420","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy","volume":"150","author":"Koren","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2022.105695_bb0425","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"2020 174 17","author":"Lavelle","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.nbd.2022.105695_bb0430","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2174\/1389200219666180813144834","article-title":"Probiotic supplementation in patients with Alzheimer's Dementia - An explorative intervention study","volume":"15","author":"Leblhuber","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.nbd.2022.105695_bb0435","first-page":"1","article-title":"Beneficial effect of estrogen on nigrostriatal dopaminergic neurons in drug-na\u00efve postmenopausal Parkinson's disease","volume":"2019 91 9","author":"Lee","year":"2019","journal-title":"Sci. Report."},{"key":"10.1016\/j.nbd.2022.105695_bb0440","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.119.316448","article-title":"Gut microbiota\u2013derived short-chain fatty acids promote poststroke recovery in aged mice","volume":"127","author":"Lee","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.nbd.2022.105695_bb0445","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nbt.2942","article-title":"An integrated catalog of reference genes in the human gut microbiome","volume":"32","author":"Li","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.nbd.2022.105695_bb0450","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-019-1552-1","article-title":"Change of intestinal microbiota in cerebral ischemic stroke patients","volume":"19","author":"Li","year":"2019","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0455","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/jnc.15031","article-title":"Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer's disease","volume":"155","author":"Li","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2022.105695_bb0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/metabo11010029","article-title":"Gut microbiota dysbiosis is associated with elevated bile acids in parkinson's disease","volume":"11","author":"Li","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.nbd.2022.105695_bb0465","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.parkreldis.2018.05.007","article-title":"Gut microbiota in patients with Parkinson's disease in southern China","volume":"53","author":"Lin","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0470","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-019-1528-y","article-title":"Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson's disease","volume":"16","author":"Lin","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2022.105695_bb0475","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bbi.2019.05.008","article-title":"Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort","volume":"80","author":"Liu","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2022.105695_bb0480","article-title":"Lactic acid bacteria feeding reversed the malformed eye structures and ameliorated gut microbiota profiles of Drosophila melanogaster Alzheimer's Disease model","author":"Liu","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0485","series-title":"High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis","author":"Liu","year":"2021"},{"key":"10.1016\/j.nbd.2022.105695_bb0490","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-64173-3","article-title":"Bifidobacteria shape host neural circuits during postnatal development by promoting synapse formation and microglial function","volume":"10","author":"Luck","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2022.105695_bb0495","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1002\/art.39783","article-title":"Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine","volume":"68","author":"Maeda","year":"2016","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.nbd.2022.105695_bb0500","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jalz.2018.07.217","article-title":"Altered bile acid profile associates with cognitive impairment in Alzheimer's disease\u2014An emerging role for gut microbiome","volume":"15","author":"MahmoudianDehkordi","year":"2019","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2022.105695_bb0505","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-019-0352-2","article-title":"Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice","volume":"14","author":"Maldonado Weng","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2022.105695_bb0510","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.expneurol.2013.08.011","article-title":"Differential effects of aging and sex on stroke induced inflammation across the lifespan","volume":"249","author":"Manwani","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2022.105695_bb0515","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3233\/JAD-200306","article-title":"Short-chain fatty acids and lipopolysaccharide as mediators between gut dysbiosis and amyloid pathology in Alzheimer's disease","volume":"78","author":"Marizzoni","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0520","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)31561-0","article-title":"Sex and gender: modifiers of health, disease, and medicine","volume":"396","author":"Mauvais-Jarvis","year":"2020","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.nbd.2022.105695_bb0525","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.18632\/aging.100997","article-title":"Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones","volume":"8","author":"McCullough","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.nbd.2022.105695_bb0530","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/ene.13398","article-title":"More than constipation \u2013 bowel symptoms in Parkinson's disease and their connection to gut microbiota","volume":"24","author":"Mertsalmi","year":"2017","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2022.105695_bb0535","article-title":"The oral microbiome of early stage Parkinson's disease and its relationship with functional measures of motor and non-motor function","volume":"14","author":"Mihaila","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0540","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1111\/1462-2920.15517","article-title":"Combined hormonal contraceptives are associated with minor changes in composition and diversity in gut microbiota of healthy women","volume":"23","author":"Mihajlovic","year":"2021","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0545","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187307","article-title":"Progression of Parkinson's disease is associated with gut dysbiosis: two-year follow-up study","volume":"12","author":"Minato","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0550","doi-asserted-by":"crossref","DOI":"10.1038\/srep30028","article-title":"Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease","volume":"6","author":"Minter","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2022.105695_bb0555","first-page":"241","article-title":"The gut microbiota\u2013brain axis in behaviour and brain disorders","volume":"2020 194 19","author":"Morais","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0560","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s40168-017-0300-8","article-title":"Control of lupus nephritis by changes of gut microbiota","volume":"5","author":"Mu","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.nbd.2022.105695_bb0565","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1128\/AEM.72.2.1027-1033.2006","article-title":"Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study","volume":"72","author":"Mueller","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0570","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/CIRCRESAHA.110.236687","article-title":"Estrogen signaling and cardiovascular disease","volume":"109","author":"Murphy","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.nbd.2022.105695_bb0575","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ebiom.2019.08.032","article-title":"Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment","volume":"47","author":"Nagpal","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.nbd.2022.105695_bb0580","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.590370","article-title":"Microbiota transplant in the treatment of obesity and diabetes: current and future perspectives","volume":"11","author":"Napolitano","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0585","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fendo.2017.00349","article-title":"Early microbes modify immune system development and metabolic homeostasis\u2014The \u201cRestaurant\u201d hypothesis revisited","volume":"8","author":"Nash","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.nbd.2022.105695_bb0590","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2022.105695_bb0595","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2019-318822","article-title":"GI infections are associated with an increased risk of Parkinson's disease","author":"Nerius","year":"2020","journal-title":"Gut."},{"key":"10.1016\/j.nbd.2022.105695_bb0600","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jalz.2018.08.012","article-title":"Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: relationship to neuroimaging and CSF biomarkers","volume":"15","author":"Nho","year":"2019","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2022.105695_bb0605","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","article-title":"Gut microbiota and IBD: causation or correlation?","volume":"2017 1410 14","author":"Ni","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.nbd.2022.105695_bb0610","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s00702-016-1612-8","article-title":"Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson's disease","volume":"123","author":"Niu","year":"2016","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nbd.2022.105695_bb0615","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/acn3.724","article-title":"Metabolomics-based identification of metabolic alterations in PARK2","volume":"6","author":"Okuzumi","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.nbd.2022.105695_bb0620","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/19490976.2016.1203502","article-title":"Sex differences and hormonal effects on gut microbiota composition in mice","volume":"7","author":"Org","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.nbd.2022.105695_bb0625","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00200","article-title":"Murine gut microbiome association with APOE alleles","volume":"11","author":"Parikh","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2022.105695_bb0630","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1007\/s12975-019-00760-5","article-title":"Reproductive senescence and ischemic stroke remodel the gut microbiome and modulate the effects of estrogen treatment in female rats","volume":"11","author":"Park","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.nbd.2022.105695_bb0635","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.parkreldis.2017.02.026","article-title":"Oral and nasal microbiota in Parkinson's disease","volume":"38","author":"Pereira","year":"2017","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0640","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1007\/s10517-017-3700-7","article-title":"Analysis of gut microbiota in patients with parkinson\u2019s disease","volume":"162","author":"Petrov","year":"2017","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.nbd.2022.105695_bb0645","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.parkreldis.2019.06.003","article-title":"Dysbiosis of gut microbiota in a selected population of Parkinson's patients","volume":"65","author":"Pietrucci","year":"2019","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0650","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson's disease: a systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0655","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbi.2018.02.016","article-title":"Alteration of the fecal microbiota in Chinese patients with Parkinson's disease","volume":"70","author":"Qian","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2022.105695_bb0660","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1093\/brain\/awaa201","article-title":"Gut metagenomics-derived genes as potential biomarkers of Parkinson's disease","volume":"143","author":"Qian","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2022.105695_bb0665","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1128\/AEM.65.9.3763-3766.1999","article-title":"The scientific basis for probiotic strains of lactobacillus","volume":"65","author":"Reid","year":"1999","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0670","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1212\/01.wnl.0000280573.30975.6a","article-title":"Increased risk of parkinsonism in women who underwent oophorectomy before menopause","volume":"70","author":"Rocca","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2022.105695_bb0675","article-title":"Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation","volume":"7","author":"Romano","year":"2021","journal-title":"npj Park. Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0680","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/acn3.214","article-title":"A systems-level \u201cmisunderstanding\u201d: the plasma metabolome in Huntington's disease","volume":"2","author":"Rosas","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.nbd.2022.105695_bb0685","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1161\/STROKEAHA.120.030643","article-title":"Gastrointestinal disorders and risk of first-ever ischemic stroke","volume":"51","author":"Roth","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2022.105695_bb0690","article-title":"The relationship between the gut microbiome and mild cognitive impairment in patients without dementia: a cross-sectional study conducted in Japan","volume":"9","author":"Saji","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2022.105695_bb0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105568","article-title":"The association between cerebral small vessel disease and the gut microbiome: a cross-sectional analysis","volume":"30","author":"Saji","year":"2021","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0700","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2022.105695_bb0705","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53111","article-title":"A gut bacterial amyloid promotes a-synuclein aggregation and motor impairment in mice","volume":"9","author":"Sampson","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2022.105695_bb0710","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2042-6410-4-10","article-title":"Sex differences matter in the gut: effect on mucosal immune activation and inflammation","volume":"4","author":"Sankaran-Walters","year":"2013","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.nbd.2022.105695_bb0715","first-page":"371","article-title":"The microbiome and human cancer","volume":"80-.)","author":"Sepich-Poore","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.nbd.2022.105695_bb0720","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2021.110258","article-title":"Gut microbiota alteration and modulation in psychiatric disorders: Current evidence on fecal microbiota transplantation","volume":"109","author":"Settanni","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105695_bb0725","doi-asserted-by":"crossref","DOI":"10.1002\/ana.25250","article-title":"Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome","volume":"84","author":"Spychala","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2022.105695_bb0730","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/nm.4194","article-title":"Translocation and dissemination of commensal bacteria in post-stroke infection","volume":"2016 2211 22","author":"Stanley","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2022.105695_bb0735","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13293-014-0011-9","article-title":"Sexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL\/6 mice","volume":"5","author":"Steegenga","year":"2014","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.nbd.2022.105695_bb0740","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.3233\/JAD-180556","article-title":"Bioactive food abates metabolic and synaptic alterations by modulation of gut microbiota in a mouse model of Alzheimer's disease","volume":"66","author":"Syeda","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0745","doi-asserted-by":"crossref","first-page":"E8141","DOI":"10.1073\/pnas.1617460113","article-title":"Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice","volume":"113","author":"Tan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105695_bb0750","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ana.25982","article-title":"Gut microbial ecosystem in Parkinson disease: new clinicobiological insights from multi-omics","volume":"89","author":"Tan","year":"2021","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2022.105695_bb0755","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12548","article-title":"Steroids, stress and the gut microbiome-brain axis","volume":"30","author":"Tetel","year":"2018","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.nbd.2022.105695_bb0760","doi-asserted-by":"crossref","first-page":"8221","DOI":"10.1096\/fj.201900071R","article-title":"APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology","volume":"33","author":"Tran","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2022.105695_bb0765","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00281-018-0716-7","article-title":"The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility","volume":"41","author":"Vemuri","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.nbd.2022.105695_bb0770","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fcimb.2020.00098","article-title":"Fecal microbiota transplantation in neurological disorders","volume":"10","author":"Vendrik","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0775","first-page":"E139","article-title":"Heart disease and stroke statistics\u20142020 update: A report from the American Heart Association","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.nbd.2022.105695_bb0780","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2018.04.003","article-title":"Small intestinal bacterial overgrowth in Parkinson's disease: tribulations of a trial","author":"Vizcarra","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2022.105695_bb0785","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13601-y","article-title":"Gut microbiome alterations in Alzheimer's disease","volume":"7","author":"Vogt","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2022.105695_bb0790","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-018-0451-2","article-title":"The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease","volume":"10","author":"Vogt","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nbd.2022.105695_bb0795","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2012.06.031","article-title":"Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome","volume":"143","author":"Vrieze","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nbd.2022.105695_bb0800","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington's disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.nbd.2022.105695_bb0805","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200729","article-title":"The murine female intestinal microbiota does not shift throughout the estrous cycle","volume":"13","author":"Wallace","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105695_bb0810","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3389\/fnins.2019.01102","article-title":"Alterations of the gut microbiota in multiple system atrophy patients","volume":"13","author":"Wan","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2022.105695_bb0815","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.nbd.2003.08.009","article-title":"Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice","volume":"14","author":"Wang","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0820","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/ane.13196","article-title":"C-type lectin-like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease","volume":"141","author":"Wang","year":"2020","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.nbd.2022.105695_bb0825","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa110","article-title":"Gut dysbiosis in Huntington's disease: associations among gut microbiota, cognitive performance and clinical outcomes","volume":"2","author":"Wasser","year":"2020","journal-title":"Brain Commun."},{"key":"10.1016\/j.nbd.2022.105695_bb0830","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/STROKEAHA.115.011800","article-title":"Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke","volume":"47","author":"Winek","year":"2016","journal-title":"Stroke."},{"key":"10.1016\/j.nbd.2022.105695_bb0835","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-019-2488-4","article-title":"Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death","volume":"23","author":"Xu","year":"2019","journal-title":"Crit. Care"},{"key":"10.1016\/j.nbd.2022.105695_bb0840","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3389\/fphar.2019.01360","article-title":"Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target","volume":"0","author":"Yang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.nbd.2022.105695_bb0845","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/jnc.14928","article-title":"Enteric short-chain fatty acids promote proliferation of human neural progenitor cells","volume":"154","author":"Yang","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2022.105695_bb0850","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2022.105695_bb0855","article-title":"Dysbiosis of gut microbiota with reduced trimethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack","volume":"4","author":"Yin","year":"2015","journal-title":"J. Am. Hear. Assoc. Cardiovasc. Cerebrovasc. Dis."},{"key":"10.1016\/j.nbd.2022.105695_bb0860","doi-asserted-by":"crossref","DOI":"10.1186\/s12934-020-01412-2","article-title":"Sexual dimorphism of gut microbiota at different pubertal status","volume":"19","author":"Yuan","year":"2020","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.nbd.2022.105695_bb0865","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2019.00004","article-title":"Higher risk of stroke is correlated with increased opportunistic pathogen load and reduced levels of butyrate-producing bacteria in the gut","volume":"9","author":"Zeng","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0870","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s10571-019-00714-3","article-title":"Prognostic value of plasma trimethylamine N-oxide levels in patients with acute ischemic stroke","volume":"39","author":"Zhai","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2022.105695_bb0875","first-page":"12993","article-title":"Associations of OSAHS complicated by cerebral infarction with intestinal flora, inflammatory factors, homocysteine and adiponectin expression","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.nbd.2022.105695_bb0880","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10072-019-04040-w","article-title":"Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study","volume":"41","author":"Zhu","year":"2020","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.nbd.2022.105695_bb0885","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.molmet.2018.04.003","article-title":"Sex differences in obesity, lipid metabolism, and inflammation-A role for the sex chromosomes?","volume":"15","author":"Zore","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.nbd.2022.105695_bb0890","first-page":"1","article-title":"Engineered Akkermansia muciniphila: a promising agent against diseases (Review)","volume":"20","author":"Zou","year":"2020","journal-title":"Exp. Ther. Med."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996122000870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996122000870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:31:56Z","timestamp":1760851916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996122000870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":177,"alternative-id":["S0969996122000870"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2022.105695","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut dysbiosis and age-related neurological diseases in females","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2022.105695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105695"}}