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Lett."},{"key":"10.1016\/j.nbd.2022.105697_bb0345","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuropharm.2016.03.036","article-title":"Metabotropic glutamate receptors as therapeutic targets in Parkinson\u2019s disease: an update from the last 5 years of research","volume":"115","author":"Litim","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2022.105697_bb0350","doi-asserted-by":"crossref","first-page":"20051","DOI":"10.1073\/pnas.0908005106","article-title":"Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells","volume":"106","author":"Luk","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105697_bb0355","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0306-4522(90)90041-2","article-title":"Electrophysiological properties of nigrothalamic neurons after 6-hydroxydopamine lesions in the rat","volume":"38","author":"MacLeod","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2022.105697_bb0360","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa0708514","article-title":"Subthalamic nucleus stimulation in severe obsessive-compulsive disorder","volume":"359","author":"Mallet","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2022.105697_bb0365","doi-asserted-by":"crossref","first-page":"13668","DOI":"10.1073\/pnas.1835724100","article-title":"Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson\u2019s disease treatment","volume":"100","author":"Marino","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. 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Sci."},{"key":"10.1016\/j.nbd.2022.105697_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(98)00189-4","article-title":"Time-dependent changes in striatal glutamate synapses following a 6-hydroxydopamine lesion","volume":"88","author":"Meshul","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2022.105697_bb0400","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1124\/jpet.117.245100","article-title":"Safinamide differentially modulates in vivo glutamate and GABA release in the rat Hippocampus and basal ganglia","volume":"364","author":"Morari","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2022.105697_bb0405","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s40262-016-0449-5","article-title":"Clinical pharmacokinetics and pharmacodynamics of safinamide","volume":"56","author":"M\u00fcller","year":"2017","journal-title":"Clin. 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Disord."},{"key":"10.1016\/j.nbd.2022.105697_bb0420","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1002\/mds.28671","article-title":"Transcranial magnetic stimulation exerts \u201crejuvenation\u201d effects on corticostriatal synapses after partial dopamine depletion","volume":"36","author":"Natale","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2022.105697_bb0425","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1523\/JNEUROSCI.19-08-02938.1999","article-title":"The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells","volume":"19","author":"Nawy","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105697_bb0430","doi-asserted-by":"crossref","first-page":"8772","DOI":"10.1523\/JNEUROSCI.0901-14.2014","article-title":"Striatal cholinergic neurotransmission requires VGLUT3","volume":"34","author":"Nelson","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105697_bb0435","first-page":"S7","article-title":"Pathophysiologic basis of surgery for Parkinson\u2019s disease","volume":"55","author":"Obeso","year":"2000","journal-title":"Neurology"},{"issue":"Suppl. 3","key":"10.1016\/j.nbd.2022.105697_bb0440","doi-asserted-by":"crossref","first-page":"S548","DOI":"10.1002\/mds.22062","article-title":"Functional organization of the basal ganglia: therapeutic implications for Parkinson\u2019s disease","volume":"23","author":"Obeso","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2022.105697_bb0445","doi-asserted-by":"crossref","first-page":"14182","DOI":"10.1523\/JNEUROSCI.2149-10.2010","article-title":"Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition","volume":"30","author":"Paille","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105697_bb0450","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/syn.890020612","article-title":"Unilateral lesion of the nigrostriatal pathway decreases the firing rate and alters the firing pattern of globus pallidus neurons in the rat","volume":"2","author":"Pan","year":"1988","journal-title":"Synapse"},{"key":"10.1016\/j.nbd.2022.105697_bb0455","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/1531-8249(199911)46:5<732::AID-ANA8>3.0.CO;2-Q","article-title":"Internal globus pallidus discharge is nearly suppressed during levodopa-induced dyskinesias","volume":"46","author":"Papa","year":"1999","journal-title":"Ann. 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(Vienna)"},{"key":"10.1016\/j.nbd.2022.105697_bb0475","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1093\/brain\/awh190","article-title":"Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism","volume":"127","author":"Picconi","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2022.105697_bb0480","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/23281","article-title":"A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus","volume":"400","author":"Plenz","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2022.105697_bb0485","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nn.2848","article-title":"Synaptically driven state transitions in distal dendrites of striatal spiny neurons","volume":"14","author":"Plotkin","year":"2011","journal-title":"Nat. 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Neurosci."},{"key":"10.1016\/j.nbd.2022.105697_bb0505","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009308","article-title":"Modeling Parkinson\u2019s disease in primates: the MPTP model","volume":"2","author":"Porras","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.nbd.2022.105697_bb0510","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.expneurol.2013.09.014","article-title":"Modeling Parkinson\u2019s disease in monkeys for translational studies, a critical analysis","volume":"256","author":"Potts","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2022.105697_bb0515","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.neuron.2020.09.028","article-title":"Dopamine oppositely modulates state transitions in striosome and matrix direct pathway striatal spiny neurons","volume":"108","author":"Prager","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2022.105697_bb0520","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.parkreldis.2014.05.003","article-title":"Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias","volume":"20","author":"Rascol","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2022.105697_bb0525","doi-asserted-by":"crossref","first-page":"8559","DOI":"10.1523\/JNEUROSCI.20-22-08559.2000","article-title":"Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonism","volume":"20","author":"Raz","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105697_bb0530","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0306-4522(98)00319-4","article-title":"The basal ganglia: a vertebrate solution to the selection problem?","volume":"89","author":"Redgrave","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2022.105697_bb0535","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.neuron.2018.05.018","article-title":"Glutamatergic signaling in the central nervous system: ionotropic and metabotropic receptors in concert","volume":"98","author":"Reiner","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2022.105697_bb0540","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1111\/j.1460-9568.2004.03591.x","article-title":"Chronic L-DOPA treatment increases extracellular glutamate levels and GLT1 expression in the basal ganglia in a rat model of Parkinson\u2019s disease","volume":"20","author":"Robelet","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105697_bb0545","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/brain\/124.9.1777","article-title":"The subthalamic nucleus in Parkinson\u2019s disease: somatotopic organization and physiological characteristics","volume":"124","author":"Rodriguez-Oroz","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2022.105697_bb0550","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/nm1495","article-title":"Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes","volume":"12","author":"Roy","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2022.105697_bb0555","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1016\/j.celrep.2018.05.059","article-title":"Aberrant striatal activity in parkinsonism and levodopa-induced dyskinesia","volume":"23","author":"Ryan","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2022.105697_bb0560","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00441-004-0938-y","article-title":"Classic toxin-induced animal models of Parkinson\u2019s disease: 6-OHDA and MPTP","volume":"318","author":"Schober","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.nbd.2022.105697_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108024","article-title":"Effects of safinamide on the glutamatergic striatal network in experimental Parkinson's disease","volume":"170","author":"Sciaccaluga","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2022.105697_bb0570","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.coph.2018.03.003","article-title":"mGlu receptors in the treatment of Parkinson\u2019s disease and L-DOPA-induced dyskinesia","volume":"38","author":"Sebastianutto","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2022.105697_bb0575","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pneurobio.2011.10.005","article-title":"Glutamatergic mechanisms in the dyskinesias induced by pharmacological dopamine replacement and deep brain stimulation for the treatment of Parkinson\u2019s disease","volume":"96","author":"Sgambato-Faure","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2022.105697_bb0580","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1172\/JCI133398","article-title":"Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine","volume":"130","author":"Shen","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2022.105697_bb0585","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.molbrainres.2005.01.012","article-title":"Absence of inclusion body formation in the MPTP mouse model of Parkinson\u2019s disease","volume":"134","author":"Shimoji","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2022.105697_bb0590","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1152\/jn.00910.2014","article-title":"Dopamine regulates distinctively the activity patterns of striatal output neurons in advanced parkinsonian primates","volume":"113","author":"Singh","year":"2015","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2022.105697_bb0595","doi-asserted-by":"crossref","first-page":"9629","DOI":"10.1073\/pnas.1606792113","article-title":"Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson\u2019s disease","volume":"113","author":"Singh","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105697_bb0600","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.celrep.2017.12.095","article-title":"Glutamatergic tuning of hyperactive striatal projection neurons controls the motor response to dopamine replacement in parkinsonian primates","volume":"22","author":"Singh","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2022.105697_bb0605","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fnsys.2014.00005","article-title":"The thalamostriatal system in normal and diseased states","volume":"8","author":"Smith","year":"2014","journal-title":"Front. Syst. 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A."},{"key":"10.1016\/j.nbd.2022.105697_bb0645","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.neuron.2018.12.004","article-title":"Cholinergic interneurons amplify Thalamostriatal excitation of striatal indirect pathway neurons in Parkinson\u2019s disease models","volume":"101","author":"Tanimura","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2022.105697_bb0650","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1523\/JNEUROSCI.4082-10.2011","article-title":"The distinct role of medium spiny neurons and cholinergic interneurons in the D(2)\/A(2)A receptor interaction in the striatum: implications for Parkinson\u2019s disease","volume":"31","author":"Tozzi","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105697_bb0655","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.biopsych.2015.08.013","article-title":"Alpha-Synuclein produces early behavioral alterations via striatal cholinergic synaptic dysfunction by interacting with GluN2D N-methyl-D-aspartate receptor subunit","volume":"79","author":"Tozzi","year":"2016","journal-title":"Biol. 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