{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:43:05Z","timestamp":1790480585146,"version":"4.1.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.nbd.2022.105698","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T13:42:18Z","timestamp":1647610938000},"page":"105698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Inflammation in dementia with Lewy bodies"],"prefix":"10.1016","volume":"168","author":[{"given":"Jay","family":"Amin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Erskine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Donaghy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajenthan","family":"Surendranathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Swann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy P.","family":"Kunicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Boche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian G.","family":"McKeith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Teeling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.nbd.2022.105698_bb0005","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.nbd.2011.01.029","article-title":"Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission","volume":"42","author":"Alvarez-Erviti","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.nbd.2022.105698_bb0010","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/jnnp-2020-323603","article-title":"Peripheral immunophenotype in dementia with Lewy bodies and Alzheimer\u2019s disease: an observational clinical study","volume":"91","author":"Amin","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41398-020-00954-8","article-title":"Neuroinflammation in dementia with Lewy bodies: a human post-mortem study","volume":"10","author":"Amin","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105698_bb0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40478-015-0209-z","article-title":"Disease-related microglia heterogeneity in the hippocampus of Alzheimer\u2019s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging","volume":"3","author":"Bachstetter","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"issue":"6","key":"10.1016\/j.nbd.2022.105698_bb0025","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1128\/JVI.02949-15","article-title":"Alpha-Synuclein expression restricts RNA viral infections in the brain","volume":"90","author":"Beatman","year":"2015","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nan.12011","article-title":"Review: activation patterns of microglia and their identification in the human brain","volume":"39","author":"Boche","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"13","key":"10.1016\/j.nbd.2022.105698_bb0035","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1007\/s00259-019-04462-w","article-title":"Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer\u2019s disease","volume":"46","author":"Boche","year":"2019","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"4","key":"10.1016\/j.nbd.2022.105698_bb0040","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1750-3639.2011.00550.x","article-title":"Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation","volume":"22","author":"Bonneh-Barkay","year":"2012","journal-title":"Brain Pathol. (Zurich, Switzerland)"},{"key":"10.1016\/j.nbd.2022.105698_bb0045","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1742-2094-9-259","article-title":"The gamma chain subunit of fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia","volume":"9","author":"Cao","year":"2012","journal-title":"J. Neuroinflammation"},{"issue":"12","key":"10.1016\/j.nbd.2022.105698_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126517","article-title":"Alpha-Synuclein as a prominent actor in the inflammatory Synaptopathy of Parkinson\u2019s disease","volume":"22","author":"Cardinale","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0055","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1038\/s41467-021-21937-3","article-title":"The release of toxic oligomers from \u03b1-synuclein fibrils induces dysfunction in neuronal cells","volume":"12","author":"Cascella","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00702-010-0485-5","article-title":"CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson\u2019s disease","volume":"118","author":"Castellani","year":"2011","journal-title":"J. Neural Transm. (Vienna, Austria: 1996)"},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0065","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/WAD.0b013e3182969905","article-title":"Proinflammatory cytokines and the clinical features of dementia with lewy bodies","volume":"29","author":"Clough","year":"2015","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.nbd.2022.105698_bb0070","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1742-2094-8-166","article-title":"The acute inflammatory response to intranigral alpha-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation","volume":"8","author":"Couch","year":"2011","journal-title":"J. Neuroinflammation"},{"issue":"10","key":"10.1016\/j.nbd.2022.105698_bb0075","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.biopsych.2010.08.025","article-title":"YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer\u2019s disease","volume":"68","author":"Craig-Schapiro","year":"2010","journal-title":"Biol. Psychiatry"},{"issue":"376","key":"10.1016\/j.nbd.2022.105698_bb0080","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2005965","article-title":"Activation of MyD88-dependent TLR1\/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders","volume":"8","author":"Daniele","year":"2015","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0085","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-018-1171-z","article-title":"Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration","volume":"15","author":"Duffy","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"12","key":"10.1016\/j.nbd.2022.105698_bb0090","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1084\/jem.20021546","article-title":"CD36 mediates the innate host response to beta-amyloid","volume":"197","author":"El Khoury","year":"2003","journal-title":"J. Exp. Med."},{"issue":"1\u20132","key":"10.1016\/j.nbd.2022.105698_bb0095","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jneuroim.2007.07.009","article-title":"Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation","volume":"189","author":"Ernst","year":"2007","journal-title":"J. Neuroimmunol."},{"issue":"6","key":"10.1016\/j.nbd.2022.105698_bb0100","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/mds.27333","article-title":"Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies","volume":"33","author":"Erskine","year":"2018","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0105","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00401-017-1787-6","article-title":"Regional levels of physiological alpha-synuclein are directly associated with Lewy body pathology","volume":"135","author":"Erskine","year":"2018","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.nbd.2022.105698_bb0110","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00401-021-02266-7","article-title":"Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders","volume":"141","author":"Erskine","year":"2021","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.nbd.2022.105698_bb0115","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/glia.22437","article-title":"Toll-like receptor 4 is required for alpha-synuclein dependent activation of microglia and astroglia","volume":"61","author":"Fellner","year":"2013","journal-title":"Glia."},{"issue":"3","key":"10.1016\/j.nbd.2022.105698_bb0120","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jalz.2017.09.014","article-title":"The limbic and neocortical contribution of alpha-synuclein, tau, and amyloid beta; to disease duration in dementia with Lewy bodies","volume":"14","author":"Ferman","year":"2018","journal-title":"Alzheimers Dement."},{"issue":"24","key":"10.1016\/j.nbd.2022.105698_bb0125","doi-asserted-by":"crossref","first-page":"e3257","DOI":"10.1212\/WNL.0000000000010943","article-title":"\u03b2-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies","volume":"95","author":"Ferreira","year":"2020","journal-title":"Neurology."},{"issue":"6","key":"10.1016\/j.nbd.2022.105698_bb0130","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.parkreldis.2010.03.007","article-title":"Lewy body dementia: the caregiver experience of clinical care","volume":"16","author":"Galvin","year":"2010","journal-title":"Parkinsonism Relat. Disord."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0135","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13024-019-0335-3","article-title":"Microglia affect alpha-synuclein cell-to-cell transfer in a mouse model of Parkinson\u2019s disease","volume":"14","author":"George","year":"2019","journal-title":"Mol. Neurodegener."},{"issue":"9","key":"10.1016\/j.nbd.2022.105698_bb0140","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.it.2020.07.007","article-title":"The role of astrocytes in CNS inflammation","volume":"41","author":"Giovannoni","year":"2020","journal-title":"Trends Immunol."},{"issue":"9","key":"10.1016\/j.nbd.2022.105698_bb0145","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1001\/archneur.60.9.1218","article-title":"Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer disease","volume":"60","author":"Gomez-Tortosa","year":"2003","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2022.105698_bb0150","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3233\/JAD-171133","article-title":"Alzheimer\u2019s amyloid-beta is an antimicrobial peptide: a review of the evidence","volume":"62","author":"Gosztyla","year":"2018","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0155","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1474-4422(17)30400-3","article-title":"Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study","volume":"17","author":"Guerreiro","year":"2018","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0160","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/bpa.12763","article-title":"Characterization of the 18 kDa translocator protein (TSPO) expression in post-mortem normal and Alzheimer\u2019s disease brains","volume":"30","author":"Gui","year":"2020","journal-title":"Brain Pathol."},{"issue":"7","key":"10.1016\/j.nbd.2022.105698_bb0165","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/nan.12554","article-title":"Review: clinical, neuropathological and genetic features of Lewy body dementias","volume":"45","author":"Hansen","year":"2019","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"4","key":"10.1016\/j.nbd.2022.105698_bb0170","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2022.105698_bb0175","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/mp.2017.246","article-title":"Markers of microglia in post-mortem brain samples from patients with Alzheimer\u2019s disease: a systematic review","volume":"23","author":"Hopperton","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105698_bb0180","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3389\/fimmu.2019.00480","article-title":"CSF cytokines in aging, multiple sclerosis, and dementia","volume":"10","author":"Hu","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0185","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00401-018-1907-y","article-title":"Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson\u2019s disease pathogenesis","volume":"137","author":"Hughes","year":"2019","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0190","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.parkreldis.2012.07.002","article-title":"In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson\u2019s disease","volume":"19","author":"Iannaccone","year":"2013","journal-title":"Parkinsonism Relat. Disord."},{"issue":"2","key":"10.1016\/j.nbd.2022.105698_bb0195","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00401-004-0919-y","article-title":"Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains","volume":"109","author":"Imamura","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2022.105698_bb0200","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3389\/fnins.2016.00408","article-title":"Alpha-Synuclein oligomers-neurotoxic molecules in Parkinson\u2019s disease and other Lewy body disorders","volume":"10","author":"Ingelsson","year":"2016","journal-title":"Front. Neurosci."},{"issue":"33","key":"10.1016\/j.nbd.2022.105698_bb0205","doi-asserted-by":"crossref","first-page":"14063","DOI":"10.1073\/pnas.0900096106","article-title":"Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration","volume":"106","author":"Jang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13195-018-0350-6","article-title":"Clinical prevalence of Lewy body dementia","volume":"10","author":"Kane","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nbd.2022.105698_bb0215","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/ncomms2534","article-title":"Neuron-released oligomeric alpha-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia","volume":"4","author":"Kim","year":"2013","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.nbd.2022.105698_bb0220","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/jnnp-2017-317134","article-title":"Peripheral inflammation in prodromal Alzheimer\u2019s and Lewy body dementias","volume":"89","author":"King","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"9","key":"10.1016\/j.nbd.2022.105698_bb0225","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3390\/ph14090847","article-title":"Alpha-Synuclein PET tracer development\u2014an overview about current efforts","volume":"14","author":"Korat","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.nbd.2022.105698_bb0230","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.4049\/jimmunol.1100216","article-title":"Misfolded truncated protein tau induces innate immune response via MAPK pathway","volume":"187","author":"Kovac","year":"2011","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.nbd.2022.105698_bb0235","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S1474-4422(20)30346-X","article-title":"PET imaging of neuroinflammation in neurological disorders","volume":"19","author":"Kreisl","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2022.105698_bb0240","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1742-2094-5-37","article-title":"Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation","volume":"5","author":"Lee","year":"2008","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0245","doi-asserted-by":"crossref","first-page":"615","DOI":"10.4049\/jimmunol.0903480","article-title":"Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1","volume":"185","author":"Lee","year":"2010","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0250","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13024-017-0226-4","article-title":"YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias","volume":"12","author":"Llorens","year":"2017","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0255","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1212\/WNL.55.1.132","article-title":"Activated microglia in dementia with Lewy bodies","volume":"55","author":"Mackenzie","year":"2000","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.nbd.2022.105698_bb0260","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbadis.2003.09.004","article-title":"Phagocytosis of apoptotic cells and the resolution of inflammation","volume":"1639","author":"Maderna","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2022.105698_bb0265","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neurobiolaging.2020.11.006","article-title":"Imaging tau burden in dementia with Lewy bodies using [(18)F]-AV1451 positron emission tomography","volume":"101","author":"Mak","year":"2021","journal-title":"Neurobiol. Aging"},{"issue":"12","key":"10.1016\/j.nbd.2022.105698_bb0270","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1073\/pnas.1906466117","article-title":"Disruption of cellular proteostasis by H1N1 influenza a virus causes alpha-synuclein aggregation","volume":"117","author":"Marreiros","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.nbd.2022.105698_bb0275","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/alz.12291","article-title":"Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia","volume":"17","author":"McAleese","year":"2021","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0280","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0285","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1038\/s41598-019-44173-8","article-title":"Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer\u2019s disease","volume":"9","author":"Morenas-Rodr\u00edguez","year":"2019","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.nbd.2022.105698_bb0290","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S1474-4422(17)30074-1","article-title":"The prognosis of dementia with Lewy bodies","volume":"16","author":"Mueller","year":"2017","journal-title":"Lancet Neurol."},{"issue":"5726","key":"10.1016\/j.nbd.2022.105698_bb0295","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0300","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-019-0306-8","article-title":"Dementia with Lewy bodies: an update and outlook","volume":"14","author":"Outeiro","year":"2019","journal-title":"Mol. Neurodegener."},{"issue":"2","key":"10.1016\/j.nbd.2022.105698_bb0305","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.bbrc.2016.08.052","article-title":"Functional characterization of alpha-synuclein protein with antimicrobial activity","volume":"478","author":"Park","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.nbd.2022.105698_bb0310","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","article-title":"Microglial priming in neurodegenerative disease","volume":"10","author":"Perry","year":"2014","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0315","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jagp.2019.06.007","article-title":"Postmortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation","volume":"28","author":"Rajkumar","year":"2020","journal-title":"Am. J. Geriatr. Psychiatry"},{"issue":"6","key":"10.1016\/j.nbd.2022.105698_bb0320","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1111\/j.1471-4159.2007.05087.x","article-title":"Nitrated alpha-synuclein-activated microglial profiling for Parkinson\u2019s disease","volume":"104","author":"Reynolds","year":"2008","journal-title":"J. Neurochem."},{"issue":"Pt 10","key":"10.1016\/j.nbd.2022.105698_bb0325","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1093\/brain\/aws234","article-title":"Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies","volume":"135","author":"Schneider","year":"2012","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.nbd.2022.105698_bb0330","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/archneur.57.6.817","article-title":"Cortical inflammation in Alzheimer disease but not dementia with Lewy bodies","volume":"57","author":"Shepherd","year":"2000","journal-title":"Arch. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2022.105698_bb0335","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41580-018-0089-8","article-title":"Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins","volume":"20","author":"Singh","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0340","first-page":"21","article-title":"Imaging of neuroinflammation in dementia: a review","volume":"87","author":"Stefaniak","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105698_bb0345","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbi.2015.10.012","article-title":"Microglia in dementia with Lewy bodies","volume":"55","author":"Streit","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"12","key":"10.1016\/j.nbd.2022.105698_bb0350","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/brain\/awy265","article-title":"Early microglial activation and peripheral inflammation in dementia with Lewy bodies","volume":"141","author":"Surendranathan","year":"2018","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.nbd.2022.105698_bb0355","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/gps.5365","article-title":"Prospective longitudinal evaluation of cytokines in mild cognitive impairment due toADand Lewy body disease","volume":"35","author":"Thomas","year":"2020","journal-title":"Int. J. Geriatr. Psychopharmacol."},{"issue":"6","key":"10.1016\/j.nbd.2022.105698_bb0360","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00702-017-1726-7","article-title":"Holocranohistochemistry enables the visualization of alpha-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects","volume":"124","author":"Tomlinson","year":"2017","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"15","key":"10.1016\/j.nbd.2022.105698_bb0365","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025847118","article-title":"Soluble alpha-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia","volume":"118","author":"Trudler","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105698_bb0370","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jocn.2020.04.058","article-title":"Plasma cytokine profile in synucleinophaties with dementia","volume":"78","author":"Usenko","year":"2020","journal-title":"J. Clin. Neurosci."},{"issue":"4","key":"10.1016\/j.nbd.2022.105698_bb0375","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1017\/S0033291713000494","article-title":"The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies","volume":"44","author":"Vann Jones","year":"2014","journal-title":"Psychol. Med."},{"issue":"6","key":"10.1016\/j.nbd.2022.105698_bb0380","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00702-017-1702-2","article-title":"Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts","volume":"124","author":"Walker","year":"2017","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"5","key":"10.1016\/j.nbd.2022.105698_bb0385","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/jnc.14698","article-title":"Clinical and neuropathological differences between Parkinson\u2019s disease, Parkinson\u2019s disease dementia and dementia with Lewy bodies - current issues and future directions","volume":"150","author":"Walker","year":"2019","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.nbd.2022.105698_bb0390","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2217\/nmt.12.41","article-title":"Differentiating dementia with Lewy bodies and Alzheimer\u2019s disease using MRI","volume":"2","author":"Watson","year":"2012","journal-title":"Neurodegen. Dis. Manag."},{"issue":"2","key":"10.1016\/j.nbd.2022.105698_bb0395","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.expneurol.2012.06.025","article-title":"Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein","volume":"237","author":"Watson","year":"2012","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0400","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/imcb.12301","article-title":"The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer\u2019s disease","volume":"98","author":"Webers","year":"2020","journal-title":"Immunol. Cell Biol."},{"issue":"1","key":"10.1016\/j.nbd.2022.105698_bb0405","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13195-015-0145-y","article-title":"Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients","volume":"7","author":"Wennstrom","year":"2015","journal-title":"Alzheimers Res. Ther."},{"issue":"8","key":"10.1016\/j.nbd.2022.105698_bb0410","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/acn3.50837","article-title":"Translocator protein in late stage Alzheimer\u2019s disease and dementia with Lewy bodies brains","volume":"6","author":"Xu","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"5","key":"10.1016\/j.nbd.2022.105698_bb0415","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00005-015-0351-0","article-title":"Inflammation in Alzheimer\u2019s disease and molecular genetics: recent update","volume":"63","author":"Zhang","year":"2015","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"5","key":"10.1016\/j.nbd.2022.105698_bb0420","first-page":"541","article-title":"Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research","volume":"13","author":"Zhou","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996122000900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996122000900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:33:34Z","timestamp":1760852014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996122000900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":84,"alternative-id":["S0969996122000900"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2022.105698","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation in dementia with Lewy bodies","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2022.105698","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105698"}}