{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:35:03Z","timestamp":1793032503137,"version":"4.5.0"},"reference-count":247,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009019","name":"Shenzhen University","doi-asserted-by":"publisher","award":["860-000002111208"],"award-info":[{"award-number":["860-000002111208"]}],"id":[{"id":"10.13039\/501100009019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601113"],"award-info":[{"award-number":["81601113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900836"],"award-info":[{"award-number":["31900836"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771174"],"award-info":[{"award-number":["81771174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471112"],"award-info":[{"award-number":["81471112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.nbd.2022.105824","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T12:19:22Z","timestamp":1658492362000},"page":"105824","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Current understanding of the interactions between metal ions and Apolipoprotein E in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"172","author":[{"given":"Yanhui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2022.105824_bb0005","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00775-019-01731-9","article-title":"Redox active metals in neurodegenerative diseases","volume":"24","author":"Acevedo","year":"2019","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0010","doi-asserted-by":"crossref","first-page":"8252","DOI":"10.1074\/jbc.M110.128512","article-title":"Copper promotes the trafficking of the amyloid precursor protein","volume":"286","author":"Acevedo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0015","doi-asserted-by":"crossref","first-page":"11007","DOI":"10.1074\/jbc.M113.538710","article-title":"Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells","volume":"289","author":"Acevedo","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0020","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1523\/JNEUROSCI.5255-09.2010","article-title":"Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer\u2019s disease?","volume":"30","author":"Adlard","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.650930","article-title":"Cadmium, an environmental contaminant, Exacerbates Alzheimer's pathology in the Aged Mice's Brain","volume":"13","author":"Ali","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0030","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An english translation of Alzheimer\u2019s 1907 paper, \u201cUber eine eigenartige Erkankung der Hirnrinde\u201d","volume":"8","author":"Alzheimer","year":"1995","journal-title":"Clin. Anat."},{"key":"10.1016\/j.nbd.2022.105824_bb0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/01.jnen.0000196133.74087.cb","article-title":"Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain","volume":"65","author":"Arai","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb0040","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1523\/JNEUROSCI.17-02-00516.1997","article-title":"Plastic neuronal remodeling is impaired in patients with Alzheimer\u2019s disease carrying apolipoprotein epsilon 4 allele","volume":"17","author":"Arendt","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101494","article-title":"Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine\/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis","volume":"32","author":"Ashraf","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.nbd.2022.105824_bb0050","doi-asserted-by":"crossref","first-page":"12817","DOI":"10.1074\/jbc.273.21.12817","article-title":"Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis","volume":"273","author":"Atwood","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0055","doi-asserted-by":"crossref","first-page":"6760","DOI":"10.1038\/ncomms7760","article-title":"Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE","volume":"6","author":"Ayton","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2022.105824_bb0060","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1001\/jamaneurol.2016.4406","article-title":"Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-epsilon4 Carriers","volume":"74","author":"Ayton","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb0065","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1093\/brain\/awx137","article-title":"Cerebral quantitative susceptibility mapping predicts amyloid-beta-related cognitive decline","volume":"140","author":"Ayton","year":"2017","journal-title":"Brain."},{"key":"10.1016\/j.nbd.2022.105824_bb0070","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/s41380-019-0375-7","article-title":"Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology","volume":"25","author":"Ayton","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105824_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2020.101904","article-title":"Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE epsilon4, sex and age","volume":"198","author":"Ayton","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2022.105824_bb0080","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3233\/JAD-210158","article-title":"The Association of Essential Metals with APOE Genotype in Alzheimer's Disease","volume":"82","author":"Babic Leko","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb0085","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13195-020-00710-6","article-title":"Effect of APOE epsilon4 genotype on amyloid-beta and tau accumulation in Alzheimer\u2019s disease","volume":"12","author":"Baek","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nbd.2022.105824_bb0090","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3233\/JAD-200282","article-title":"Heavy Metals Exposure and Alzheimer\u2019s Disease and Related Dementias","volume":"76","author":"Bakulski","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb0095","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/ng1197-263","article-title":"Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition","volume":"17","author":"Bales","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2022.105824_bb0100","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrn2194","article-title":"Tau-mediated neurodegeneration in Alzheimer\u2019s disease and related disorders","volume":"8","author":"Ballatore","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0105","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jtemb.2015.11.005","article-title":"Iron-induced oxidative stress activates AKT and ERK1\/2 and decreases Dyrk1B and PRMT1 in neuroblastoma SH-SY5Y cells","volume":"34","author":"Bautista","year":"2016","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.nbd.2022.105824_bb0110","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1471-4159.2004.02731.x","article-title":"Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts","volume":"91","author":"Bellingham","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2022.105824_bb0115","doi-asserted-by":"crossref","first-page":"20378","DOI":"10.1074\/jbc.M400805200","article-title":"Copper depletion down-regulates expression of the Alzheimer\u2019s disease amyloid-beta precursor protein gene","volume":"279","author":"Bellingham","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0120","doi-asserted-by":"crossref","first-page":"35514","DOI":"10.1038\/srep35514","article-title":"Colocalization of cerebral iron with amyloid beta in mild cognitive impairment","volume":"6","author":"van Bergen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2022.105824_bb0125","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.neuroimage.2018.03.021","article-title":"Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and beta-amyloid as an indicator of cognitive performance at high age","volume":"174","author":"van Bergen","year":"2018","journal-title":"Neuroimage."},{"key":"10.1016\/j.nbd.2022.105824_bb0130","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/biof.1003","article-title":"Selenium and cognitive impairment: a brief-review based on results from the EVA study","volume":"38","author":"Berr","year":"2012","journal-title":"Biofactors."},{"key":"10.1016\/j.nbd.2022.105824_bb0135","doi-asserted-by":"crossref","first-page":"552","DOI":"10.2174\/1570159X18666200122122512","article-title":"Role of Oxidative Stress and Metal Toxicity in the Progression of Alzheimer's Disease","volume":"18","author":"Birla","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.nbd.2022.105824_bb0140","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.bbamcr.2008.11.011","article-title":"Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells","volume":"1793","author":"Boom","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2022.105824_bb0145","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1523\/JNEUROSCI.4315-03.2004","article-title":"Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice","volume":"24","author":"Brecht","year":"2004","journal-title":"J. Neurosci."},{"issue":"215\u2013217","key":"10.1016\/j.nbd.2022.105824_bb0150","article-title":"Iron inhibits the secretion of apolipoprotein E in cultured human adipocytes","volume":"6","author":"Britton","year":"2018","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.nbd.2022.105824_bb0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neurobiolaging.2020.06.022","article-title":"Cell death and survival pathways in Alzheimer\u2019s disease: an integrative hypothesis testing approach utilizing -omic data sets","volume":"95","author":"Brokaw","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2022.105824_bb0160","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/0960327119889654","article-title":"The association between heavy metal and serum cholesterol levels in the US population: national health and nutrition examination survey 2009-2012","volume":"39","author":"Buhari","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.nbd.2022.105824_bb0165","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1096\/fj.14-252874","article-title":"Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration","volume":"28","author":"Burk","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2022.105824_bb0170","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-2236(03)00067-5","article-title":"The metallobiology of Alzheimer\u2019s disease","volume":"26","author":"Bush","year":"2003","journal-title":"Trends Neurosci."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2022.105824_bb0175","first-page":"S277","article-title":"The metal theory of Alzheimer\u2019s disease","volume":"33","author":"Bush","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb0180","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1126\/science.8073293","article-title":"Rapid induction of Alzheimer A beta amyloid formation by zinc","volume":"265","author":"Bush","year":"1994","journal-title":"Science."},{"key":"10.1016\/j.nbd.2022.105824_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104795","article-title":"Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer\u2019s disease","volume":"138","author":"Butterfield","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb0190","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1039\/c5mt00075k","article-title":"Selenium, selenoproteins and neurodegenerative diseases","volume":"7","author":"Cardoso","year":"2015","journal-title":"Metallomics."},{"key":"10.1016\/j.nbd.2022.105824_bb0195","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1021\/acschemneuro.7b00014","article-title":"The APOE epsilon4 Allele is associated with lower selenium levels in the brain: implications for Alzheimer\u2019s Disease","volume":"8","author":"Cardoso","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0200","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3233\/JAD-160622","article-title":"Selenium levels in serum, red blood cells, and cerebrospinal fluid of alzheimer\u2019s disease patients: a report from the australian imaging, biomarker & lifestyle flagship study of ageing (AIBL)","volume":"57","author":"Cardoso","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb0205","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/mp.2016.196","article-title":"Glutathione peroxidase 4: a new player in neurodegeneration?","volume":"22","author":"Cardoso","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105824_bb0210","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.3389\/fimmu.2018.02122","article-title":"Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2022.105824_bb0215","doi-asserted-by":"crossref","first-page":"12011","DOI":"10.1073\/pnas.0914984107","article-title":"ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105824_bb0220","first-page":"38","article-title":"Apolipoprotein E deletion has no effect on copper-induced oxidative stress in the mice brain","author":"Chen","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.nbd.2022.105824_bb0225","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neuron.2020.10.008","article-title":"Apolipoprotein E: structural insights and links to Alzheimer Disease pathogenesis","volume":"109","author":"Chen","year":"2021","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2022.105824_bb0230","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/mp.2013.194","article-title":"APOE2 enhances neuroprotection against Alzheimer\u2019s disease through multiple molecular mechanisms","volume":"19","author":"Conejero-Goldberg","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105824_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100715","article-title":"Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism","volume":"296","author":"Cooper","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0240","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science."},{"key":"10.1016\/j.nbd.2022.105824_bb0245","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3233\/JAD-180151","article-title":"Zinc exacerbates tau pathology in a Tau Mouse model","volume":"64","author":"Craven","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb0250","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1038\/s41380-020-0800-y","article-title":"Alzheimer risk factors age and female sex induce cortical Abeta aggregation by raising extracellular zinc","volume":"25","author":"Datki","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105824_bb0255","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00204-015-1540-7","article-title":"Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3beta enzyme, beta-amyloid and tau protein levels","volume":"90","author":"Del Pino","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.nbd.2022.105824_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101716","article-title":"Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer\u2019s disease from a ferroptosis perspective","volume":"184","author":"Derry","year":"2020","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2022.105824_bb0265","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2022.105824_bb0270","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1021\/bi0272151","article-title":"Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence","volume":"42","author":"Dong","year":"2003","journal-title":"Biochemistry."},{"key":"10.1016\/j.nbd.2022.105824_bb0275","doi-asserted-by":"crossref","first-page":"15317","DOI":"10.1523\/JNEUROSCI.4026-09.2009","article-title":"ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo","volume":"29","author":"Dumanis","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0280","doi-asserted-by":"crossref","first-page":"13509","DOI":"10.1021\/acs.inorgchem.9b00995","article-title":"Copper-targeting approaches in Alzheimer's disease: how to improve the fallouts obtained from in vitro studies","volume":"58","author":"Esmieu","year":"2019","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0285","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.690372","article-title":"Cholesterol and Alzheimer\u2019s disease; from risk genes to pathological effects","volume":"13","author":"Feringa","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0290","doi-asserted-by":"crossref","first-page":"e2586","DOI":"10.1212\/WNL.0000000000010868","article-title":"Contribution of iron and Abeta to age differences in entorhinal and hippocampal subfield volume","volume":"95","author":"Foster","year":"2020","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2022.105824_bb0295","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrn1671","article-title":"The neurobiology of zinc in health and disease","volume":"6","author":"Frederickson","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0300","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1523\/JNEUROSCI.0297-04.2004","article-title":"Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer\u2019s disease","volume":"24","author":"Friedlich","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0305","doi-asserted-by":"crossref","first-page":"7889","DOI":"10.1523\/JNEUROSCI.23-21-07889.2003","article-title":"Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice","volume":"23","author":"Fryer","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111582","article-title":"Isoform-specific effects of apolipoprotein E on hydrogen peroxide-induced apoptosis in human induced pluripotent stem cell (iPSC)-derived cortical neurons","volume":"22","author":"Gao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2022.105824_bb0315","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1017\/S1368980009005102","article-title":"Selenium level is associated with apoE epsilon4 in rural elderly Chinese","volume":"12","author":"Gao","year":"2009","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.nbd.2022.105824_bb0320","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1074\/jbc.M116.754101","article-title":"Zinc and copper differentially modulate amyloid precursor protein processing by gamma-secretase and amyloid-beta peptide production","volume":"292","author":"Gerber","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0325","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1471-4159.2006.04079.x","article-title":"Deposition of iron and beta-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets","volume":"99","author":"Ghribi","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2022.105824_bb0330","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neuroimage.2019.02.019","article-title":"Imaging beta amyloid aggregation and iron accumulation in Alzheimer\u2019s disease using quantitative susceptibility mapping MRI","volume":"191","author":"Gong","year":"2019","journal-title":"Neuroimage."},{"key":"10.1016\/j.nbd.2022.105824_bb0335","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s12011-021-02765-4","article-title":"Serum copper and zinc concentrations and cognitive impairment in older adults aged 60 years and older","volume":"200","author":"Gong","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.nbd.2022.105824_bb0340","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1212\/WNL.0000000000003234","article-title":"Relative effect of APOE epsilon4 on neuroimaging biomarker changes across the lifespan","volume":"87","author":"Gonneaud","year":"2016","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2022.105824_bb0345","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1046\/j.1365-2362.1999.00471.x","article-title":"Serum zinc, copper, insulin and lipids in Alzheimer\u2019s disease epsilon 4 apolipoprotein E allele carriers","volume":"29","author":"Gonzalez","year":"1999","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.nbd.2022.105824_bb0350","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s12263-012-0282-x","article-title":"Apolipoprotein E genotype affects tissue metallothionein levels: studies in targeted gene replacement mice","volume":"7","author":"Graeser","year":"2012","journal-title":"Genes Nutr."},{"key":"10.1016\/j.nbd.2022.105824_bb0355","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/hep.23712","article-title":"Hepatic iron loading in mice increases cholesterol biosynthesis","volume":"52","author":"Graham","year":"2010","journal-title":"Hepatology."},{"key":"10.1016\/j.nbd.2022.105824_bb0360","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13024-018-0298-9","article-title":"New insights into the role of TREM2 in Alzheimer's disease","volume":"13","author":"Gratuze","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2022.105824_bb0365","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/s41593-019-0539-4","article-title":"A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation","volume":"22","author":"Grubman","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0370","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u2019s disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2022.105824_bb0375","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13195-015-0105-6","article-title":"Follow-up plasma apolipoprotein E levels in the Australian imaging, biomarkers and lifestyle flagship study of ageing (AIBL) cohort","volume":"7","author":"Gupta","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nbd.2022.105824_bb0380","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.neulet.2009.12.035","article-title":"Selenium attenuates A beta production and A beta-induced neuronal death","volume":"469","author":"Gwon","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2022.105824_bb0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059005","article-title":"Cu(2+) affects amyloid-beta (1-42) aggregation by increasing peptide-peptide binding forces","volume":"8","author":"Hane","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105824_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577185","article-title":"Microglia heterogeneity and neurodegeneration: The emerging paradigm of the role of immunity in Alzheimer's disease","volume":"341","author":"Hashemiaghdam","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2022.105824_bb0395","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1007\/s12035-020-01982-7","article-title":"Silencing of LRP1 exacerbates inflammatory response Via TLR4\/NF-kappaB\/MAPKs signaling pathways in APP\/PS1 transgenic mice","volume":"57","author":"He","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2022.105824_bb0400","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1093\/jnen\/nlw067","article-title":"Apolipoprotein E genotype affects size of ApoE complexes in cerebrospinal fluid","volume":"75","author":"Heinsinger","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb0405","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb0410","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s40478-019-0847-7","article-title":"Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype","volume":"7","author":"Hesse","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2022.105824_bb0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tibs.2004.11.001","article-title":"A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions","volume":"30","author":"Heyninck","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.nbd.2022.105824_bb0420","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1073\/pnas.050004797","article-title":"Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer\u2019s disease","volume":"97","author":"Holtzman","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105824_bb0425","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006312","article-title":"Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease","volume":"2","author":"Holtzman","year":"2012","journal-title":"Cold Spring Harb Perspect Med."},{"key":"10.1016\/j.nbd.2022.105824_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(94)01079-X","article-title":"Families of zinc metalloproteases","volume":"354","author":"Hooper","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2022.105824_bb0435","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1074\/jbc.AAC118.003576","article-title":"Role of apolipoprotein E in beta-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Abeta in vitro and brain Abeta deposition in vivo","volume":"293","author":"Hori","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0440","doi-asserted-by":"crossref","first-page":"26464","DOI":"10.1074\/jbc.272.42.26464","article-title":"Zinc-induced Alzheimer\u2019s Abeta1-40 aggregation is mediated by conformational factors","volume":"272","author":"Huang","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0445","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.molmed.2010.04.004","article-title":"Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer\u2019s disease","volume":"16","author":"Huang","year":"2010","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.nbd.2022.105824_bb0450","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1385\/JMN:23:3:189","article-title":"Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease","volume":"23","author":"Huang","year":"2004","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0455","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.celrep.2014.06.047","article-title":"Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation","volume":"8","author":"Huang","year":"2014","journal-title":"Cell Rep."},{"issue":"427\u2013441","key":"10.1016\/j.nbd.2022.105824_bb0460","article-title":"ApoE2, ApoE3, and ApoE4 differentially stimulate APP transcription and abeta secretion","volume":"168","author":"Huang","year":"2017","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2022.105824_bb0465","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.jmb.2019.01.018","article-title":"Metal toxicity links to Alzheimer\u2019s disease and neuroinflammation","volume":"431","author":"Huat","year":"2019","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.nbd.2022.105824_bb0470","doi-asserted-by":"crossref","first-page":"21899","DOI":"10.1074\/jbc.M109.019521","article-title":"Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease","volume":"284","author":"Hung","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1013\u20131023","key":"10.1016\/j.nbd.2022.105824_bb0475","article-title":"Age-Dependent Effects of apoE reduction using antisense oligonucleotides in a model of beta-amyloidosis","volume":"96","author":"Huynh","year":"2017","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2022.105824_bb0480","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1021\/acschemneuro.8b00034","article-title":"Effect of sodium selenate on hippocampal proteome of 3xTg-AD Mice-exploring the antioxidant dogma of selenium against Alzheimer's disease","volume":"9","author":"Iqbal","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0485","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.brainres.2009.04.010","article-title":"Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer\u2019s type","volume":"1281","author":"Ishrat","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2022.105824_bb0490","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-5728(89)90115-X","article-title":"Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease","volume":"24","author":"Itagaki","year":"1989","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2022.105824_bb0495","doi-asserted-by":"crossref","first-page":"e498","DOI":"10.1016\/S2666-7568(21)00150-1","article-title":"Blood cholesterol and risk of dementia in more than 1\u00b7 8 million people over two decades: a retrospective cohort study","volume":"2","author":"Iwagami","year":"2021","journal-title":"Lancet Healthy Longevity."},{"key":"10.1016\/j.nbd.2022.105824_bb0500","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/jnc.15519","article-title":"Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease","volume":"159","author":"Jakaria","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2022.105824_bb0505","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.freeradbiomed.2011.10.446","article-title":"Elevated labile Cu is associated with oxidative pathology in Alzheimer disease","volume":"52","author":"James","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2022.105824_bb0510","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acschemneuro.6b00362","article-title":"Iron, copper, and zinc concentration in Abeta Plaques in the APP\/PS1 mouse model of Alzheimer\u2019s disease correlates with metal levels in the surrounding neuropil","volume":"8","author":"James","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0515","first-page":"54","article-title":"The correlation between accumulation of amyloid beta with enhanced neuroinflammation and cognitive impairment after intraventricular hemorrhage","volume":"131","author":"Jiang","year":"2018","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.nbd.2022.105824_bb0520","doi-asserted-by":"crossref","first-page":"9270","DOI":"10.1021\/bi700508n","article-title":"Redox reactions of copper complexes formed with different beta-amyloid peptides and their neuropathological [correction of neuropathalogical] relevance","volume":"46","author":"Jiang","year":"2007","journal-title":"Biochemistry."},{"key":"10.1016\/j.nbd.2022.105824_bb0525","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2008.04.010","article-title":"ApoE promotes the proteolytic degradation of Abeta","volume":"58","author":"Jiang","year":"2008","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2022.105824_bb0530","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/oxfordjournals.jbchem.a124796","article-title":"Characterization of an upstream regulatory element of the human apolipoprotein E gene, and purification of its binding protein from the human placenta","volume":"117","author":"Jo","year":"1995","journal-title":"J. Biochem."},{"key":"10.1016\/j.nbd.2022.105824_bb0535","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2022.105824_bb0540","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12035-020-02096-w","article-title":"Molecular Mechanisms of metal toxicity in the Pathogenesis of Alzheimer\u2019s disease","volume":"58","author":"Kabir","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2022.105824_bb0545","article-title":"APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old-aged adults","volume":"12","author":"Kagerer","year":"2020","journal-title":"Alzheimers Dement (Amst)."},{"key":"10.1016\/j.nbd.2022.105824_bb0550","doi-asserted-by":"crossref","first-page":"14231","DOI":"10.1073\/pnas.94.26.14231","article-title":"Classification of mononuclear zinc metal sites in protein structures","volume":"94","author":"Karlin","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105824_bb0555","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.conb.2011.08.002","article-title":"Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer\u2019s disease","volume":"21","author":"Keene","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.nbd.2022.105824_bb0560","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40478-021-01126-5","article-title":"Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients","volume":"9","author":"Kenkhuis","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2022.105824_bb0565","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.stemcr.2022.04.006","article-title":"Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia","volume":"17","author":"Kenkhuis","year":"2022","journal-title":"Stem Cell Reports."},{"key":"10.1016\/j.nbd.2022.105824_bb0570","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/WNR.0b013e32834c0a2d","article-title":"Zinc stimulates tau S214 phosphorylation by the activation of Raf\/mitogen-activated protein kinase-kinase\/extracellular signal-regulated kinase pathway","volume":"22","author":"Kim","year":"2011","journal-title":"Neuroreport."},{"key":"10.1016\/j.nbd.2022.105824_bb0575","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13195-021-00931-3","article-title":"Serum zinc levels and in vivo beta-amyloid deposition in the human brain","volume":"13","author":"Kim","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nbd.2022.105824_bb0580","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1111\/j.1471-4159.2009.05901.x","article-title":"Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD","volume":"108","author":"Kitazawa","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2022.105824_bb0585","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/toxsci\/kfw081","article-title":"Copper exposure perturbs brain inflammatory responses and impairs clearance of amyloid-beta","volume":"152","author":"Kitazawa","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.nbd.2022.105824_bb0590","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.neuroscience.2010.10.027","article-title":"Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2","volume":"171","author":"Klein","year":"2010","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2022.105824_bb0595","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1093\/brain\/aws127","article-title":"Apolipoprotein E4 effects in Alzheimer\u2019s disease are mediated by synaptotoxic oligomeric amyloid-beta","volume":"135","author":"Koffie","year":"2012","journal-title":"Brain."},{"key":"10.1016\/j.nbd.2022.105824_bb0600","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.dadm.2019.01.010","article-title":"ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-beta copathology","volume":"11","author":"Koriath","year":"2019","journal-title":"Alzheimers Dement (Amst)."},{"key":"10.1016\/j.nbd.2022.105824_bb0605","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev-pathmechdis-030421-112756","article-title":"Apolipoprotein E and Alzheimer\u2019s Disease: findings, hypotheses, and potential mechanisms","volume":"17","author":"Koutsodendris","year":"2022","journal-title":"Annu. Rev. Pathol."},{"issue":"566-581","key":"10.1016\/j.nbd.2022.105824_bb0610","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity."},{"key":"10.1016\/j.nbd.2022.105824_bb0615","doi-asserted-by":"crossref","first-page":"23403","DOI":"10.1016\/S0021-9258(17)31529-6","article-title":"Isoform-specific binding of apolipoprotein E to beta-amyloid","volume":"269","author":"LaDu","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0620","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1073\/pnas.96.7.3922","article-title":"Constitutive and regulated alpha-secretase cleavage of Alzheimer\u2019s amyloid precursor protein by a disintegrin metalloprotease","volume":"96","author":"Lammich","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105824_bb0625","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1017\/S1355617716000990","article-title":"The elusive nature of APOE epsilon4 in mid-adulthood: understanding the cognitive profile","volume":"23","author":"Lancaster","year":"2017","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.nbd.2022.105824_bb0630","doi-asserted-by":"crossref","first-page":"10141","DOI":"10.1523\/JNEUROSCI.1054-16.2016","article-title":"Genetic restoration of plasma ApoE improves cognition and partially restores synaptic defects in ApoE-deficient mice","volume":"36","author":"Lane-Donovan","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0635","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1039\/C4CS00005F","article-title":"Cholesterol and metal ions in Alzheimer\u2019s disease","volume":"43","author":"Lee","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.nbd.2022.105824_bb0640","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.1073\/pnas.092034699","article-title":"Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice","volume":"99","author":"Lee","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105824_bb0645","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s10534-010-9354-9","article-title":"Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain","volume":"23","author":"Lee","year":"2010","journal-title":"Biometals."},{"key":"10.1016\/j.nbd.2022.105824_bb0650","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1038\/s41598-018-23122-x","article-title":"Zinc ion rapidly induces toxic, off-pathway amyloid-beta oligomers distinct from amyloid-beta derived diffusible ligands in Alzheimer\u2019s disease","volume":"8","author":"Lee","year":"2018","journal-title":"Sci. Rep."},{"issue":"202","key":"10.1016\/j.nbd.2022.105824_bb0655","first-page":"e1","article-title":"Transferrin and HFE genes interact in Alzheimer\u2019s disease risk: the Epistasis Project","volume":"33","author":"Lehmann","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2022.105824_bb0660","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nm.2613","article-title":"Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export","volume":"18","author":"Lei","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2022.105824_bb0665","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.REV120.008207","article-title":"The essential elements of Alzheimer's disease","volume":"296","author":"Lei","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0670","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1039\/C3MT00258F","article-title":"Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog","volume":"6","author":"Leong","year":"2014","journal-title":"Implic. Biol. Function. Metallomics."},{"key":"10.1016\/j.nbd.2022.105824_bb0675","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.neuroimage.2009.05.063","article-title":"Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer\u2019s disease","volume":"47","author":"Leskovjan","year":"2009","journal-title":"Neuroimage."},{"key":"10.1016\/j.nbd.2022.105824_bb0680","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3892\/etm.2012.562","article-title":"The effect of cadmium on Abeta levels in APP\/PS1 transgenic mice","volume":"4","author":"Li","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.nbd.2022.105824_bb0685","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3233\/JAD-190419","article-title":"Neuron-specific apolipoprotein E4 (1-272) fragment induces tau hyperphosphorylation and axonopathy via triggering endoplasmic reticulum stress","volume":"71","author":"Liang","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb0690","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1523\/JNEUROSCI.0646-14.2014","article-title":"Anti-ApoE antibody given after plaque onset decreases Abeta accumulation and improves brain function in a mouse model of Abeta amyloidosis","volume":"34","author":"Liao","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0695","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.neuron.2018.06.011","article-title":"APOE4 causes widespread molecular and cellular alterations associated with Alzheimer\u2019s disease phenotypes in human iPSC-derived brain cell types","volume":"98","author":"Lin","year":"2018","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2022.105824_bb0700","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.parkreldis.2011.12.005","article-title":"Apolipoprotein E gene (APOE) genotype in Wilson\u2019s disease: impact on clinical presentation","volume":"18","author":"Litwin","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2022.105824_bb0705","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10534-020-00247-z","article-title":"Dietary cadmium exposure causes elevation of blood ApoE with triglyceride level in mice","volume":"33","author":"Liu","year":"2020","journal-title":"Biometals."},{"key":"10.1016\/j.nbd.2022.105824_bb0710","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.neurobiolaging.2005.04.008","article-title":"Premorbid effects of APOE on synaptic proteins in human temporal neocortex","volume":"27","author":"Love","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2022.105824_bb0715","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbi.2008.09.003","article-title":"Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway","volume":"23","author":"Lu","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2022.105824_bb0720","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101865","article-title":"Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice","volume":"40","author":"Ma","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.nbd.2022.105824_bb0725","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science."},{"key":"10.1016\/j.nbd.2022.105824_bb0730","first-page":"36","article-title":"Cholesterol, transferrin saturation, and the development of dementia and Alzheimer\u2019s disease: results from an 18-year population-based cohort","volume":"37","author":"Mainous","year":"2005","journal-title":"Fam. Med."},{"key":"10.1016\/j.nbd.2022.105824_bb0735","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bcp.2019.02.033","article-title":"Inhibition of MMPs and ADAM\/ADAMTS","volume":"165","author":"Malemud","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2022.105824_bb0740","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fnagi.2013.00037","article-title":"Effects of hemochromatosis and transferrin gene mutations on peripheral iron dyshomeostasis in mild cognitive impairment and Alzheimer's and Parkinson's diseases","volume":"5","author":"Mariani","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0745","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1097\/00001756-199611040-00025","article-title":"A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity","volume":"7","author":"Marques","year":"1996","journal-title":"Neuroreport."},{"key":"10.1016\/j.nbd.2022.105824_bb0750","doi-asserted-by":"crossref","first-page":"fcac083","DOI":"10.1093\/braincomms\/fcac083","article-title":"Emerging insights into synapse dysregulation in Alzheimer's disease","volume":"4","author":"Martinez-Serra","year":"2022","journal-title":"Brain Commun."},{"key":"10.1016\/j.nbd.2022.105824_bb0755","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer's disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2022.105824_bb0760","doi-asserted-by":"crossref","first-page":"44670","DOI":"10.1074\/jbc.M204379200","article-title":"Overexpression of Alzheimer\u2019s disease amyloid-beta opposes the age-dependent elevations of brain copper and iron","volume":"277","author":"Maynard","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0765","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12940-016-0155-7","article-title":"Blood cadmium levels and Alzheimer\u2019s disease mortality risk in older US adults","volume":"15","author":"Min","year":"2016","journal-title":"Environ. Health"},{"key":"10.1016\/j.nbd.2022.105824_bb0770","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng0996-55","article-title":"Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides","volume":"14","author":"Miyata","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2022.105824_bb0775","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1021\/bi982437d","article-title":"Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations","volume":"38","author":"Moir","year":"1999","journal-title":"Biochemistry."},{"key":"10.1016\/j.nbd.2022.105824_bb0780","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3233\/JAD-151037","article-title":"Patterns of brain iron accumulation in vascular dementia and Alzheimer\u2019s dementia using quantitative susceptibility mapping imaging","volume":"51","author":"Moon","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb0785","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20235979","article-title":"Zinc binding to tau influences aggregation kinetics and oligomer distribution","volume":"20","author":"Moreira","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2022.105824_bb0790","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s11064-018-2629-1","article-title":"Understanding the role of ApoE fragments in Alzheimer\u2019s Disease","volume":"44","author":"Munoz","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2022.105824_bb0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107962","article-title":"In vivo chimeric Alzheimer's disease modeling of apolipoprotein E4 toxicity in human neurons","volume":"32","author":"Najm","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2022.105824_bb0800","first-page":"1","article-title":"Genome-wide analysis identified abundant genetic modulators of contributions of the apolipoprotein E alleles to Alzheimer\u2019s disease risk","volume":"1","author":"Nazarian","year":"2022","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2022.105824_bb0805","doi-asserted-by":"crossref","first-page":"7377","DOI":"10.1074\/jbc.M409071200","article-title":"Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide","volume":"280","author":"Nelson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0810","article-title":"Associative interactions among zinc, apolipoprotein E, and amyloid-beta in the amyloid pathology","volume":"21","author":"Oh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2022.105824_bb0815","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3233\/JAD-131892","article-title":"Differences in nutritional status between very mild Alzheimer\u2019s disease patients and healthy controls","volume":"41","author":"Olde Rikkert","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb0820","doi-asserted-by":"crossref","first-page":"14934","DOI":"10.1073\/pnas.93.25.14934","article-title":"ZnT-3, a putative transporter of zinc into synaptic vesicles","volume":"93","author":"Palmiter","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105824_bb0825","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41593-018-0296-9","article-title":"Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE","volume":"22","author":"Parhizkar","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0830","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuro.2017.03.001","article-title":"Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-kappaB pathways","volume":"60","author":"Phuagkhaopong","year":"2017","journal-title":"Neurotoxicology."},{"key":"10.1016\/j.nbd.2022.105824_bb0835","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1093\/emboj\/cdf568","article-title":"The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing","volume":"21","author":"Pietrzik","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2022.105824_bb0840","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1089\/ars.2020.8134","article-title":"Preventive and therapeutic strategies in Alzheimer's disease: focus on oxidative stress, redox metals, and ferroptosis","volume":"34","author":"Plascencia-Villa","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2022.105824_bb0850","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/2051-5960-1-55","article-title":"The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer\u2019s disease","volume":"1","author":"Raha","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2022.105824_bb0855","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2018.01.021","article-title":"Traumatic brain injury and Alzheimer's disease: the cerebrovascular link","volume":"28","author":"Ramos-Cejudo","year":"2018","journal-title":"EBioMedicine."},{"key":"10.1016\/j.nbd.2022.105824_bb0860","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/ana.24326","article-title":"Plasma levels of apolipoprotein E and risk of dementia in the general population","volume":"77","author":"Rasmussen","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb0865","doi-asserted-by":"crossref","first-page":"9611","DOI":"10.1523\/JNEUROSCI.1400-19.2019","article-title":"ApoE4 alters ABCA1 membrane trafficking in astrocytes","volume":"39","author":"Rawat","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0870","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41467-019-14279-8","article-title":"Exceptionally low likelihood of Alzheimer\u2019s dementia in APOE2 homozygotes from a 5,000-person neuropathological study","volume":"11","author":"Reiman","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2022.105824_bb0875","article-title":"Decreased copper in Alzheimer's disease brain is predominantly in the soluble extractable fraction","volume":"2013","author":"Rembach","year":"2013","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb0880","doi-asserted-by":"crossref","first-page":"11445","DOI":"10.1523\/JNEUROSCI.1972-08.2008","article-title":"Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels","volume":"28","author":"Riddell","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb0885","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/130.5.1407S","article-title":"Zinc-altered immune function and cytokine production","volume":"130","author":"Rink","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.nbd.2022.105824_bb0890","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1742-2094-11-111","article-title":"Human APOE4 increases microglia reactivity at Abeta plaques in a mouse model of Abeta deposition","volume":"11","author":"Rodriguez","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2022.105824_bb0895","doi-asserted-by":"crossref","first-page":"45518","DOI":"10.1074\/jbc.M207435200","article-title":"An iron-responsive element type II in the 5\u2019-untranslated region of the Alzheimer\u2019s amyloid precursor protein transcript","volume":"277","author":"Rogers","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0900","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.03.099","article-title":"The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to abeta plaques","volume":"27","author":"Sala Frigerio","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2022.105824_bb0905","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1172\/JCI117407","article-title":"Apolipoprotein E associates with beta amyloid peptide of Alzheimer\u2019s disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3","volume":"94","author":"Sanan","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2022.105824_bb0910","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73456","article-title":"Aging is associated with increased brain iron through cortex-derived hepcidin expression","volume":"11","author":"Sato","year":"2022","journal-title":"Elife."},{"key":"10.1016\/j.nbd.2022.105824_bb0915","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","article-title":"Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer\u2019s disease","volume":"43","author":"Saunders","year":"1993","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2022.105824_bb0920","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/ana.24369","article-title":"APOEepsilon2 is associated with milder clinical and pathological Alzheimer disease","volume":"77","author":"Serrano-Pozo","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb0925","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1474-4422(20)30412-9","article-title":"APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches","volume":"20","author":"Serrano-Pozo","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb0930","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2022.105824_bb0935","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/bioinformatics\/btm618","article-title":"Prediction of zinc-binding sites in proteins from sequence","volume":"24","author":"Shu","year":"2008","journal-title":"Bioinformatics."},{"key":"10.1016\/j.nbd.2022.105824_bb0940","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1474-4422(22)00087-4","article-title":"Dynamics of neuroinflammation in Alzheimer's disease","volume":"21","author":"Smirnov","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb0945","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/00001756-199602290-00010","article-title":"Alzheimer\u2019s beta-amyloid peptide is conformationally modified by apolipoprotein E in vitro","volume":"7","author":"Soto","year":"1996","journal-title":"Neuroreport."},{"key":"10.1016\/j.nbd.2022.105824_bb0950","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/brain\/awaa089","article-title":"Relationship between cortical iron and tau aggregation in Alzheimer's disease","volume":"143","author":"Spotorno","year":"2020","journal-title":"Brain."},{"key":"10.1016\/j.nbd.2022.105824_bb0955","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1212\/WNL.59.8.1153","article-title":"Elevation of serum copper levels in Alzheimer\u2019s disease","volume":"59","author":"Squitti","year":"2002","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2022.105824_bb0960","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1212\/01.wnl.0000338568.28960.3f","article-title":"Longitudinal prognostic value of serum \u201cfree\u201d copper in patients with Alzheimer disease","volume":"72","author":"Squitti","year":"2009","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2022.105824_bb0965","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2022.105824_bb0970","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.neurobiolaging.2007.10.012","article-title":"Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid","volume":"30","author":"Strozyk","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2022.105824_bb0975","doi-asserted-by":"crossref","first-page":"11174","DOI":"10.1074\/jbc.M111.309070","article-title":"Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A)","volume":"287","author":"Sun","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb0980","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1039\/c2mt20018j","article-title":"Proposed glucocorticoid-mediated zinc signaling in the hippocampus","volume":"4","author":"Takeda","year":"2012","journal-title":"Metallomics."},{"issue":"2213-2233","key":"10.1016\/j.nbd.2022.105824_bb0985","article-title":"Cholesterol and matrisome pathways dysregulated in astrocytes and microglia","volume":"185","author":"Tcw","year":"2022","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2022.105824_bb0990","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-005-1053-1","article-title":"Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner","volume":"110","author":"Thal","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2022.105824_bb0995","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1038\/s41380-020-0688-6","article-title":"APOEepsilon4 potentiates the relationship between amyloid-beta and tau pathologies","volume":"26","author":"Therriault","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105824_bb1000","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193867","article-title":"Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in cognitive impairment diseases","volume":"13","author":"Tisato","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105824_bb1005","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1523\/JNEUROSCI.17-15-05678.1997","article-title":"Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated","volume":"17","author":"Tolar","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb1010","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41380-020-0762-0","article-title":"Amyloidogenic processing of Alzheimer's disease beta-amyloid precursor protein induces cellular iron retention","volume":"25","author":"Tsatsanis","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105824_bb1015","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/nan.12529","article-title":"Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease","volume":"45","author":"Tzioras","year":"2019","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.nbd.2022.105824_bb1020","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41582-018-0072-1","article-title":"TREM2 - a key player in microglial biology and Alzheimer disease","volume":"14","author":"Ulland","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb1025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1750-1326-8-13","article-title":"In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis","volume":"8","author":"Ulrich","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2022.105824_bb1030","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/jnc.12244","article-title":"Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells","volume":"126","author":"Urrutia","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2022.105824_bb1035","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s12011-018-1492-x","article-title":"Brain selenium in Alzheimer\u2019s disease (BRAIN SEAD Study): a systematic review and meta-analysis","volume":"189","author":"Varikasuvu","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.nbd.2022.105824_bb1040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061117","article-title":"Mammalian metallothionein-3: new functional and structural insights","volume":"18","author":"Vasak","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2022.105824_bb1045","doi-asserted-by":"crossref","first-page":"E1807","DOI":"10.1073\/pnas.1220484110","article-title":"ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE\/Abeta association in physiological conditions","volume":"110","author":"Verghese","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105824_bb1050","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/2047-9158-3-24","article-title":"Modulation of tau phosphorylation by environmental copper","volume":"3","author":"Voss","year":"2014","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.nbd.2022.105824_bb1055","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/ana.25455","article-title":"Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease","volume":"85","author":"Wadhwani","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb1060","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/898034","article-title":"Cadmium and its neurotoxic effects","volume":"2013","author":"Wang","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.nbd.2022.105824_bb1065","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2021.03.024","article-title":"Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia","volume":"109","author":"Wang","year":"2021","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2022.105824_bb1070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/toxsci\/kfx202","article-title":"Cadmium exposure impairs cognition and olfactory memory in male C57BL\/6 mice","volume":"161","author":"Wang","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.nbd.2022.105824_bb1075","first-page":"118","article-title":"Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105824_bb1080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40035-020-00189-z","article-title":"Current understanding of metal ions in the pathogenesis of Alzheimer's disease","volume":"9","author":"Wang","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.nbd.2022.105824_bb1085","article-title":"Mass spectrometry quantification revealed accumulation of C-terminal fragment of apolipoprotein E in the Alzheimer\u2019s frontal cortex","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105824_bb1090","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12502","article-title":"Copper chelators promote nonamyloidogenic processing of AbetaPP via MT1\/2 \/CREB-dependent signaling pathways in AbetaPP\/PS1 transgenic mice","volume":"65","author":"Wang","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.nbd.2022.105824_bb1095","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1001\/jamaneurol.2018.3139","article-title":"Association of apolipoprotein E epsilon4 with transactive response DNA-binding protein 43","volume":"75","author":"Wennberg","year":"2018","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2022.105824_bb1100","doi-asserted-by":"crossref","first-page":"12676","DOI":"10.1073\/pnas.94.23.12676","article-title":"Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey","volume":"94","author":"Wenzel","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2022.105824_bb1105","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0006-8993(99)01861-2","article-title":"Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice","volume":"842","author":"White","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2022.105824_bb1110","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1016\/j.neurobiolaging.2014.06.015","article-title":"Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer\u2019s disease: association with cognitive impairment","volume":"35","author":"Whitfield","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2022.105824_bb1115","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/s41467-019-09613-z","article-title":"Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age","volume":"10","author":"Wingo","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2022.105824_bb1120","first-page":"1030","article-title":"Acceleration of Alzheimer\u2019s fibril formation by apolipoprotein E in vitro","volume":"145","author":"Wisniewski","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2022.105824_bb1125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114174","article-title":"beta-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin","volume":"9","author":"Wong","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2022.105824_bb1130","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00775-017-1463-2","article-title":"Ebselen ameliorates beta-amyloid pathology, tau pathology, and cognitive impairment in triple-transgenic Alzheimer's disease mice","volume":"22","author":"Xie","year":"2017","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb1135","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fnagi.2014.00121","article-title":"Interactions of metals and Apolipoprotein E in Alzheimer's disease","volume":"6","author":"Xu","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb1140","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.nbd.2015.06.016","article-title":"Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way","volume":"81","author":"Xu","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb1145","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3233\/JAD-150797","article-title":"Iron regulates apolipoprotein E expression and secretion in neurons and astrocytes","volume":"51","author":"Xu","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2022.105824_bb1150","doi-asserted-by":"crossref","first-page":"25511","DOI":"10.1074\/jbc.M311256200","article-title":"Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer","volume":"279","author":"Xu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2022.105824_bb1155","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1046\/j.1471-4159.2002.t01-1-01061.x","article-title":"Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer\u2019s disease","volume":"82","author":"Yamamoto","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2022.105824_bb1160","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1096\/fj.02-0285fje","article-title":"Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity","volume":"16","author":"Yao","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2022.105824_bb1165","first-page":"91","article-title":"ERK activation induced by selenium treatment significantly downregulates beta\/gamma-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M","volume":"24","author":"Yim","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.nbd.2022.105824_bb1170","doi-asserted-by":"crossref","first-page":"6580","DOI":"10.1038\/srep06580","article-title":"Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice","volume":"4","author":"Yong","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2022.105824_bb1175","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1021\/acs.biochem.8b00572","article-title":"The human amyloid precursor protein binds copper ions dominated by a picomolar-affinity site in the Helix-Rich E2 domain","volume":"57","author":"Young","year":"2018","journal-title":"Biochemistry."},{"key":"10.1016\/j.nbd.2022.105824_bb1180","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/iub.1611","article-title":"Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A","volume":"69","author":"Yu","year":"2017","journal-title":"IUBMB Life"},{"key":"10.1016\/j.nbd.2022.105824_bb1185","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12974-015-0343-3","article-title":"Cu(II) enhances the effect of Alzheimer's amyloid-beta peptide on microglial activation","volume":"12","author":"Yu","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2022.105824_bb1190","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/s41593-021-00851-3","article-title":"Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer\u2019s disease","volume":"24","author":"Zalocusky","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2022.105824_bb1195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.brainres.2008.03.066","article-title":"An observational study on the influence of the APOE-epsilon4 allele on the correlation between \u2018free\u2019 copper toxicosis and EEG activity in Alzheimer disease","volume":"1215","author":"Zappasodi","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2022.105824_bb1200","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/s42003-021-02898-1","article-title":"Cadmium exposure modulates the gut-liver axis in an Alzheimer's disease mouse model","volume":"4","author":"Zhang","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.nbd.2022.105824_bb1205","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/toxsci\/kfz218","article-title":"The effects of gene-environment interactions between cadmium exposure and Apolipoprotein E4 on memory in a mouse model of Alzheimer's Disease","volume":"173","author":"Zhang","year":"2020","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.nbd.2022.105824_bb1210","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainresbull.2008.03.014","article-title":"Abundant expression of zinc transporters in the amyloid plaques of Alzheimer\u2019s disease brain","volume":"77","author":"Zhang","year":"2008","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2022.105824_bb1215","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/glia.20416","article-title":"Cellular iron status influences the functional relationship between microglia and oligodendrocytes","volume":"54","author":"Zhang","year":"2006","journal-title":"Glia."},{"key":"10.1016\/j.nbd.2022.105824_bb1220","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.redox.2017.11.001","article-title":"alpha-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice","volume":"14","author":"Zhang","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.nbd.2022.105824_bb1225","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1039\/C6MT00117C","article-title":"Selenomethionine reduces the deposition of beta-amyloid plaques by modulating beta-secretase and enhancing selenoenzymatic activity in a mouse model of Alzheimer\u2019s disease","volume":"8","author":"Zhang","year":"2016","journal-title":"Metallomics."},{"key":"10.1016\/j.nbd.2022.105824_bb1230","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1038\/s41467-020-19264-0","article-title":"APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids","volume":"11","author":"Zhao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2022.105824_bb1235","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.biopsych.2017.03.003","article-title":"Apolipoprotein E, receptors, and modulation of Alzheimer's disease","volume":"83","author":"Zhao","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2022.105824_bb1240","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1074\/jbc.R800009200","article-title":"Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure","volume":"284","author":"Zhong","year":"2009","journal-title":"J. Biol. Chem."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996122002169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996122002169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:01:20Z","timestamp":1778792480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996122002169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":247,"alternative-id":["S0969996122002169"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2022.105824","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current understanding of the interactions between metal ions and Apolipoprotein E in Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2022.105824","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105824"}}