{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:23:52Z","timestamp":1786994632238,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.nbd.2023.106015","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T11:46:30Z","timestamp":1674474390000},"page":"106015","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Early derangement of axonal mitochondria occurs in a mouse model of progressive but not relapsing-remitting multiple sclerosis"],"prefix":"10.1016","volume":"178","author":[{"given":"Daniela","family":"Buonvicino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ranieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Guasti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Pistolesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino Iurato","family":"La Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rapizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Chiarugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2023.106015_bb0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1750-1326-8-32","article-title":"Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics","volume":"8","author":"Alavi","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2023.106015_bb0010","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/jnr.20842","article-title":"Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the Shiverer mouse","volume":"83","author":"Andrews","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2023.106015_bb0015","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1097\/j.pain.0000000000001291","article-title":"Trigeminal ganglion transcriptome analysis in 2 rat models of medication-overuse headache reveals coherent and widespread induction of pronociceptive gene expression patterns","volume":"159","author":"Buonvicino","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2023.106015_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113065","article-title":"Neuroimmunological characterization of a mouse model of primary progressive experimental autoimmune encephalomyelitis and effects of immunosuppressive or neuroprotective strategies on disease evolution","volume":"322","author":"Buonvicino","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2023.106015_bb0025","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1111\/bph.15058","article-title":"Neuroprotection induced by dexpramipexole delays disease progression in a mouse model of progressive multiple sclerosis","volume":"177","author":"Buonvicino","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106015_bb0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuroscience.2021.04.002","article-title":"Treatment with non-specific HDAC inhibitors administered after disease onset does not delay evolution in a mouse model of progressive multiple sclerosis","volume":"465","author":"Buonvicino","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2023.106015_bb0035","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/1352458518805246","article-title":"Animal models of multiple sclerosis: from rodents to zebrafish","volume":"25","author":"Burrows","year":"2019","journal-title":"Mult. Scler."},{"key":"10.1016\/j.nbd.2023.106015_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/1873-3468.13013","article-title":"Mitochondrial dysfunction and axon degeneration in progressive multiple sclerosis","author":"Campbell","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2023.106015_bb0045","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1177\/1352458514544537","article-title":"The central role of mitochondria in axonal degeneration in multiple sclerosis","volume":"20","author":"Campbell","year":"2014","journal-title":"Mult. Scler."},{"key":"10.1016\/j.nbd.2023.106015_bb0050","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbi.2015.06.019","article-title":"Dysregulation of sphingosine 1 phosphate receptor-1 (S1P1) signaling and regulatory lymphocyte-dependent immunosuppression in a model of post-fingolimod MS rebound","volume":"50","author":"Cavone","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2023.106015_bb0055","doi-asserted-by":"crossref","first-page":"19857","DOI":"10.1073\/pnas.0810713105","article-title":"The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors","volume":"105","author":"D\u2019Alise","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106015_bb0060","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1158\/0008-5472.CAN-20-3326","article-title":"Peripheral nerve resident macrophages and Schwann cells mediate Cancer-induced pain","volume":"81","author":"De Logu","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.nbd.2023.106015_bb0065","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1093\/hmg\/ddi307","article-title":"Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency","volume":"14","author":"Diaz","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2023.106015_bb0070","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.109.214601","article-title":"Therapeutic targeting of mitochondrial superoxide in hypertension","volume":"107","author":"Dikalova","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.nbd.2023.106015_bb0075","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuropharm.2017.01.039","article-title":"Post onset, oral rapamycin treatment delays development of mitochondrial encephalopathy only at supramaximal doses","volume":"117","author":"Felici","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2023.106015_bb0080","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/1873-3468.14021","article-title":"Mitochondrial DNA copy number in human disease: the more the better?","volume":"595","author":"Filograna","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2023.106015_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109111","article-title":"The f subunit of human ATP synthase is essential for normal mitochondrial morphology and permeability transition","volume":"35","author":"Galber","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2023.106015_bb0090","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/icb.2016.7","article-title":"Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice","volume":"94","author":"James","year":"2016","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.nbd.2023.106015_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174311","article-title":"Functional interplay between cristae biogenesis, mitochondrial dynamics and mitochondrial DNA integrity","author":"Kondadi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2023.106015_bb0100","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.tcb.2020.08.008","article-title":"Cristae membrane dynamics - a paradigm change","volume":"30","author":"Kondadi","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.nbd.2023.106015_bb0105","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000501765","article-title":"Neuroinflammation and B-cell phenotypes in cervical and lumbosacral regions of the spinal cord in experimental autoimmune encephalomyelitis in the absence of pertussis toxin","volume":"26","author":"Kummari","year":"2019","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.nbd.2023.106015_bb0110","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1177\/13524585221106290","article-title":"Mitochondrial measures in neuronally enriched extracellular vesicles predict brain and retinal atrophy in multiple sclerosis","volume":"28","author":"Ladakis","year":"2022","journal-title":"Mult. Scler. J."},{"key":"10.1016\/j.nbd.2023.106015_bb0115","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.3390\/molecules26061592","article-title":"Neuroprotective effects of thymoquinone by the modulation of ER stress and apoptotic pathway in in vitro model of excitotoxicity","volume":"26","author":"Landucci","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.nbd.2023.106015_bb0120","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s12272-019-01198-x","article-title":"Involvement of mitochondrial biogenesis during the differentiation of human periosteum-derived mesenchymal stem cells into adipocytes, chondrocytes and osteocytes","volume":"42","author":"Lee","year":"2019","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.nbd.2023.106015_bb0125","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.freeradbiomed.2010.08.018","article-title":"SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery","volume":"49","author":"Liang","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2023.106015_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5828120","article-title":"Mito-TEMPO alleviates renal fibrosis by reducing inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress","volume":"2018","author":"Liu","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.nbd.2023.106015_bb0135","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0168-9525(01)02238-7","article-title":"What regulates mitochondrial DNA copy number in animal cells?","volume":"17","author":"Moraes","year":"2001","journal-title":"Trends Genet."},{"key":"10.1016\/j.nbd.2023.106015_bb0140","series-title":"Multiple Sclerosis: Perspectives in Treatment and Pathogenesis","first-page":"173","article-title":"Experimental in vivo models of multiple sclerosis: state of the art","author":"Palumbo","year":"2017"},{"key":"10.1016\/j.nbd.2023.106015_bb0145","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jneumeth.2007.03.013","article-title":"A model of experimental autoimmune encephalomyelitis (EAE) in C57BL\/6 mice for the characterisation of intervention therapies","volume":"163","author":"Peiris","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2023.106015_bb0150","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jsb.2010.06.017","article-title":"Mitochondrial configurations in peripheral nerve suggest differential ATP production","volume":"173","author":"Perkins","year":"2011","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.nbd.2023.106015_bb0155","first-page":"1","article-title":"Mitochondrial dysfunction, oxidative stress, and neuroinflammation: intertwined roads to neurodegeneration","volume":"9","author":"Picca","year":"2020","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.nbd.2023.106015_bb0160","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1084\/jem.20090299","article-title":"Spontaneous relapsing-remitting EAE in the SJL\/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells","volume":"206","author":"P\u00f6llinger","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2023.106015_bb0165","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1530\/ERC-11-0263","article-title":"Mitochondrial function and content in pheochromocytoma\/paraganglioma of succinate dehydrogenase mutation carriers","volume":"19","author":"Rapizzi","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.nbd.2023.106015_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.61798","article-title":"Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis","volume":"10","author":"Rosenkranz","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2023.106015_bb0175","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s41593-019-0385-4","article-title":"Bassoon proteinopathy drives neurodegeneration in multiple sclerosis","volume":"22","author":"Schattling","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2023.106015_bb0180","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mito.2021.03.001","article-title":"Mitochondria-targeted antioxidant, Mito-TEMPO mitigates initiation phase of N-Nitrosodiethylamine-induced hepatocarcinogenesis","volume":"58","author":"Shetty","year":"2021","journal-title":"Mitochondrion"},{"key":"10.1016\/j.nbd.2023.106015_bb0185","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1432-1327.2000.00936.x","article-title":"Biogenesis of giant mitochondria during insect flight muscle development in the locust, Locusta migratoria (L.). transcription, translation and copy number of mitochondrial DNA","volume":"267","author":"Sogl","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.nbd.2023.106015_bb0190","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/cns.13116","article-title":"Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure","volume":"25","author":"Wang","year":"2019","journal-title":"CNS Neurosci. Ther."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123000293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123000293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:33:27Z","timestamp":1760852007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996123000293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":38,"alternative-id":["S0969996123000293"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106015","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early derangement of axonal mitochondria occurs in a mouse model of progressive but not relapsing-remitting multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106015"}}