{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:29:30Z","timestamp":1790710170049,"version":"4.1.0"},"reference-count":138,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["8109"],"award-info":[{"award-number":["8109"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT153310"],"award-info":[{"award-number":["PJT153310"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT166178"],"award-info":[{"award-number":["PJT166178"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000095","name":"Savoy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2018-12365681"],"award-info":[{"award-number":["RF-2018-12365681"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-GR 2011-2012"],"award-info":[{"award-number":["RF-GR 2011-2012"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.nbd.2023.106097","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T20:12:23Z","timestamp":1679688743000},"page":"106097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Ligand-gated mechanisms leading to ictogenesis in focal epileptic disorders"],"prefix":"10.1016","volume":"180","author":[{"given":"Massimo","family":"Avoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Di Cristo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Librizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Scalmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Shiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Uva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"de Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"L\u00e9vesque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2023.106097_bb0005","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1748-1716.1966.tb03223.x","article-title":"Entorhinal activation of dentate granule cells","volume":"66","author":"Andersen","year":"1966","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.nbd.2023.106097_bb0010","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1748-1716.1966.tb03224.x","article-title":"Excitatory synapses on hippocampal apical dendrites activated by entorhinal stimulation","volume":"66","author":"Andersen","year":"1966","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.nbd.2023.106097_bb0015","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/BF00234087","article-title":"Lamellar organization of hippocampal excitatory pathways","volume":"13","author":"Andersen","year":"1971","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0304-3940(90)90125-S","article-title":"Epileptiform discharges and a synchronous GABAergic potential induced by 4-aminopyridine in the rat immature hippocampus","volume":"117","author":"Avoli","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2023.106097_bb0025","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pneurobio.2011.07.003","article-title":"GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity","volume":"95","author":"Avoli","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0030","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1152\/jn.1993.70.3.1018","article-title":"On the synchronous activity induced by 4-aminopyridine in the CA3 subfield of juvenile rat hippocampus","volume":"70","author":"Avoli","year":"1993","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0035","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1523\/JNEUROSCI.16-12-03912.1996","article-title":"Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro","volume":"16","author":"Avoli","year":"1996","journal-title":"J. Neurosci."},{"issue":"Pt 3","key":"10.1016\/j.nbd.2023.106097_bb0040","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1113\/jphysiol.1996.sp021416","article-title":"Extracellular free potassium and calcium during synchronous activity induced by 4-aminopyridine in the juvenile rat hippocampus","volume":"493","author":"Avoli","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0045","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.nbd.2012.12.004","article-title":"Two different interictal spike patterns anticipate ictal activity in vitro","volume":"52","author":"Avoli","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0050","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1152\/jn.01128.2015","article-title":"Specific imbalance of excitatory\/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy","volume":"115","author":"Avoli","year":"2016","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2022.984802","article-title":"GABAA signaling, focal epileptiform synchronization and epileptogenesis","volume":"16","author":"Avoli","year":"2022","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.nbd.2023.106097_bb0060","doi-asserted-by":"crossref","first-page":"9308","DOI":"10.1523\/JNEUROSCI.17-23-09308.1997","article-title":"CA3-driven hippocampal-entorhinal loop controls rather than sustains in vitro limbic seizures","volume":"17","author":"Barbarosie","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0065","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1152\/jn.2000.83.3.1115","article-title":"CA3-released entorhinal seizures disclose dentate gyrus epileptogenicity and unmask a temporoammonic pathway","volume":"83","author":"Barbarosie","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0070","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1046\/j.1528-1157.2002.17402.x","article-title":"Masking synchronous GABA-mediated potentials controls limbic seizures","volume":"43","author":"Barbarosie","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106097_bb0075","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/BF00230971","article-title":"Changes in extracellular K+ evoked by GABA, THIP and baclofen in the guinea-pig hippocampal slice","volume":"84","author":"Barolet","year":"1991","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0080","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.eplepsyres.2004.06.006","article-title":"Pre-ictal synchronicity in limbic networks of mesial temporal lobe epilepsy","volume":"61","author":"Bartolomei","year":"2004","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0085","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.nbd.2017.07.008","article-title":"Time-dependent evolution of seizures in a model of mesial temporal lobe epilepsy","volume":"106","author":"Behr","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0090","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1139\/y79-218","article-title":"Hippocampal seizures and failure of inhibition","volume":"57","author":"Ben-Ari","year":"1979","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106097_bb0095","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0306-4522(03)00262-8","article-title":"Involvement of amygdala networks in epileptiform synchronization in vitro","volume":"120","author":"Benini","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2023.106097_bb0100","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2009.03.003","article-title":"Cation-chloride cotransporters and neuronal function","volume":"61","author":"Blaesse","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2023.106097_bb0105","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1113\/JP275317","article-title":"Optogenetic dissection of roles of specific cortical interneuron subtypes in GABAergic network synchronization","volume":"596","author":"Bohannon","year":"2018","journal-title":"J. Physiol."},{"issue":"24","key":"10.1016\/j.nbd.2023.106097_bb0110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/cercor\/bhs298","article-title":"Network dynamics during the progression of seizure-like events in the hippocampal-parahippocampal regions","volume":"1991","author":"Boido","year":"2014","journal-title":"Cereb. Cortex NY"},{"key":"10.1016\/j.nbd.2023.106097_bb0115","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.nbd.2010.07.015","article-title":"Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system","volume":"40","author":"Bortel","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0120","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0006-8993(92)91088-V","article-title":"Suppression of interictal bursting in hippocampus unleashes seizures in entorhinal cortex: a proepileptic effect of lowering [K+]o and raising [Ca2+]o","volume":"590","author":"Bragdon","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0125","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1111\/j.1528-1167.2005.00268.x","article-title":"Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats","volume":"46","author":"Bragin","year":"2005","journal-title":"Epilepsia"},{"issue":"Suppl. 5","key":"10.1016\/j.nbd.2023.106097_bb0130","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1528-1167.2005.01010.x","article-title":"Analysis of seizure onset on the basis of wideband EEG recordings","volume":"46","author":"Bragin","year":"2005","journal-title":"Epilepsia"},{"issue":"Suppl. 6","key":"10.1016\/j.nbd.2023.106097_bb0135","first-page":"S7","article-title":"Tiagabine pharmacology in profile","volume":"36","author":"Brodie","year":"1995","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106097_bb0140","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1113\/jphysiol.1993.sp019874","article-title":"Mechanism of mu-opioid receptor-mediated presynaptic inhibition in the rat hippocampus in vitro","volume":"470","author":"Capogna","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0145","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1152\/jn.00862.2009","article-title":"Independent epileptiform discharge patterns in the olfactory and limbic areas of the in vitro isolated Guinea pig brain during 4-aminopyridine treatment","volume":"103","author":"Carriero","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0150","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.nbd.2017.10.007","article-title":"Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation","volume":"109","author":"Chang","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0155","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/0013-4694(74)90099-6","article-title":"A glossary of terms most commonly used by clinical electroencephalographers","volume":"37","author":"Chatrian","year":"1974","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0160","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/ana.23549","article-title":"Changes in interictal spike features precede the onset of temporal lobe epilepsy","volume":"71","author":"Chauvi\u00e8re","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0165","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1152\/jn.00266.2019","article-title":"KCC2 antagonism increases neuronal network excitability but disrupts ictogenesis in vitro. - PubMed - NCBI","volume":"122","author":"Chen","year":"2019","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0170","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41467-020-14648-8","article-title":"A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy","volume":"11","author":"Chen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2023.106097_bb0175","first-page":"113","article-title":"Evidence for involvement of GABA in the action of benzodiazepines: studies on rat cerebellum","author":"Costa","year":"1975","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"10.1016\/j.nbd.2023.106097_bb0180","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1093\/brain\/awh181","article-title":"GABAA receptor-dependent synchronization leads to ictogenesis in the human dysplastic cortex","volume":"127","author":"D\u2019Antuono","year":"2004","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0185","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1113\/jphysiol.1993.sp019945","article-title":"The physiological regulation of synaptic inhibition by GABAB autoreceptors in rat hippocampus","volume":"472","author":"Davies","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0190","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0301-0082(00)00026-5","article-title":"Interictal spikes in focal epileptogenesis","volume":"63","author":"de Curtis","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0195","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/epi.13370","article-title":"GABAergic networks jump-start focal seizures","volume":"57","author":"de Curtis","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106097_bb0200","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1523\/JNEUROSCI.18-18-07543.1998","article-title":"Activity-dependent pH shifts and periodic recurrence of spontaneous interictal spikes in a model of focal epileptogenesis","volume":"18","author":"de Curtis","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0205","series-title":"Jasper\u2019s Basic Mechanisms of the Epilepsies","article-title":"Interictal epileptiform discharges in partial epilepsy: complex neurobiological mechanisms based on experimental and clinical evidence","author":"de Curtis","year":"2012"},{"key":"10.1016\/j.nbd.2023.106097_bb0210","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1113\/jphysiol.2007.143065","article-title":"Transition to seizures in the isolated immature mouse hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation","volume":"586","author":"Derchansky","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2017.11.002","article-title":"KCC2, epileptiform synchronization, and epileptic disorders","volume":"162","author":"Di Cristo","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0220","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1113\/jphysiol.1980.sp013364","article-title":"Reduced inhibition during epileptiform activity in the in vitro hippocampal slice","volume":"305","author":"Dingledine","year":"1980","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0225","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuroscience.2022.02.007","article-title":"Silencing of hippocampal somatostatin interneurons induces recurrent spontaneous limbic seizures in mice","volume":"487","author":"Drexel","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2023.106097_bb0230","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/ana.25325","article-title":"Low-voltage fast seizures in humans begin with increased interneuron firing","volume":"84","author":"Elahian","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0235","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1113\/jphysiol.2006.119297","article-title":"Cell domain-dependent changes in the glutamatergic and GABAergic drives during epileptogenesis in the rat CA1 region","volume":"578","author":"El-Hassar","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0240","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0920-1211(96)00043-5","article-title":"Introduction to temporal lobe epilepsy","volume":"26","author":"Engel","year":"1996","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0245","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev-neuro-061010-113817","article-title":"The development and application of optogenetics","volume":"34","author":"Fenno","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0250","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrneurol.2014.59","article-title":"Electrical brain stimulation for epilepsy","volume":"10","author":"Fisher","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0255","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/ana.410340604","article-title":"Characteristics of medial temporal lobe epilepsy: I. results of history and physical examination","volume":"34","author":"French","year":"1993","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0260","doi-asserted-by":"crossref","first-page":"10734","DOI":"10.1523\/JNEUROSCI.1239-10.2010","article-title":"Network bistability mediates spontaneous transitions between normal and pathological brain states","volume":"30","author":"Fr\u00f6hlich","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0265","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.nbd.2005.12.011","article-title":"Effects of gap junction blockers on human neocortical synchronization","volume":"22","author":"Gigout","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0270","series-title":"The Temporal Lobe and Limbic System","author":"Gloor","year":"1997"},{"key":"10.1016\/j.nbd.2023.106097_bb0275","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/ana.21519","article-title":"Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro","volume":"64","author":"Gnatkovsky","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0280","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1528-1167.2010.02931.x","article-title":"Identification of reproducible ictal patterns based on quantified frequency analysis of intracranial EEG signals","volume":"52","author":"Gnatkovsky","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106097_bb0285","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.nbd.2017.10.011","article-title":"Role of KCC2-dependent potassium efflux in 4-Aminopyridine-induced epileptiform synchronization","volume":"109","author":"Gonz\u00e1lez","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0290","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.expneurol.2013.05.004","article-title":"Neuronal synchrony and the transition to spontaneous seizures","volume":"248","author":"Grasse","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0295","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1152\/jn.1993.69.5.1541","article-title":"Role of HCO3- ions in depolarizing GABAA receptor-mediated responses in pyramidal cells of rat hippocampus","volume":"69","author":"Grover","year":"1993","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0300","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.nbd.2015.04.006","article-title":"KCC2 function modulates in vitro ictogenesis","volume":"79","author":"Hamidi","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0305","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuropharm.2015.04.015","article-title":"Carbonic anhydrase inhibition by acetazolamide reduces in vitro epileptiform synchronization","volume":"95","author":"Hamidi","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2023.106097_bb0310","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nn.2790","article-title":"Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy","volume":"14","author":"Huberfeld","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0315","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1152\/jn.1997.77.3.1224","article-title":"Role of intrinsic burst firing, potassium accumulation, and electrical coupling in the elevated potassium model of hippocampal epilepsy","volume":"77","author":"Jensen","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0320","doi-asserted-by":"crossref","first-page":"7662","DOI":"10.1523\/JNEUROSCI.17-20-07662.1997","article-title":"Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient","volume":"17","author":"Kaila","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0325","doi-asserted-by":"crossref","DOI":"10.1152\/jn.00248.2015","article-title":"Blockade of in vitro ictogenesis by low frequency stimulation coincides with increased epileptiform response latency","author":"Kano","year":"2015","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0330","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuropharm.2016.04.029","article-title":"Compromising KCC2 transporter activity enhances the development of continuous seizure activity","volume":"108","author":"Kelley","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2023.106097_bb0335","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1111\/j.1460-9568.2003.02984.x","article-title":"Synaptic and non-synaptic mechanisms of amygdala recruitment into temporolimbic epileptiform activities","volume":"18","author":"Klueva","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0340","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1523\/JNEUROSCI.20-18-06820.2000","article-title":"Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations","volume":"20","author":"K\u00f6hling","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2015.12.002","article-title":"Hypersynchronous ictal onset in the perirhinal cortex results from dynamic weakening in inhibition","volume":"87","author":"K\u00f6hling","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0350","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0006-8993(83)91043-0","article-title":"Participation of cortical recurrent inhibition in the genesis of spike and wave discharges in feline generalized penicillin epilepsy","volume":"267","author":"Kostopoulos","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0355","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.23915","article-title":"Low-frequency electrical stimulation of a fiber tract in temporal lobe epilepsy","volume":"74","author":"Koubeissi","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2022.106937","article-title":"Modulation of epileptiform activity by three subgroups of GABAergic interneurons in mouse somatosensory cortex","volume":"183","author":"Lado","year":"2022","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0365","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1152\/jn.1997.78.5.2582","article-title":"Ionic mechanisms of spontaneous GABAergic events in rat hippocampal slices exposed to 4-Aminopyridine","volume":"78","author":"Lamsa","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0370","doi-asserted-by":"crossref","first-page":"13264","DOI":"10.1523\/JNEUROSCI.5086-11.2012","article-title":"Two seizure-onset types reveal specific patterns of high-frequency oscillations in a model of temporal lobe epilepsy","volume":"32","author":"L\u00e9vesque","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0375","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jneumeth.2015.03.009","article-title":"Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration","volume":"260","author":"L\u00e9vesque","year":"2016","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2023.106097_bb0380","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.nbd.2015.12.011","article-title":"Interneurons spark seizure-like activity in the entorhinal cortex","volume":"87","author":"L\u00e9vesque","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0385","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1111\/ejn.13628","article-title":"Interictal oscillations and focal epileptic disorders","volume":"48","author":"L\u00e9vesque","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0390","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/ana.25572","article-title":"Paradoxical effects of optogenetic stimulation in mesial temporal lobe epilepsy","volume":"86","author":"L\u00e9vesque","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.crneur.2021.100008","article-title":"Evolution of interictal spiking during the latent period in a mouse model of mesial temporal lobe epilepsy","volume":"2","author":"L\u00e9vesque","year":"2021","journal-title":"Curr. Res. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105794","article-title":"Bilateral optogenetic activation of inhibitory cells favors ictogenesis","volume":"171","author":"L\u00e9vesque","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0405","doi-asserted-by":"crossref","first-page":"10398","DOI":"10.1523\/JNEUROSCI.3906-16.2017","article-title":"Interneuronal network activity at the onset of seizure-like events in entorhinal cortex slices","volume":"37","author":"Librizzi","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105637","article-title":"Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice","volume":"166","author":"Lisgaras","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0415","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1152\/jn.1998.79.1.352","article-title":"Participation of GABAA-mediated inhibition in ictallike discharges in the rat entorhinal cortex","volume":"79","author":"Lopantsev","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0420","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1113\/jphysiol.1987.sp016634","article-title":"Inhibitory control of local excitatory circuits in the guinea-pig hippocampus","volume":"388","author":"Miles","year":"1987","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0425","doi-asserted-by":"crossref","first-page":"10106","DOI":"10.1523\/JNEUROSCI.22-23-10106.2002","article-title":"Potassium currents during the action potential of hippocampal CA3 neurons","volume":"22","author":"Mitterdorfer","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0430","doi-asserted-by":"crossref","first-page":"10166","DOI":"10.1073\/pnas.1810134115","article-title":"Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures","volume":"115","author":"Moore","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106097_bb0435","first-page":"71","article-title":"Extracellular K+ accumulations and synchronous GABA-mediated potentials evoked by 4-aminopyridine in the adult rat hippocampus","volume":"109","author":"Morris","year":"1996","journal-title":"Exp. Brain Res. Exp. Hirnforsch. Exp. C\u00e9r\u00e9b."},{"key":"10.1016\/j.nbd.2023.106097_bb0440","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1152\/jn.1999.82.2.638","article-title":"GABA(B) receptor activation promotes seizure activity in the juvenile rat hippocampus","volume":"82","author":"Motalli","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0445","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2019.02.009","article-title":"From adagio to allegretto: the changing tempo of theta frequencies in epilepsy and its relation to interneuron function","volume":"129","author":"Moxon","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0450","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/ana.21703","article-title":"Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus","volume":"66","author":"Ogren","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0455","first-page":"167","article-title":"Allosteric ligands and their binding sites define \u03b3-aminobutyric acid (GABA) type a receptor subtypes","volume":"73","author":"Olsen","year":"2015","journal-title":"Adv. Pharmacol. San Diego Calif"},{"key":"10.1016\/j.nbd.2023.106097_bb0460","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54518","article-title":"Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy","volume":"9","author":"Paschen","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.nbd.2023.106097_bb0465","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1046\/j.1460-9568.2003.02843.x","article-title":"Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity","volume":"18","author":"Perez Velazquez","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0470","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1528-1157.1998.tb01268.x","article-title":"Antiepileptic drugs as a cause of worsening seizures","volume":"39","author":"Perucca","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106097_bb0475","first-page":"183","article-title":"Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology","author":"Perucca","year":"2013","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0480","first-page":"231","article-title":"Past and present definitions of epileptogenesis and its biomarkers","volume":"11","author":"Pitk\u00e4nen","year":"2014","journal-title":"Neurother. J. Am. Soc. Exp. Neurother."},{"key":"10.1016\/j.nbd.2023.106097_bb0485","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrn1430","article-title":"The neurobiology of antiepileptic drugs","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0490","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.nbd.2014.03.012","article-title":"Dynamics of interictal spikes and high-frequency oscillations during epileptogenesis in temporal lobe epilepsy","volume":"67C","author":"Salami","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0495","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1152\/jn.00031.2015","article-title":"Distinct EEG seizure patterns reflect different seizure generation mechanisms","volume":"113","author":"Salami","year":"2015","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0500","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/archneur.1994.00540220054014","article-title":"Clinical characteristics and predictive factors in 98 patients with complex partial seizures treated with temporal resection","volume":"51","author":"Salanova","year":"1994","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0505","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1190-22.2023","article-title":"Involvement of GABAergic interneuron subtypes in 4-aminopyridine-induced seizure-like events in mouse entorhinal cortex in vitro","author":"Scalmani","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0510","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0006-8993(80)90119-5","article-title":"Changes in excitatory and inhibitory synaptic potentials leading to epileptogenic activity","volume":"183","author":"Schwartzkroin","year":"1980","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0515","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/ana.24342","article-title":"Interneuron activity leads to initiation of low-voltage fast-onset seizures","volume":"77","author":"Shiri","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0520","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/ana.24570","article-title":"Activation of specific neuronal networks leads to different seizure onset types","volume":"79","author":"Shiri","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0525","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1523\/JNEUROSCI.2244-16.2017","article-title":"Optogenetic low-frequency stimulation of specific neuronal populations abates ictogenesis","volume":"37","author":"Shiri","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0530","doi-asserted-by":"crossref","first-page":"8291","DOI":"10.1523\/JNEUROSCI.5205-14.2015","article-title":"Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo","volume":"35","author":"Sivakumaran","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0535","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.brs.2020.07.013","article-title":"Presynaptic GABAB receptors underlie the antiepileptic effect of low-frequency electrical stimulation in the 4-aminopyridine model of epilepsy in brain slices of young rats","volume":"13","author":"Smirnova","year":"2020","journal-title":"Brain Stimul."},{"key":"10.1016\/j.nbd.2023.106097_bb0540","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/j.1528-1157.1997.tb00068.x","article-title":"Relations between EEG seizure morphology, interhemispheric spread, and mesial temporal atrophy in bitemporal epilepsy","volume":"38","author":"Spanedda","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106097_bb0545","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1528-1157.1992.tb01706.x","article-title":"Morphological patterns of seizures recorded intracranially","volume":"33","author":"Spencer","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106097_bb0550","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1126\/science.7638623","article-title":"Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors","volume":"269","author":"Staley","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.nbd.2023.106097_bb0555","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/336379a0","article-title":"Temporal integration by a slowly inactivating K+ current in hippocampal neurons","volume":"336","author":"Storm","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2023.106097_bb0560","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1111\/j.1460-9568.2007.05962.x","article-title":"Epileptiform synchronization in the rat insular and perirhinal cortices in vitro","volume":"26","author":"Sudbury","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0565","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0006-8993(87)90339-8","article-title":"Seizure-like events in brain slices: suppression by interictal activity","volume":"410","author":"Swartzwelder","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0570","doi-asserted-by":"crossref","first-page":"1250006","DOI":"10.1142\/S0129065712500062","article-title":"A novel electrical stimulation paradigm for the suppression of epileptiform activity in an in vivo model of mesial temporal lobe status epilepticus","volume":"22","author":"Tang","year":"2012","journal-title":"Int. J. Neural Syst."},{"key":"10.1016\/j.nbd.2023.106097_bb0575","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1474-4422(03)00664-1","article-title":"Brain stimulation for epilepsy","volume":"3","author":"Theodore","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0580","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.1113\/jphysiol.2013.253757","article-title":"Long-lasting hyperpolarization underlies seizure reduction by low frequency deep brain electrical stimulation","volume":"591","author":"Toprani","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0585","doi-asserted-by":"crossref","first-page":"6600","DOI":"10.1523\/JNEUROSCI.4786-14.2015","article-title":"Unit activity of hippocampal interneurons before spontaneous seizures in an animal model of temporal lobe epilepsy","volume":"35","author":"Toyoda","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0590","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/jn.1988.59.1.259","article-title":"Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice","volume":"59","author":"Traynelis","year":"1988","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0595","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1152\/jn.00207.2011","article-title":"Changes in action potential features during focal seizure discharges in the entorhinal cortex of the in vitro isolated guinea pig brain","volume":"106","author":"Trombin","year":"2011","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0600","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0028-3908(02)00156-9","article-title":"Spontaneous epileptiform activity mediated by GABA(A) receptors and gap junctions in the rat hippocampal slice following long-term exposure to GABA(B) antagonists","volume":"43","author":"Uusisaari","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2023.106097_bb0605","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1523\/JNEUROSCI.3692-14.2015","article-title":"Synchronous inhibitory potentials precede seizure-like events in acute models of focal limbic seizures","volume":"35","author":"Uva","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106097_bb0610","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1155\/NP.2000.49","article-title":"Functional and anatomic correlates of two frequently observed temporal lobe seizure-onset patterns","volume":"7","author":"Velasco","year":"2000","journal-title":"Neural Plast."},{"key":"10.1016\/j.nbd.2023.106097_bb0615","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnana.2016.00020","article-title":"Synaptic organization of perisomatic GABAergic inputs onto the principal cells of the mouse basolateral amygdala","volume":"10","author":"Vereczki","year":"2016","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.nbd.2023.106097_bb0620","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1113\/jphysiol.2009.181826","article-title":"The K+\u2013Cl\u2212 cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus","volume":"588","author":"Viitanen","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0625","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0079-6123(00)25022-X","article-title":"GABAergic excitation and K(+)-mediated volume transmission in the hippocampus","volume":"125","author":"Voipio","year":"2000","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0630","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/ana.10323","article-title":"Long-term amygdalohippocampal stimulation for refractory temporal lobe epilepsy","volume":"52","author":"Vonck","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106097_bb0635","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuron.2017.06.004","article-title":"Depolarized GABAergic signaling in subicular microcircuits mediates generalized seizure in temporal lobe epilepsy","volume":"95","author":"Wang","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2023.106097_bb0640","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2018.09.008","article-title":"Double-edged GABAergic synaptic transmission in seizures: the importance of chloride plasticity","volume":"1701","author":"Wang","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0645","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.eplepsyres.2019.03.005","article-title":"Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy","volume":"152","author":"Wang","year":"2019","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106097_bb0650","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1152\/jn.00192.2022","article-title":"Modulation of in vitro epileptiform activity by optogenetic stimulation of parvalbumin-positive interneurons","volume":"128","author":"Wang","year":"2022","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0655","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1476-5381.1993.tb12884.x","article-title":"Effects of carbamazepine and baclofen on 4-aminopyridine-induced epileptic activity in rat hippocampal slices","volume":"108","author":"Watts","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106097_bb0660","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/epi.13251","article-title":"Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy","volume":"57","author":"Weiss","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106097_bb0665","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.nbd.2018.11.014","article-title":"Interneurons and principal cell firing in human limbic areas at focal seizure onset","volume":"124","author":"Weiss","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106097_bb0670","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1007\/s00701-021-04960-7","article-title":"Multiple ictal onset patterns underlie seizure generation in seizure-free patients with temporal lobe epilepsy surgery: an SEEG study","volume":"163","author":"Xu","year":"2021","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.nbd.2023.106097_bb0675","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1152\/jn.00841.2014","article-title":"Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex","volume":"113","author":"Yekhlef","year":"2015","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0680","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuron.2011.06.004","article-title":"Optogenetics in neural systems","volume":"71","author":"Yizhar","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2023.106097_bb0685","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1152\/jn.01378.2005","article-title":"Interneuron and pyramidal cell interplay during in vitro seizure-like events","volume":"95","author":"Ziburkus","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106097_bb0690","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0014-4886(68)90022-8","article-title":"Changes in hippocampal-evoked responses induced by localized perfusion with high-potassium cerebrospinal fluid","volume":"22","author":"Zuckermann","year":"1968","journal-title":"Exp. Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123001110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123001110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:38:56Z","timestamp":1760852336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996123001110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":138,"alternative-id":["S0969996123001110"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106097","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ligand-gated mechanisms leading to ictogenesis in focal epileptic disorders","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106097"}}