{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:36:05Z","timestamp":1790948165243,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019729","name":"Japan Labour Health and Welfare Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K09685"],"award-info":[{"award-number":["JP20K09685"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K09727"],"award-info":[{"award-number":["JP20K09727"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K09728"],"award-info":[{"award-number":["JP20K09728"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K18305"],"award-info":[{"award-number":["JP20K18305"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K09602"],"award-info":[{"award-number":["JP21K09602"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.nbd.2023.106194","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:16:21Z","timestamp":1686194181000},"page":"106194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Quantitative analysis and correlative evaluation of video-oculography, micro-computed tomography, and histopathology in Pendrin-null mice"],"prefix":"10.1016","volume":"183","author":[{"given":"Hiroki","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Fujikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2023.106194_bb0005","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.neuro.31.060407.125555","article-title":"Vestibular system: the many facets of a multimodal sense","volume":"31","author":"Angelaki","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2023.106194_bb0010","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1212\/WNL.43.12.2542","article-title":"Horizontal semicircular canal variant of benign positional vertigo","volume":"43","author":"Baloh","year":"1993","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2023.106194_bb0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-3-319-93791-5_2","article-title":"Data analysis using R programming","volume":"1082","author":"Chan","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.nbd.2023.106194_bb0020","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.taap.2006.02.014","article-title":"D-methionine attenuated cisplatin-induced vestibulotoxicity through altering ATPase activities and oxidative stress in guinea pigs","volume":"215","author":"Cheng","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106194_bb0025","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1172\/JCI59353","article-title":"Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition","volume":"121","author":"Choi","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2023.106194_bb0030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/00016487509121319","article-title":"The orientation of the semicircular canals in the guinea pig","volume":"80","author":"Curthoys","year":"1975","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.nbd.2023.106194_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012765","article-title":"Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1","volume":"5","author":"Deans","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106194_bb0040","doi-asserted-by":"crossref","first-page":"21724","DOI":"10.1074\/jbc.M110.120188","article-title":"Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation","volume":"285","author":"Dror","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2023.106194_bb0045","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12635","article-title":"A mouse model for benign paroxysmal positional vertigo with genetic predisposition for displaced otoconia","volume":"19","author":"Dror","year":"2020","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2023.106194_bb0050","doi-asserted-by":"crossref","first-page":"10474","DOI":"10.1523\/JNEUROSCI.1009-09.2009","article-title":"Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses","volume":"29","author":"Dulon","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106194_bb0055","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/hmg\/10.2.153","article-title":"Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome","volume":"10","author":"Everett","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2023.106194_bb0060","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","article-title":"3D slicer as an image computing platform for the quantitative imaging network","volume":"30","author":"Fedorov","year":"2012","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.nbd.2023.106194_bb0065","doi-asserted-by":"crossref","first-page":"17191","DOI":"10.1038\/s41598-021-96596-x","article-title":"Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex","volume":"11","author":"Harada","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2023.106194_bb0070","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0006-8993(03)02505-8","article-title":"The vestibulo ocular reflex (VOR) in otoconia deficient head tilt (het) mutant mice versus wild type C57BL\/6 mice","volume":"972","author":"Harrod","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2023.106194_bb0075","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/MAO.0000000000000376","article-title":"Ex vivo visualization of the mouse otoconial layer compared with micro-computed tomography","volume":"36","author":"Honda","year":"2015","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.nbd.2023.106194_bb0080","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1152\/jn.1986.55.6.1369","article-title":"Central programming of postural movements: adaptation to altered support-surface configurations","volume":"55","author":"Horak","year":"1986","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106194_bb0085","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1159\/000335119","article-title":"SLC26A4 genotypes and phenotypes associated with enlargement of the vestibular aqueduct","volume":"28","author":"Ito","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.nbd.2023.106194_bb0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.nbd.2014.02.002","article-title":"Slc26a4-insufficiency causes fluctuating hearing loss and stria vascularis dysfunction","volume":"66","author":"Ito","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106194_bb0095","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neuroscience.2015.09.016","article-title":"Progressive irreversible hearing loss is caused by stria vascularis degeneration in an Slc26a4-insufficient mouse model of large vestibular aqueduct syndrome","volume":"310","author":"Ito","year":"2015","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2023.106194_bb0100","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3757\/jser.79.236","article-title":"Morphometric analysis of the otic capsule and otoconia in a mouse model of Pendred syndrome using X-ray computed microtomograph","volume":"79","author":"Ito","year":"2020","journal-title":"Equilib. Res."},{"key":"10.1016\/j.nbd.2023.106194_bb0105","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10162-021-00812-4","article-title":"Cochlear Pathomorphogenesis of incomplete partition type II in Slc26a4-null mice","volume":"22","author":"Ito","year":"2021","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.nbd.2023.106194_bb0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1741-7015-4-37","article-title":"Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model","volume":"4","author":"Jabba","year":"2006","journal-title":"BMC Med."},{"key":"10.1016\/j.nbd.2023.106194_bb0115","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0378-5955(99)00090-8","article-title":"Vestibular responses to linear acceleration are absent in otoconia-deficient C57BL\/6JEi-het mice","volume":"135","author":"Jones","year":"1999","journal-title":"Hear. Res."},{"key":"10.1016\/j.nbd.2023.106194_bb0120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0378-5955(90)90119-A","article-title":"Structural basis for mechanical transduction in the frog vestibular sensory apparatus: I. The otolithic membrane","volume":"45","author":"Kachar","year":"1990","journal-title":"Hear. Res."},{"key":"10.1016\/j.nbd.2023.106194_bb0125","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neurobiolaging.2016.12.007","article-title":"Aging reduces the high-frequency and short-term adaptation of the vestibulo-ocular reflex in mice","volume":"51","author":"Khan","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2023.106194_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014041","article-title":"Failure of fluid absorption in the endolymphatic sac initiates cochlear enlargement that leads to deafness in mice lacking pendrin expression","volume":"5","author":"Kim","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106194_bb0135","article-title":"Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin","volume":"6","author":"Kim","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106194_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijporl.2022.111303","article-title":"Comparison of vestibular ocular reflex and gross motor development in children with semicircular canal aplasia and hypoplasia","volume":"162","author":"Kimura","year":"2022","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.nbd.2023.106194_bb0145","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1152\/jn.00831.2007","article-title":"Architecture of the mouse utricle: macular organization and hair bundle heights","volume":"99","author":"Li","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106194_bb0150","first-page":"30","article-title":"Horizontal canal BPV","volume":"14","author":"McClure","year":"1985","journal-title":"J. Otolaryngol."},{"key":"10.1016\/j.nbd.2023.106194_bb0155","doi-asserted-by":"crossref","first-page":"F1314","DOI":"10.1152\/ajprenal.00432.2006","article-title":"Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels","volume":"292","author":"Nakaya","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.nbd.2023.106194_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.736849","article-title":"Effects of galvanic vestibular stimulation on vestibular compensation in unilaterally Labyrinthectomized mice","volume":"12","author":"Nam","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2023.106194_bb0165","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1523\/JNEUROSCI.02-05-00536.1982","article-title":"Adaptation to altered support and visual conditions during stance: patients with vestibular deficits","volume":"2","author":"Nashner","year":"1982","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106194_bb0170","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuroscience.2016.04.042","article-title":"Slc26a4 expression prevents fluctuation of hearing in a mouse model of large vestibular aqueduct syndrome","volume":"329","author":"Nishio","year":"2016","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2023.106194_bb0175","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1101\/gad.1172504","article-title":"Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase","volume":"18","author":"Paffenholz","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.nbd.2023.106194_bb0180","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroscience.2014.02.030","article-title":"Impaired standing balance: the clinical need for closing the loop","volume":"267","author":"Pasma","year":"2014","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2023.106194_bb0185","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s10162-002-3052-4","article-title":"Localization and functional studies of pendrin in the mouse inner ear provide insight about the etiology of deafness in pendred syndrome","volume":"4","author":"Royaux","year":"2003","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.nbd.2023.106194_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2018.297","article-title":"The OpenEar library of 3D models of the human temporal bone based on computed tomography and micro-slicing","volume":"6","author":"Sieber","year":"2019","journal-title":"Sci. Data"},{"key":"10.1016\/j.nbd.2023.106194_bb0195","doi-asserted-by":"crossref","first-page":"F139","DOI":"10.1152\/ajprenal.00433.2007","article-title":"Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model","volume":"294","author":"Singh","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.nbd.2023.106194_bb0200","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/BF00230530","article-title":"Adaptation and habituation of the vestibulo-ocular reflex in intact and inferior olive-lesioned rats","volume":"86","author":"Tempia","year":"1991","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nbd.2023.106194_bb0205","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1741-7015-2-30","article-title":"Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model","volume":"2","author":"Wangemann","year":"2004","journal-title":"BMC Med."},{"key":"10.1016\/j.nbd.2023.106194_bb0210","doi-asserted-by":"crossref","first-page":"F1345","DOI":"10.1152\/ajprenal.00487.2006","article-title":"Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model","volume":"292","author":"Wangemann","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.nbd.2023.106194_bb0215","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/0194599815585098","article-title":"Vestibular dysfunction in patients with enlarged vestibular aqueduct","volume":"153","author":"Zalewski","year":"2015","journal-title":"Otolaryngol. Head Neck Surg."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T11:38:28Z","timestamp":1716377908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996123002097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":43,"alternative-id":["S0969996123002097"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106194","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative analysis and correlative evaluation of video-oculography, micro-computed tomography, and histopathology in Pendrin-null mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106194","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106194"}}