{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:58:46Z","timestamp":1793239126010,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T00:00:00Z","timestamp":1686441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.nbd.2023.106198","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T01:18:46Z","timestamp":1686619126000},"page":"106198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Increased propensity for infantile spasms and altered neocortical excitation-inhibition balance in a mouse model of down syndrome carrying human chromosome 21"],"prefix":"10.1016","volume":"184","author":[{"given":"Li-Rong","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viveka","family":"Chinnasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kazuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mistuo","family":"Oshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger H.","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E.","family":"Stafstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2023.106198_bb0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-019-0143-7","article-title":"Down syndrome","volume":"6","author":"Antonarakis","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.nbd.2023.106198_bb0010","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1528-1157.1995.tb00977.x","article-title":"ACTH does not control neonatal seizures induced by administration of exogenous corticotropin-releasing hormone","volume":"36","author":"Baram","year":"1995","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106198_bb0015","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ana.410200413","article-title":"Dendritic atrophy in children with Down\u2019s syndrome","volume":"20","author":"Becker","year":"1986","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0020","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/cne.21895","article-title":"Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of down syndrome","volume":"512","author":"Belichenko","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134861","article-title":"Down syndrome cognitive phenotypes modeled in mice Trisomic for all HSA 21 homologues","volume":"10","author":"Belichenko","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106198_bb0030","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.expneurol.2011.11.033","article-title":"Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of down syndrome","volume":"233","author":"Best","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.seizure.2021.04.027","article-title":"Cognitive outcome in children with infantile spasms using a standardized treatment protocol. A five-year longitudinal study","volume":"89","author":"Bitton","year":"2021","journal-title":"Seizure"},{"key":"10.1016\/j.nbd.2023.106198_bb0040","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/epi.13034","article-title":"The GIRK2 subunit is involved in IS-like seizures induced by GABA(B) receptor agonists","volume":"56","author":"Blichowski","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106198_bb0045","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1111\/j.1528-1167.2011.03220.x","article-title":"Validation of the rat model of cryptogenic infantile spasms","volume":"52","author":"Chachua","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106198_bb0050","doi-asserted-by":"crossref","first-page":"11483","DOI":"10.1523\/JNEUROSCI.3406-07.2007","article-title":"Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of down syndrome","volume":"27","author":"Chakrabarti","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0055","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nn.2600","article-title":"Olig1 and Olig2 triplication causes developmental brain defects in down syndrome","volume":"13","author":"Chakrabarti","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0060","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1203\/PDR.0b013e31819d9076","article-title":"Infantile spasms and down syndrome: a new animal model","volume":"65","author":"Cortez","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.nbd.2023.106198_bb0065","article-title":"Altered intrinsic and network properties of neocortical neurons in the Ts65Dn mouse model of down syndrome","volume":"3","author":"Cramer","year":"2015","journal-title":"Phys. Rep."},{"key":"10.1016\/j.nbd.2023.106198_bb0070","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0166-2236(91)90178-W","article-title":"A role for GABAB receptors in excitation and inhibition of thalamocortical cells","volume":"14","author":"Crunelli","year":"1991","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0075","article-title":"Infantile spasms in children with down syndrome: identification and treatment response","volume":"6","author":"Daniels","year":"2019","journal-title":"Glob. Pediatr. Health"},{"key":"10.1016\/j.nbd.2023.106198_bb0080","first-page":"117","article-title":"Segmental trisomy as a mouse model for down syndrome","volume":"384","author":"Davisson","year":"1993","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.nbd.2023.106198_bb0085","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nn.3890","article-title":"Early depolarizing GABA controls critical-period plasticity in the rat visual cortex","volume":"18","author":"Deidda","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0090","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nm.3827","article-title":"Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of down syndrome","volume":"21","author":"Deidda","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2023.106198_bb0095","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s00335-011-9356-0","article-title":"Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome","volume":"22","author":"Duchon","year":"2011","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.nbd.2023.106198_bb0100","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2016.10.024","article-title":"Tapping the brakes: cellular and synaptic mechanisms that regulate thalamic oscillations","volume":"92","author":"Fogerson","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2023.106198_bb0105","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.stemcr.2022.05.001","article-title":"Altered patterning of trisomy 21 interneuron progenitors","volume":"17","author":"Giffin-Rao","year":"2022","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.nbd.2023.106198_bb0110","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00005072-199409000-00011","article-title":"Development of the superior temporal neocortex is anomalous in trisomy 21","volume":"53","author":"Golden","year":"1994","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0115","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s10571-006-9066-4","article-title":"Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a down syndrome mouse model","volume":"26","author":"Harashima","year":"2006","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106198_bb0120","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/cne.20844","article-title":"Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of down syndrome","volume":"494","author":"Harashima","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tins.2011.11.001","article-title":"Trisomy 21 and early brain development","volume":"35","author":"Haydar","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1528-1157.1984.tb04195.x","article-title":"Hypsarrhythmia: variations on the theme","volume":"25","author":"Hrachovy","year":"1984","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106198_bb0135","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.tins.2007.05.007","article-title":"Thalamic synchrony and dynamic regulation of global forebrain oscillations","volume":"30","author":"Huguenard","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0140","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1523\/JNEUROSCI.14-09-05485.1994","article-title":"Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects","volume":"14","author":"Huguenard","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/epi4.12264","article-title":"Treatment of infantile spasms","volume":"3","author":"Hussain","year":"2018","journal-title":"Epilepsia Open"},{"issue":"1","key":"10.1016\/j.nbd.2023.106198_bb0150","first-page":"5","article-title":"Infantile spasms: an update on pre-clinical models and EEG mechanisms","volume":"7","author":"Janicot","year":"2020","journal-title":"Children (Basel)"},{"key":"10.1016\/j.nbd.2023.106198_bb0155","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/ana.24749","article-title":"Infantile spasms in down syndrome: rescue by knockdown of the GIRK2 channel","volume":"80","author":"Joshi","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0160","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.eplepsyres.2018.06.006","article-title":"Kcnj6(GIRK2) trisomy is not sufficient for conferring the susceptibility to infantile spasms seen in the Ts65Dn mouse model of down syndrome","volume":"145","author":"Joshi","year":"2018","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106198_bb0165","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/epi4.12412","article-title":"Epileptic spasms in individuals with down syndrome: a review of the current literature","volume":"5","author":"Kats","year":"2020","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.nbd.2023.106198_bb0170","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56223","article-title":"A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21","volume":"9","author":"Kazuki","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2023.106198_bb0175","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1523\/JNEUROSCI.1766-04.2004","article-title":"Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of down syndrome","volume":"24","author":"Kleschevnikov","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0180","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.nbd.2011.10.009","article-title":"Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of down syndrome","volume":"45","author":"Kleschevnikov","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106198_bb0185","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1528-1167.2007.01377.x","article-title":"A new animal model of infantile spasms with unprovoked persistent seizures","volume":"49","author":"Lee","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106198_bb0190","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1111\/epi.17008","article-title":"Brain state-dependent high-frequency activity as a biomarker for abnormal neocortical networks in an epileptic spasms animal model","volume":"62","author":"Lee","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106198_bb0195","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/brain\/awp107","article-title":"Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females","volume":"132","author":"Marsh","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2023.106198_bb0200","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/j.1528-1167.2011.03127.x","article-title":"The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: evidence from the United Kingdom infantile spasms study","volume":"52","author":"O\u2019Callaghan","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106198_bb0205","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.neuron.2016.01.042","article-title":"Down syndrome developmental brain transcriptome reveals defective oligodendrocyte differentiation and myelination","volume":"89","author":"Olmos-Serrano","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2023.106198_bb0210","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.pediatrneurol.2011.08.010","article-title":"Genetic and biologic classification of infantile spasms","volume":"45","author":"Paciorkowski","year":"2011","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0215","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1111\/j.1528-1167.2010.02657.x","article-title":"Infantile spasms: a U.S. consensus report","volume":"51","author":"Pellock","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106198_bb0220","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0014-4886(84)90041-4","article-title":"Synaptic development in the human fetus: a morphometric analysis of normal and Down\u2019s syndrome neocortex","volume":"83","author":"Petit","year":"1984","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0225","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.nbd.2016.11.002","article-title":"APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal beta-catenin levels, neonatal spasms, and chronic seizures","volume":"98","author":"Pirone","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106198_bb0230","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1523\/JNEUROSCI.0915-09.2009","article-title":"A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment","volume":"29","author":"Price","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0235","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1001\/archneur.1991.00530150088024","article-title":"Seizure disorders in Down syndrome","volume":"48","author":"Pueschel","year":"1991","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0240","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00335-011-9357-z","article-title":"Molecular characterization of the translocation breakpoints in the down syndrome mouse model Ts65Dn","volume":"22","author":"Reinholdt","year":"2011","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.nbd.2023.106198_bb0245","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1055\/s-2008-1059590","article-title":"A long-term follow-up study of 214 children with the syndrome of infantile spasms","volume":"13","author":"Riikonen","year":"1982","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.nbd.2023.106198_bb0250","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pediatrneurol.2012.09.006","article-title":"Treatment outcomes of west syndrome in infants with down syndrome","volume":"48","author":"Sanmaneechai","year":"2013","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0255","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pediatrneurol.2020.11.001","article-title":"Excitatory\/inhibitory synaptic ratios in Polymicrogyria and down syndrome help explain Epileptogenesis in malformations","volume":"116","author":"Sarnat","year":"2021","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0260","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.nbd.2009.11.011","article-title":"A model of symptomatic infantile spasms syndrome","volume":"37","author":"Scantlebury","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106198_bb0265","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1523\/JNEUROSCI.2723-18.2019","article-title":"Enhanced dendritic inhibition and impaired NMDAR activation in a mouse model of down syndrome","volume":"39","author":"Schulz","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0270","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1113\/jphysiol.2009.179887","article-title":"Both synaptic and intrinsic mechanisms underlie the different properties of population bursts in the hippocampal CA3 area of immature versus adult rats","volume":"587","author":"Shao","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106198_bb0275","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1528-1157.1996.tb00535.x","article-title":"Early clinical and EEG features of infantile spasms in down syndrome","volume":"37","author":"Silva","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106198_bb0280","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1111\/j.1460-9568.2006.04757.x","article-title":"Intrinsic bursting of immature CA3 pyramidal neurons and consequent giant depolarizing potentials are driven by a persistent Na+ current and terminated by a slow Ca2+ \u2212activated K+ current","volume":"23","author":"Sipila","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0285","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.eplepsyres.2009.09.005","article-title":"Thalamo-cortical mechanisms of sleep spindles and spike-wave discharges in rat model of absence epilepsy (a review)","volume":"89","author":"Sitnikova","year":"2010","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106198_bb0290","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.eplepsyres.2009.01.016","article-title":"Electroencephalographic precursors of spike-wave discharges in a genetic rat model of absence epilepsy: power spectrum and coherence EEG analyses","volume":"84","author":"Sitnikova","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106198_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/jn.2001.85.1.1","article-title":"Short- and long-term changes in CA1 network excitability after kainate treatment in rats","volume":"85","author":"Smith","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106198_bb0300","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0014-2999(92)90623-C","article-title":"Evidence for GABAB-mediated mechanisms in experimental generalized absence seizures","volume":"213","author":"Snead","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106198_bb0305","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.nbd.2014.04.016","article-title":"Excitation\/inhibition balance and learning are modified by Dyrk1a gene dosage","volume":"69","author":"Souchet","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106198_bb0310","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0074-7742(02)49023-X","article-title":"Infantile spasms: criteria for an animal model","volume":"49","author":"Stafstrom","year":"2002","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106198_bb0315","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1469-8749.1994.tb11894.x","article-title":"Infantile spasms in children with down syndrome","volume":"36","author":"Stafstrom","year":"1994","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0320","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1469-8749.1991.tb05108.x","article-title":"Seizures in children with down syndrome: etiology, characteristics and outcome","volume":"33","author":"Stafstrom","year":"1991","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0325","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.ebiom.2015.07.038","article-title":"Involvement of potassium and cation channels in hippocampal abnormalities of embryonic Ts65Dn and Tc1 Trisomic mice","volume":"2","author":"Stern","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.nbd.2023.106198_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111312","article-title":"Molecular convergence between down syndrome and fragile X syndrome identified using human pluripotent stem cell models","volume":"40","author":"Susco","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2023.106198_bb0335","series-title":"Jasper\u2019s Basic Mechanisms of the Epilepsies","first-page":"272","article-title":"On the basic mechanisms of infantile spasms","author":"Swann","year":"2012"},{"key":"10.1016\/j.nbd.2023.106198_bb0340","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1055\/s-0035-1556768","article-title":"Neurodevelopmental outcomes in children with down syndrome and infantile spasms","volume":"13","author":"Tapp","year":"2015","journal-title":"J. Pediatr. Neurol."},{"key":"10.1016\/j.nbd.2023.106198_bb0345","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1515\/revneuro-2019-0030","article-title":"Seizure initiation in infantile spasms vs. focal seizures: proposed common cellular mechanisms","volume":"31","author":"Traub","year":"2020","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.nbd.2023.106198_bb0350","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1152\/jn.00207.2011","article-title":"Changes in action potential features during focal seizure discharges in the entorhinal cortex of the in vitro isolated guinea pig brain","volume":"106","author":"Trombin","year":"2011","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106198_bb0355","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.jpeds.2013.07.022","article-title":"Electroclinical features and long-term outcome of cryptogenic epilepsy in children with down syndrome","volume":"163","author":"Verrotti","year":"2013","journal-title":"J. Pediatr."},{"key":"10.1016\/j.nbd.2023.106198_bb0360","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.eplepsyres.2014.11.012","article-title":"Neurodevelopmental outcome of infantile spasms: a systematic review and meta-analysis","volume":"109","author":"Widjaja","year":"2015","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106198_bb0365","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1152\/jn.2001.85.3.1067","article-title":"Excitatory synaptic input to granule cells increases with time after kainate treatment","volume":"85","author":"Wuarin","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106198_bb0370","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1007\/s13311-021-01072-z","article-title":"Loss of CC2D1A in glutamatergic neurons results in autistic-like features in mice","volume":"18","author":"Yang","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2023.106198_bb0375","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1093\/hmg\/ddq179","article-title":"A mouse model of down syndrome trisomic for all human chromosome 21 syntenic regions","volume":"19","author":"Yu","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2023.106198_bb0380","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58731","article-title":"Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of down syndrome","volume":"9","author":"Zorrilla de San Martin","year":"2020","journal-title":"Elife"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T10:37:07Z","timestamp":1729766227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996123002139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":76,"alternative-id":["S0969996123002139"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106198","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased propensity for infantile spasms and altered neocortical excitation-inhibition balance in a mouse model of down syndrome carrying human chromosome 21","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106198"}}