{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:32:32Z","timestamp":1790710352560,"version":"4.1.0"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"CDMRP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["APP1091593"],"award-info":[{"award-number":["APP1091593"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["APP1176426"],"award-info":[{"award-number":["APP1176426"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["APP1087172"],"award-info":[{"award-number":["APP1087172"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.nbd.2023.106217","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T13:50:01Z","timestamp":1687960201000},"page":"106217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Effects of the T-type calcium channel CaV3.2 R1584P mutation on absence seizure susceptibility in GAERS and NEC congenic rats models"],"prefix":"10.1016","volume":"184","author":[{"given":"Pablo M.","family":"Casillas-Espinosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runxuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanditha M.","family":"Nandakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Braine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim L.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence J.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2023.106217_bb0005","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-1-4020-6191-2_8","article-title":"Calcium channelopathies: voltage-gated calcium channels","volume":"45","author":"Adams","year":"2007","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.nbd.2023.106217_bb0010","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ajhg.2019.05.020","volume":"105","year":"2019","journal-title":"Am J Hum Genet."},{"key":"10.1016\/j.nbd.2023.106217_bb0015","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/ana.410430405","article-title":"Epilepsies in twins: Genetics of the major epilepsy syndromes","volume":"43","author":"Berkovic","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroimage.2008.12.019","article-title":"Morphometric abnormalities and hyperanxiety in genetically epileptic rats: a model of psychiatric comorbidity?","volume":"45","author":"Bouilleret","year":"2009","journal-title":"Neuroimage."},{"key":"10.1016\/j.nbd.2023.106217_bb0025","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(00)81877-2","article-title":"Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse","volume":"88","author":"Burgess","year":"1997","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2023.106217_bb0030","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.bbamem.2012.07.028","article-title":"T-type calcium channels in burst-firing, network synchrony, and epilepsy","volume":"1828","author":"Cain","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2023.106217_bb0035","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/humu.24017","article-title":"CACNA1H variants are not a cause of monogenic epilepsy","volume":"41","author":"Calhoun","year":"2020","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.nbd.2023.106217_bb0040","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/310501a0","article-title":"A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones","volume":"310","author":"Carbone","year":"1984","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2023.106217_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130012","article-title":"Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model","volume":"10","author":"Casillas Espinosa","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106217_bb0050","series-title":"Harmonization of the Pipeline for Seizure Detection to Phenotype Post-Traumatic Epilepsy in a Preclinical Multicenter Study on Post-Traumatic Epileptogenesis","author":"Casillas Espinosa","year":"2019"},{"issue":"Suppl. 9","key":"10.1016\/j.nbd.2023.106217_bb0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/epi.12034","article-title":"Regulators of synaptic transmission: roles in the pathogenesis and treatment of epilepsy","volume":"53","author":"Casillas-Espinosa","year":"2012","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2023.106217_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179924","article-title":"Evaluating whole genome sequence data from the Genetic Absence Epilepsy Rat from Strasbourg and its related non-epileptic strain","volume":"12","author":"Casillas-Espinosa","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106217_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101677","article-title":"Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy","volume":"182","author":"Casillas-Espinosa","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106217_bb0070","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/epi.14691","article-title":"A universal automated tool for reliable detection of seizures in rodent models of acquired and genetic epilepsy","volume":"60","author":"Casillas-Espinosa","year":"2019","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2023.106217_bb0075","doi-asserted-by":"crossref","first-page":"101677","DOI":"10.1016\/j.pneurobio.2019.101677","article-title":"Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy","volume":"182","author":"Casillas-Espinosa","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106217_bb0080","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78877","article-title":"Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy","volume":"12","author":"Casillas-Espinosa","year":"2023","journal-title":"Elife."},{"key":"10.1016\/j.nbd.2023.106217_bb0085","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ana.10607","article-title":"Association between genetic variation of CACNA1H and childhood absence epilepsy","volume":"54","author":"Chen","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0090","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.eplepsyres.2006.01.009","article-title":"Evaluation of CACNA1H in European patients with childhood absence epilepsy","volume":"69","author":"Chioza","year":"2006","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106217_bb0095","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pediatrneurol.2018.11.017","article-title":"Expanding the phenotypic spectrum of CACNA1H mutations","volume":"93","author":"Chourasia","year":"2019","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0100","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0920-1211(92)90029-S","article-title":"Genetic models of absence epilepsy, with emphasis on the WAG\/Rij strain of rats","volume":"12","author":"Coenen","year":"1992","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106217_bb0105","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2174\/187152706779025526","article-title":"The role of T-channels in the generation of thalamocortical rhythms","volume":"5","author":"Contreras","year":"2006","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.nbd.2023.106217_bb0110","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrn811","article-title":"Childhood absence epilepsy: genes, channels, neurons and networks","volume":"3","author":"Crunelli","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0301-0082(97)00091-9","article-title":"Pathophysiological mechanisms of genetic absence epilepsy in the rat","volume":"55","author":"Danober","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106217_bb0120","first-page":"307","article-title":"Thalamic regulation of epileptic spike and wave discharges","volume":"9","author":"de Curtis","year":"1994","journal-title":"Funct. Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0125","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jneumeth.2015.05.022","article-title":"The genetic absence epilepsy rat from Strasbourg as a model to decipher the neuronal and network mechanisms of generalized idiopathic epilepsies","volume":"260","author":"Depaulis","year":"2016","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2023.106217_bb0130","first-page":"1649","article-title":"The initiation of bursts in thalamic neurons and the cortical control of thalamic sensitivity","volume":"357","author":"Destexhe","year":"2002","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.nbd.2023.106217_bb0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.nbd.2016.05.005","article-title":"Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety","volume":"93","author":"Dezsi","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106217_bb0140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1056\/NEJM200107053450103","article-title":"The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel","volume":"345","author":"Ducros","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2023.106217_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186864","article-title":"Modulation of T-type Ca2+ channels by lavender and rosemary extracts","volume":"12","author":"El Alaoui","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106217_bb0150","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.pediatrneurol.2008.07.030","article-title":"Stepwise developmental regression associated with novel CACNA1A mutation","volume":"39","author":"Guerin","year":"2008","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23116063","article-title":"An integrated multi-omic network analysis identifies seizure-associated dysregulated pathways in the GAERS model of absence epilepsy","volume":"23","author":"Harutyunyan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"Suppl. 2","key":"10.1016\/j.nbd.2023.106217_bb0160","first-page":"S31","article-title":"Psychiatric comorbidity in chronic epilepsy: identification, consequences, and treatment of major depression","volume":"41","author":"Hermann","year":"2000","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2023.106217_bb0165","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1474-4422(08)70018-8","article-title":"The neurobehavioural comorbidities of epilepsy: can a natural history be developed?","volume":"7","author":"Hermann","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0170","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/ana.20028","article-title":"Genetic variation of CACNA1H in idiopathic generalized epilepsy","volume":"55","author":"Heron","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0175","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/ana.21169","article-title":"Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants","volume":"62","author":"Heron","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0180","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.prrv.2005.09.005","article-title":"Transgenic mice","volume":"7","author":"Hickman-Davis","year":"2006","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.nbd.2023.106217_bb0185","doi-asserted-by":"crossref","first-page":"11366","DOI":"10.1523\/JNEUROSCI.1861-14.2014","article-title":"Role of the dorsal medial habenula in the regulation of voluntary activity, motor function, hedonic state, and primary reinforcement","volume":"34","author":"Hsu","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0190","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1523\/JNEUROSCI.12-10-03804.1992","article-title":"A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus","volume":"12","author":"Huguenard","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0195","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/geno.2000.6497","article-title":"Genome-tagged mice (GTM): two sets of genome-wide congenic strains","volume":"74","author":"Iakoubova","year":"2001","journal-title":"Genomics."},{"issue":"Suppl. 9","key":"10.1016\/j.nbd.2023.106217_bb0200","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1528-1167.2005.00309.x","article-title":"Epidemiology of idiopathic generalized epilepsies","volume":"46","author":"Jallon","year":"2005","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2023.106217_bb0205","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1093\/cercor\/bhx174","article-title":"Building up absence seizures in the somatosensory cortex: from network to cellular epileptogenic processes","volume":"27","author":"Jarre","year":"2017","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2023.106217_bb0210","article-title":"A statistical analysis plan for a randomized clinical trial to evaluate the efficacy and safety of ethosuximide in patients with treatment-resistant depression","volume":"98","author":"Jiang","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.nbd.2023.106217_bb0215","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1113\/jphysiol.2006.110395","article-title":"CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus","volume":"574","author":"Joksovic","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106217_bb0220","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.expneurol.2007.09.026","article-title":"Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation","volume":"209","author":"Jones","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0225","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.rbp.2012.04.007","article-title":"Psychiatric comorbidities in temporal lobe epilepsy: possible relationships between psychotic disorders and involvement of limbic circuits","volume":"34","author":"Kandratavicius","year":"2012","journal-title":"Rev. Bras. Psiquiatr."},{"issue":"Suppl. 4","key":"10.1016\/j.nbd.2023.106217_bb0230","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yebeh.2003.10.004","article-title":"Depression in epilepsy: a frequently neglected multifaceted disorder","volume":"4","author":"Kanner","year":"2003","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2023.106217_bb0235","doi-asserted-by":"crossref","first-page":"9681","DOI":"10.1074\/jbc.C400006200","article-title":"Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy","volume":"279","author":"Khosravani","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2023.106217_bb0240","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ana.20458","article-title":"Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy","volume":"57","author":"Khosravani","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0245","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/jhg.2010.151","article-title":"Evidence for epistatic interactions in antiepileptic drug resistance","volume":"56","author":"Kim","year":"2011","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.nbd.2023.106217_bb0250","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1113\/jphysiol.2006.122028","article-title":"Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model","volume":"578","author":"Kole","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106217_bb0255","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1474-4422(16)30359-3","volume":"16","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0260","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.1523\/JNEUROSCI.18-13-04842.1998","article-title":"On the action of the anti-absence drug ethosuximide in the rat and cat thalamus","volume":"18","author":"Leresche","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0265","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neulet.2006.06.073","article-title":"New variants in the CACNA1H gene identified in childhood absence epilepsy","volume":"406","author":"Liang","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2023.106217_bb0270","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1469-1809.2006.00332.x","article-title":"Common polymorphisms in the CACNA1H gene associated with childhood absence epilepsy in Chinese Han population","volume":"71","author":"Liang","year":"2007","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.nbd.2023.106217_bb0275","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"key":"10.1016\/j.nbd.2023.106217_bb0280","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1528-1157.1995.tb01060.x","article-title":"Absence epilepsies","volume":"36","author":"Loiseau","year":"1995","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2023.106217_bb0285","first-page":"63","article-title":"A genetic form of petit mal absence in Wistar rats","volume":"140","author":"Marescaux","year":"1984","journal-title":"Rev. Neurol. (Paris)"},{"key":"10.1016\/j.nbd.2023.106217_bb0290","first-page":"37","article-title":"Genetic absence epilepsy in rats from Strasbourg--a review","volume":"35","author":"Marescaux","year":"1992","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.nbd.2023.106217_bb0295","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/ng1197-280","article-title":"Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains","volume":"17","author":"Markel","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2023.106217_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12101287","article-title":"Sucrose preference test as a measure of anhedonic behavior in a chronic unpredictable mild stress model of depression: outstanding issues","volume":"12","author":"Markov","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.nbd.2023.106217_bb0305","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/epi.12738","article-title":"Anxiety and locomotion in genetic absence epilepsy rats from Strasbourg (GAERS): inclusion of Wistar rats as a second control","volume":"55","author":"Marques-Carneiro","year":"2014","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2023.106217_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2020.106537","article-title":"Contribution of rare genetic variants to drug response in absence epilepsy","volume":"170","author":"Myers","year":"2021","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106217_bb0315","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1126\/science.572084","article-title":"Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering","volume":"204","author":"Noebels","year":"1979","journal-title":"Science."},{"key":"10.1016\/j.nbd.2023.106217_bb0320","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1528-1157.2003.25002.x","article-title":"Behavioral disorders in pediatric epilepsy: unmet psychiatric need","volume":"44","author":"Ott","year":"2003","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2023.106217_bb0325","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrg1327","article-title":"Genomic variants in exons and introns: identifying the splicing spoilers","volume":"5","author":"Pagani","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.nbd.2023.106217_bb0330","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1528-1167.2006.00482.x","article-title":"Functional analysis of Ca3.2 T-type calcium channel mutations linked to childhood absence epilepsy","volume":"47","author":"Peloquin","year":"2006","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2023.106217_bb0335","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physrev.00018.2002","article-title":"Molecular physiology of low-voltage-activated t-type calcium channels","volume":"83","author":"Perez-Reyes","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.nbd.2023.106217_bb0340","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1385\/MN:25:1:031","article-title":"Calcium channels and channelopathies of the central nervous system","volume":"25","author":"Pietrobon","year":"2002","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106217_bb0345","first-page":"386","article-title":"Neurobiology of migraine nature reviews","volume":"4","author":"Pietrobon","year":"2003","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2023.106217_bb0350","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1017\/S1472928807000209","article-title":"Cellular and network mechanisms of genetically-determined absence seizures","volume":"3","author":"Pinault","year":"2005","journal-title":"Thalamus Relat. Syst."},{"key":"10.1016\/j.nbd.2023.106217_bb0355","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1523\/JNEUROSCI.0753-07.2007","article-title":"Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures","volume":"27","author":"Polack","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0360","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1523\/JNEUROSCI.5295-08.2009","article-title":"A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy","volume":"29","author":"Powell","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0365","series-title":"Seizure Expression, Behavior, and Brain Morphology Differences in Colonies of Genetic Absence Epilepsy Rats from Strasbourg Epilepsia","author":"Powell","year":"2014"},{"key":"10.1016\/j.nbd.2023.106217_bb0370","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.0013-9580.2004.50303.x","article-title":"Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS)","volume":"45","author":"Rudolf","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106217_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2019.03.008","article-title":"Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis","volume":"156","author":"Santana-Gomez","year":"2019","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106217_bb0380","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ibneur.2022.10.012","article-title":"The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities","volume":"13","author":"Sarkisova","year":"2022","journal-title":"IBRO Neurosci. Rep."},{"key":"10.1016\/j.nbd.2023.106217_bb0385","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0166-4328(03)00090-1","article-title":"Depressive-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG\/Rij rats with genetic absence epilepsy","volume":"144","author":"Sarkisova","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2023.106217_bb0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2011.09.005","article-title":"The relevance of individual genetic background and its role in animal models of epilepsy","volume":"97","author":"Schauwecker","year":"2011","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106217_bb0395","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/ijnp\/pyy083","article-title":"Making sense of rodent models of anhedonia","volume":"21","author":"Scheggi","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.nbd.2023.106217_bb0400","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.741292","article-title":"Neural burst firing and its roles in mental and neurological disorders","volume":"15","author":"Shao","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0405","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1474-4422(14)70076-6","article-title":"The challenge and promise of anti-epileptic therapy development in animal models","volume":"13","author":"Simonato","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2023.106217_bb0410","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02986826","article-title":"Methods for the study of histocompatibility genes","volume":"49","author":"Snell","year":"1948","journal-title":"J. Genet."},{"key":"10.1016\/j.nbd.2023.106217_bb0415","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1111\/j.0953-816X.2004.03392.x","article-title":"An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy","volume":"19","author":"Strauss","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0420","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0169-328X(99)00307-1","article-title":"Low-voltage-activated calcium channel subunit expression in a genetic model of absence epilepsy in the rat","volume":"75","author":"Talley","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2023.106217_bb0425","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1111\/j.1528-1167.2007.01222.x","article-title":"Psychiatric comorbidity in epilepsy: a population-based analysis","volume":"48","author":"Tellez Zenteno","year":"2007","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2023.106217_bb0430","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003120","article-title":"T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures","volume":"4","author":"Tringham","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2023.106217_bb0435","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1523\/JNEUROSCI.15-04-03110.1995","article-title":"Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy","volume":"15","author":"Tsakiridou","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0440","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0006-8993(86)80011-7","article-title":"Ontogeny of spontaneous petit mal-like seizures in Wistar rats","volume":"395","author":"Vergnes","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2023.106217_bb0445","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0201-20.2020","article-title":"T-Type Calcium Channels Contribute to Burst Firing in a Subpopulation of Medial Habenula Neurons","volume":"7","author":"Vickstrom","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.nbd.2023.106217_bb0450","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1523\/JNEUROSCI.0847-05.2005","article-title":"Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel","volume":"25","author":"Vitko","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0455","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1523\/JNEUROSCI.1817-06.2007","article-title":"The I-II loop controls plasma membrane expression and gating of Ca(v)3.2 T-type Ca2+ channels: a paradigm for childhood absence epilepsy mutations","volume":"27","author":"Vitko","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0460","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/genetics\/146.3.1061","article-title":"Genotype selection to rapidly breed congenic strains","volume":"146","author":"Weil","year":"1997","journal-title":"Genetics."},{"key":"10.1016\/j.nbd.2023.106217_bb0465","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1152\/jn.1988.59.1.212","article-title":"Electrophysiological properties of neurons in the lateral habenula nucleus: an in vitro study","volume":"59","author":"Wilcox","year":"1988","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106217_bb0470","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.chc.2005.05.007","article-title":"A genetic epidemiologic perspective on comorbidity of depression and anxiety","volume":"14","author":"Williamson","year":"2005","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"key":"10.1016\/j.nbd.2023.106217_bb0475","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.yebeh.2019.05.032","article-title":"Multiunit cluster firing patterns of piriform cortex and mediodorsal thalamus in absence epilepsy","volume":"97","author":"Young","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2023.106217_bb0480","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00424-009-0772-x","article-title":"Role of voltage-gated calcium channels in epilepsy","volume":"460","author":"Zamponi","year":"2010","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.nbd.2023.106217_bb0485","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1523\/JNEUROSCI.0992-04.2004","article-title":"Elevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma","volume":"24","author":"Zhang","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106217_bb0490","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/hmg\/ddl068","article-title":"A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies","volume":"15","author":"Zhong","year":"2006","journal-title":"Hum. Mol. Genet."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:01:53Z","timestamp":1778792513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996123002322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":98,"alternative-id":["S0969996123002322"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106217","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of the T-type calcium channel CaV3.2 R1584P mutation on absence seizure susceptibility in GAERS and NEC congenic rats models","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106217"}}