{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:07:34Z","timestamp":1788559654053,"version":"build-2803163510"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.nbd.2023.106226","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T03:10:08Z","timestamp":1689217808000},"page":"106226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration"],"prefix":"10.1016","volume":"184","author":[{"given":"Marcello","family":"Serra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bassareo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Nuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Errico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Servillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathik","family":"Parekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Thiolat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Bezard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Calabresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sulzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolo","family":"Carta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Usiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2023.106226_bb0005","doi-asserted-by":"crossref","DOI":"10.1007\/s00702-013-1149-z","article-title":"A further update on the role of excitotoxicity in the pathogenesis of Parkinson\u2019s disease","volume":"121","author":"Ambrosi","year":"2014","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nbd.2023.106226_bb0010","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-015-0067-y","article-title":"Novel (hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson\u2019s disease","volume":"11","author":"Baranyi","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2023.106226_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2018.02.002","article-title":"Binding of alpha-synuclein to partially oxidized glyceraldehyde-3-phosphate dehydrogenase induces subsequent inactivation of the enzyme","volume":"642","author":"Barinova","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.nbd.2023.106226_bb0020","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neurobiolaging.2017.01.010","article-title":"Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice","volume":"53","author":"Belloli","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2023.106226_bb0025","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7219732","article-title":"Impact of aging in microglia-mediated d-serine balance in the CNS","volume":"2018","author":"Beltr\u00e1n-Castillo","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.nbd.2023.106226_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/35086062","article-title":"Pathophysiology of levodopa-induced dyskinesia: potential for new therapies","author":"Bezard","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0035","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0610-20.2020","article-title":"\u03bc opioid receptor agonism for L-DOPA-induced dyskinesia in Parkinson\u2019s disease","volume":"40","author":"Bezard","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2017.10.002","article-title":"Compensatory mechanisms in Parkinson\u2019s disease: circuits adaptations and role in disease modification","author":"Blesa","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2023.106226_bb0045","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2818.2006.01706.x","article-title":"A guided tour into subcellular colocalization analysis in light microscopy","author":"Bolte","year":"2006","journal-title":"J. Microsc."},{"key":"10.1016\/j.nbd.2023.106226_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.tins.2017.04.001","article-title":"The role of astrocyte dysfunction in Parkinson\u2019s disease pathogenesis","author":"Booth","year":"2017","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0055","doi-asserted-by":"crossref","DOI":"10.1111\/j.1460-9568.1992.tb00119.x","article-title":"Long-term potentiation in the striatum is unmasked by removing the voltage-dependent magnesium block of NMDA receptor channels","volume":"4","author":"Calabresi","year":"1992","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105697","article-title":"Striatal glutamatergic hyperactivity in Parkinson\u2019s disease","author":"Campanelli","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106226_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2014.00009","article-title":"Serine racemase: a key player in apoptosis and necrosis","volume":"6","author":"Canu","year":"2014","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2014.00258","article-title":"Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?","volume":"6","author":"Charron","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0075","series-title":"Amino Acids.","article-title":"Direct and indirect presynaptic control of dopamine release by excitatory amino acids","author":"Ch\u00e9ramy","year":"1998"},{"key":"10.1016\/j.nbd.2023.106226_bb0080","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1007\/s00213-014-3536-z","article-title":"MDMA administration during adolescence exacerbates MPTP-induced cognitive impairment and neuroinflammation in the hippocampus and prefrontal cortex","volume":"231","author":"Costa","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nbd.2023.106226_bb0085","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1007\/s11064-020-03014-1","article-title":"d-serine, the shape-shifting NMDA receptor co-agonist","volume":"45","author":"Coyle","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2023.106226_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110672","article-title":"Glucose metabolism impairment in Parkinson\u2019s disease","volume":"199","author":"Dai","year":"2023","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2023.106226_bb0095","article-title":"Individual amino acid supplementation can improve energy metabolism and decrease ROS production in neuronal cells overexpressing alpha-Synuclein","volume":"19","author":"Delic","year":"2017","journal-title":"Neuro. Mol. Med."},{"key":"10.1016\/j.nbd.2023.106226_bb0100","article-title":"Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson \u2019 s disease patients","volume":"106203","author":"Di Maio","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106226_bb0105","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuint.2015.07.005","article-title":"Alterations in the motor cortical and striatal glutamatergic system and d-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson\u2019s disease","volume":"88","author":"El Arfani","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2023.106226_bb0110","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1093\/cercor\/bhu076","article-title":"Widespread monoaminergic dysregulation of both motor and non-motor circuits in parkinsonism and dyskinesia","volume":"25","author":"Engeln","year":"2015","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2023.106226_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174452","article-title":"Effect of the glycine transporter 1 inhibitor ALX-5407 on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset","volume":"910","author":"Frouni","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106226_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175090","article-title":"Effect of glycine transporter 1 inhibition with bitopertin on parkinsonism and L-DOPA induced dyskinesia in the 6-OHDA-lesioned rat","volume":"929","author":"Frouni","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106226_bb0125","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.200364497","article-title":"l-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons","volume":"97","author":"Furuya","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106226_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2014.10.011","article-title":"Targeting glutamatergic synapses in Parkinson\u2019s disease","author":"Gardoni","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106226_bb0135","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1017\/S1461145711001015","article-title":"d-serine adjuvant treatment alleviates behavioural and motor symptoms in Parkinson\u2019s disease","volume":"15","author":"Gelfin","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.nbd.2023.106226_bb0140","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1002\/1873-3468.14417","article-title":"Astrocytic d-amino acid oxidase degrades d-serine in the hindbrain","volume":"596","author":"Gonda","year":"2022","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2023.106226_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2018.00110","article-title":"D-3-phosphoglycerate dehydrogenase","author":"Grant","year":"2018","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2004.11.008","article-title":"Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson\u2019s disease","volume":"48","author":"Hallett","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2023.106226_bb0155","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awh029","article-title":"The subthalamic nucleus in the context of movement disorders","author":"Hamani","year":"2004","journal-title":"Brain."},{"key":"10.1016\/j.nbd.2023.106226_bb0160","series-title":"Insulin-Regulated Serine and Lipid Metabolism Drive Peripheral Neuropathy","author":"Handzlik","year":"2022"},{"key":"10.1016\/j.nbd.2023.106226_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/mds.25306","article-title":"Glycine site agonists of the N-methyl-d-aspartate receptor and Parkinson\u2019s disease: a hypothesis","volume":"28","author":"Heresco-Levy","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2023.106226_bb0170","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbr.2011.01.028","article-title":"Effects of D-cycloserine on MPTP-induced behavioral and neurological changes: potential for treatment of Parkinson\u2019s disease dementia","volume":"219","author":"Ho","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2023.106226_bb0175","doi-asserted-by":"crossref","DOI":"10.1006\/geno.1994.1577","article-title":"Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15","volume":"24","author":"Hofmann","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/j.nbd.2023.106226_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/nu14091987","article-title":"Serine metabolism in health and disease and as a conditionally essential amino acid","author":"Hole\u010dek","year":"2022","journal-title":"Nutrients."},{"key":"10.1016\/j.nbd.2023.106226_bb0185","first-page":"1","article-title":"Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia","volume":"8","author":"Hulme","year":"2022","journal-title":"Npj Park Dis."},{"key":"10.1016\/j.nbd.2023.106226_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2018.05.039","article-title":"The plastic d-serine signaling pathway: sliding from neurons to glia and vice-versa","author":"Ivanov","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2023.106226_bb0195","doi-asserted-by":"crossref","DOI":"10.1111\/ene.14470","article-title":"Cerebrospinal and blood levels of amino acids as potential biomarkers for Parkinson\u2019s disease: review and meta-analysis","author":"Jim\u00e9nez-Jim\u00e9nez","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2023.106226_bb0200","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1722677115","article-title":"ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d-serine and neurodevelopment","volume":"115","author":"Kaplan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106226_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/ana.410200106","article-title":"Elevated \u03b3-aminobutyric acid level in striatal but not extrastriatal brain regions in Parkinson\u2019s disease: correlation with striatal dopamine loss","volume":"20","author":"Kish","year":"1986","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106226_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188912","article-title":"Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in d-amino acid oxidase: phenotype and loss of spinal cord motor neurons","volume":"12","author":"Kondori","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106226_bb0215","doi-asserted-by":"crossref","DOI":"10.1111\/j.1471-4159.1991.tb02565.x","article-title":"Glutamatergic control of dopamine release in the rat striatum: evidence for presynaptic N-methyl-d-aspartate receptors on dopaminergic nerve terminals","volume":"56","author":"Krebs","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2023.106226_bb0220","series-title":"ASC Transporters Mediate d-Serine Transport into Astrocytes Adjacent to Synapses in the Mouse Brain","author":"Krishnan","year":"2023"},{"key":"10.1016\/j.nbd.2023.106226_bb0225","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cmet.2020.02.004","article-title":"Impairment of glycolysis-derived l-serine production in astrocytes contributes to cognitive deficits in Alzheimer\u2019s disease","volume":"31","author":"Le Douce","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2023.106226_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.200800459","article-title":"Determination of d,l-serine in midbrain of Parkinson\u2019s disease mouse by capillary electrophoresis with in-column light-emitting diode induced fluorescence detection","volume":"32","author":"Li","year":"2009","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.nbd.2023.106226_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111271","article-title":"Insulin and serine metabolism as sex-specific hallmarks of Alzheimer\u2019s disease in the human hippocampus","volume":"40","author":"Maffioli","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2023.106226_bb0240","doi-asserted-by":"crossref","DOI":"10.1007\/s12640-017-9814-x","article-title":"l-serine: a naturally-occurring amino acid with therapeutic potential","author":"Metcalf","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.nbd.2023.106226_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2006.11.053","article-title":"Internet-enabled high-resolution brain mapping and virtual microscopy","volume":"35","author":"Mikula","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2023.106226_bb0250","doi-asserted-by":"crossref","DOI":"10.1002\/mds.26103","article-title":"Presynaptic effects of levodopa and their possible role in dyskinesia","author":"Mosharov","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2023.106226_bb0255","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-020-03574-z","article-title":"L-serine synthesis via the phosphorylated pathway in humans","author":"Murtas","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2023.106226_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22084231","article-title":"Biochemical and biophysical characterization of recombinant human 3-phosphoglycerate dehydrogenase","volume":"22","author":"Murtas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.nbd.2023.106226_bb0265","first-page":"1","article-title":"The levels of the NMDA receptor co-agonist d-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson\u2019s disease patients","volume":"91","author":"Nuzzo","year":"2019","journal-title":"Sci. Report."},{"key":"10.1016\/j.nbd.2023.106226_bb0270","doi-asserted-by":"crossref","DOI":"10.1002\/mds.27115","article-title":"Past, present, and future of Parkinson\u2019s disease: a special essay on the 200th anniversary of the shaking palsy","author":"Obeso","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2023.106226_bb0275","series-title":"The Mouse Brain in Stereotaxic Coordinates, Compact","author":"Paxinos","year":"2008"},{"key":"10.1016\/j.nbd.2023.106226_bb0280","doi-asserted-by":"crossref","DOI":"10.1111\/j.1471-4159.2008.05268.x","article-title":"Pre-synaptic dopaminergic compensation after moderate nigrostriatal damage in non-human primates","volume":"105","author":"Perez","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2023.106226_bb0285","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1172\/JCI92300","article-title":"Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury","volume":"127","author":"Perez","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2023.106226_bb0290","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-7091-0932-8_24","article-title":"Synaptic dysfunction in Parkinson\u2019s disease","volume":"970","author":"Picconi","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.nbd.2023.106226_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108693","article-title":"Neuroinflammation and L-dopa-induced abnormal involuntary movements in 6-hydroxydopamine-lesioned rat model of Parkinson\u2019s disease are counteracted by combined administration of a 5-HT1A\/1B receptor agonist and A2A receptor antagonist","volume":"196","author":"Pinna","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2023.106226_bb0300","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/bph.15349","article-title":"Presynaptic release-regulating NMDA receptors in isolated nerve terminals: a narrative review","volume":"178","author":"Pittaluga","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106226_bb0305","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-201217","article-title":"The role of d-amino acids in Alzheimer\u2019s disease","author":"Piubelli","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2023.106226_bb0310","series-title":"The Human Phosphorylated Pathway\u202f: A Multienzyme Metabolic Assembly for l- Serine Biosynthesis","author":"Rabattoni","year":"2023"},{"key":"10.1016\/j.nbd.2023.106226_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/0304-3940(88)90292-3","article-title":"Free amino acids in the brain of patients with Parkinson\u2019s disease","volume":"94","author":"Rinne","year":"1988","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2023.106226_bb0320","article-title":"Distinctive roles of d-amino acids in the homochiral world: chirality of amino acids modulates mammalian physiology and pathology","author":"Sasabe","year":"2019","journal-title":"Keio J. Med."},{"key":"10.1016\/j.nbd.2023.106226_bb0325","doi-asserted-by":"crossref","DOI":"10.1038\/sj.emboj.7601840","article-title":"d-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis","volume":"26","author":"Sasabe","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2023.106226_bb0330","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1114639109","article-title":"d-amino acid oxidase controls motoneuron degeneration through d-serine","volume":"109","author":"Sasabe","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106226_bb0335","doi-asserted-by":"crossref","DOI":"10.1517\/14728222.2012.664135","article-title":"Bioenergetics failure in neurodegenerative diseases: Back to the future","author":"Saxena","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.nbd.2023.106226_bb0340","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12640-009-9061-x","article-title":"Progressive dopaminergic degeneration in the chronic MPTPp mouse model of Parkinson\u2019s disease","volume":"16","author":"Schintu","year":"2009","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.nbd.2023.106226_bb0345","doi-asserted-by":"crossref","first-page":"16778","DOI":"10.1523\/JNEUROSCI.3041-12.2013","article-title":"Glycine transporter-1 inhibition promotes striatal axon sprouting via NMDA receptors in dopamine neurons","volume":"33","author":"Schmitz","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0350","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0006-8993(00)02036-9","article-title":"Effects of the partial glycine agonist d-cycloserine on cognitive functioning in chronic low dose MPTP-treated monkeys","volume":"860","author":"Schneider","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2023.106226_bb0355","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.3390\/ijms21197325","article-title":"Advances in d-amino acids in neurological research","volume":"21","author":"Seckler","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2023.106226_bb0360","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71329-8","article-title":"Metabolic alterations in Parkinson\u2019s disease astrocytes","volume":"10","author":"Sonninen","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2023.106226_bb0365","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1416117112","article-title":"Glycolytic flux controls d-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes","volume":"112","author":"Suzuki","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106226_bb0370","doi-asserted-by":"crossref","DOI":"10.1177\/1759091417713905","article-title":"Heterogeneity of d-serine distribution in the human central nervous system","volume":"9","author":"Suzuki","year":"2017","journal-title":"ASN Neuro."},{"key":"10.1016\/j.nbd.2023.106226_bb0375","doi-asserted-by":"crossref","DOI":"10.1186\/s12991-016-0113-3","article-title":"Multi-regression analysis revealed a relationship between l-serine and methionine, a component of one-carbon metabolism, in the normal control but not in the schizophrenia","volume":"15","author":"Takano","year":"2016","journal-title":"Ann. General Psychiatry"},{"key":"10.1016\/j.nbd.2023.106226_bb0380","doi-asserted-by":"crossref","DOI":"10.1002\/glia.24161","article-title":"Inhibition of glial d-serine release rescues synaptic damage after brain injury","volume":"70","author":"Tapanes","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2023.106226_bb0385","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1471-4159.2011.07601.x","article-title":"Paradoxical roles of serine racemase and d-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis","volume":"120","author":"Thompson","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2023.106226_bb0390","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1502740112","article-title":"Targeting \u03b2-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson\u2019s disease","volume":"112","author":"Urs","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106226_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/ph14070609","article-title":"Chronic red bull consumption during adolescence: effect on mesocortical and mesolimbic dopamine transmission and cardiovascular system in adult rats","volume":"14","author":"Vargiu","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.nbd.2023.106226_bb0400","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-021-00265-y","article-title":"Astrocyte dysfunction in Parkinson\u2019s disease: from the perspectives of transmitted \u03b1-synuclein and genetic modulation","author":"Wang","year":"2021","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.nbd.2023.106226_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.tins.2016.09.007","article-title":"The rise and fall of the d-serine-mediated Gliotransmission hypothesis","author":"Wolosker","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0410","doi-asserted-by":"crossref","first-page":"7691","DOI":"10.1523\/JNEUROSCI.21-19-07691.2001","article-title":"3-phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia\/astrocyte lineage and olfactory ensheathing glia in the mouse brain","volume":"21","author":"Yamasaki","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0415","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.726665","article-title":"l-Serine, an endogenous amino acid, is a potential neuroprotective agent for neurological disease and injury","author":"Ye","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2023.106226_bb0420","series-title":"d-serine supplement Ameliorates MPP+-Induced Neurotoxicity Via Attenuating DAPK1-Associated Pathway in Parkinson\u2019s Disease Models","author":"Zhang","year":"2021"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T10:39:19Z","timestamp":1729766359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996123002413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":84,"alternative-id":["S0969996123002413"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106226","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106226"}}