{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:48:48Z","timestamp":1790718528119,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.nbd.2023.106260","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T16:19:12Z","timestamp":1691770752000},"page":"106260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Kainate receptors modulate the microstructure of synchrony during dentate gyrus epileptiform activity"],"prefix":"10.1016","volume":"185","author":[{"given":"Lucas","family":"Goirand-Lopez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Moulinier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Vigier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Boileau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Carleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah F.","family":"Muldoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Marissal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Cr\u00e9pel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2023.106260_bb0005","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1152\/physrev.00055.2003","article-title":"Adult neurogenesis: from precursors to network and physiology","volume":"85","author":"Abrous","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.nbd.2023.106260_bb0010","doi-asserted-by":"crossref","first-page":"9681","DOI":"10.1523\/JNEUROSCI.2800-04.2004","article-title":"Cell type-specific synaptic dynamics of synchronized bursting in the juvenile CA3 rat hippocampus","volume":"24","author":"Aradi","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0015","doi-asserted-by":"crossref","first-page":"10811","DOI":"10.1523\/JNEUROSCI.0388-11.2011","article-title":"Synaptic Kainate receptors in interplay with INaP shift the sparse firing of dentate granule cells to a sustained rhythmic mode in temporal lobe epilepsy","volume":"31","author":"Artinian","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0020","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/ana.24348","article-title":"Impaired neuronal operation through aberrant intrinsic plasticity in epilepsy: aberrant intrinsic plasticity","volume":"77","author":"Artinian","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106260_bb0025","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.1523\/JNEUROSCI.14-09-05525.1994","article-title":"Kainate receptor gene expression in the developing rat brain","volume":"14","author":"Bahn","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/ana.26723","article-title":"GluK2 is a target for gene therapy in drug-resistant temporal lobe epilepsy","author":"Boileau","year":"2023","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106260_bb0035","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1152\/jn.01369.2007","article-title":"Changes in granule cell firing rates precede locally recorded spontaneous seizures by minutes in an animal model of temporal lobe epilepsy","volume":"99","author":"Bower","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106260_bb0040","series-title":"Jasper\u2019s Basic Mechanisms of the Epilepsies [Internet]","article-title":"Mossy Fiber sprouting in the dentate gyrus. Jasper\u2019s basic mechanisms of the epilepsies","author":"Buckmaster","year":"2012"},{"key":"10.1016\/j.nbd.2023.106260_bb0045","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1523\/JNEUROSCI.19-02-00653.1999","article-title":"Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice","volume":"19","author":"Bureau","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0920-1211(88)90056-3","article-title":"Epileptiform activity induced by 4-aminopyridine in immature hippocampus","volume":"2","author":"Chesnut","year":"1988","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106260_bb0055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.coph.2014.11.012","article-title":"Physiopathology of kainate receptors in epilepsy","volume":"20","author":"Cr\u00e9pel","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106260_bb0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1113\/jphysiol.1986.sp016279","article-title":"Involvement of N-methyl-D-aspartate receptors in epileptiform bursting in the rat hippocampal slice","volume":"380","author":"Dingledine","year":"1986","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2023.106260_bb0065","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1021\/jm061041u","article-title":"Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists","volume":"50","author":"Dolman","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.nbd.2023.106260_bb0070","series-title":"Progress in Brain Research","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0079-6123(07)63041-6","article-title":"Epileptogenesis in the dentate gyrus: a critical perspective","author":"Dudek","year":"2007"},{"key":"10.1016\/j.nbd.2023.106260_bb0075","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1523\/JNEUROSCI.23-21-07873.2003","article-title":"Transition from Interictal to ictal activity in limbic networks in vitro","volume":"23","author":"Dzhala","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0080","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1523\/JNEUROSCI.1469-05.2005","article-title":"Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats","volume":"25","author":"Epsztein","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0085","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1073\/pnas.1216958110","article-title":"Spatially clustered neuronal assemblies comprise the microstructure of synchrony in chronically epileptic networks","volume":"110","author":"Feldt Muldoon","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106260_bb0090","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1523\/JNEUROSCI.23-12-05381.2003","article-title":"Short-term frequency-dependent plasticity at recurrent mossy Fiber synapses of the epileptic brain","volume":"23","author":"Feng","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0095","doi-asserted-by":"crossref","first-page":"10416","DOI":"10.1523\/JNEUROSCI.2074-04.2004","article-title":"Stimulus and potassium-induced epileptiform activity in the human dentate gyrus from patients with and without hippocampal sclerosis","volume":"24","author":"Gabriel","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0100","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nn887","article-title":"Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo","volume":"5","author":"Henze","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0105","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/epi.13376","article-title":"Hilar somatostatin interneuron loss reduces dentate gyrus inhibition in a mouse model of temporal lobe epilepsy","volume":"57","author":"Hofmann","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106260_bb0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0920-1211(96)00054-X","article-title":"Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures","volume":"26","author":"Houser","year":"1996","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2023.106260_bb0115","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF01908075","article-title":"Comparing partitions","volume":"2","author":"Hubert","year":"1985","journal-title":"J. Classif."},{"key":"10.1016\/j.nbd.2023.106260_bb0120","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hipo.450030209","article-title":"Spatial selectivity of unit activity in the hippocampal granular layer","volume":"3","author":"Jung","year":"1993","journal-title":"Hippocampus"},{"key":"10.1016\/j.nbd.2023.106260_bb0125","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1523\/JNEUROSCI.23-06-02440.2003","article-title":"Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy","volume":"23","author":"Kobayashi","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0130","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0005-14.2014","article-title":"Cerebellar directed Optogenetic intervention inhibits spontaneous hippocampal seizures in a mouse model of temporal lobe epilepsy","volume":"1","author":"Krook-Magnuson","year":"2014","journal-title":"eneuro"},{"key":"10.1016\/j.nbd.2023.106260_bb0135","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1152\/jn.2000.84.6.2868","article-title":"NMDA receptor-dependent plasticity of granule cell spiking in the dentate gyrus of Normal and epileptic rats","volume":"84","author":"Lynch","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106260_bb0140","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/ncomms2318","article-title":"Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus","volume":"3","author":"Marissal","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2023.106260_bb0145","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/s41593-018-0225-y","article-title":"Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia","volume":"21","author":"Marissal","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0150","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.neuron.2016.04.001","article-title":"Transsynaptic modulation of Kainate receptor functions by C1q-like proteins","volume":"90","author":"Matsuda","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2023.106260_bb0155","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuron.2005.10.034","article-title":"Threshold behavior in the initiation of hippocampal population bursts","volume":"49","author":"Menendez De La Prida","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2023.106260_bb0160","doi-asserted-by":"crossref","DOI":"10.3791\/52353-v","article-title":"Organotypic slice cultures for studies of postnatal neurogenesis","author":"Mosa","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.nbd.2023.106260_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108699","article-title":"Regulation and dysregulation of neuronal circuits by KARs","volume":"197","author":"Mulle","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2023.106260_bb0170","doi-asserted-by":"crossref","first-page":"9497","DOI":"10.1523\/JNEUROSCI.19-21-09497.1999","article-title":"Replay and time compression of recurring spike sequences in the Hippocampus","volume":"19","author":"N\u00e1dasdy","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1167.2010.02792.x","article-title":"Jasper's basic mechanisms of the epilepsies workshop: Jasper's basic mechanisms of the epilepsies","volume":"51","author":"Noebels","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2023.106260_bb0180","series-title":"Jasper\u2019s Basic Mechanisms of the Epilepsies","article-title":"Neurogenesis and epilepsy","author":"Parent","year":"2012"},{"key":"10.1016\/j.nbd.2023.106260_bb0185","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.celrep.2014.06.032","article-title":"Contribution of aberrant GluK2-containing Kainate receptors to chronic seizures in temporal lobe epilepsy","volume":"8","author":"Peret","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2023.106260_bb0190","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuropharm.2008.08.002","article-title":"Antagonism of recombinant and native GluK3-containing kainate receptors","volume":"56","author":"Perrais","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2023.106260_bb0195","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/cercor\/bhs022","article-title":"Selective block of postsynaptic Kainate receptors reveals their function at hippocampal mossy Fiber synapses","volume":"23","author":"Pinheiro","year":"2013","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2023.106260_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.609123","article-title":"Dentate granule cells recruited in the home environment display distinctive properties","volume":"14","author":"Pl\u00e9au","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0205","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65786","article-title":"Synchronous activity patterns in the dentate gyrus during immobility","volume":"10","author":"Pofahl","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.nbd.2023.106260_bb0210","doi-asserted-by":"crossref","first-page":"43724","DOI":"10.1038\/srep43724","article-title":"Time-lapse imaging reveals highly dynamic structural maturation of postnatally born dentate granule cells in organotypic entorhino-hippocampal slice cultures","volume":"7","author":"Radic","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2023.106260_bb0215","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1523\/JNEUROSCI.0922-21.2022","article-title":"Activation of Extrasynaptic Kainate receptors drives hilar mossy cell activity","volume":"42","author":"Ramos","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0220","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0306-4522(87)90237-5","article-title":"Kainate binding sites in the hippocampal mossy fibers: localization and plasticity","volume":"20","author":"Represa","year":"1987","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2023.106260_bb0225","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1523\/JNEUROSCI.5853-11.2012","article-title":"A candidate mechanism underlying the variance of Interictal spike propagation","volume":"32","author":"Sabolek","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0230","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.1523\/JNEUROSCI.1787-07.2007","article-title":"Subthreshold dendritic signal processing and coincidence detection in dentate gyrus granule cells","volume":"27","author":"Schmidt-Hieber","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0235","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1471-4159.2003.01979.x","article-title":"Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sprouting","volume":"87","author":"Shetty","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2023.106260_bb0240","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ana.410260303","article-title":"Mossy fiber synaptic reorganization in the epileptic human temporal lobe","volume":"26","author":"Sutula","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106260_bb0245","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1523\/JNEUROSCI.05-04-01016.1985","article-title":"Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats","volume":"5","author":"Tauck","year":"1985","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106260_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/630853","article-title":"A review of the epidemiology of temporal lobe epilepsy","volume":"2012","author":"T\u00e9llez-Zenteno","year":"2012","journal-title":"Epilepsy Res. Treatment"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:41:02Z","timestamp":1760852462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996123002759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":50,"alternative-id":["S0969996123002759"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106260","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kainate receptors modulate the microstructure of synchrony during dentate gyrus epileptiform activity","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106260","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106260"}}