{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:11:04Z","timestamp":1791875464303,"version":"4.3.4"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.nbd.2023.106273","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:30:32Z","timestamp":1693225832000},"page":"106273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogenesis by upregulating autophagy via the AMPK\/mTOR pathway"],"prefix":"10.1016","volume":"186","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningxiao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2023.106273_bb0005","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/nn2014","article-title":"Local self-renewal can sustain CNS microglia maintenance and function throughout adult life","volume":"10","author":"Ajami","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2023.106273_bb0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nyas.14305","article-title":"Molecular regulation of autophagy machinery by mTOR-dependent and -independent pathways","volume":"1467","author":"Al-Bari","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2023.106273_bb0015","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1074\/jbc.M117.817635","article-title":"TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway","volume":"293","author":"Almasi","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2023.106273_bb0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJM199801013380104","article-title":"A population-based study of seizures after traumatic brain injuries","volume":"338","author":"Annegers","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2023.106273_bb0025","doi-asserted-by":"crossref","first-page":"14132","DOI":"10.1038\/s41598-019-50661-8","article-title":"The human transient receptor potential Melastatin 2 Ion Channel modulates ROS through Nrf2","volume":"9","author":"Bao","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2023.106273_bb0030","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/aps.2018.31","article-title":"TRPM2: a candidate therapeutic target for treating neurological diseases","volume":"39","author":"Belrose","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.nbd.2023.106273_bb0035","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCRESAHA.118.313854","article-title":"ATF6 regulates cardiac hypertrophy by transcriptional induction of the mTORC1 activator","volume":"124","author":"Blackwood","year":"2019","journal-title":"Rheb. Circ. Res."},{"key":"10.1016\/j.nbd.2023.106273_bb0040","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0306-4522(98)00401-1","article-title":"Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy","volume":"89","author":"Bouilleret","year":"1999","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2023.106273_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.910988","article-title":"Brain region-specific microglial and astrocytic activation in response to systemic lipopolysaccharides exposure","volume":"14","author":"Brandi","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2023.106273_bb0050","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0013-4694(82)90134-1","article-title":"Long-term effects of intrahippocampal kainic acid injection in rats: a method for inducing spontaneous recurrent seizures","volume":"53","author":"Cavalheiro","year":"1982","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.nbd.2023.106273_bb0055","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1038\/ncomms5486","article-title":"Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain","volume":"5","author":"Chen","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2023.106273_bb0060","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41419-020-2454-8","article-title":"Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy","volume":"11","author":"Chen","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2023.106273_bb0065","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.4161\/auto.29647","article-title":"Autophagy in microglia degrades extracellular beta-amyloid fibrils and regulates the NLRP3 inflammasome","volume":"10","author":"Cho","year":"2014","journal-title":"Autophagy."},{"key":"10.1016\/j.nbd.2023.106273_bb0070","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2174\/0929867325666181031144605","article-title":"Autophagy modulators and neuroinflammation","volume":"27","author":"Cho","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.nbd.2023.106273_bb0075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1742-2094-6-38","article-title":"Cellular injury and neuroinflammation in children with chronic intractable epilepsy","volume":"6","author":"Choi","year":"2009","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2023.106273_bb0080","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrneurol.2013.36","article-title":"Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers","volume":"9","author":"DeKosky","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2023.106273_bb0085","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","article-title":"Autophagy in inflammation, infection, and immunometabolism","volume":"54","author":"Deretic","year":"2021","journal-title":"Immunity."},{"key":"10.1016\/j.nbd.2023.106273_bb0090","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/15548627.2017.1402992","article-title":"Autophagy balances inflammation in innate immunity","volume":"14","author":"Deretic","year":"2018","journal-title":"Autophagy."},{"key":"10.1016\/j.nbd.2023.106273_bb0095","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nri3532","article-title":"Autophagy in infection, inflammation and immunity","volume":"13","author":"Deretic","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.nbd.2023.106273_bb0100","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tins.2012.11.008","article-title":"Glia and epilepsy: excitability and inflammation","volume":"36","author":"Devinsky","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2023.106273_bb0105","doi-asserted-by":"crossref","first-page":"18024","DOI":"10.1038\/nrdp.2018.24","article-title":"Epilepsy","volume":"4","author":"Devinsky","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.nbd.2023.106273_bb0110","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/glia.23006","article-title":"Microglia-neuron communication in epilepsy","volume":"65","author":"Eyo","year":"2017","journal-title":"Glia."},{"key":"10.1016\/j.nbd.2023.106273_bb0115","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14224","article-title":"Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy","author":"Fan","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.nbd.2023.106273_bb0120","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.seizure.2011.01.010","article-title":"Overexpression of mu-calpain in the anterior temporal neocortex of patients with intractable epilepsy correlates with clinicopathological characteristics","volume":"20","author":"Feng","year":"2011","journal-title":"Seizure."},{"key":"10.1016\/j.nbd.2023.106273_bb0125","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/298757a0","article-title":"Kainic acid stimulates excitatory neurotransmitter release at presynaptic receptor","volume":"298","author":"Ferkany","year":"1982","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2023.106273_bb0130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1117729","article-title":"A clonogenic bone marrow progenitor specific for macrophages and dendritic cells","volume":"311","author":"Fogg","year":"2006","journal-title":"Science."},{"key":"10.1016\/j.nbd.2023.106273_bb0135","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/10799890600637506","article-title":"Tissue distribution profiles of the human TRPM cation channel family","volume":"26","author":"Fonfria","year":"2006","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.nbd.2023.106273_bb0140","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/1742-2094-10-151","article-title":"Involvement of interleukin-1beta in the autophagic process of microglia: relevance to Alzheimer\u2019s disease","volume":"10","author":"Francois","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2023.106273_bb0145","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1007\/s11064-022-03634-9","article-title":"Electroacupuncture promotes autophagy by regulating the AKT\/mTOR signaling pathway in temporal lobe epilepsy","volume":"47","author":"Gao","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2023.106273_bb0150","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance","volume":"66","author":"Garcia","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2023.106273_bb0155","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol. Cell"},{"issue":"1091\u20131107","key":"10.1016\/j.nbd.2023.106273_bb0160","article-title":"Mapping the mouse cell atlas by microwell-seq","volume":"172","author":"Han","year":"2018","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2023.106273_bb0165","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-2157-4","article-title":"Construction of a human cell landscape at single-cell level","volume":"581","author":"Han","year":"2020","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2023.106273_bb0170","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1523\/JNEUROSCI.4703-11.2012","article-title":"TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice","volume":"32","author":"Haraguchi","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106273_bb0175","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/glia.20322","article-title":"Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors","volume":"53","author":"Hayashi","year":"2006","journal-title":"Glia."},{"key":"10.1016\/j.nbd.2023.106273_bb0180","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.nbd.2023.106273_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106824","article-title":"Transient receptor potential melastatin 2 contributes to neuroinflammation and negatively regulates cognitive outcomes in a pilocarpine-induced mouse model of epilepsy","volume":"87","author":"Hu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.nbd.2023.106273_bb0190","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7356266","article-title":"Deficiency of ROS-activated TRPM2 channel protects neurons from cerebral ischemia-reperfusion injury through upregulating autophagy","volume":"2021","author":"Hu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.nbd.2023.106273_bb0195","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20080281","article-title":"The TSC1-TSC2 complex: a molecular switchboard controlling cell growth","volume":"412","author":"Huang","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2023.106273_bb0200","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jep.2016.10.040","article-title":"Baicalein attenuates alpha-synuclein aggregation, inflammasome activation and autophagy in the MPP(+)-treated nigrostriatal dopaminergic system in vivo","volume":"194","author":"Hung","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.nbd.2023.106273_bb0205","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nm.2399","article-title":"The immunology of stroke: from mechanisms to translation","volume":"17","author":"Iadecola","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2023.106273_bb0210","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2023.106273_bb0215","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4161\/cam.1.3.4937","article-title":"UDP facilitates microglial phagocytosis through P2Y6 receptors","volume":"1","author":"Inoue","year":"2007","journal-title":"Cell Adhes. Migr."},{"key":"10.1016\/j.nbd.2023.106273_bb0220","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.biopha.2018.01.067","article-title":"Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR\/Ulk1 pathway","volume":"99","author":"Jiang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.nbd.2023.106273_bb0225","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2023.106273_bb0230","first-page":"1713","article-title":"Regulation of mTORC1 and its impact on gene expression at a glance","volume":"126","author":"Laplante","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2023.106273_bb0235","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0306-4522(92)90500-2","article-title":"Turnover of resident microglia in the normal adult mouse brain","volume":"48","author":"Lawson","year":"1992","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2023.106273_bb0240","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1016\/j.neubiorev.2013.10.011","article-title":"The kainic acid model of temporal lobe epilepsy","volume":"37","author":"Levesque","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nbd.2023.106273_bb0245","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-981-15-0602-4_4","article-title":"AMPK and autophagy","volume":"1206","author":"Li","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.nbd.2023.106273_bb0250","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.chom.2014.01.009","article-title":"Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses","volume":"15","author":"Liang","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.nbd.2023.106273_bb0255","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2023.106273_bb0260","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"key":"10.1016\/j.nbd.2023.106273_bb0265","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fphar.2019.00239","article-title":"TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies","volume":"10","author":"Malko","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106273_bb0270","doi-asserted-by":"crossref","first-page":"6514","DOI":"10.1038\/ncomms7514","article-title":"TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus","volume":"6","author":"Matsuda","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2023.106273_bb0275","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev-immunol-042617-053253","article-title":"Autophagy and inflammation","volume":"36","author":"Matsuzawa-Ishimoto","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.nbd.2023.106273_bb0280","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1523\/JNEUROSCI.2451-17.2018","article-title":"TRPM2 channel aggravates CNS inflammation and cognitive impairment via activation of microglia in chronic cerebral hypoperfusion","volume":"38","author":"Miyanohara","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106273_bb0285","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.4103\/1673-5374.274331","article-title":"Autophagy and inflammation in ischemic stroke","volume":"15","author":"Mo","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.nbd.2023.106273_bb0290","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.molbrainres.2003.09.007","article-title":"Potentiation of NMDA receptor-mediated synaptic responses by microglia","volume":"119","author":"Moriguchi","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2023.106273_bb0295","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/glia.23265","article-title":"A critical role of TRPM2 channel in Abeta(42) -induced microglial activation and generation of tumor necrosis factor-alpha","volume":"66","author":"Alawieyah Syed Mortadza","year":"2018","journal-title":"Glia."},{"key":"10.1016\/j.nbd.2023.106273_bb0300","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.nbd.2023.106273_bb0305","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1523\/JNEUROSCI.2260-18.2019","article-title":"mTOR hyperactivity levels influence the severity of epilepsy and associated neuropathology in an experimental model of tuberous sclerosis complex and focal cortical dysplasia","volume":"39","author":"Nguyen","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106273_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13010083","article-title":"Biomarkers of drug resistance in temporal lobe epilepsy in adults","volume":"13","author":"Panina","year":"2023","journal-title":"Metabolites."},{"key":"10.1016\/j.nbd.2023.106273_bb0315","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2023.106273_bb0320","doi-asserted-by":"crossref","first-page":"E197","DOI":"10.1073\/pnas.1111098109","article-title":"Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission","volume":"109","author":"Pascual","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106273_bb0325","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41583-019-0126-4","article-title":"Neuron-glia interactions in the pathophysiology of epilepsy","volume":"20","author":"Patel","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2023.106273_bib536","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2012"},{"key":"10.1016\/j.nbd.2023.106273_bb0335","series-title":"Epileptogenesis","first-page":"5","author":"Pitkanen","year":"2015"},{"key":"10.1016\/j.nbd.2023.106273_bb0340","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S1474-4422(16)00112-5","article-title":"Advances in the development of biomarkers for epilepsy","volume":"15","author":"Pitkanen","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2023.106273_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030598","article-title":"Autophagy and microglia: novel partners in neurodegeneration and aging","volume":"18","author":"Plaza-Zabala","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2023.106273_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131705","article-title":"Immediate epileptogenesis after kainate-induced status epilepticus in C57BL\/6J mice: evidence from long term continuous video-EEG telemetry","volume":"10","author":"Puttachary","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106273_bb0355","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1212\/WNL.8.6.435","article-title":"Focal seizures due to chronic localized encephalitis","volume":"8","author":"Rasmussen","year":"1958","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2023.106273_bb0360","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.nbd.2007.08.012","article-title":"Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy","volume":"29","author":"Ravizza","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106273_bb0365","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrn1430","article-title":"The neurobiology of antiepileptic drugs","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2023.106273_bb0370","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2017.07.001","article-title":"Extracellular vesicles: novel promising delivery systems for therapy of brain diseases","volume":"262","author":"Rufino-Ramos","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.nbd.2023.106273_bb0375","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.seizure.2014.03.003","article-title":"Factors predicting the outcome following medical treatment of mesial temporal epilepsy with hippocampal sclerosis","volume":"23","author":"Sanchez","year":"2014","journal-title":"Seizure."},{"key":"10.1016\/j.nbd.2023.106273_bb0380","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S1474-4422(18)30238-2","article-title":"Selective autophagy as a potential therapeutic target for neurodegenerative disorders","volume":"17","author":"Scrivo","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2023.106273_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105534","article-title":"TRPM2 contributes to neuroinflammation and cognitive deficits in a cuprizone-induced multiple sclerosis model via NLRP3 inflammasome","volume":"160","author":"Shao","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106273_bb0390","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ni.3273","article-title":"Autophagy and autophagy-related proteins in the immune system","volume":"16","author":"Shibutani","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.nbd.2023.106273_bb0395","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrm3757","article-title":"Making new contacts: the mTOR network in metabolism and signalling crosstalk","volume":"15","author":"Shimobayashi","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.nbd.2023.106273_bb0400","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/glia.20468","article-title":"Microglia derived from aging mice exhibit an altered inflammatory profile","volume":"55","author":"Sierra","year":"2007","journal-title":"Glia."},{"key":"10.1016\/j.nbd.2023.106273_bb0405","doi-asserted-by":"crossref","first-page":"1094351","DOI":"10.3389\/fphar.2022.1094351","article-title":"Trilateral association of autophagy, mTOR and Alzheimer\u2019s disease: potential pathway in the development for Alzheimer\u2019s disease therapy","volume":"13","author":"Subramanian","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.nbd.2023.106273_bb0410","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0079-6123(08)61757-4","article-title":"Kainic acid-induced excitotoxicity in neurons and glial cells","volume":"94","author":"Sun","year":"1992","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2023.106273_bb0415","doi-asserted-by":"crossref","first-page":"39921","DOI":"10.1074\/jbc.M306553200","article-title":"Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K","volume":"278","author":"Tabancay","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2023.106273_bb0420","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/ana.25149","article-title":"Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy","volume":"83","author":"Talos","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106273_bb0425","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/1531-8249(199905)45:5<568::AID-ANA4>3.0.CO;2-P","article-title":"Neuroimaging evidence of progressive neuronal loss and dysfunction in temporal lobe epilepsy","volume":"45","author":"Tasch","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106273_bb0430","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet."},{"key":"10.1016\/j.nbd.2023.106273_bb0435","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/aps.2017.194","article-title":"The role of TRPM2 channels in neurons, glial cells and the blood-brain barrier in cerebral ischemia and hypoxia","volume":"39","author":"Turlova","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.nbd.2023.106273_bb0440","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1111\/j.1528-1167.2005.00298.x","article-title":"Brain inflammation in epilepsy: experimental and clinical evidence","volume":"46","author":"Vezzani","year":"2005","journal-title":"Epilepsia."},{"key":"10.1016\/j.nbd.2023.106273_bb0445","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy","volume":"7","author":"Vezzani","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2023.106273_bb0450","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1093\/brain\/awf203","article-title":"Disease modification in partial epilepsy","volume":"125","author":"Walker","year":"2002","journal-title":"Brain."},{"key":"10.1016\/j.nbd.2023.106273_bb0455","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1385\/MN:31:1-3:003","article-title":"Kainic acid-mediated excitotoxicity as a model for neurodegeneration","volume":"31","author":"Wang","year":"2005","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106273_bb0460","doi-asserted-by":"crossref","first-page":"20036","DOI":"10.1074\/jbc.M702376200","article-title":"PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding","volume":"282","author":"Wang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2023.106273_bb0465","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12989-020-00353-3","article-title":"Silica nanoparticles induce lung inflammation in mice via ROS\/PARP\/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction","volume":"17","author":"Wang","year":"2020","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.nbd.2023.106273_bb0470","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12974-016-0786-1","article-title":"Inflammation in epileptogenesis after traumatic brain injury","volume":"14","author":"Webster","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2023.106273_bb0475","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1523\/JNEUROSCI.0980-08.2009","article-title":"Development of spontaneous recurrent seizures after kainate-induced status epilepticus","volume":"29","author":"Williams","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106273_bb0480","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.it.2015.08.008","article-title":"Microglia: dynamic mediators of synapse development and plasticity","volume":"36","author":"Wu","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.nbd.2023.106273_bb0485","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature25023","article-title":"Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40","volume":"552","author":"Yang","year":"2017","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2023.106273_bb0490","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41467-020-20522-4","article-title":"Structural insights into TSC complex assembly and GAP activity on Rheb","volume":"12","author":"Yang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2023.106273_bb0495","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/jnc.14042","article-title":"The role of autophagy in pro-inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro","volume":"142","author":"Ye","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2023.106273_bb0500","first-page":"6918","article-title":"Genetic knockout of TRPM2 increases neuronal excitability of hippocampal neurons by inhibiting Kv7 channel in epilepsy","volume":"59","author":"Ying","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106273_bb0505","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.21331","article-title":"Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex","volume":"63","author":"Zeng","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2023.106273_bb0510","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1523\/JNEUROSCI.0066-09.2009","article-title":"The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy","volume":"29","author":"Zeng","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106273_bb0515","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejmech.2018.04.045","article-title":"Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors","volume":"152","author":"Zhang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.nbd.2023.106273_bb0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108443","article-title":"Down-regulation of TRPM2 attenuates hepatic ischemia\/reperfusion injury through activation of autophagy and inhibition of NLRP3 inflammasome pathway","volume":"104","author":"Zhang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.nbd.2023.106273_bb0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105836","article-title":"TRPM2 channel regulates cytokines production in astrocytes and aggravates brain disorder during lipopolysaccharide-induced endotoxin sepsis","volume":"75","author":"Zhu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.nbd.2023.106273_bb0530","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030728","article-title":"Balancing mTOR signaling and autophagy in the treatment of Parkinson\u2019s disease","volume":"20","author":"Zhu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2023.106273_bb0535","doi-asserted-by":"crossref","DOI":"10.3390\/cells11172621","article-title":"Molecular mechanism and regulation of autophagy and its potential role in epilepsy","volume":"11","author":"Zhu","year":"2022","journal-title":"Cells."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T20:56:23Z","timestamp":1729112183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996123002887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":107,"alternative-id":["S0969996123002887"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106273","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogenesis by upregulating autophagy via the AMPK\/mTOR pathway","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106273"}}