{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:15:20Z","timestamp":1792080920561,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K22472"],"award-info":[{"award-number":["JP19K22472"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H02672"],"award-info":[{"award-number":["JP21H02672"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.nbd.2023.106280","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T01:00:37Z","timestamp":1693789237000},"page":"106280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Loss of synaptic ribbons is an early cause in ROS-induced acquired sensorineural hearing loss"],"prefix":"10.1016","volume":"186","author":[{"given":"Shunkou","family":"Kurasawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Mohri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Tabuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Ueyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2023.106280_bb0005","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1515\/revneuro-2020-0002","article-title":"Cochlear synaptopathy: new findings in animal and human research","volume":"31","author":"Aedo","year":"2020","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.nbd.2023.106280_bb0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.15252\/emmm.201606230","article-title":"Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy","volume":"9","author":"Benkafadar","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2023.106280_bb0015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnsyn.2017.00014","article-title":"Piccolo promotes vesicle replenishment at a fast central auditory synapse","volume":"9","author":"Butola","year":"2017","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.nbd.2023.106280_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2019.107880","article-title":"Novel oral multifunctional antioxidant prevents noise-induced hearing loss and hair cell loss","volume":"388","author":"Chen","year":"2020","journal-title":"Hear. Res."},{"key":"10.1016\/j.nbd.2023.106280_bb0025","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1016\/j.febslet.2015.08.030","article-title":"Cochlear hair cells: the sound-sensing machines","volume":"589","author":"Goutman","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2023.106280_bb0030","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.heares.2016.12.010","article-title":"Translational issues in cochlear synaptopathy","volume":"349","author":"Hickox","year":"2017","journal-title":"Hear. Res."},{"key":"10.1016\/j.nbd.2023.106280_bb0035","doi-asserted-by":"crossref","first-page":"7497","DOI":"10.1523\/JNEUROSCI.0782-16.2016","article-title":"Noise-induced loss of hair cells and cochlear synaptopathy are mediated by the activation of AMPK","volume":"36","author":"Hill","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106280_bb0040","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1523\/JNEUROSCI.1317-18.2019","article-title":"Light-activated ROS production induces synaptic autophagy","volume":"39","author":"Hoffmann","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106280_bb0045","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1113\/JP280018","article-title":"Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea","volume":"598","author":"Jeng","year":"2020","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.nbd.2023.106280_bb0050","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.heares.2011.11.007","article-title":"Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice","volume":"283","author":"Kane","year":"2012","journal-title":"Hear. Res."},{"key":"10.1016\/j.nbd.2023.106280_bb0055","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1021\/acsnano.9b08078","article-title":"Oxidation of reduced graphene oxide via cellular redox signaling modulates actin-mediated neurotransmission","volume":"14","author":"Kang","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.nbd.2023.106280_bb0060","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1021\/pr2008972","article-title":"Protein composition of immunoprecipitated synaptic ribbons","volume":"11","author":"Kantardzhieva","year":"2012","journal-title":"J. Proteome Res."},{"issue":"442\u2013454","key":"10.1016\/j.nbd.2023.106280_bb0065","article-title":"Mechanotransduction-dependent control of stereocilia dimensions and row identity in inner hair cells","volume":"30","author":"Krey","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.nbd.2023.106280_bb0070","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding insult to injury: cochlear nerve degeneration after \u201ctemporary\u201d noise-induced hearing loss","volume":"29","author":"Kujawa","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106280_bb0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.heares.2019.03.003","article-title":"Translating animal models to human therapeutics in noise-induced and age-related hearing loss","volume":"377","author":"Kujawa","year":"2019","journal-title":"Hear. Res."},{"key":"10.1016\/j.nbd.2023.106280_bb0080","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.heares.2016.11.013","article-title":"Cellular mechanisms of noise-induced hearing loss","volume":"349","author":"Kurabi","year":"2017","journal-title":"Hear. Res."},{"key":"10.1016\/j.nbd.2023.106280_bb0085","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1089\/ars.2009.2637","article-title":"Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases","volume":"11","author":"Leto","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2023.106280_bb0090","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12916-021-02169-0","article-title":"A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens","volume":"19","author":"Liu","year":"2021","journal-title":"BMC Med."},{"key":"10.1016\/j.nbd.2023.106280_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13024-017-0150-7","article-title":"NADPH oxidase in brain injury and neurodegenerative disorders","volume":"12","author":"Ma","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2023.106280_bb0100","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13073-016-0273-4","article-title":"Correction of the auditory phenotype in C57BL\/6N mice via CRISPR\/Cas9-mediated homology directed repair","volume":"8","author":"Mianne","year":"2016","journal-title":"Genome Med."},{"key":"10.1016\/j.nbd.2023.106280_bb0105","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/dneu.20957","article-title":"Oxidative stress in synapse development and function","volume":"72","author":"Milton","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106280_bb0110","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1523\/JNEUROSCI.2672-20.2021","article-title":"Nox3-derived superoxide in cochleae induces sensorineural hearing loss","volume":"41","author":"Mohri","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106280_bb0115","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/jnc.14451","article-title":"Hearing vulnerability after noise exposure in a mouse model of reactive oxygen species overproduction","volume":"146","author":"Morioka","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2023.106280_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008826","article-title":"Congenital hearing impairment associated with peripheral cochlear nerve dysmyelination in glycosylation-deficient muscular dystrophy","volume":"16","author":"Morioka","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2023.106280_bb0125","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1089\/ars.2010.3110","article-title":"Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat","volume":"13","author":"Mukherjea","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2023.106280_bb0130","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nrd4533","article-title":"New treatment options for hearing loss","volume":"14","author":"Muller","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.nbd.2023.106280_bb0135","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1080\/14992020902858959","article-title":"Development of distortion product otoacoustic emissions in C57BL\/6J mice","volume":"48","author":"Narui","year":"2009","journal-title":"Int. J. Audiol."},{"key":"10.1016\/j.nbd.2023.106280_bb0140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"Noben-Trauth","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2023.106280_bb0145","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/1873-3468.12972","article-title":"Regulation of neuronal development and function by ROS","volume":"592","author":"Oswald","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2023.106280_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.756449","article-title":"Synaptic release potentiation at aging auditory ribbon synapses","volume":"13","author":"Peineau","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2023.106280_bb0155","article-title":"Oxidative stress and inflammation caused by cisplatin ototoxicity","volume":"10","author":"Ramkumar","year":"2021","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.nbd.2023.106280_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101434","article-title":"Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss","volume":"30","author":"Rousset","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.nbd.2023.106280_bb0165","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1177\/1073858409340253","article-title":"The making of synaptic ribbons: how they are built and what they do","volume":"15","author":"Schmitz","year":"2009","journal-title":"Neuroscientist."},{"key":"10.1016\/j.nbd.2023.106280_bb0170","series-title":"The Epidemiology of Deafness","first-page":"9","author":"Sheffield","year":"2019"},{"key":"10.1016\/j.nbd.2023.106280_bb0175","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1007\/s00405-016-4378-6","article-title":"Role of antioxidants in prevention of age-related hearing loss: a review of literature","volume":"274","author":"Tavanai","year":"2017","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.nbd.2023.106280_bb0180","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1007\/s12035-017-0661-9","article-title":"Vertebrate presynaptic active zone assembly: a role accomplished by diverse molecular and cellular mechanisms","volume":"55","author":"Torres","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106280_bb0185","first-page":"2040","article-title":"Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells","volume":"127","author":"Ueyama","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2023.106280_bb0190","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.15252\/emmm.201606609","article-title":"Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss","volume":"8","author":"Ueyama","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"75\u201384","key":"10.1016\/j.nbd.2023.106280_bb0195","article-title":"Rac-dependent signaling from keratinocytes promotes differentiation of intradermal white adipocytes","volume":"140","author":"Ueyama","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.nbd.2023.106280_bb0200","doi-asserted-by":"crossref","first-page":"8815990","DOI":"10.1155\/2020\/8815990","article-title":"Protection of cochlear ribbon synapses and prevention of hidden hearing loss","volume":"2020","author":"Wei","year":"2020","journal-title":"Neural Plast."},{"key":"10.1016\/j.nbd.2023.106280_bb0205","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuroscience.2018.07.053","article-title":"Primary neural degeneration in the human cochlea: evidence for hidden hearing loss in the aging ear","volume":"407","author":"Wu","year":"2019","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2023.106280_bb0210","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1523\/JNEUROSCI.0937-20.2020","article-title":"Age-related hearing loss is dominated by damage to inner ear sensory cells, not the cellular battery that powers them","volume":"40","author":"Wu","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106280_bb0215","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fncel.2015.00276","article-title":"Age-related hearing impairment and the triad of acquired hearing loss","volume":"9","author":"Yang","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2023.106280_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2020.107926","article-title":"C.753A>G genome editing of a Cdh23(ahl) allele delays age-related hearing loss and degeneration of cochlear hair cells in C57BL\/6J mice","volume":"389","author":"Yasuda","year":"2020","journal-title":"Hear. Res."},{"key":"10.1016\/j.nbd.2023.106280_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10092221","article-title":"Two loci contribute to age-related hearing loss resistance in the Japanese wild-derived inbred MSM\/Ms mice","volume":"10","author":"Yasuda","year":"2022","journal-title":"Biomedicines."},{"key":"10.1016\/j.nbd.2023.106280_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113280","article-title":"SIRT3-mediated deacetylation protects inner hair cell synapses in a H2O2-induced oxidative stress model in vitro","volume":"418","author":"Zhao","year":"2022","journal-title":"Exp. Cell Res."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123002954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T20:56:38Z","timestamp":1729112198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996123002954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":46,"alternative-id":["S0969996123002954"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106280","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of synaptic ribbons is an early cause in ROS-induced acquired sensorineural hearing loss","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106280"}}