{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:57:49Z","timestamp":1793239069319,"version":"4.5.0"},"reference-count":117,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006975","name":"Indiana Clinical and Translational Sciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001108"],"award-info":[{"award-number":["UL1TR001108"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR078663"],"award-info":[{"award-number":["AR078663"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.nbd.2023.106359","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T02:27:06Z","timestamp":1700447226000},"page":"106359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model"],"prefix":"10.1016","volume":"190","author":[{"given":"Laura E.","family":"Hawley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Stringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail J.","family":"Deal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Folz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Goodlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Roper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2023.106359_bb0005","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1021\/pr2011582","article-title":"Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome","volume":"11","author":"Ahmed","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0010","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.nbd.2005.12.006","article-title":"DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects","volume":"22","author":"Ahn","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106359_bb0015","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1086\/520000","article-title":"Classification of human chromosome 21 gene-expression variations in down syndrome: impact on disease phenotypes","volume":"81","author":"Ait Yahya-Graison","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0020","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jneumeth.2008.05.003","article-title":"The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting","volume":"172","author":"Aldridge","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2023.106359_bb0025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.nbd.2012.11.017","article-title":"Normalization of Dyrk1A expression by AAV2\/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of down syndrome","volume":"52","author":"Altafaj","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106359_bb0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-019-0143-7","article-title":"Down syndrome","volume":"6","author":"Antonarakis","year":"2020","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.nbd.2023.106359_bb0035","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nature04678","article-title":"NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21","volume":"441","author":"Arron","year":"2006","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2023.106359_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/genes12111833","article-title":"Dyrk1a from gene function in development and physiology to dosage correction across life span in down syndrome","volume":"12","author":"Atas-Ozcan","year":"2021","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.nbd.2023.106359_bb0045","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1176\/ajp.156.4.564","article-title":"MRI volumes of the hippocampus and amygdala in adults with Down\u2019s syndrome with and without dementia","volume":"156","author":"Aylward","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.nbd.2023.106359_bb0050","article-title":"Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1\/Yey mouse models of down syndrome","volume":"11","author":"Aziz","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.nbd.2023.106359_bb0055","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/hmg\/9.2.195","article-title":"Discovery and genetic localization of down syndrome cerebellar phenotypes using the Ts65Dn mouse","volume":"9","author":"Baxter","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0060","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/18715273113126660186","article-title":"DYRK1A: a potential drug target for multiple down syndrome neuropathologies","volume":"13","author":"Becker","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.nbd.2023.106359_bb0065","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cne.20337","article-title":"Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome","volume":"480","author":"Belichenko","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2023.106359_bb0070","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cne.21433","article-title":"Synaptic and cognitive abnormalities in mouse models of down syndrome: exploring genotype-phenotype relationships","volume":"504","author":"Belichenko","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2023.106359_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134861","article-title":"Down syndrome cognitive phenotypes modeled in mice Trisomic for all HSA 21 homologues","volume":"10","author":"Belichenko","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106359_bb0080","doi-asserted-by":"crossref","first-page":"8769","DOI":"10.1523\/JNEUROSCI.0534-10.2010","article-title":"Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for down syndrome","volume":"30","author":"Bianchi","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0085","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13293-015-0043-9","article-title":"Sex differences in protein expression in the mouse brain and their perturbations in a model of down syndrome","volume":"6","author":"Block","year":"2015","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.nbd.2023.106359_bb0090","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.nbd.2023.106359_bb0095","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/jnen\/63.5.429","article-title":"Transgenic mouse in vivo library of human down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration","volume":"63","author":"Branchi","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2023.106359_bb0100","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ajhg.2008.08.012","article-title":"DYRK1A-dosage imbalance perturbs NRSF\/REST levels, deregulating pluripotency and embryonic stem cell fate in down syndrome","volume":"83","author":"Canzonetta","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0105","doi-asserted-by":"crossref","first-page":"11483","DOI":"10.1523\/JNEUROSCI.3406-07.2007","article-title":"Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of down syndrome","volume":"27","author":"Chakrabarti","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0110","doi-asserted-by":"crossref","first-page":"17597","DOI":"10.1074\/jbc.M111101200","article-title":"Dynamin is a minibrain kinase\/dual specificity Yak1-related kinase 1A substrate","volume":"277","author":"Chen-Hwang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2023.106359_bb0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00726-002-0337-1","article-title":"Protein levels of genes encoded on chromosome 21 in fetal down syndrome brain: challenging the gene dosage effect hypothesis (part II)","volume":"24","author":"Cheon","year":"2003","journal-title":"Amino Acids"},{"key":"10.1016\/j.nbd.2023.106359_bb0120","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1111\/j.1471-4159.2009.06277.x","article-title":"Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn down syndrome mouse model","volume":"110","author":"Choi","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2023.106359_bb0125","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/hipo.20308","article-title":"Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with down syndrome and in Ts65Dn mice","volume":"17","author":"Contestabile","year":"2007","journal-title":"Hippocampus."},{"key":"10.1016\/j.nbd.2023.106359_bb0130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fncel.2017.00054","article-title":"The GABAergic hypothesis for cognitive disabilities in down syndrome","volume":"11","author":"Contestabile","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0135","doi-asserted-by":"crossref","first-page":"201ra120","DOI":"10.1126\/scitranslmed.3005983","article-title":"Hedgehog agonist therapy corrects structural and cognitive deficits in a down syndrome mouse model","volume":"5","author":"Das","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2023.106359_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-444-54299-1.00001-7","article-title":"Therapeutic approaches in the improvement of cognitive performance in down syndrome: past, present, and future","volume":"197","author":"De la Torre","year":"2012","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neulet.2006.11.026","article-title":"Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with down syndrome","volume":"413","author":"Dowjat","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2023.106359_bb0150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2990.2007.00899.x","article-title":"Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly down syndrome individuals","volume":"34","author":"Downes","year":"2008","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106359_bb0155","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fnbeh.2016.00104","article-title":"DYRK1A, a dosage-sensitive gene involved in neurodevelopmental disorders, is a target for drug development in down syndrome","volume":"10","author":"Duchon","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0160","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s00335-011-9356-0","article-title":"Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome","volume":"22","author":"Duchon","year":"2011","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.nbd.2023.106359_bb0165","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/hmg\/ddab012","article-title":"Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in down syndrome mouse models","volume":"30","author":"Duchon","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0170","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049721","article-title":"Ts66Yah, a mouse model of down syndrome with improved construct and face validity","volume":"15","author":"Duchon","year":"2022","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.nbd.2023.106359_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072457","article-title":"Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting","volume":"8","author":"Eaton","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106359_bb0180","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/B978-0-444-54299-1.00007-8","article-title":"Human and mouse model cognitive phenotypes in down syndrome: implications for assessment","volume":"197","author":"Edgin","year":"2012","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0185","doi-asserted-by":"crossref","first-page":"6636","DOI":"10.1128\/MCB.22.18.6636-6647.2002","article-title":"Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice","volume":"22","author":"Fotaki","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2023.106359_bb0190","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neuron.2009.03.029","article-title":"Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity","volume":"62","author":"Frank","year":"2009","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2023.106359_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021879","article-title":"Development, problem behavior, and quality of life in a population based sample of eight-year-old children with down syndrome","volume":"6","author":"van Gameren-Oosterom","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106359_bb0200","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/j.jpeds.2013.06.054","article-title":"Problem behavior of individuals with down syndrome in a nationwide cohort assessed in late adolescence","volume":"163","author":"van Gameren-Oosterom","year":"2013","journal-title":"J. Pediatr."},{"key":"10.1016\/j.nbd.2023.106359_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106572","article-title":"Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and Neuromorphological alterations found in a mouse model of down syndrome","volume":"9","author":"Garcia-Cerro","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2023.106359_bb0210","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nbd.2017.06.010","article-title":"Normalizing the gene dosage of Dyrk1A in a mouse model of down syndrome rescues several Alzheimer\u2019s disease phenotypes","volume":"106","author":"Garcia-Cerro","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106359_bb0215","first-page":"103","article-title":"Pharmacological approaches to improving cognitive function in down syndrome: current status and considerations","volume":"9","author":"Gardiner","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.nbd.2023.106359_bb0220","doi-asserted-by":"crossref","first-page":"10426","DOI":"10.1038\/s41598-020-67133-z","article-title":"Evaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult down syndrome mice","volume":"10","author":"Goodlett","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2023.106359_bb0225","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1523\/JNEUROSCI.2513-15.2016","article-title":"Absence of prenatal forebrain defects in the Dp(16)1Yey\/+ mouse model of down syndrome","volume":"36","author":"Goodliffe","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0230","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1074\/jbc.M310794200","article-title":"Characterization of cyclin L2, a novel cyclin with an arginine\/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors","volume":"279","author":"de Graaf","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2023.106359_bb0235","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1750-3639.2007.00113.x","article-title":"Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with down syndrome","volume":"18","author":"Guidi","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2023.106359_bb0240","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1006\/geno.1999.5775","article-title":"Human minibrain homologue (MNBH\/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in down syndrome","volume":"57","author":"Guimera","year":"1999","journal-title":"Genomics."},{"key":"10.1016\/j.nbd.2023.106359_bb0245","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1460-9568.2008.06092.x","article-title":"The spatio-temporal and subcellular expression of the candidate down syndrome gene Mnb\/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development","volume":"27","author":"Hammerle","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0250","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1242\/dev.066167","article-title":"Transient expression of Mnb\/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling","volume":"138","author":"Hammerle","year":"2011","journal-title":"Development."},{"key":"10.1016\/j.nbd.2023.106359_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173404","article-title":"Sexually dimorphic DYRK1A overexpression on postnatal day 15 in the Ts65Dn mouse model of down syndrome: effects of pharmacological targeting on behavioral phenotypes","volume":"217","author":"Hawley","year":"2022","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nbd.2023.106359_bb0260","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tins.2011.11.001","article-title":"Trisomy 21 and early brain development","volume":"35","author":"Haydar","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0265","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1242\/dmm.029728","article-title":"Rodent models in down syndrome research: impact and future opportunities","volume":"10","author":"Herault","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.nbd.2023.106359_bb0270","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1042\/BJ20112040","article-title":"Co-ordination of cell cycle and differentiation in the developing nervous system","volume":"444","author":"Hindley","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2023.106359_bb0275","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2014723118","article-title":"Consequences of aneuploidy in human fibroblasts with trisomy 21","volume":"118","author":"Hwang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106359_bb0280","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1093\/hmg\/ddv364","article-title":"Genetic dissection of the down syndrome critical region","volume":"24","author":"Jiang","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0285","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jnr.23279","article-title":"Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A)","volume":"92","author":"Kaczmarski","year":"2014","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0290","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1101\/gr.1951304","article-title":"Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome","volume":"14","author":"Kahlem","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0295","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ajhg.2021.12.015","article-title":"A transchromosomic rat model with human chromosome 21 shows robust down syndrome features","volume":"109","author":"Kazuki","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0300","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1091\/mbc.e04-12-1085","article-title":"DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1","volume":"16","author":"Kelly","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.nbd.2023.106359_bb0305","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1212\/WNL.44.6.1039","article-title":"Magnetic resonance imaging analysis of age-related changes in the brains of individuals with Down\u2019s syndrome","volume":"44","author":"Kesslak","year":"1994","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2023.106359_bb0310","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.2217\/epi-2019-0135","article-title":"Aneuploidy and gene expression: is there dosage compensation?","volume":"11","author":"Kojima","year":"2019","journal-title":"Epigenomics."},{"key":"10.1016\/j.nbd.2023.106359_bb0315","doi-asserted-by":"crossref","first-page":"12031","DOI":"10.1073\/pnas.0813248106","article-title":"The genetic architecture of down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies","volume":"106","author":"Korbel","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106359_bb0320","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1096\/fj.07-104539","article-title":"Overexpression of Dyrk1A contributes to neurofibrillary degeneration in down syndrome","volume":"22","author":"Liu","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2023.106359_bb0325","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/s41467-017-01422-6","article-title":"Systematic proteome and proteostasis profiling in human trisomy 21 fibroblast cells","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2023.106359_bb0330","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ygeno.2007.08.005","article-title":"Gene expression profiling in the adult down syndrome brain","volume":"90","author":"Lockstone","year":"2007","journal-title":"Genomics."},{"key":"10.1016\/j.nbd.2023.106359_bb0335","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainres.2006.05.022","article-title":"Hippocampal hypocellularity in the Ts65Dn mouse originates early in development","volume":"1104","author":"Lorenzi","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0340","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/dmcn.15517","article-title":"State-of-the-art therapy for down syndrome","volume":"65","author":"Lorenzon","year":"2023","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.nbd.2023.106359_bb0345","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1101\/gr.2090904","article-title":"Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome","volume":"14","author":"Lyle","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0350","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ejhg.2008.214","article-title":"Genotype-phenotype correlations in down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21","volume":"17","author":"Lyle","year":"2009","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0355","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3104\/reports.313","article-title":"Mental health, behaviour and intellectual abilities of people with down syndrome","volume":"11","author":"Maatta","year":"2006","journal-title":"Downs Syndr. Res. Pract."},{"key":"10.1016\/j.nbd.2023.106359_bb0360","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0888-7543(03)00035-1","article-title":"Global up-regulation of chromosome 21 gene expression in the developing down syndrome brain","volume":"81","author":"Mao","year":"2003","journal-title":"Genomics."},{"key":"10.1016\/j.nbd.2023.106359_bb0365","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2005-6-13-r107","article-title":"Primary and secondary transcriptional effects in the developing human down syndrome brain and heart","volume":"6","author":"Mao","year":"2005","journal-title":"Genome Biol."},{"key":"10.1016\/j.nbd.2023.106359_bb0370","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ridd.2016.09.019","article-title":"Growing up with down syndrome: development from 6 months to 10.7 years","volume":"59","author":"Marchal","year":"2016","journal-title":"Res. Dev. Disabil."},{"key":"10.1016\/j.nbd.2023.106359_bb0375","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0006-8993(02)04069-6","article-title":"Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system","volume":"964","author":"Marti","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0380","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.nbd.2003.10.002","article-title":"Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in down syndrome motor dysfunction","volume":"15","author":"Martinez de Lagran","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2023.106359_bb0385","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0166-4328(02)00026-8","article-title":"Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for down syndrome","volume":"134","author":"Martinez-Cue","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0390","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1601-183X.2005.00175.x","article-title":"Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for down syndrome","volume":"5","author":"Martinez-Cue","year":"2006","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2023.106359_bb0395","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00359-019-01376-8","article-title":"A new view of sexual differentiation of mammalian brain","volume":"206","author":"McCarthy","year":"2020","journal-title":"J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol."},{"key":"10.1016\/j.nbd.2023.106359_bb0400","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000348677","article-title":"Novel PCR assay for determining the genetic sex of mice","volume":"7","author":"McFarlane","year":"2013","journal-title":"Sex. Dev."},{"key":"10.1016\/j.nbd.2023.106359_bb0405","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/nn1325","article-title":"Sexual differentiation of the vertebrate nervous system","volume":"7","author":"Morris","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0410","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.tig.2020.09.017","article-title":"All creatures great and small: new approaches for understanding down syndrome genetics","volume":"37","author":"Moyer","year":"2021","journal-title":"Trends Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0415","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ebiom.2015.01.010","article-title":"DYRK1A-mediated cyclin D1 degradation in neural stem cells contributes to the neurogenic cortical defects in down syndrome","volume":"2","author":"Najas","year":"2015","journal-title":"EBioMedicine."},{"key":"10.1016\/j.nbd.2023.106359_bb0420","first-page":"108","article-title":"An appropriate loading control for western blot analysis in animal models of myocardial ischemic infarction","volume":"12","author":"Nie","year":"2017","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.nbd.2023.106359_bb0425","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0896-6273(03)00632-9","article-title":"Neurogenesis and the cell cycle","volume":"40","author":"Ohnuma","year":"2003","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2023.106359_bb0430","doi-asserted-by":"crossref","first-page":"244","DOI":"10.5607\/en.2013.22.4.244","article-title":"New perspectives of Dyrk1A role in neurogenesis and Neuropathologic features of down syndrome","volume":"22","author":"Park","year":"2013","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.nbd.2023.106359_bb0435","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.mcn.2007.07.007","article-title":"Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of down syndrome","volume":"36","author":"Park","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0440","doi-asserted-by":"crossref","first-page":"31895","DOI":"10.1074\/jbc.M110.147520","article-title":"Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells","volume":"285","author":"Park","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2023.106359_bb0445","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1176\/appi.ajp.158.10.1659","article-title":"Neuroanatomy of Down\u2019s syndrome: a high-resolution MRI study","volume":"158","author":"Pinter","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.nbd.2023.106359_bb0450","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1212\/WNL.45.2.356","article-title":"Selective neuroanatomic abnormalities in Down\u2019s syndrome and their cognitive correlates: evidence from MRI morphometry","volume":"45","author":"Raz","year":"1995","journal-title":"Neurology."},{"key":"10.1016\/j.nbd.2023.106359_bb0455","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1095-177","article-title":"A mouse model for down syndrome exhibits learning and behaviour deficits","volume":"11","author":"Reeves","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0460","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00335-011-9357-z","article-title":"Molecular characterization of the translocation breakpoints in the down syndrome mouse model Ts65Dn","volume":"22","author":"Reinholdt","year":"2011","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.nbd.2023.106359_bb0465","series-title":"Purification of RNA using TRIzol (TRI reagent)","author":"Rio","year":"2010"},{"key":"10.1016\/j.nbd.2023.106359_bb0470","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0020050","article-title":"Understanding the basis for down syndrome phenotypes","volume":"2","author":"Roper","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0475","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1073\/pnas.0510750103","article-title":"Defective cerebellar response to mitogenic hedgehog signaling in down [corrected] syndrome mice","volume":"103","author":"Roper","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2023.106359_bb0480","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1534\/genetics.105.050898","article-title":"Perinatal loss of Ts65Dn down syndrome mice","volume":"172","author":"Roper","year":"2006","journal-title":"Genetics."},{"key":"10.1016\/j.nbd.2023.106359_bb0485","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/bs.pbr.2019.09.001","article-title":"Influence of allelic differences in down syndrome","volume":"251","author":"Roper","year":"2020","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0490","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/hmg\/ddg217","article-title":"Global disruption of the cerebellar transcriptome in a down syndrome mouse model","volume":"12","author":"Saran","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0495","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2023.106359_bb0500","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2023.106359_bb0505","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.4161\/cc.29104","article-title":"The down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and cyclin D1 and induces cell cycle exit and neuronal differentiation","volume":"13","author":"Soppa","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.nbd.2023.106359_bb0510","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuroscience.2016.07.031","article-title":"Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65dn mouse model of down syndrome","volume":"333","author":"Stagni","year":"2016","journal-title":"Neuroscience."},{"key":"10.1016\/j.nbd.2023.106359_bb0515","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2017.07.026","article-title":"Neurogenesis impairment: an early developmental defect in down syndrome","volume":"114","author":"Stagni","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2023.106359_bb0520","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.physbeh.2017.05.003","article-title":"Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes","volume":"177","author":"Stringer","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.nbd.2023.106359_bb0525","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/mgg3.334","article-title":"Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve down syndrome deficits","volume":"5","author":"Stringer","year":"2017","journal-title":"Mol. Genet. Genomic. Med."},{"key":"10.1016\/j.nbd.2023.106359_bb0530","doi-asserted-by":"crossref","first-page":"14818","DOI":"10.1038\/s41598-017-13858-3","article-title":"Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation","volume":"7","author":"Sullivan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2023.106359_bb0535","doi-asserted-by":"crossref","first-page":"R91","DOI":"10.1186\/gb-2007-8-5-r91","article-title":"Gene expression variation in Down's syndrome mice allows prioritization of candidate genes","volume":"8","author":"Sultan","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.nbd.2023.106359_bb0540","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1742-4658.2010.07954.x","article-title":"MNB\/DYRK1A as a multiple regulator of neuronal development","volume":"278","author":"Tejedor","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.nbd.2023.106359_bb0545","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1084\/jem.20150002","article-title":"DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing cyclin D3","volume":"212","author":"Thompson","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2023.106359_bb0550","first-page":"1207","article-title":"Down syndrome: MR quantification of brain structures and comparison with normal control subjects","volume":"12","author":"Weis","year":"1991","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nbd.2023.106359_bb0555","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1021\/pr1011476","article-title":"Coomassie staining as loading control in Western blot analysis","volume":"10","author":"Welinder","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.nbd.2023.106359_bb0560","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj3550597","article-title":"The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site","volume":"355","author":"Woods","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2023.106359_bb0565","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1523\/JNEUROSCI.5746-12.2013","article-title":"Modeling transformations of neurodevelopmental sequences across mammalian species","volume":"33","author":"Workman","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0570","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1093\/hmg\/ddad056","article-title":"Dissection of a down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome","volume":"32","author":"Xing","year":"2023","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2023.106359_bb0575","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1523\/JNEUROSCI.4711-09.2010","article-title":"Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells","volume":"30","author":"Yabut","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2023.106359_bb0580","doi-asserted-by":"crossref","first-page":"39819","DOI":"10.1074\/jbc.M104091200","article-title":"Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells","volume":"276","author":"Yang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2023.106359_bb0585","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41598-017-00682-y","article-title":"Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn down syndrome mice","volume":"7","author":"Yin","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123003753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996123003753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:38:40Z","timestamp":1760852320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996123003753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":117,"alternative-id":["S0969996123003753"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106359","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2023.106359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106359"}}