{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:35:39Z","timestamp":1791876939121,"version":"4.3.4"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG055943"],"award-info":[{"award-number":["AG055943"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32AG055378"],"award-info":[{"award-number":["T32AG055378"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.nbd.2024.106429","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T01:09:15Z","timestamp":1706836155000},"page":"106429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The amyloid precursor protein intracellular domain induces sleep disruptions and its nuclear localization fluctuates in circadian pacemaker neurons in Drosophila and mice"],"prefix":"10.1016","volume":"192","author":[{"given":"Dani M.","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Cravetchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen S.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Kretzschmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2024.106429_bb0005","doi-asserted-by":"crossref","first-page":"435","DOI":"10.18632\/aging.100764","article-title":"Premature aging of the hippocampal neurogenic niche in adult Bmal1-deficient mice","volume":"7","author":"Ali","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.nbd.2024.106429_bb0010","doi-asserted-by":"crossref","first-page":"333","DOI":"10.5664\/jcsm.26597","article-title":"Insomnia and daytime napping in older adults","volume":"2","author":"Ancoli-Israel","year":"2006","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.nbd.2024.106429_bb0015","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/01677060802471718","article-title":"The mushroom body of adult Drosophila characterized by GAL4 drivers","volume":"23","author":"Aso","year":"2009","journal-title":"J. Neurogenet."},{"key":"10.1016\/j.nbd.2024.106429_bb0020","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fnmol.2018.00122","article-title":"Drosophila RSK influences the pace of the circadian clock by negative regulation of protein kinase Shaggy activity","volume":"11","author":"Beck","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2024.106429_bb0025","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/074873049601100204","article-title":"Melatonin and light induce phase shifts of circadian activity rhythms in the C3H\/HeN mouse","volume":"11","author":"Benloucif","year":"1996","journal-title":"J. Biol. Rhythm."},{"key":"10.1016\/j.nbd.2024.106429_bb0030","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/0748730415573167","article-title":"Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus","volume":"30","author":"Besing","year":"2015","journal-title":"J. Biol. Rhythm."},{"key":"10.1016\/j.nbd.2024.106429_bb0035","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.nbd.2015.02.012","article-title":"Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila","volume":"77","author":"Blake","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106429_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135741","article-title":"Amyloid-beta peptide exacerbates the memory deficit caused by amyloid precursor protein loss-of-function in Drosophila","volume":"10","author":"Bourdet","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2024.106429_bb0045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pneurobio.2017.05.005","article-title":"Small things matter: implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer\u2019s disease","volume":"156","author":"Bukhari","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106429_bb0050","doi-asserted-by":"crossref","first-page":"24601","DOI":"10.1074\/jbc.M402248200","article-title":"Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation","volume":"279","author":"Cao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2024.106429_bb0055","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.nbd.2008.10.014","article-title":"Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function","volume":"33","author":"Carmine-Simmen","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106429_bb0060","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cell.2014.02.024","article-title":"Identification of a circadian output circuit for rest:activity rhythms in Drosophila","volume":"157","author":"Cavanaugh","year":"2014","journal-title":"Cell."},{"key":"10.1016\/j.nbd.2024.106429_bb0065","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.smrv.2016.02.002","article-title":"Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer\u2019s disease","volume":"31","author":"Cedernaes","year":"2017","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.nbd.2024.106429_bb0070","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1210\/en.2007-0804","article-title":"Minireview: entrainment of the suprachiasmatic clockwork in diurnal and nocturnal mammals","volume":"148","author":"Challet","year":"2007","journal-title":"Endocrinology."},{"key":"10.1016\/j.nbd.2024.106429_bb0075","first-page":"445","article-title":"The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer\u2019s disease","volume":"7","author":"Chen","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.nbd.2024.106429_bb0080","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/phen.12164","article-title":"Circadian rhythm in mRNA expression of the glutathione synthesis gene Gclc is controlled by peripheral glial clocks in Drosophila melanogaster","volume":"41","author":"Chow","year":"2016","journal-title":"Physiol. Entomol."},{"key":"10.1016\/j.nbd.2024.106429_bb0085","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ydbio.2009.08.003","article-title":"Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact eyeless protein is necessary for normal eye and brain development in Drosophila","volume":"334","author":"Clements","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.nbd.2024.106429_bb0090","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.neuron.2010.01.032","article-title":"Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior","volume":"65","author":"Crocker","year":"2010","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2024.106429_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.03.087","article-title":"APP-mediated signaling prevents memory decline in Alzheimer\u2019s disease mouse model","volume":"27","author":"Deyts","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2024.106429_bb0100","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1126\/science.1202249","article-title":"Inducing sleep by remote control facilitates memory consolidation in Drosophila","volume":"332","author":"Donlea","year":"2011","journal-title":"Science."},{"key":"10.1016\/j.nbd.2024.106429_bb0105","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.neuron.2014.03.008","article-title":"Neuronal machinery of sleep homeostasis in Drosophila","volume":"81","author":"Donlea","year":"2014","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2024.106429_bb0110","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1534\/genetics.115.185157","article-title":"Circadian rhythms and sleep in Drosophila melanogaster","volume":"205","author":"Dubowy","year":"2017","journal-title":"Genetics."},{"key":"10.1016\/j.nbd.2024.106429_bb0115","doi-asserted-by":"crossref","first-page":"13233","DOI":"10.1073\/pnas.93.23.13233","article-title":"The cell surface metalloprotease\/disintegrin Kuzbanian is required for axonal extension in Drosophila","volume":"93","author":"Fambrough","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106429_bb0120","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cger.2017.06.009","article-title":"Sleep in the elderly: unanswered questions","volume":"33","author":"Feinsilver","year":"2017","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.nbd.2024.106429_bb0125","doi-asserted-by":"crossref","first-page":"9617","DOI":"10.1523\/JNEUROSCI.1488-20.2020","article-title":"Dopamine signaling in wake-promoting clock neurons is not required for the Normal regulation of sleep in Drosophila","volume":"40","author":"Fernandez-Chiappe","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106429_bb0130","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fneur.2018.00056","article-title":"Light and cognition: roles for circadian rhythms, sleep, and arousal","volume":"9","author":"Fisk","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2024.106429_bb0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3233\/JAD-2012-112186","article-title":"Evidence that the amyloid-beta protein precursor intracellular domain, AICD, derives from beta-secretase-generated C-terminal fragment","volume":"30","author":"Flammang","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2024.106429_bb0140","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1001\/archneur.59.9.1381","article-title":"Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease","volume":"59","author":"Fukumoto","year":"2002","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2024.106429_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069363","article-title":"Turnover of amyloid precursor protein family members determines their nuclear signaling capability","volume":"8","author":"Gersbacher","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2024.106429_bb0150","doi-asserted-by":"crossref","first-page":"18367","DOI":"10.1073\/pnas.0907652106","article-title":"Alzheimer\u2019s disease-like pathological features in transgenic mice expressing the APP intracellular domain","volume":"106","author":"Ghosal","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106429_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011609","article-title":"Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer\u2019s disease-like traits in vivo","volume":"5","author":"Giliberto","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2024.106429_bb0160","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1242\/jcs.048090","article-title":"Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway","volume":"122","author":"Goodger","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2024.106429_bb0165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000434629","article-title":"Sleep and cognitive decline: a strong bidirectional relationship. It is time for specific recommendations on routine assessment and the Management of Sleep Disorders in patients with mild cognitive impairment and dementia","volume":"74","author":"Guarnieri","year":"2015","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.nbd.2024.106429_bb0170","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/psyg.12319","article-title":"Sleep disorders in the elderly: a growing challenge","volume":"18","author":"Gulia","year":"2018","journal-title":"Psychogeriatrics."},{"key":"10.1016\/j.nbd.2024.106429_bb0175","doi-asserted-by":"crossref","first-page":"R714","DOI":"10.1016\/j.cub.2005.08.019","article-title":"The circadian timekeeping system of Drosophila","volume":"15","author":"Hardin","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.nbd.2024.106429_bb0180","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.conb.2013.05.004","article-title":"Circadian clocks and neurodegenerative diseases: time to aggregate?","volume":"23","author":"Hastings","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106429_bb0185","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-ento-020117-043201","article-title":"Sleep in Insects","volume":"63","author":"Helfrich-Forster","year":"2018","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.nbd.2024.106429_bb0190","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0896-6273(01)00277-X","article-title":"The circadian clock of fruit flies is blind after elimination of all known photoreceptors","volume":"30","author":"Helfrich-Forster","year":"2001","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2024.106429_bb0195","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0896-6273(00)80877-6","article-title":"Rest in Drosophila is a sleep-like state","volume":"25","author":"Hendricks","year":"2000","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2024.106429_bb0200","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/0748730402239673","article-title":"Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster","volume":"18","author":"Hendricks","year":"2003","journal-title":"J. Biol. Rhythm."},{"key":"10.1016\/j.nbd.2024.106429_bb0205","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/ana.10208","article-title":"Increased expression of the amyloid precursor beta-secretase in Alzheimer\u2019s disease","volume":"51","author":"Holsinger","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2024.106429_bb0210","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nature04811","article-title":"Sleep in Drosophila is regulated by adult mushroom bodies","volume":"441","author":"Joiner","year":"2006","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2024.106429_bb0215","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle","volume":"326","author":"Kang","year":"2009","journal-title":"Science."},{"key":"10.1016\/j.nbd.2024.106429_bb0220","doi-asserted-by":"crossref","first-page":"40288","DOI":"10.1074\/jbc.C100447200","article-title":"The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner","volume":"276","author":"Kimberly","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2024.106429_bb0225","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1523\/JNEUROSCI.2009-15.2015","article-title":"The APP intracellular domain is required for Normal synaptic morphology, synaptic plasticity, and Hippocampus-dependent behavior","volume":"35","author":"Klevanski","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106429_bb0230","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrn3208","article-title":"The circadian clock and pathology of the ageing brain","volume":"13","author":"Kondratova","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2024.106429_bb0235","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/156720512799361673","article-title":"AICD nuclear signaling and its possible contribution to Alzheimer\u2019s disease","volume":"9","author":"Konietzko","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.nbd.2024.106429_bb0240","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2217\/nmt.14.33","article-title":"The sleep-wake cycle and Alzheimer\u2019s disease: what do we know?","volume":"4","author":"Lim","year":"2014","journal-title":"Neurodegener Dis. Manag."},{"key":"10.1016\/j.nbd.2024.106429_bb0245","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3389\/fphys.2017.01131","article-title":"Age-related changes in the expression of the circadian clock protein PERIOD in Drosophila glial cells","volume":"8","author":"Long","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.nbd.2024.106429_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106068","article-title":"Relationships between the circadian system and Alzheimer\u2019s disease-like symptoms in Drosophila","volume":"9","author":"Long","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2024.106429_bb0255","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1523\/JNEUROSCI.10-12-03849.1990","article-title":"Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor","volume":"10","author":"Luo","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106429_bb0260","doi-asserted-by":"crossref","first-page":"5758","DOI":"10.1038\/s41467-021-26031-2","article-title":"Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling","volume":"12","author":"Machado Almeida","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2024.106429_bb0265","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.525970","article-title":"Local sleep and Alzheimer\u2019s disease pathophysiology","volume":"14","author":"Mander","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2024.106429_bb0270","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fphar.2015.00029","article-title":"Circadian clock disruption in neurodegenerative diseases: cause and effect?","volume":"6","author":"Musiek","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.nbd.2024.106429_bb0275","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1172\/JCI70317","article-title":"Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration","volume":"123","author":"Musiek","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2024.106429_bb0280","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s12576-016-0439-2","article-title":"The suprachiasmatic nucleus: age-related decline in biological rhythms","volume":"66","author":"Nakamura","year":"2016","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.nbd.2024.106429_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-014-1347-2","article-title":"The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes","volume":"129","author":"Nhan","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2024.106429_bb0290","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.neurobiolaging.2006.06.023","article-title":"Alpha- and beta-secretase activity as a function of age and beta-amyloid in down syndrome and normal brain","volume":"28","author":"Nistor","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2024.106429_bb0295","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/417329a","article-title":"Circadian rhythms from flies to human","volume":"417","author":"Panda","year":"2002","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2024.106429_bb0300","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.neuron.2008.10.042","article-title":"PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit","volume":"60","author":"Parisky","year":"2008","journal-title":"Neuron."},{"key":"10.1016\/j.nbd.2024.106429_bb0305","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1534\/genetics.112.144667","article-title":"Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep","volume":"192","author":"Pirooznia","year":"2012","journal-title":"Genetics."},{"key":"10.1016\/j.nbd.2024.106429_bb0310","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nature04739","article-title":"A dynamic role for the mushroom bodies in promoting sleep in Drosophila","volume":"441","author":"Pitman","year":"2006","journal-title":"Nature."},{"key":"10.1016\/j.nbd.2024.106429_bb0315","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.25659","article-title":"Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein","volume":"6","author":"Pousinha","year":"2017","journal-title":"Elife."},{"key":"10.1016\/j.nbd.2024.106429_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.08.103","article-title":"The amyloid precursor protein C-terminal domain alters CA1 neuron firing, modifying Hippocampus oscillations and impairing spatial memory encoding","volume":"29","author":"Pousinha","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2024.106429_bb0325","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fnmol.2016.00130","article-title":"Amyloid precursor proteins are dynamically trafficked and processed during neuronal development","volume":"9","author":"Ramaker","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2024.106429_bb0330","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tcb.2009.10.005","article-title":"Healthy clocks, healthy body, healthy mind","volume":"20","author":"Reddy","year":"2010","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.nbd.2024.106429_bb0335","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0092-8674(00)81676-1","article-title":"A PDF neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila","volume":"99","author":"Renn","year":"1999","journal-title":"Cell."},{"issue":"817\u2013823","key":"10.1016\/j.nbd.2024.106429_bb0340","article-title":"Drosophila full-length amyloid precursor protein is required for visual working memory and prevents age-related memory impairment","volume":"28","author":"Rieche","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.nbd.2024.106429_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076094","article-title":"Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation","volume":"8","author":"Riese","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2024.106429_bb0350","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/neu.480220503","article-title":"Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development","volume":"22","author":"Robinow","year":"1991","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106429_bb0355","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1084\/jem.20141788","article-title":"Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer\u2019s disease","volume":"211","author":"Roh","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2024.106429_bb0360","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1083\/jcb.200505078","article-title":"Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain","volume":"171","author":"Ryan","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2024.106429_bb0365","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11910-017-0745-y","article-title":"Circadian disruption associated with Alzheimer\u2019s disease","volume":"17","author":"Saeed","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.nbd.2024.106429_bb0370","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2024.106429_bb0375","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2174\/18756190MTA21MjAf3","article-title":"Circadian rhythm disruption and Alzheimer\u2019s disease: the dynamics of a vicious cycle","volume":"19","author":"Sharma","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.nbd.2024.106429_bb0380","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1126\/science.287.5459.1834","article-title":"Correlates of sleep and waking in Drosophila melanogaster","volume":"287","author":"Shaw","year":"2000","journal-title":"Science."},{"key":"10.1016\/j.nbd.2024.106429_bb0385","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1128\/MCB.00030-10","article-title":"In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity","volume":"30","author":"Stempfle","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2024.106429_bb0390","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.586013","article-title":"Influence of aging on the retina and visual motion processing for optokinetic responses in mice","volume":"14","author":"Sugita","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2024.106429_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(03)00089-3","article-title":"Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory","volume":"70","author":"Turner","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106429_bb0400","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.neurobiolaging.2009.09.002","article-title":"Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain","volume":"32","author":"Vogt","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2024.106429_bb0405","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41386-019-0478-5","article-title":"Bidirectional relationship between sleep and Alzheimer\u2019s disease: role of amyloid, tau, and other factors","volume":"45","author":"Wang","year":"2020","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.nbd.2024.106429_bb0410","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1055\/s-0037-1604351","article-title":"Sleep disturbance, cognitive decline, and dementia: a review","volume":"37","author":"Wennberg","year":"2017","journal-title":"Semin. Neurol."},{"key":"10.1016\/j.nbd.2024.106429_bb0415","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.nbd.2011.12.047","article-title":"Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration","volume":"46","author":"Wentzell","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106429_bb0420","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12877-019-1408-4","article-title":"Daytime napping and successful aging among older adults in China: a cross-sectional study","volume":"20","author":"Xin","year":"2020","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.nbd.2024.106429_bb0425","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.944283","article-title":"Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer\u2019s disease","volume":"14","author":"Xiong","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2024.106429_bb0430","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1534\/genetics.114.171660","article-title":"Epigenetic control of learning and memory in Drosophila by Tip60 HAT action","volume":"198","author":"Xu","year":"2014","journal-title":"Genetics."},{"key":"10.1016\/j.nbd.2024.106429_bb0435","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/nm0103-3","article-title":"Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease","volume":"9","author":"Yang","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2024.106429_bb0440","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cger.2018.01.008","article-title":"Sleep disorders in the elderly","volume":"34","author":"Yaremchuk","year":"2018","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.nbd.2024.106429_bb0445","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.psc.2015.07.010","article-title":"Sleep disturbances in the elderly","volume":"38","author":"Zdanys","year":"2015","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.nbd.2024.106429_bb0450","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbrc.2011.07.040","article-title":"Wnt\/beta-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity","volume":"412","author":"Zhou","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124000287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124000287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:42:16Z","timestamp":1760852536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996124000287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":90,"alternative-id":["S0969996124000287"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106429","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The amyloid precursor protein intracellular domain induces sleep disruptions and its nuclear localization fluctuates in circadian pacemaker neurons in Drosophila and mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106429","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106429"}}