{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:53:24Z","timestamp":1781902404075,"version":"3.54.5"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA9550-17-1-0193"],"award-info":[{"award-number":["FA9550-17-1-0193"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P01NS092525"],"award-info":[{"award-number":["5P01NS092525"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.nbd.2024.106502","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T12:03:42Z","timestamp":1712750622000},"page":"106502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease"],"prefix":"10.1016","volume":"195","author":[{"given":"Yingli","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Pope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Carmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Johnstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarai","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire Cecile","family":"Bacon-Brenes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Shoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korbin M.","family":"Kleczko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Frydman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Mobley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2024.106502_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.689332","article-title":"Huntingtin and the synapse","volume":"15","author":"Barron","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2024.106502_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105574","article-title":"Synaptic pathology in Huntington\u2019s disease: beyond the corticostriatal pathway","volume":"162","author":"Barry","year":"2022","journal-title":"Neurobiol. Dis."},{"issue":"254","key":"10.1016\/j.nbd.2024.106502_bb0015","article-title":"BDNF signaling and survival of striatal neurons","volume":"8","author":"Baydyuk","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"7154","key":"10.1016\/j.nbd.2024.106502_bb0020","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature06022","article-title":"Global changes to the ubiquitin system in Huntington\u2019s disease","volume":"448","author":"Bennett","year":"2007","journal-title":"Nature"},{"issue":"82","key":"10.1016\/j.nbd.2024.106502_bb0025","article-title":"Cortical and striatal circuits in Huntington\u2019s disease","volume":"14","author":"Blumenstock","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2024.106502_bb0030","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1196\/annals.1427.018","article-title":"Mitochondria and Huntington\u2019s disease pathogenesis: insight from genetic and chemical models","volume":"1147","author":"Browne","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2024.106502_bb0035","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nbd.2015.12.009","article-title":"Impaired development of cortico-striatal synaptic connectivity in a cell culture model of Huntington\u2019s disease","volume":"87","author":"Buren","year":"2016","journal-title":"Neurobiol. Dis."},{"issue":"10","key":"10.1016\/j.nbd.2024.106502_bb0040","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrd.2018.133","article-title":"Therapeutic approaches to Huntington disease: from the bench to the clinic","volume":"17","author":"Caron","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0045","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1073858420972662","article-title":"Synaptic dysfunction in Huntington\u2019s disease: lessons from genetic animal models","volume":"28","author":"Cepeda","year":"2022","journal-title":"Neuroscientist"},{"key":"10.1016\/j.nbd.2024.106502_bb0050","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3389\/fnmol.2018.00478","article-title":"Altered synaptic vesicle release and ca(2+) influx at single presynaptic terminals of cortical neurons in a Knock-in mouse model of Huntington\u2019s disease","volume":"11","author":"Chen","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2024.106502_bb0055","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.pharmthera.2018.11.006","article-title":"Synaptic dysfunction in Alzheimer\u2019s disease: mechanisms and therapeutic strategies","volume":"195","author":"Chen","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.nbd.2024.106502_bb0060","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1523\/JNEUROSCI.17-07-02295.1997","article-title":"Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport","volume":"17","author":"Conner","year":"1997","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2024.106502_bb0065","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1152\/jn.00093.2016","article-title":"A comparison of computational methods for detecting bursts in neuronal spike trains and their application to human stem cell-derived neuronal networks","volume":"116","author":"Cotterill","year":"2016","journal-title":"J. Neurophysiol."},{"issue":"2\u20133","key":"10.1016\/j.nbd.2024.106502_bb0070","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainresbull.2006.10.016","article-title":"Abnormal cortical synaptic plasticity in a mouse model of Huntington\u2019s disease","volume":"72","author":"Cummings","year":"2007","journal-title":"Brain Res. Bull."},{"issue":"4","key":"10.1016\/j.nbd.2024.106502_bb0075","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000322540","article-title":"Impaired long-term potentiation in the prefrontal cortex of Huntington\u2019s disease mouse models: rescue by D1 dopamine receptor activation","volume":"8","author":"Dallerac","year":"2011","journal-title":"Neurodegener. Dis."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0080","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1038\/s41598-017-04232-4","article-title":"Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson\u2019s disease","volume":"7","author":"Fang","year":"2017","journal-title":"Sci. Rep."},{"issue":"1\u20132","key":"10.1016\/j.nbd.2024.106502_bb0085","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0006-8993(00)02237-X","article-title":"Brain-derived neurotrophic factor in Huntington disease","volume":"866","author":"Ferrer","year":"2000","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.nbd.2024.106502_bb0090","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007476","article-title":"Huntington\u2019s disease","volume":"3","author":"Finkbeiner","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0095","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s13311-013-0244-z","article-title":"Treatment of Huntington's disease","volume":"11","author":"Frank","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2024.106502_bb0100","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1146\/annurev.biochem.70.1.603","article-title":"Folding of newly translated proteins in vivo: the role of molecular chaperones","volume":"70","author":"Frydman","year":"2001","journal-title":"Annu. Rev. Biochem."},{"issue":"13","key":"10.1016\/j.nbd.2024.106502_bb0105","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1002\/j.1460-2075.1992.tb05582.x","article-title":"Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits","volume":"11","author":"Frydman","year":"1992","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0110","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.nbd.2024.106502_bb0115","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.cell.2019.03.012","article-title":"The chaperonin TRiC\/CCT associates with Prefoldin through a conserved electrostatic Interface essential for cellular Proteostasis","volume":"177","author":"Gestaut","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1750-1326-6-71","article-title":"Conditional BDNF release under pathological conditions improves Huntington\u2019s disease pathology by delaying neuronal dysfunction","volume":"6","author":"Giralt","year":"2011","journal-title":"Mol. Neurodegener."},{"issue":"24","key":"10.1016\/j.nbd.2024.106502_bb0125","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice","volume":"28","author":"Gray","year":"2008","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2024.106502_bb0130","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"Group, T. H. s. D. C. R","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2024.106502_bb0135","doi-asserted-by":"crossref","first-page":"12646","DOI":"10.1038\/ncomms12646","article-title":"VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington\u2019s disease","volume":"7","author":"Guo","year":"2016","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.nbd.2024.106502_bb0140","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1002\/j.1460-2075.1990.tb07423.x","article-title":"Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain","volume":"9","author":"Hofer","year":"1990","journal-title":"EMBO J."},{"issue":"34","key":"10.1016\/j.nbd.2024.106502_bb0145","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.1523\/JNEUROSCI.0168-16.2016","article-title":"Mutant huntingtin impairs BDNF release from astrocytes by disrupting conversion of Rab3a-GTP into Rab3a-GDP","volume":"36","author":"Hong","year":"2016","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0150","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00441-020-03278-7","article-title":"Local TrkB signaling: themes in development and neural plasticity","volume":"382","author":"Johnstone","year":"2020","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.nbd.2024.106502_bb0155","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/843206","article-title":"Functional subunits of eukaryotic chaperonin CCT\/TRiC in protein folding","volume":"2011","author":"Kabir","year":"2011","journal-title":"J. Amino Acids"},{"issue":"8","key":"10.1016\/j.nbd.2024.106502_bb0160","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1073\/pnas.1119472109","article-title":"Subunit order of eukaryotic TRiC\/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling","volume":"109","author":"Kalisman","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"22","key":"10.1016\/j.nbd.2024.106502_bb0165","doi-asserted-by":"crossref","first-page":"12893","DOI":"10.1073\/pnas.96.22.12893","article-title":"Activity-dependent regulation of synaptic clustering in a hippocampal culture system","volume":"96","author":"Kavalali","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"10","key":"10.1016\/j.nbd.2024.106502_bb0170","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/ncb1478","article-title":"Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state","volume":"8","author":"Kitamura","year":"2006","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.nbd.2024.106502_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094562","article-title":"Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97\/18 mouse model of Huntington disease","volume":"9","author":"Kolodziejczyk","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2024.106502_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.785703","article-title":"Innovative therapeutic approaches for Huntington\u2019s disease: from nucleic acids to GPCR-targeting small molecules","volume":"15","author":"Komatsu","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/JHD-170282","article-title":"HttQ111\/+ Huntington\u2019s disease Knock-in mice exhibit brain region-specific morphological changes and synaptic dysfunction","volume":"7","author":"Kovalenko","year":"2018","journal-title":"J. Huntingtons Dis."},{"key":"10.1016\/j.nbd.2024.106502_bb0190","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/978-1-4939-7825-0_23","article-title":"Translating antisense technology into a treatment for Huntington\u2019s disease","volume":"1780","author":"Lane","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.nbd.2024.106502_bb0195","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1038\/ncomms3753","article-title":"Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress","volume":"4","author":"Leitman","year":"2013","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.nbd.2024.106502_bb0200","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.str.2012.03.007","article-title":"The molecular architecture of the eukaryotic chaperonin TRiC\/CCT","volume":"20","author":"Leitner","year":"2012","journal-title":"Structure"},{"issue":"6","key":"10.1016\/j.nbd.2024.106502_bb0205","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/jnc.13713","article-title":"Synaptopathies: synaptic dysfunction in neurological disorders - a review from students to students","volume":"138","author":"Lepeta","year":"2016","journal-title":"J. Neurochem."},{"issue":"10","key":"10.1016\/j.nbd.2024.106502_bb0210","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.molmed.2003.08.006","article-title":"Huntington\u2019s disease: a synaptopathy?","volume":"9","author":"Li","year":"2003","journal-title":"Trends Mol. Med."},{"issue":"5","key":"10.1016\/j.nbd.2024.106502_bb0215","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0166-2236(94)90099-X","article-title":"Neurotrophic factors: from molecule to man","volume":"17","author":"Lindsay","year":"1994","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2024.106502_bb0220","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-3-642-45106-5_9","article-title":"BDNF and synaptic plasticity, cognitive function, and dysfunction","volume":"220","author":"Lu","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"issue":"20","key":"10.1016\/j.nbd.2024.106502_bb0225","first-page":"3743","article-title":"Axonal ER ca<sup>2+<\/sup> release selectively enhances activity-independent glutamate release in a Huntington disease model","volume":"43","author":"Mackay","year":"2023","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.nbd.2024.106502_bb0230","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0896-6273(90)90089-X","article-title":"NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression","volume":"5","author":"Maisonpierre","year":"1990","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.nbd.2024.106502_bb0235","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3390\/ijms23020780","article-title":"Impact of ER stress and ER-mitochondrial crosstalk in huntington\u2019s disease","volume":"23","author":"Maity","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.nbd.2024.106502_bb0240","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0245","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s disease: a clinical review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"issue":"Pt 3","key":"10.1016\/j.nbd.2024.106502_bb0250","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1113\/jphysiol.2007.142448","article-title":"Corticostriatal synaptic function in mouse models of Huntington\u2019s disease: early effects of huntingtin repeat length and protein load","volume":"585","author":"Milnerwood","year":"2007","journal-title":"J. Physiol."},{"issue":"10","key":"10.1016\/j.nbd.2024.106502_bb0255","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/hmg\/ddl092","article-title":"Early development of aberrant synaptic plasticity in a mouse model of Huntington\u2019s disease","volume":"15","author":"Milnerwood","year":"2006","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.nbd.2024.106502_bb0260","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0361-9230(01)00611-6","article-title":"Abnormalities in the synaptic vesicle fusion machinery in Huntington\u2019s disease","volume":"56","author":"Morton","year":"2001","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2024.106502_bb0265","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.77455","article-title":"BDNF\/TrkB signaling endosomes in axons coordinate CREB\/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons","volume":"12","author":"Moya-Alvarado","year":"2023","journal-title":"eLife"},{"issue":"13","key":"10.1016\/j.nbd.2024.106502_bb0270","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1523\/JNEUROSCI.20-13-05115.2000","article-title":"Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington\u2019s disease mutation","volume":"20","author":"Murphy","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106502_bb0275","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuroscience.2012.05.043","article-title":"Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington\u2019s disease","volume":"251","author":"Nithianantharajah","year":"2013","journal-title":"Neuroscience"},{"issue":"17","key":"10.1016\/j.nbd.2024.106502_bb0280","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1073\/pnas.0307697101","article-title":"Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation","volume":"101","author":"Nollen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"16","key":"10.1016\/j.nbd.2024.106502_bb0285","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1523\/JNEUROSCI.4998-12.2013","article-title":"Acute suppression of spontaneous neurotransmission drives synaptic potentiation","volume":"33","author":"Nosyreva","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106502_bb0290","series-title":"International Review of Neurobiology","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/B978-0-12-381328-2.00013-4","article-title":"Huntington\u2019s disease: Clinical presentation and treatment","volume":"vol. 98","author":"Novak","year":"2011"},{"issue":"3","key":"10.1016\/j.nbd.2024.106502_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11910-021-01093-3","article-title":"Huntington\u2019s disease: new frontiers in therapeutics","volume":"21","author":"Pan","year":"2021","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0300","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"Park","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0305","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11263-013-0615-2","article-title":"Coupling image restoration and segmentation: a generalized linear model\/Bregman perspective","volume":"104","author":"Paul","year":"2013","journal-title":"Int. J. Comput. Vis."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0310","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2014.05.032","article-title":"Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington\u2019s disease","volume":"83","author":"Plotkin","year":"2014","journal-title":"Neuron"},{"issue":"25","key":"10.1016\/j.nbd.2024.106502_bb0315","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1093\/hmg\/ddv426","article-title":"A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington\u2019s disease","volume":"24","author":"Puigdellivol","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.nbd.2024.106502_bb0320","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nprot.2014.037","article-title":"Segmentation and quantification of subcellular structures in fluorescence microscopy images using Squassh","volume":"9","author":"Rizk","year":"2014","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0325","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/hmg\/ddl440","article-title":"The first 17 amino acids of huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis","volume":"16","author":"Rockabrand","year":"2007","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.nbd.2024.106502_bb0330","doi-asserted-by":"crossref","first-page":"26706","DOI":"10.3390\/ijms161125975","article-title":"Contribution of the type II chaperonin, TRiC\/CCT, to oncogenesis","volume":"16","author":"Roh","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106502_bb0335","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington\u2019s disease: a clinical review","volume":"5","author":"Roos","year":"2010","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.nbd.2024.106502_bb0340","doi-asserted-by":"crossref","DOI":"10.1017\/S0033583515000219","article-title":"Delayed emergence of subdiffraction-sized mutant huntingtin fibrils following inclusion body formation","volume":"49","author":"Sahl","year":"2016","journal-title":"Q. Rev. Biophys."},{"issue":"4","key":"10.1016\/j.nbd.2024.106502_bb0345","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.pneurobio.2010.08.004","article-title":"Regulation of local translation at the synapse by BDNF","volume":"92","author":"Santos","year":"2010","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.nbd.2024.106502_bb0350","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/mds.26620","article-title":"Early synaptic dysfunction in Parkinson\u2019s disease: insights from animal models","volume":"31","author":"Schirinzi","year":"2016","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0355","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12915-018-0526-3","article-title":"Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease","volume":"16","author":"Schmidt","year":"2018","journal-title":"BMC Biol."},{"issue":"5594","key":"10.1016\/j.nbd.2024.106502_bb0360","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer\u2019s disease is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.nbd.2024.106502_bb0365","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/0896-6273(95)90345-3","article-title":"Widespread expression of Huntington\u2019s disease gene (IT15) protein product","volume":"14","author":"Sharp","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106502_bb0370","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18065","article-title":"Control of the structural landscape and neuronal proteotoxicity of mutant huntingtin by domains flanking the polyQ tract","volume":"5","author":"Shen","year":"2016","journal-title":"eLife"},{"issue":"4","key":"10.1016\/j.nbd.2024.106502_bb0375","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/jnc.14723","article-title":"Alterations in synaptic function and plasticity in Huntington disease","volume":"150","author":"Smith-Dijak","year":"2019","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.nbd.2024.106502_bb0380","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.1222663110","article-title":"Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant huntingtin cellular phenotypes","volume":"110","author":"Sontag","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.nbd.2024.106502_bb0385","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1074\/jbc.M113.526129","article-title":"Brain-derived neurotrophic factor (BDNF)-induced mitochondrial motility arrest and presynaptic docking contribute to BDNF-enhanced synaptic transmission","volume":"289","author":"Su","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2024.106502_bb0390","series-title":"Synaptic Loss and Neurodegeneration","first-page":"681029","volume":"vol. 15","author":"Subramanian","year":"2021"},{"issue":"10","key":"10.1016\/j.nbd.2024.106502_bb0395","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/ncb1477","article-title":"The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions","volume":"8","author":"Tam","year":"2006","journal-title":"Nat. Cell Biol."},{"issue":"12","key":"10.1016\/j.nbd.2024.106502_bb0400","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nsmb.1700","article-title":"The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation","volume":"16","author":"Tam","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"9","key":"10.1016\/j.nbd.2024.106502_bb0405","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.180138","article-title":"Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models","volume":"8","author":"Taoufik","year":"2018","journal-title":"Open Biol."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0410","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/emboj\/18.1.85","article-title":"In vivo newly translated polypeptides are sequestered in a protected folding environment","volume":"18","author":"Thulasiraman","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2024.106502_bb0415","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.conb.2017.10.019","article-title":"Molecular insights into cortico-striatal miscommunications in Huntington\u2019s disease","volume":"48","author":"Veldman","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0420","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.celrep.2017.12.013","article-title":"Reconstituting Corticostriatal network on-a-Chip reveals the contribution of the presynaptic compartment to Huntington\u2019s disease","volume":"22","author":"Virlogeux","year":"2018","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.nbd.2024.106502_bb0425","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"9557","key":"10.1016\/j.nbd.2024.106502_bb0430","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0435","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s41467-023-36096-w","article-title":"CryoET reveals organelle phenotypes in Huntington disease patient iPSC-derived and mouse primary neurons","volume":"14","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"issue":"44","key":"10.1016\/j.nbd.2024.106502_bb0440","doi-asserted-by":"crossref","first-page":"14708","DOI":"10.1523\/JNEUROSCI.1637-10.2010","article-title":"BDNF overexpression in the forebrain rescues Huntington\u2019s disease phenotypes in YAC128 mice","volume":"30","author":"Xie","year":"2010","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2024.106502_bb0445","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0306-4522(96)00613-6","article-title":"Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system","volume":"78","author":"Yan","year":"1997","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.nbd.2024.106502_bb0450","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/dneu.20765","article-title":"Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease","volume":"70","author":"Yoshii","year":"2010","journal-title":"Dev. Neurobiol."},{"issue":"1","key":"10.1016\/j.nbd.2024.106502_bb0455","doi-asserted-by":"crossref","first-page":"16976","DOI":"10.1038\/s41598-018-34883-w","article-title":"Decreased BDNF release in cortical neurons of a Knock-in mouse model of Huntington\u2019s disease","volume":"8","author":"Yu","year":"2018","journal-title":"Sci. Rep."},{"issue":"38","key":"10.1016\/j.nbd.2024.106502_bb0460","doi-asserted-by":"crossref","first-page":"E5655","DOI":"10.1073\/pnas.1603020113","article-title":"TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington\u2019s disease","volume":"113","author":"Zhao","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5\u20136","key":"10.1016\/j.nbd.2024.106502_bb0465","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","article-title":"Role of brain-derived neurotrophic factor in Huntington\u2019s disease","volume":"81","author":"Zuccato","year":"2007","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.nbd.2024.106502_bb0470","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrneurol.2009.54","article-title":"Brain-derived neurotrophic factor in neurodegenerative diseases","volume":"5","author":"Zuccato","year":"2009","journal-title":"Nat. Rev. Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124001013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124001013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:49:19Z","timestamp":1778518159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996124001013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":94,"alternative-id":["S0969996124001013"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106502","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.11.25.517123","asserted-by":"object"}]},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106502"}}